Palmitoyl Serinol

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  • Identifiers

    CAS number
    126127-31-9

    Molecular formula
    C19H39NO3

    SMILES
    CCCCCCCCCCCCCCCC(=O)NC(CO)CO

    Safety labels

  • Odor profile

    Fragrance
    Waxy 39.34%
    Odorless 36.25%
    Fatty 31.6%
    Savory 31.42%
    Oily 31.41%
    Fishy 28.58%
    Meaty 26.55%
    Fresh 25.71%
    Cooling 24.91%
    Citrus 24.43%

     

    Flavor
    Odorless 37.73%
    Bland 37.04%
    Mild 35.32%
    Fatty 29.3%
    Waxy 26.67%
    Faint 26.5%
    Slightly waxy 22.55%
    Bay oil 21.49%
    Delicate 20.78%
    Beer 20.24%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    5.6

    pKa est.
    7.12 (neutral)

    Molecular weight
    329.5 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    461°C

    Flash point

    • 216.13 ˚C est.

  • Synonyms

    • Palmitoyl Serinol
    • N-(1,3-dihydroxypropan-2-yl)hexadecanamide
    • DTXSID80432042
    • RefChem:1094286
    • DTXCID40382872
    • 126127-31-9
    • N-Palmitoyl serinol
    • Neuromide
    • Hexadecanamide, N-[2-hydroxy-1-(hydroxymethyl)ethyl]-
    • N-Palmitoylserinol
    • N-(1,3-Dihydroxypropan-2-yl)palmitamide
    • Z0RQQ7PY44
    • N-(2-Hydroxy-1-(hydroxymethyl)ethyl)hexadecanamide
    • Hexadecanamide, N-(2-hydroxy-1-(hydroxymethyl)ethyl)-
    • N-[2-Hydroxy-1-(hydroxymethyl)ethyl]hexadecanamide
    • Palmitoylserinol
    • starbld0016658
    • UNII-Z0RQQ7PY44
    • N-Palmitoyl serinol [INCI]
    • SCHEMBL679967
    • orb1689077
    • CHEBI:178697
    • HMS3649C09
    • LMFA08020197
    • N-palmitoyl-2-amino-1,3-propanediol
    • AKOS027327155
    • 2-(hexadecanoylamino)propane-1,3-diol
    • DB-221253
    • HY-125407
    • CS-0091134
    • N-(1,3-dihydroxy-2-propanyl)hexadecanamide
    • SR-01000946558
    • SR-01000946558-1
    • N-[2-Hydroxy-1-(hydroxymethyl)ethyl]-Hexadecanamide
    • 126127-31-9

  • Applications

    Palmitoyl Serinol (CAS 126127-31-9) is primarily viewed as a lipid-like intermediate used in the synthesis of sphingolipid-like compounds and other complex lipid derivatives for cosmetic applications. In formulation practice, it can function as a mild surfactant/emulsifier to improve stability and dispersion in skin and hair care products. It is also employed as a conditioning/emollient component in personal care formulations and may be evaluated as an additive for polymers and coatings to modulate surface properties. Additionally, Palmitoyl Serinol may serve as a precursor for more advanced lipid derivatives used in agricultural formulations or industrial applications, subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 11.82
    methanol 27.09
    isopropanol 11.53
    water 0.13
    ethyl acetate 29.3
    n-propanol 14.87
    acetone 30.9
    n-butanol 16.84
    acetonitrile 10.38
    DMF 99.33
    toluene 10.31
    isobutanol 15.5
    1,4-dioxane 45.67
    methyl acetate 25.43
    THF 180.8
    2-butanone 37.8
    n-pentanol 17.8
    sec-butanol 16.7
    n-hexane 2.33
    ethylene glycol 3.07
    NMP 230.82
    cyclohexane 9.34
    DMSO 241.59
    n-butyl acetate 51.09
    n-octanol 22.46
    chloroform 98.29
    n-propyl acetate 62.47
    acetic acid 41.52
    dichloromethane 96.21
    cyclohexanone 165.56
    propylene glycol 8.96
    isopropyl acetate 40.1
    DMAc 196.48
    2-ethoxyethanol 54.56
    isopentanol 25.18
    n-heptane 2.94
    ethyl formate 27.56
    1,2-dichloroethane 74.45
    n-hexanol 16.15
    2-methoxyethanol 56.15
    isobutyl acetate 44.58
    tetrachloromethane 24.65
    n-pentyl acetate 86.42
    transcutol 252.28
    n-heptanol 22.96
    ethylbenzene 11.76
    MIBK 50.11
    2-propoxyethanol 50.2
    tert-butanol 31.91
    MTBE 29.54
    2-butoxyethanol 76.37
    propionic acid 31.25
    o-xylene 15.44
    formic acid 14.76
    diethyl ether 13.97
    m-xylene 11.77
    p-xylene 17.52
    chlorobenzene 25.33
    dimethyl carbonate 16.72
    n-octane 2.09
    formamide 26.62
    cyclopentanone 172.14
    2-pentanone 40.92
    anisole 28.0
    cyclopentyl methyl ether 68.41
    gamma-butyrolactone 172.9
    1-methoxy-2-propanol 58.94
    pyridine 47.36
    3-pentanone 34.87
    furfural 134.23
    n-dodecane 1.39
    diethylene glycol 30.31
    diisopropyl ether 10.32
    tert-amyl alcohol 34.86
    acetylacetone 71.16
    n-hexadecane 1.63
    acetophenone 55.1
    methyl propionate 31.42
    isopentyl acetate 58.19
    trichloroethylene 132.73
    n-nonanol 23.11
    cyclohexanol 43.19
    benzyl alcohol 27.72
    2-ethylhexanol 19.19
    isooctanol 25.0
    dipropyl ether 25.71
    1,2-dichlorobenzene 38.59
    ethyl lactate 39.37
    propylene carbonate 101.73
    n-methylformamide 34.37
    2-pentanol 14.46
    n-pentane 1.49
    1-propoxy-2-propanol 53.63
    1-methoxy-2-propyl acetate 62.53
    2-(2-methoxypropoxy) propanol 63.21
    mesitylene 11.52
    ε-caprolactone 143.6
    p-cymene 13.21
    epichlorohydrin 136.41
    1,1,1-trichloroethane 71.3
    2-aminoethanol 11.14
    morpholine-4-carbaldehyde 139.33
    sulfolane 393.02
    2,2,4-trimethylpentane 3.22
    2-methyltetrahydrofuran 92.84
    n-hexyl acetate 75.1
    isooctane 1.78
    2-(2-butoxyethoxy)ethanol 88.45
    sec-butyl acetate 46.45
    tert-butyl acetate 68.45
    decalin 5.73
    glycerin 22.06
    diglyme 200.39
    acrylic acid 25.51
    isopropyl myristate 22.32
    n-butyric acid 64.23
    acetyl acetate 30.08
    di(2-ethylhexyl) phthalate 27.37
    ethyl propionate 44.9
    nitromethane 74.07
    1,2-diethoxyethane 61.35
    benzonitrile 32.39
    trioctyl phosphate 21.56
    1-bromopropane 30.01
    gamma-valerolactone 238.63
    n-decanol 14.36
    triethyl phosphate 39.7
    4-methyl-2-pentanol 15.67
    propionitrile 14.26
    vinylene carbonate 73.01
    1,1,2-trichlorotrifluoroethane 151.14
    DMS 41.09
    cumene 11.82
    2-octanol 18.77
    2-hexanone 51.81
    octyl acetate 30.44
    limonene 21.64
    1,2-dimethoxyethane 117.32
    ethyl orthosilicate 39.6
    tributyl phosphate 28.77
    diacetone alcohol 90.42
    N,N-dimethylaniline 28.23
    acrylonitrile 18.07
    aniline 17.95
    1,3-propanediol 20.95
    bromobenzene 26.29
    dibromomethane 58.33
    1,1,2,2-tetrachloroethane 146.82
    2-methyl-cyclohexyl acetate 57.0
    tetrabutyl urea 43.37
    diisobutyl methanol 16.24
    2-phenylethanol 26.42
    styrene 12.59
    dioctyl adipate 46.55
    dimethyl sulfate 56.91
    ethyl butyrate 54.23
    methyl lactate 32.01
    butyl lactate 72.34
    diethyl carbonate 32.51
    propanediol butyl ether 65.62
    triethyl orthoformate 51.1
    p-tert-butyltoluene 13.25
    methyl 4-tert-butylbenzoate 74.59
    morpholine 76.58
    tert-butylamine 17.85
    n-dodecanol 9.8
    dimethoxymethane 41.64
    ethylene carbonate 65.04
    cyrene 84.93
    2-ethoxyethyl acetate 91.04
    2-ethylhexyl acetate 47.72
    1,2,4-trichlorobenzene 50.08
    4-methylpyridine 41.98
    dibutyl ether 33.47
    2,6-dimethyl-4-heptanol 16.24
    DEF 82.31
    dimethyl isosorbide 130.58
    tetrachloroethylene 99.34
    eugenol 65.37
    triacetin 94.98
    span 80 58.33
    1,4-butanediol 11.13
    1,1-dichloroethane 46.62
    2-methyl-1-pentanol 24.61
    methyl formate 24.56
    2-methyl-1-butanol 23.25
    n-decane 3.0
    butyronitrile 18.97
    3,7-dimethyl-1-octanol 23.35
    1-chlorooctane 17.47
    1-chlorotetradecane 4.95
    n-nonane 2.76
    undecane 1.9
    tert-butylcyclohexane 4.53
    cyclooctane 2.75
    cyclopentanol 49.13
    tetrahydropyran 65.79
    tert-amyl methyl ether 32.91
    2,5,8-trioxanonane 112.63
    1-hexene 7.86
    2-isopropoxyethanol 45.6
    2,2,2-trifluoroethanol 27.18
    methyl butyrate 78.82

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction