Palmitoyl Proline

Overview IFRA Request a quote

  • Identifiers

    CAS number
    59441-32-6

    Molecular formula
    C21H39NO3

    SMILES
    CCCCCCCCCCCCCCCC(=O)N1CCC[C@H]1C(=O)O

    Safety labels

  • Odor profile

    Fragrance
    Waxy 40.47%
    Odorless 36.05%
    Fatty 31.2%
    Oily 29.07%
    Woody 28.12%
    Herbal 28.06%
    Fresh 26.81%
    Savory 25.85%
    Citrus 25.81%
    Animal 25.7%

     

    Flavor
    Odorless 33.97%
    Bland 33.62%
    Mild 31.21%
    Fatty 30.52%
    Waxy 27.53%
    Faint 23.77%
    Slightly waxy 22.31%
    Oily 21.92%
    Bay oil 21.25%
    Herbal 21.17%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    7.4

    pKa est.
    6.77 (neutral)

    Molecular weight
    353.5 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    484°C

    Flash point

    • 222.58 ˚C est.

  • Synonyms

    • 59441-32-6
    • 1-(1-Oxohexadecyl)-L-proline
    • palmitoyl proline
    • L-Proline, 1-(1-oxohexadecyl)-
    • I49727TDYF
    • SEPIFEEL ONE
    • EINECS 261-763-5
    • N-PALMITOYL-L-PROLINE
    • RefChem:858433
    • PALMITOYL PROLINE [INCI]
    • 261-763-5
    • (S)-1-Palmitoylpyrrolidine-2-carboxylic acid
    • N-palmitoyl proline
    • MFCD00756936
    • (2S)-1-hexadecanoylpyrrolidine-2-carboxylic acid
    • n-palmitoylproline
    • 1-Hexadecanoyl-L-proline
    • UNII-I49727TDYF
    • N-hexadecanoyl-l-proline
    • SCHEMBL247341
    • DTXSID50974848
    • CHEBI:165557
    • LMFA08020117
    • AKOS025311511
    • (S)-1-Palmitoylpyrrolidine-2-carboxylicacid
    • NS00056513
    • A1-35584
    • Q27280415
    • 59441-32-6

  • Applications

    Palmitoyl proline (CAS 59441-32-6) is a lipophilic derivative of the amino acid proline and is often evaluated in cosmetics as a skin-conditioning peptide derivative, contributing to emollience and serving as a carrier for other actives when formulated as a palmitoylated peptide. It is also used as an intermediate in peptide synthesis for pharmaceutical and cosmetic development. In coatings and adhesives, it can function as a surface-modifying additive or a surfactant to improve compatibility with lipophilic components. Additionally, in specialty formulations, it may serve as a carrier or solubilizer for fragrance or other actives, subject to regulatory constraints.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 207.26
    methanol 291.84
    isopropanol 184.96
    water 0.62
    ethyl acetate 363.52
    n-propanol 204.55
    acetone 349.73
    n-butanol 191.88
    acetonitrile 167.04
    DMF 645.52
    toluene 120.68
    isobutanol 166.23
    1,4-dioxane 298.43
    methyl acetate 274.31
    THF 805.66
    2-butanone 392.14
    n-pentanol 136.97
    sec-butanol 193.11
    n-hexane 10.65
    ethylene glycol 16.45
    NMP 987.24
    cyclohexane 38.79
    DMSO 623.65
    n-butyl acetate 328.43
    n-octanol 76.68
    chloroform 792.15
    n-propyl acetate 396.94
    acetic acid 267.24
    dichloromethane 916.94
    cyclohexanone 926.32
    propylene glycol 44.14
    isopropyl acetate 335.4
    DMAc 974.4
    2-ethoxyethanol 287.97
    isopentanol 196.85
    n-heptane 6.23
    ethyl formate 230.66
    1,2-dichloroethane 615.65
    n-hexanol 88.25
    2-methoxyethanol 330.12
    isobutyl acetate 255.36
    tetrachloromethane 153.38
    n-pentyl acetate 428.84
    transcutol 742.05
    n-heptanol 87.89
    ethylbenzene 72.32
    MIBK 269.42
    2-propoxyethanol 232.84
    tert-butanol 211.97
    MTBE 238.45
    2-butoxyethanol 280.14
    propionic acid 236.98
    o-xylene 100.97
    formic acid 92.77
    diethyl ether 161.49
    m-xylene 86.1
    p-xylene 111.78
    chlorobenzene 260.37
    dimethyl carbonate 115.98
    n-octane 5.15
    formamide 204.71
    cyclopentanone 895.25
    2-pentanone 376.47
    anisole 167.32
    cyclopentyl methyl ether 344.43
    gamma-butyrolactone 943.21
    1-methoxy-2-propanol 302.66
    pyridine 480.15
    3-pentanone 267.41
    furfural 630.84
    n-dodecane 3.96
    diethylene glycol 116.36
    diisopropyl ether 62.18
    tert-amyl alcohol 224.37
    acetylacetone 440.21
    n-hexadecane 4.75
    acetophenone 272.69
    methyl propionate 278.52
    isopentyl acetate 325.11
    trichloroethylene 1021.39
    n-nonanol 75.88
    cyclohexanol 259.95
    benzyl alcohol 170.05
    2-ethylhexanol 71.69
    isooctanol 86.18
    dipropyl ether 93.24
    1,2-dichlorobenzene 277.03
    ethyl lactate 158.49
    propylene carbonate 553.72
    n-methylformamide 300.96
    2-pentanol 134.94
    n-pentane 9.95
    1-propoxy-2-propanol 194.15
    1-methoxy-2-propyl acetate 306.61
    2-(2-methoxypropoxy) propanol 185.23
    mesitylene 58.65
    ε-caprolactone 840.56
    p-cymene 47.9
    epichlorohydrin 876.89
    1,1,1-trichloroethane 547.05
    2-aminoethanol 77.69
    morpholine-4-carbaldehyde 653.17
    sulfolane 1137.86
    2,2,4-trimethylpentane 12.73
    2-methyltetrahydrofuran 576.0
    n-hexyl acetate 335.97
    isooctane 6.05
    2-(2-butoxyethoxy)ethanol 264.04
    sec-butyl acetate 282.16
    tert-butyl acetate 342.14
    decalin 19.94
    glycerin 72.77
    diglyme 595.92
    acrylic acid 173.85
    isopropyl myristate 88.13
    n-butyric acid 492.87
    acetyl acetate 239.94
    di(2-ethylhexyl) phthalate 97.94
    ethyl propionate 293.63
    nitromethane 526.26
    1,2-diethoxyethane 284.26
    benzonitrile 234.74
    trioctyl phosphate 68.94
    1-bromopropane 294.32
    gamma-valerolactone 1187.34
    n-decanol 46.31
    triethyl phosphate 123.1
    4-methyl-2-pentanol 86.1
    propionitrile 187.47
    vinylene carbonate 421.34
    1,1,2-trichlorotrifluoroethane 538.98
    DMS 209.44
    cumene 54.17
    2-octanol 74.85
    2-hexanone 295.28
    octyl acetate 128.01
    limonene 79.42
    1,2-dimethoxyethane 500.63
    ethyl orthosilicate 116.9
    tributyl phosphate 98.63
    diacetone alcohol 329.59
    N,N-dimethylaniline 122.09
    acrylonitrile 219.15
    aniline 171.24
    1,3-propanediol 148.68
    bromobenzene 267.28
    dibromomethane 525.13
    1,1,2,2-tetrachloroethane 892.2
    2-methyl-cyclohexyl acetate 203.06
    tetrabutyl urea 138.75
    diisobutyl methanol 46.76
    2-phenylethanol 134.82
    styrene 96.07
    dioctyl adipate 159.52
    dimethyl sulfate 255.01
    ethyl butyrate 243.97
    methyl lactate 146.8
    butyl lactate 273.22
    diethyl carbonate 145.16
    propanediol butyl ether 188.66
    triethyl orthoformate 169.69
    p-tert-butyltoluene 42.93
    methyl 4-tert-butylbenzoate 247.56
    morpholine 506.04
    tert-butylamine 114.89
    n-dodecanol 30.93
    dimethoxymethane 275.68
    ethylene carbonate 405.03
    cyrene 229.04
    2-ethoxyethyl acetate 448.41
    2-ethylhexyl acetate 243.67
    1,2,4-trichlorobenzene 339.86
    4-methylpyridine 442.82
    dibutyl ether 119.88
    2,6-dimethyl-4-heptanol 46.76
    DEF 525.72
    dimethyl isosorbide 355.11
    tetrachloroethylene 587.65
    eugenol 222.17
    triacetin 339.09
    span 80 164.81
    1,4-butanediol 68.14
    1,1-dichloroethane 504.43
    2-methyl-1-pentanol 156.06
    methyl formate 172.64
    2-methyl-1-butanol 194.28
    n-decane 8.26
    butyronitrile 226.75
    3,7-dimethyl-1-octanol 77.63
    1-chlorooctane 62.15
    1-chlorotetradecane 17.57
    n-nonane 7.01
    undecane 5.37
    tert-butylcyclohexane 13.81
    cyclooctane 8.71
    cyclopentanol 277.84
    tetrahydropyran 460.78
    tert-amyl methyl ether 201.27
    2,5,8-trioxanonane 309.7
    1-hexene 58.24
    2-isopropoxyethanol 223.91
    2,2,2-trifluoroethanol 154.54
    methyl butyrate 466.62

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction