Palmitoyl carnosine

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  • Identifiers

    CAS number
    324755-72-8

    Molecular formula
    C25H44N4O4

    SMILES
    CCCCCCCCCCCCCCCC(=O)NCCC(=O)N[C@@H](CC1=CN=CN1)C(=O)O

    Safety labels

  • Odor profile

    Fragrance
    Odorless 48.66%
    Savory 42.18%
    Meaty 38.07%
    Cooling 31.68%
    Fishy 22.53%
    Animal 20.7%
    Cooked 20.18%
    Fatty 19.96%
    Milky 19.66%
    Roasted 19.64%

     

    Flavor
    Odorless 47.26%
    Bland 41.2%
    Bitter 36.51%
    Mild 29.81%
    Faint 21.6%
    Sweet-like 20.17%
    Slightly waxy 19.83%
    Cedarleaf 19.63%
    Bay oil 19.4%
    Lovage 18.9%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    5.9

    pKa est.
    7.44 (neutral)

    Molecular weight
    464.6 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Very slow

    Boiling point est.
    559°C

    Flash point

    • 304.25 ˚C est.

  • Synonyms

    • Palmitoyl carnosine
    • 324755-72-8
    • P-CAR
    • UNII-22EMA5D703
    • 22EMA5D703
    • L-Histidine, N-(1-oxohexadecyl)-beta-alanyl-
    • DTXSID70186209
    • L-HISTIDINE, N-(1-OXOHEXADECYL)-.BETA.-ALANYL-
    • RefChem:169734
    • DTXCID30108700
    • PALMITOYL CARNOSINE [INCI]
    • (3-palmitamidopropanoyl)-L-histidine
    • (2S)-2-[3-(hexadecanoylamino)propanoylamino]-3-(1h-imidazol-5-yl)propanoic acid
    • SCHEMBL127678
    • orb1701828
    • SCHEMBL29713992
    • LNXLHAWHHNDIDC-QFIPXVFZSA-N
    • AKOS040747246
    • N-Hexadecanoyl-beta-alanyl-L-histidine
    • HY-115852
    • CS-0370066
    • Q27253647
    • 324755-72-8

  • Applications

    Palmitoyl carnosine (CAS 324755-72-8) is used primarily in cosmetics and personal care as a lipophilic antioxidant and skin-conditioning agent, helping to protect formulations from oxidative degradation and support product stability. It is also evaluated as an excipient with antioxidant and stabilizing properties in topical pharmaceutical formulations. In polymer and plastics applications, it can be considered as an antioxidant/stabilizer additive to improve processing stability and long-term performance of materials. In coatings and inks, it has been investigated as a radical-scavenging additive to enhance durability and shelf life of formulated products.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 6.78
    methanol 17.65
    isopropanol 3.97
    water 1.24
    ethyl acetate 3.5
    n-propanol 6.62
    acetone 10.13
    n-butanol 4.72
    acetonitrile 2.26
    DMF 78.07
    toluene 1.29
    isobutanol 4.38
    1,4-dioxane 6.55
    methyl acetate 5.86
    THF 21.2
    2-butanone 11.52
    n-pentanol 5.34
    sec-butanol 5.83
    n-hexane 0.26
    ethylene glycol 3.18
    NMP 157.28
    cyclohexane 0.26
    DMSO 75.71
    n-butyl acetate 3.33
    n-octanol 2.12
    chloroform 8.12
    n-propyl acetate 4.66
    acetic acid 29.86
    dichloromethane 8.4
    cyclohexanone 24.62
    propylene glycol 7.44
    isopropyl acetate 3.1
    DMAc 206.98
    2-ethoxyethanol 19.27
    isopentanol 3.9
    n-heptane 0.15
    ethyl formate 5.8
    1,2-dichloroethane 5.52
    n-hexanol 2.01
    2-methoxyethanol 23.09
    isobutyl acetate 3.01
    tetrachloromethane 1.99
    n-pentyl acetate 5.74
    transcutol 38.7
    n-heptanol 2.64
    ethylbenzene 1.12
    MIBK 3.84
    2-propoxyethanol 10.58
    tert-butanol 3.67
    MTBE 2.76
    2-butoxyethanol 12.96
    propionic acid 13.16
    o-xylene 1.65
    formic acid 28.67
    diethyl ether 1.57
    m-xylene 1.02
    p-xylene 1.9
    chlorobenzene 1.83
    dimethyl carbonate 5.66
    n-octane 0.12
    formamide 35.64
    cyclopentanone 31.39
    2-pentanone 6.23
    anisole 2.76
    cyclopentyl methyl ether 5.83
    gamma-butyrolactone 34.68
    1-methoxy-2-propanol 16.14
    pyridine 9.24
    3-pentanone 6.41
    furfural 33.14
    n-dodecane 0.07
    diethylene glycol 9.05
    diisopropyl ether 0.53
    tert-amyl alcohol 6.69
    acetylacetone 9.46
    n-hexadecane 0.08
    acetophenone 6.96
    methyl propionate 6.63
    isopentyl acetate 3.57
    trichloroethylene 13.07
    n-nonanol 2.23
    cyclohexanol 5.8
    benzyl alcohol 5.66
    2-ethylhexanol 1.38
    isooctanol 2.16
    dipropyl ether 1.53
    1,2-dichlorobenzene 2.49
    ethyl lactate 7.25
    propylene carbonate 16.76
    n-methylformamide 24.64
    2-pentanol 2.52
    n-pentane 0.16
    1-propoxy-2-propanol 7.66
    1-methoxy-2-propyl acetate 6.64
    2-(2-methoxypropoxy) propanol 13.46
    mesitylene 0.62
    ε-caprolactone 24.44
    p-cymene 0.7
    epichlorohydrin 20.68
    1,1,1-trichloroethane 4.32
    2-aminoethanol 8.71
    morpholine-4-carbaldehyde 58.34
    sulfolane 89.95
    2,2,4-trimethylpentane 0.2
    2-methyltetrahydrofuran 10.05
    n-hexyl acetate 5.33
    isooctane 0.06
    2-(2-butoxyethoxy)ethanol 15.52
    sec-butyl acetate 3.42
    tert-butyl acetate 4.02
    decalin 0.23
    glycerin 17.11
    diglyme 30.33
    acrylic acid 15.83
    isopropyl myristate 1.41
    n-butyric acid 13.02
    acetyl acetate 3.12
    di(2-ethylhexyl) phthalate 3.7
    ethyl propionate 4.0
    nitromethane 31.3
    1,2-diethoxyethane 5.22
    benzonitrile 3.48
    trioctyl phosphate 2.28
    1-bromopropane 2.15
    gamma-valerolactone 58.21
    n-decanol 1.38
    triethyl phosphate 4.05
    4-methyl-2-pentanol 1.46
    propionitrile 2.46
    vinylene carbonate 14.11
    1,1,2-trichlorotrifluoroethane 44.13
    DMS 6.0
    cumene 0.99
    2-octanol 1.76
    2-hexanone 6.74
    octyl acetate 2.45
    limonene 0.99
    1,2-dimethoxyethane 20.29
    ethyl orthosilicate 3.9
    tributyl phosphate 3.13
    diacetone alcohol 11.34
    N,N-dimethylaniline 3.94
    acrylonitrile 3.98
    aniline 3.75
    1,3-propanediol 9.87
    bromobenzene 1.42
    dibromomethane 4.05
    1,1,2,2-tetrachloroethane 14.37
    2-methyl-cyclohexyl acetate 4.27
    tetrabutyl urea 5.75
    diisobutyl methanol 0.77
    2-phenylethanol 3.39
    styrene 1.11
    dioctyl adipate 3.62
    dimethyl sulfate 23.34
    ethyl butyrate 3.34
    methyl lactate 11.29
    butyl lactate 9.7
    diethyl carbonate 2.43
    propanediol butyl ether 13.75
    triethyl orthoformate 4.23
    p-tert-butyltoluene 0.62
    methyl 4-tert-butylbenzoate 10.3
    morpholine 15.26
    tert-butylamine 1.51
    n-dodecanol 0.85
    dimethoxymethane 13.5
    ethylene carbonate 10.29
    cyrene 23.2
    2-ethoxyethyl acetate 9.24
    2-ethylhexyl acetate 2.82
    1,2,4-trichlorobenzene 4.31
    4-methylpyridine 7.89
    dibutyl ether 1.73
    2,6-dimethyl-4-heptanol 0.77
    DEF 16.75
    dimethyl isosorbide 18.02
    tetrachloroethylene 9.76
    eugenol 10.99
    triacetin 10.9
    span 80 9.25
    1,4-butanediol 6.25
    1,1-dichloroethane 3.66
    2-methyl-1-pentanol 4.95
    methyl formate 13.93
    2-methyl-1-butanol 5.45
    n-decane 0.15
    butyronitrile 2.43
    3,7-dimethyl-1-octanol 1.56
    1-chlorooctane 0.79
    1-chlorotetradecane 0.25
    n-nonane 0.14
    undecane 0.1
    tert-butylcyclohexane 0.18
    cyclooctane 0.1
    cyclopentanol 8.59
    tetrahydropyran 5.57
    tert-amyl methyl ether 3.66
    2,5,8-trioxanonane 19.23
    1-hexene 1.04
    2-isopropoxyethanol 10.86
    2,2,2-trifluoroethanol 18.42
    methyl butyrate 7.81

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction