Palmitic anhydride

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  • Identifiers

    CAS number
    623-65-4

    Molecular formula
    C32H62O3

    SMILES
    CCCCCCCCCCCCCCCC(=O)OC(=O)CCCCCCCCCCCCCCC

    Safety labels

    Corrosive
    Corrosive

  • Odor profile

    Fragrance
    Waxy 78.92%
    Fatty 71.57%
    Oily 49.81%
    Odorless 34.56%
    Creamy 27.51%
    Sweet 21.72%
    Dairy 21.24%
    Milky 18.16%
    Soapy 16.72%
    Buttery 16.64%

     

    Flavor
    Waxy 53.94%
    Fatty 53.33%
    Mild 41.08%
    Oily 37.56%
    Bland 35.92%
    Faint 33.9%
    Fat 33.56%
    Coconut 29.58%
    Odorless 27.79%
    Slightly waxy 26.09%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    14.6

    pKa est.
    8.52 (weak base)

    Molecular weight
    494.8 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    518°C

    Flash point

    • 240.1 ˚C est.

  • Synonyms

    • Palmitic anhydride
    • 623-65-4
    • Palmitic acid anhydride
    • Hexadecanoic acid, anhydride
    • UNII-33JHB8GS96
    • 33JHB8GS96
    • EINECS 210-805-0
    • NSC 285112
    • NSC-285112
    • DTXSID601014660
    • RefChem:169716
    • DTXCID20818407
    • 210-805-0
    • QWZBEFCPZJWDKC-UHFFFAOYSA-N
    • Hexadecanoic anhydride
    • hexadecanoyl hexadecanoate
    • MFCD00008992
    • C32H62O3
    • Hexadecanoic acid, 1,1'-anhydride
    • n-hexadecanoic anhydride
    • Hexadecanoic anhydride #
    • Palmitic anhydride, 97%
    • hexadecanoic acid anhydride
    • SCHEMBL149967
    • orb2564072
    • Clindamycin Palmitate Impurity 101
    • NSC285112
    • SBB058699
    • STL453734
    • AKOS016013112
    • HY-W093183
    • LS-15339
    • DB-054142
    • CS-0141240
    • NS00043848
    • P0008
    • ST51037397
    • D82036
    • F621918
    • Q27256276
    • 623-65-4

  • Applications

    Palmitic anhydride, CAS number: 623-65-4, serves primarily as an acylating agent and synthetic intermediate for introducing palmitoyl groups into organic molecules, enabling the production of palmitoyl esters and amides. In cosmetics and personal care, it is used to prepare palmitoyl derivatives that function as emollients or surfactant components. In the fragrance industry, it can be a precursor to long-chain palmitate esters used in perfumery formulations. In coatings and inks, it can act as a fatty acyl modifier to adjust lubricity and film-forming properties. In polymers and plastics, it supports introducing fatty acyl functionality to modify processing and performance. In pharmaceutical/medicinal chemistry, it is used as a lipidizing acylating agent to attach palmitoyl groups to drug molecules or to synthesize lipidated probes.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 5.62
    methanol 7.13
    isopropanol 6.18
    water 0.09
    ethyl acetate 74.78
    n-propanol 9.72
    acetone 51.96
    n-butanol 10.88
    acetonitrile 17.99
    DMF 112.08
    toluene 43.68
    isobutanol 10.8
    1,4-dioxane 79.49
    methyl acetate 55.75
    THF 283.07
    2-butanone 79.83
    n-pentanol 12.34
    sec-butanol 13.75
    n-hexane 9.57
    ethylene glycol 1.02
    NMP 580.52
    cyclohexane 42.81
    DMSO 121.47
    n-butyl acetate 91.24
    n-octanol 24.31
    chloroform 356.92
    n-propyl acetate 100.5
    acetic acid 31.3
    dichloromethane 380.14
    cyclohexanone 323.16
    propylene glycol 3.01
    isopropyl acetate 80.22
    DMAc 324.83
    2-ethoxyethanol 32.95
    isopentanol 16.24
    n-heptane 8.57
    ethyl formate 37.67
    1,2-dichloroethane 213.11
    n-hexanol 11.38
    2-methoxyethanol 29.52
    isobutyl acetate 71.12
    tetrachloromethane 83.47
    n-pentyl acetate 183.17
    transcutol 238.83
    n-heptanol 19.67
    ethylbenzene 35.25
    MIBK 78.5
    2-propoxyethanol 37.04
    tert-butanol 16.81
    MTBE 47.98
    2-butoxyethanol 62.36
    propionic acid 31.85
    o-xylene 47.93
    formic acid 7.73
    diethyl ether 31.29
    m-xylene 36.53
    p-xylene 56.72
    chlorobenzene 103.62
    dimethyl carbonate 36.88
    n-octane 5.71
    formamide 17.62
    cyclopentanone 359.53
    2-pentanone 76.2
    anisole 70.31
    cyclopentyl methyl ether 156.24
    gamma-butyrolactone 345.32
    1-methoxy-2-propanol 36.38
    pyridine 137.0
    3-pentanone 86.7
    furfural 233.73
    n-dodecane 3.08
    diethylene glycol 13.03
    diisopropyl ether 23.03
    tert-amyl alcohol 31.04
    acetylacetone 145.47
    n-hexadecane 3.83
    acetophenone 123.88
    methyl propionate 69.51
    isopentyl acetate 100.5
    trichloroethylene 439.29
    n-nonanol 27.32
    cyclohexanol 45.17
    benzyl alcohol 34.48
    2-ethylhexanol 20.01
    isooctanol 24.15
    dipropyl ether 53.48
    1,2-dichlorobenzene 160.13
    ethyl lactate 44.71
    propylene carbonate 214.32
    n-methylformamide 34.42
    2-pentanol 12.07
    n-pentane 5.09
    1-propoxy-2-propanol 48.79
    1-methoxy-2-propyl acetate 113.59
    2-(2-methoxypropoxy) propanol 85.14
    mesitylene 31.65
    ε-caprolactone 295.31
    p-cymene 31.03
    epichlorohydrin 300.8
    1,1,1-trichloroethane 275.55
    2-aminoethanol 3.81
    morpholine-4-carbaldehyde 223.56
    sulfolane 729.77
    2,2,4-trimethylpentane 8.71
    2-methyltetrahydrofuran 205.42
    n-hexyl acetate 164.34
    isooctane 4.1
    2-(2-butoxyethoxy)ethanol 93.08
    sec-butyl acetate 89.3
    tert-butyl acetate 135.76
    decalin 20.0
    glycerin 7.23
    diglyme 255.7
    acrylic acid 26.22
    isopropyl myristate 52.5
    n-butyric acid 64.28
    acetyl acetate 75.67
    di(2-ethylhexyl) phthalate 48.19
    ethyl propionate 99.52
    nitromethane 97.11
    1,2-diethoxyethane 113.35
    benzonitrile 58.95
    trioctyl phosphate 32.52
    1-bromopropane 95.17
    gamma-valerolactone 411.98
    n-decanol 16.61
    triethyl phosphate 85.64
    4-methyl-2-pentanol 12.54
    propionitrile 23.47
    vinylene carbonate 155.03
    1,1,2-trichlorotrifluoroethane 207.71
    DMS 96.68
    cumene 27.66
    2-octanol 22.1
    2-hexanone 88.5
    octyl acetate 63.89
    limonene 53.92
    1,2-dimethoxyethane 112.56
    ethyl orthosilicate 79.9
    tributyl phosphate 49.82
    diacetone alcohol 104.03
    N,N-dimethylaniline 62.16
    acrylonitrile 27.71
    aniline 38.79
    1,3-propanediol 7.64
    bromobenzene 136.0
    dibromomethane 213.6
    1,1,2,2-tetrachloroethane 443.68
    2-methyl-cyclohexyl acetate 125.08
    tetrabutyl urea 87.37
    diisobutyl methanol 19.14
    2-phenylethanol 30.89
    styrene 40.95
    dioctyl adipate 107.71
    dimethyl sulfate 123.92
    ethyl butyrate 116.9
    methyl lactate 36.12
    butyl lactate 108.86
    diethyl carbonate 69.61
    propanediol butyl ether 48.78
    triethyl orthoformate 107.18
    p-tert-butyltoluene 29.16
    methyl 4-tert-butylbenzoate 166.88
    morpholine 104.54
    tert-butylamine 13.38
    n-dodecanol 11.07
    dimethoxymethane 56.9
    ethylene carbonate 128.91
    cyrene 113.61
    2-ethoxyethyl acetate 185.53
    2-ethylhexyl acetate 94.12
    1,2,4-trichlorobenzene 214.33
    4-methylpyridine 128.82
    dibutyl ether 75.07
    2,6-dimethyl-4-heptanol 19.14
    DEF 132.33
    dimethyl isosorbide 256.79
    tetrachloroethylene 256.21
    eugenol 108.37
    triacetin 213.84
    span 80 81.48
    1,4-butanediol 4.54
    1,1-dichloroethane 153.17
    2-methyl-1-pentanol 19.88
    methyl formate 29.0
    2-methyl-1-butanol 17.89
    n-decane 7.67
    butyronitrile 25.68
    3,7-dimethyl-1-octanol 29.57
    1-chlorooctane 40.56
    1-chlorotetradecane 11.7
    n-nonane 7.27
    undecane 4.5
    tert-butylcyclohexane 13.32
    cyclooctane 12.21
    cyclopentanol 50.21
    tetrahydropyran 132.92
    tert-amyl methyl ether 65.4
    2,5,8-trioxanonane 140.62
    1-hexene 20.98
    2-isopropoxyethanol 32.65
    2,2,2-trifluoroethanol 26.59
    methyl butyrate 142.34

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction