Palmitoyl Tetrapeptide-7

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  • Identifiers

    CAS number
    221227-05-0

    Molecular formula
    C34H62N8O7

    SMILES
    CCCCCCCCCCCCCCCC(=O)NCC(=O)N[C@@H](CCC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)O

    Safety labels

  • Odor profile

    Fragrance
    Odorless 54.17%
    Savory 41.43%
    Cooling 34.17%
    Meaty 32.44%
    Fishy 27.24%
    Animal 20.21%
    Cooked 18.66%
    Milky 18.51%
    Oily 17.91%
    Mint 16.76%

     

    Flavor
    Bitter 52.72%
    Odorless 47.41%
    Bland 36.4%
    Mild 24.92%
    Sweet-like 20.91%
    Cedarleaf 19.53%
    Nitrile 19.43%
    Faint 19.05%
    Oriental 18.71%
    Lovage 18.44%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    3.6

    pKa est.
    3.34 (weak acid)

    Molecular weight
    694.9 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    1631°C

    Flash point

    • 312.66 ˚C est.

  • Synonyms

    • 221227-05-0
    • Palmitoyl tetrapeptide-7
    • N-Palmitoylrigin
    • Palmitoyl-GQPR
    • UNII-Q41S464P1R
    • DTXSID10176644
    • Q41S464P1R
    • l-Arginine, N-(1-oxohexadecyl)glycyl-l-glutaminyl-l-prolyl-
    • (2S)-2-(((2S)-1-((2S)-4-carbamoyl-2-(2-hexadecanamidoacetamido)butanoyl)pyrrolidin-2-yl)formamido)-5-((diaminomethylidene)amino)pentanoic acid
    • (2S)-2-{[(2S)-1-[(2S)-4-carbamoyl-2-(2-hexadecanamidoacetamido)butanoyl]pyrrolidin-2-yl]formamido}-5-[(diaminomethylidene)amino]pentanoic acid
    • RefChem:169743
    • DTXCID7099135
    • PALMITOYL TETRAPEPTIDE-7 [INCI]
    • Pal-Gly-Gln-Pro-Arg-OH
    • Palmitoyl Tetrapeptide-3
    • PALMITOYL TETRAPEPTIDE 3
    • MFCD11977710
    • (2S)-2-[[(2S)-1-[(2S)-5-amino-2-[[2-(hexadecanoylamino)acetyl]amino]-5-oxopentanoyl]pyrrolidine-2-carbonyl]amino]-5-(diaminomethylideneamino)pentanoic acid
    • Palmitoyl tetrapeptide 7
    • Palmitoyl tetrapeptide-7?
    • orb1296779
    • SCHEMBL1163313
    • SCHEMBL29376047
    • IHRKJQSLKLYWBQ-QKDODKLFSA-N
    • C34H62N8O7
    • Palmitoyl Tetrapeptide-7 (Powder)
    • HY-P0064
    • Palmitoyl Tetrapeptide-7 (Liquid)
    • MFCD28975964
    • AKOS030528646
    • AKOS040763877
    • DB14137
    • FR73584
    • DA-76572
    • DS-19563
    • FP146820
    • SY253681
    • CS-0015089
    • NS00073471
    • C74122
    • palmitoylglycyl-L-glutaminyl-L-prolyl-L-arginine
    • Q27286972
    • N-Hexadecanoylglycyl-L-glutaminyl-L-prolyl-N~5~-(diaminomethylidene)-L-ornithine
    • (2S)-2-[[(2S)-1-[(2S)-5-amino-2-[[2-(hexadecanoylamino)acetyl]amino]-5-oxo-pentanoyl]pyrrolidine-2-carbonyl]amino]-5-guanidino-pentanoic acid
    • (S)-2-[(S)-1-[(S)-5-Amino-5-oxo-2-(2-palmitamidoacetamido)pentanoyl]pyrrolidine-2-carboxamido]-5-[(diaminomethylene)amino]pentanoic Acid
    • 221227-05-0

  • Applications

    Palmitoyl Tetrapeptide-7 (CAS 221227-05-0) is primarily used in cosmetics and personal care as a lipophilic peptide active incorporated into serums, creams, and gels to support skin matrix remodeling, stimulate collagen production, and modestly modulate inflammatory processes. It is also evaluated for topical dermatology and pharmaceutical formulations and is commonly studied in research contexts related to wound healing and tissue repair, rather than as a proven therapeutic. In formulation development, it can serve as a lipid-anchored peptide building block for integration into lipid-based delivery systems and carrier matrices to enhance compatibility and performance of skin-care products. The peptide is sometimes explored in biomaterials and surface-functionalization research for skin-contact coatings and hydrogels, where peptide conjugation may influence biocompatibility and bioactivity in experimental settings.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 4.58
    methanol 15.85
    isopropanol 1.85
    water 2.9
    ethyl acetate 2.29
    n-propanol 2.86
    acetone 5.04
    n-butanol 1.66
    acetonitrile 2.04
    DMF 32.56
    toluene 0.55
    isobutanol 1.24
    1,4-dioxane 3.2
    methyl acetate 3.37
    THF 6.92
    2-butanone 4.06
    n-pentanol 1.45
    sec-butanol 1.58
    n-hexane 0.09
    ethylene glycol 6.18
    NMP 62.61
    cyclohexane 0.06
    DMSO 44.45
    n-butyl acetate 1.23
    n-octanol 0.53
    chloroform 3.78
    n-propyl acetate 1.98
    acetic acid 37.54
    dichloromethane 4.4
    cyclohexanone 6.09
    propylene glycol 7.54
    isopropyl acetate 1.4
    DMAc 53.0
    2-ethoxyethanol 10.3
    isopentanol 0.88
    n-heptane 0.05
    ethyl formate 4.82
    1,2-dichloroethane 2.47
    n-hexanol 0.56
    2-methoxyethanol 18.93
    isobutyl acetate 0.94
    tetrachloromethane 0.94
    n-pentyl acetate 1.5
    transcutol 16.76
    n-heptanol 0.74
    ethylbenzene 0.35
    MIBK 1.08
    2-propoxyethanol 5.49
    tert-butanol 1.03
    MTBE 0.59
    2-butoxyethanol 5.41
    propionic acid 7.95
    o-xylene 0.48
    formic acid 58.53
    diethyl ether 0.76
    m-xylene 0.33
    p-xylene 0.53
    chlorobenzene 0.85
    dimethyl carbonate 4.82
    n-octane 0.04
    formamide 45.94
    cyclopentanone 10.82
    2-pentanone 2.51
    anisole 1.11
    cyclopentyl methyl ether 1.76
    gamma-butyrolactone 17.08
    1-methoxy-2-propanol 9.73
    pyridine 4.78
    3-pentanone 2.32
    furfural 21.69
    n-dodecane 0.02
    diethylene glycol 7.91
    diisopropyl ether 0.16
    tert-amyl alcohol 1.23
    acetylacetone 5.22
    n-hexadecane 0.02
    acetophenone 2.71
    methyl propionate 3.63
    isopentyl acetate 0.94
    trichloroethylene 6.14
    n-nonanol 0.57
    cyclohexanol 1.2
    benzyl alcohol 2.38
    2-ethylhexanol 0.31
    isooctanol 0.46
    dipropyl ether 0.55
    1,2-dichlorobenzene 1.06
    ethyl lactate 3.86
    propylene carbonate 8.7
    n-methylformamide 19.74
    2-pentanol 0.71
    n-pentane 0.06
    1-propoxy-2-propanol 3.25
    1-methoxy-2-propyl acetate 2.87
    2-(2-methoxypropoxy) propanol 4.56
    mesitylene 0.17
    ε-caprolactone 7.44
    p-cymene 0.18
    epichlorohydrin 9.83
    1,1,1-trichloroethane 1.57
    2-aminoethanol 8.92
    morpholine-4-carbaldehyde 31.16
    sulfolane 41.51
    2,2,4-trimethylpentane 0.03
    2-methyltetrahydrofuran 2.7
    n-hexyl acetate 1.32
    isooctane 0.01
    2-(2-butoxyethoxy)ethanol 6.2
    sec-butyl acetate 1.17
    tert-butyl acetate 1.16
    decalin 0.05
    glycerin 20.72
    diglyme 12.05
    acrylic acid 13.0
    isopropyl myristate 0.35
    n-butyric acid 6.69
    acetyl acetate 2.74
    di(2-ethylhexyl) phthalate 0.99
    ethyl propionate 1.89
    nitromethane 32.62
    1,2-diethoxyethane 1.77
    benzonitrile 1.55
    trioctyl phosphate 0.62
    1-bromopropane 0.8
    gamma-valerolactone 28.23
    n-decanol 0.36
    triethyl phosphate 1.27
    4-methyl-2-pentanol 0.31
    propionitrile 1.36
    vinylene carbonate 8.7
    1,1,2-trichlorotrifluoroethane 27.58
    DMS 2.48
    cumene 0.27
    2-octanol 0.39
    2-hexanone 2.15
    octyl acetate 0.68
    limonene 0.2
    1,2-dimethoxyethane 8.96
    ethyl orthosilicate 0.98
    tributyl phosphate 0.86
    diacetone alcohol 3.83
    N,N-dimethylaniline 1.15
    acrylonitrile 2.78
    aniline 1.76
    1,3-propanediol 8.33
    bromobenzene 0.68
    dibromomethane 1.8
    1,1,2,2-tetrachloroethane 5.39
    2-methyl-cyclohexyl acetate 1.0
    tetrabutyl urea 1.5
    diisobutyl methanol 0.14
    2-phenylethanol 1.16
    styrene 0.41
    dioctyl adipate 0.95
    dimethyl sulfate 15.88
    ethyl butyrate 1.26
    methyl lactate 8.58
    butyl lactate 3.34
    diethyl carbonate 0.95
    propanediol butyl ether 6.22
    triethyl orthoformate 1.31
    p-tert-butyltoluene 0.16
    methyl 4-tert-butylbenzoate 3.17
    morpholine 6.0
    tert-butylamine 0.34
    n-dodecanol 0.23
    dimethoxymethane 8.75
    ethylene carbonate 5.42
    cyrene 9.93
    2-ethoxyethyl acetate 3.37
    2-ethylhexyl acetate 0.71
    1,2,4-trichlorobenzene 1.66
    4-methylpyridine 3.35
    dibutyl ether 0.45
    2,6-dimethyl-4-heptanol 0.14
    DEF 6.25
    dimethyl isosorbide 5.5
    tetrachloroethylene 4.23
    eugenol 3.64
    triacetin 3.98
    span 80 3.4
    1,4-butanediol 4.09
    1,1-dichloroethane 1.6
    2-methyl-1-pentanol 0.97
    methyl formate 15.71
    2-methyl-1-butanol 1.14
    n-decane 0.05
    butyronitrile 1.13
    3,7-dimethyl-1-octanol 0.28
    1-chlorooctane 0.2
    1-chlorotetradecane 0.07
    n-nonane 0.04
    undecane 0.03
    tert-butylcyclohexane 0.03
    cyclooctane 0.03
    cyclopentanol 2.46
    tetrahydropyran 1.58
    tert-amyl methyl ether 0.7
    2,5,8-trioxanonane 7.06
    1-hexene 0.32
    2-isopropoxyethanol 4.6
    2,2,2-trifluoroethanol 22.01
    methyl butyrate 3.06

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction