Palmitamidopropylamine oxide

Overview IFRA Request a quote

  • Identifiers

    CAS number
    67806-12-6

    Molecular formula
    C21H44N2O2

    SMILES
    CCCCCCCCCCCCCCCC(=O)NCCC[N+](C)(C)[O-]

    Safety labels

  • Odor profile

    Fragrance
    Waxy 36.92%
    Fishy 35.09%
    Meaty 31.37%
    Savory 30.9%
    Animal 30.43%
    Odorless 29.41%
    Fatty 28.63%
    Cooling 28.52%
    Woody 25.94%
    Oily 25.83%

     

    Flavor
    Bland 36.19%
    Mild 27.98%
    Odorless 26.01%
    Faint 22.33%
    Slightly waxy 20.99%
    Delicate 20.7%
    Bay oil 19.59%
    Skunky 19.11%
    Cedarleaf 19.1%
    Diterpene 19.07%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    6.7

    pKa est.
    7.09 (neutral)

    Molecular weight
    356.6 g/mol

    Flash point

    • -282.33 ˚C est.

  • Synonyms

    • Palmitamidopropylamine oxide
    • QF1C1278XX
    • DTXSID2070631
    • Hexadecanamide, N-(3-(dimethyloxidoamino)propyl)-
    • Hexadecanamide, N-[3-(dimethyloxidoamino)propyl]-
    • RefChem:858402
    • DTXCID9045055
    • PALMITAMIDOPROPYLAMINE OXIDE [INCI]
    • 614-145-8
    • 67806-12-6
    • 3-(hexadecanoylamino)-N,N-dimethylpropan-1-amine oxide
    • Hexadecanamide, N-(3-(dimethylamino)propyl)-N-oxide
    • UNII-QF1C1278XX
    • SCHEMBL2521253
    • PBWFDNJGWNCAPS-UHFFFAOYSA-N
    • NS00013933
    • Palmitylamidopropyl-N,N-dimethylamine, oxide
    • N,N-dimethyl-3-palmitamidopropan-1-amine oxide
    • 3-(hexadecanoylamino)propyldimethylamine-N-oxide
    • N-(3-(Dimethylamino)propyl)hexadecanamide-N-oxide
    • 3-Hexadecanamido-N,N-dimethylpropan-1-amine N-oxide
    • Q27287226
    • 67806-12-6

  • Applications

    Palmitamidopropylamine oxide (CAS 67806-12-6) is a mild amphoteric surfactant with a long palmitoyl tail, commonly used as a cleansing and emulsifying agent in personal care formulations such as shampoos, body washes, and facial cleansers, where it provides gentle cleansing with moderate foaming. It is also employed in household cleaners as an emulsifier, dispersant, and stabilizer in detergent formulations. In industrial settings, it serves as a surfactant to improve wetting, dispersion, and emulsification in paints, coatings, and inks, and as a processing aid in polymer formulations to enhance pigment dispersion and component compatibility. It may also function as an intermediate or additive in cosmetic and polymer processing to optimize texture and formulation stability.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 21.63
    methanol 42.27
    isopropanol 14.0
    water 0.41
    ethyl acetate 58.45
    n-propanol 23.06
    acetone 52.13
    n-butanol 21.22
    acetonitrile 22.36
    DMF 119.37
    toluene 27.11
    isobutanol 21.23
    1,4-dioxane 73.15
    methyl acetate 54.15
    THF 151.77
    2-butanone 68.46
    n-pentanol 20.73
    sec-butanol 21.92
    n-hexane 4.37
    ethylene glycol 5.66
    NMP 316.79
    cyclohexane 14.99
    DMSO 144.23
    n-butyl acetate 59.41
    n-octanol 23.52
    chloroform 313.37
    n-propyl acetate 74.56
    acetic acid 111.05
    dichloromethane 264.92
    cyclohexanone 209.17
    propylene glycol 12.65
    isopropyl acetate 50.29
    DMAc 289.24
    2-ethoxyethanol 63.85
    isopentanol 24.89
    n-heptane 3.6
    ethyl formate 48.35
    1,2-dichloroethane 143.02
    n-hexanol 18.2
    2-methoxyethanol 66.38
    isobutyl acetate 51.42
    tetrachloromethane 65.2
    n-pentyl acetate 80.62
    transcutol 296.93
    n-heptanol 20.61
    ethylbenzene 21.12
    MIBK 47.15
    2-propoxyethanol 59.89
    tert-butanol 24.76
    MTBE 31.86
    2-butoxyethanol 69.12
    propionic acid 59.76
    o-xylene 32.25
    formic acid 49.45
    diethyl ether 24.36
    m-xylene 22.08
    p-xylene 32.14
    chlorobenzene 59.66
    dimethyl carbonate 25.62
    n-octane 2.07
    formamide 61.24
    cyclopentanone 199.23
    2-pentanone 54.93
    anisole 45.56
    cyclopentyl methyl ether 83.87
    gamma-butyrolactone 223.64
    1-methoxy-2-propanol 55.55
    pyridine 88.44
    3-pentanone 61.31
    furfural 211.41
    n-dodecane 1.41
    diethylene glycol 35.78
    diisopropyl ether 11.49
    tert-amyl alcohol 34.37
    acetylacetone 87.57
    n-hexadecane 1.67
    acetophenone 79.45
    methyl propionate 57.19
    isopentyl acetate 63.33
    trichloroethylene 306.31
    n-nonanol 24.44
    cyclohexanol 53.84
    benzyl alcohol 40.43
    2-ethylhexanol 20.8
    isooctanol 21.1
    dipropyl ether 27.61
    1,2-dichlorobenzene 84.83
    ethyl lactate 46.37
    propylene carbonate 142.68
    n-methylformamide 57.95
    2-pentanol 15.75
    n-pentane 2.64
    1-propoxy-2-propanol 53.71
    1-methoxy-2-propyl acetate 74.01
    2-(2-methoxypropoxy) propanol 85.12
    mesitylene 16.77
    ε-caprolactone 207.06
    p-cymene 17.36
    epichlorohydrin 208.61
    1,1,1-trichloroethane 158.49
    2-aminoethanol 17.16
    morpholine-4-carbaldehyde 191.71
    sulfolane 378.49
    2,2,4-trimethylpentane 4.48
    2-methyltetrahydrofuran 112.86
    n-hexyl acetate 85.3
    isooctane 1.66
    2-(2-butoxyethoxy)ethanol 102.06
    sec-butyl acetate 56.04
    tert-butyl acetate 67.49
    decalin 7.89
    glycerin 29.6
    diglyme 219.74
    acrylic acid 55.85
    isopropyl myristate 24.59
    n-butyric acid 89.36
    acetyl acetate 57.74
    di(2-ethylhexyl) phthalate 36.42
    ethyl propionate 61.55
    nitromethane 164.0
    1,2-diethoxyethane 70.82
    benzonitrile 49.09
    trioctyl phosphate 22.91
    1-bromopropane 60.52
    gamma-valerolactone 282.12
    n-decanol 14.78
    triethyl phosphate 53.13
    4-methyl-2-pentanol 13.85
    propionitrile 22.41
    vinylene carbonate 121.65
    1,1,2-trichlorotrifluoroethane 257.51
    DMS 61.15
    cumene 18.37
    2-octanol 15.63
    2-hexanone 60.41
    octyl acetate 35.41
    limonene 28.92
    1,2-dimethoxyethane 116.41
    ethyl orthosilicate 51.53
    tributyl phosphate 33.91
    diacetone alcohol 73.81
    N,N-dimethylaniline 38.72
    acrylonitrile 32.36
    aniline 38.7
    1,3-propanediol 25.5
    bromobenzene 60.64
    dibromomethane 149.93
    1,1,2,2-tetrachloroethane 295.43
    2-methyl-cyclohexyl acetate 73.66
    tetrabutyl urea 46.39
    diisobutyl methanol 13.47
    2-phenylethanol 36.33
    styrene 23.74
    dioctyl adipate 56.67
    dimethyl sulfate 80.58
    ethyl butyrate 64.55
    methyl lactate 42.42
    butyl lactate 70.71
    diethyl carbonate 44.74
    propanediol butyl ether 63.92
    triethyl orthoformate 64.79
    p-tert-butyltoluene 15.6
    methyl 4-tert-butylbenzoate 84.27
    morpholine 106.99
    tert-butylamine 16.01
    n-dodecanol 9.61
    dimethoxymethane 52.18
    ethylene carbonate 99.53
    cyrene 102.57
    2-ethoxyethyl acetate 111.02
    2-ethylhexyl acetate 58.43
    1,2,4-trichlorobenzene 110.53
    4-methylpyridine 78.68
    dibutyl ether 34.21
    2,6-dimethyl-4-heptanol 13.47
    DEF 104.58
    dimethyl isosorbide 151.83
    tetrachloroethylene 212.39
    eugenol 76.82
    triacetin 140.2
    span 80 69.88
    1,4-butanediol 12.88
    1,1-dichloroethane 105.01
    2-methyl-1-pentanol 26.93
    methyl formate 43.77
    2-methyl-1-butanol 27.99
    n-decane 3.35
    butyronitrile 24.49
    3,7-dimethyl-1-octanol 23.74
    1-chlorooctane 20.19
    1-chlorotetradecane 5.58
    n-nonane 3.05
    undecane 2.04
    tert-butylcyclohexane 5.72
    cyclooctane 4.14
    cyclopentanol 53.3
    tetrahydropyran 87.16
    tert-amyl methyl ether 41.71
    2,5,8-trioxanonane 135.21
    1-hexene 13.53
    2-isopropoxyethanol 50.9
    2,2,2-trifluoroethanol 68.44
    methyl butyrate 90.91

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction