Palmitoyl Arginine

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  • Identifiers

    CAS number
    58725-47-6

    Molecular formula
    C22H44N4O3

    SMILES
    CCCCCCCCCCCCCCCC(=O)N[C@@H](CCCN=C(N)N)C(=O)O

    Safety labels

  • Odor profile

    Fragrance
    Odorless 42.98%
    Savory 38.17%
    Meaty 36.07%
    Cooling 32.47%
    Fishy 29.69%
    Animal 23.89%
    Fresh 21.84%
    Fatty 21.64%
    Oily 21.32%
    Waxy 20.57%

     

    Flavor
    Odorless 40.42%
    Bland 36.66%
    Mild 30.36%
    Faint 23.77%
    Bitter 22.67%
    Slightly waxy 20.53%
    Herbal 20.33%
    Bay oil 19.76%
    Cedarleaf 19.66%
    Delicate 19.48%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    5.7

    pKa est.
    8.44 (weak base)

    Molecular weight
    412.6 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    569°C

    Flash point

    • 240.18 ˚C est.

  • Synonyms

    • PALMITOYL ARGININE
    • N2-(1-Oxohexadecyl)-L-arginine
    • 58725-47-6
    • EINECS 261-410-5
    • N-Palmitoyl-L-arginine
    • UNII-2F8GZ263AP
    • 2F8GZ263AP
    • AMISAFE AP-01
    • L-Arginine, N2-(1-oxohexadecyl)-
    • RefChem:169733
    • PALMITOYL ARGININE [INCI]
    • (2S)-5-(diaminomethylideneamino)-2-(hexadecanoylamino)pentanoic acid
    • SCHEMBL2340732
    • mono-Nalpha-palmitoyl-L-arginine
    • DB-326986
    • NS00053849
    • Q27254672
    • 58725-47-6

  • Applications

    Palmitoyl Arginine (CAS 58725-47-6) is a lipid-modified amino acid derivative used mainly in cosmetics and personal care as a conditioning agent and emollient; it may function as a surfactant-like modifier to improve texture, spreadability, and formulation stability, and it is often evaluated as an intermediate for the synthesis of other lipid-conjugated amino acid derivatives. In industrial contexts, it can be incorporated into polymer and coating formulations to impart hydrophobic character and to tune film properties, and it is sometimes explored for use in varnishes, inks, or specialty coatings. It can also appear in niche household cleaning formulations as a lipophilic modifier, and in pharmaceutical topical development as a carrier component in lipid-based delivery systems, subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 3.17
    methanol 7.85
    isopropanol 1.36
    water 0.78
    ethyl acetate 1.08
    n-propanol 2.22
    acetone 2.66
    n-butanol 1.55
    acetonitrile 0.72
    DMF 13.32
    toluene 0.91
    isobutanol 1.37
    1,4-dioxane 2.31
    methyl acetate 1.3
    THF 9.22
    2-butanone 2.45
    n-pentanol 2.05
    sec-butanol 1.43
    n-hexane 0.21
    ethylene glycol 1.53
    NMP 36.31
    cyclohexane 0.22
    DMSO 44.19
    n-butyl acetate 1.51
    n-octanol 1.07
    chloroform 5.04
    n-propyl acetate 1.97
    acetic acid 11.68
    dichloromethane 4.76
    cyclohexanone 8.51
    propylene glycol 2.77
    isopropyl acetate 1.16
    DMAc 34.86
    2-ethoxyethanol 7.55
    isopentanol 1.31
    n-heptane 0.13
    ethyl formate 2.31
    1,2-dichloroethane 2.92
    n-hexanol 1.18
    2-methoxyethanol 8.34
    isobutyl acetate 1.42
    tetrachloromethane 1.52
    n-pentyl acetate 2.37
    transcutol 19.62
    n-heptanol 1.54
    ethylbenzene 0.85
    MIBK 1.55
    2-propoxyethanol 5.5
    tert-butanol 1.48
    MTBE 0.81
    2-butoxyethanol 6.86
    propionic acid 3.97
    o-xylene 1.1
    formic acid 13.27
    diethyl ether 0.49
    m-xylene 0.78
    p-xylene 1.36
    chlorobenzene 1.25
    dimethyl carbonate 1.69
    n-octane 0.1
    formamide 13.62
    cyclopentanone 11.34
    2-pentanone 1.83
    anisole 1.46
    cyclopentyl methyl ether 2.96
    gamma-butyrolactone 12.44
    1-methoxy-2-propanol 5.84
    pyridine 4.11
    3-pentanone 1.73
    furfural 13.87
    n-dodecane 0.06
    diethylene glycol 4.86
    diisopropyl ether 0.28
    tert-amyl alcohol 1.97
    acetylacetone 3.72
    n-hexadecane 0.07
    acetophenone 3.59
    methyl propionate 1.64
    isopentyl acetate 1.72
    trichloroethylene 7.08
    n-nonanol 1.18
    cyclohexanol 2.39
    benzyl alcohol 2.95
    2-ethylhexanol 0.86
    isooctanol 1.21
    dipropyl ether 0.88
    1,2-dichlorobenzene 1.77
    ethyl lactate 3.13
    propylene carbonate 6.75
    n-methylformamide 6.8
    2-pentanol 0.78
    n-pentane 0.11
    1-propoxy-2-propanol 4.01
    1-methoxy-2-propyl acetate 3.18
    2-(2-methoxypropoxy) propanol 6.26
    mesitylene 0.55
    ε-caprolactone 8.67
    p-cymene 0.61
    epichlorohydrin 7.82
    1,1,1-trichloroethane 2.47
    2-aminoethanol 3.53
    morpholine-4-carbaldehyde 17.71
    sulfolane 39.38
    2,2,4-trimethylpentane 0.11
    2-methyltetrahydrofuran 3.49
    n-hexyl acetate 2.17
    isooctane 0.05
    2-(2-butoxyethoxy)ethanol 7.8
    sec-butyl acetate 1.41
    tert-butyl acetate 1.83
    decalin 0.21
    glycerin 6.77
    diglyme 14.09
    acrylic acid 5.04
    isopropyl myristate 0.74
    n-butyric acid 4.77
    acetyl acetate 1.48
    di(2-ethylhexyl) phthalate 2.02
    ethyl propionate 1.58
    nitromethane 9.02
    1,2-diethoxyethane 2.39
    benzonitrile 1.91
    trioctyl phosphate 1.35
    1-bromopropane 1.03
    gamma-valerolactone 20.77
    n-decanol 0.76
    triethyl phosphate 2.21
    4-methyl-2-pentanol 0.65
    propionitrile 0.72
    vinylene carbonate 6.06
    1,1,2-trichlorotrifluoroethane 19.42
    DMS 2.43
    cumene 0.81
    2-octanol 0.88
    2-hexanone 2.51
    octyl acetate 1.18
    limonene 0.73
    1,2-dimethoxyethane 7.68
    ethyl orthosilicate 2.17
    tributyl phosphate 1.75
    diacetone alcohol 4.8
    N,N-dimethylaniline 2.12
    acrylonitrile 1.29
    aniline 2.09
    1,3-propanediol 4.0
    bromobenzene 1.1
    dibromomethane 2.61
    1,1,2,2-tetrachloroethane 7.74
    2-methyl-cyclohexyl acetate 2.64
    tetrabutyl urea 2.98
    diisobutyl methanol 0.52
    2-phenylethanol 2.21
    styrene 0.85
    dioctyl adipate 1.88
    dimethyl sulfate 7.25
    ethyl butyrate 1.62
    methyl lactate 4.08
    butyl lactate 4.85
    diethyl carbonate 1.24
    propanediol butyl ether 7.01
    triethyl orthoformate 2.23
    p-tert-butyltoluene 0.59
    methyl 4-tert-butylbenzoate 5.34
    morpholine 4.75
    tert-butylamine 0.68
    n-dodecanol 0.5
    dimethoxymethane 4.28
    ethylene carbonate 4.46
    cyrene 11.07
    2-ethoxyethyl acetate 3.68
    2-ethylhexyl acetate 1.38
    1,2,4-trichlorobenzene 2.7
    4-methylpyridine 3.05
    dibutyl ether 0.8
    2,6-dimethyl-4-heptanol 0.52
    DEF 4.25
    dimethyl isosorbide 11.21
    tetrachloroethylene 6.35
    eugenol 5.63
    triacetin 4.92
    span 80 4.95
    1,4-butanediol 2.61
    1,1-dichloroethane 1.71
    2-methyl-1-pentanol 1.87
    methyl formate 4.53
    2-methyl-1-butanol 1.49
    n-decane 0.12
    butyronitrile 0.87
    3,7-dimethyl-1-octanol 0.84
    1-chlorooctane 0.5
    1-chlorotetradecane 0.19
    n-nonane 0.1
    undecane 0.08
    tert-butylcyclohexane 0.16
    cyclooctane 0.11
    cyclopentanol 3.5
    tetrahydropyran 2.06
    tert-amyl methyl ether 1.06
    2,5,8-trioxanonane 9.48
    1-hexene 0.6
    2-isopropoxyethanol 4.57
    2,2,2-trifluoroethanol 7.19
    methyl butyrate 2.81

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction