p-Toluidine

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  • Identifiers

    CAS number
    106-49-0

    Molecular formula
    C7H9N

    SMILES
    CC1=CC=C(C=C1)N

    Safety labels

    Acute Toxic
    Acute Toxic

    Health Hazard
    Health

    Environmental Hazard
    Environmental

  • Odor profile

    Fragrance
    Floral 60.84%
    Sweet 53.69%
    Animal 44.88%
    Phenolic 41.88%
    Woody 36.4%
    Musty 29.42%
    Leathery 29.22%
    Smoky 28.12%
    Medicinal 26.35%
    Oily 26.26%

     

    Flavor
    Phenolic 44.51%
    Medicinal 37.13%
    Plastic 31.34%
    Sulfurous 27.6%
    Phenol 27.34%
    Sweet 26.48%
    Meaty 25.95%
    Naphthyl 23.65%
    Garlic 23.46%
    Guaiacol 23.43%

     

    Odor impact est.
    Low

    Odor threshold

    • Odor Threshold Low: 0.02 [mmHg]. Odor Threshold High: 3.2 [mmHg]. Odor threshold from AIHA

  • Properties

    XLogP3-AA
    1.4

    pKa est.
    5.71 (weak acid)

    Molecular weight
    107.15 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Moderately fast

    Melting point expt.

    • 112.1 °F (USCG, 1999)
    • 43.6 °C
    • 44-45 °C
    • 112 °F
    • 111 °F

    Boiling point

    • 393 °F at 760 mmHg (USCG, 1999)
    • 200.4 °C
    • 200 °C
    • 393 °F

    Flash point

    • 87.52 ˚C est.
    • 188 °F (USCG, 1999)
    • 87 °C
    • 190 °F (88 °C) (closed cup)
    • 87 °C c.c.
    • 188 °F

    Solubility expt.

    • 0.7 % (NIOSH, 2024)
    • Very soluble in ethanol, pyridine; soluble in diethyl ether, acetone, carbon tetrachloride
    • Freely soluble in alcohol, ether, acetone, methanol, carbon disulfide, oils, dilute acids
    • In water, 6.50 g/L (6.50X10+3 mg/L) at 15 °C
    • Solubility in water, g/100ml at 20 °C: 0.75 (poor)
    • 0.7%

  • Synonyms

    • p-Toluidine
    • 4-Methylaniline
    • 106-49-0
    • 4-Toluidine
    • 4-Methylbenzenamine
    • p-Tolylamine
    • 4-AMINOTOLUENE
    • Benzenamine, 4-methyl-
    • p-Methylaniline
    • p-Toluidin
    • p-Aminotoluene
    • p-Methylbenzenamine
    • 1-Amino-4-methylbenzene
    • Naphtol AS-KG
    • Naphtol AS-KGLL
    • para-toluidine
    • Aniline, p-methyl-
    • 4-Aminotoluen
    • Toluidine, p-
    • 4-Amino-1-methylbenzene
    • RCRA waste number U353
    • Tolylamine
    • p-Toluidyna
    • p-Toluidyna [Polish]
    • C.I. Azoic Coupling Component 107
    • NSC 15350
    • 12221-03-3
    • CCRIS 598
    • AZOIC COUPLING COMPONENT 107
    • C.I. 37107
    • 4methylaniline
    • 26915-12-8
    • DTXSID6021872
    • HSDB 2044
    • 4-tolylamine
    • UNII-I1D0KL7I4U
    • EINECS 203-403-1
    • Aniline, 4-methyl-
    • CHEBI:37825
    • AI3-19858
    • 4-METHYLBENZAMINE
    • NSC-15350
    • P-TOLUIDINE [MI]
    • I1D0KL7I4U
    • CHEMBL58521
    • P-TOLUIDINE [USP-RS]
    • 4-AMINOTOLUENE [HSDB]
    • DTXCID601872
    • EC 203-403-1
    • P-TOLUIDINE [USP IMPURITY]
    • MFCD00007906
    • p-Toluidyna (Polish)
    • 4-methylphenylamine
    • AMINOBENZOIC ACID IMPURITY D [EP IMPURITY]
    • P-TOLUIDINE (USP-RS)
    • p-Toluidin [Czech]
    • 4-Aminotoluen [Czech]
    • P-TOLUIDINE (USP IMPURITY)
    • CAS-106-49-0
    • CI Azoic Coupling Component 107
    • AMINOBENZOIC ACID IMPURITY D (EP IMPURITY)
    • 4-Methyl-1-aminobenzene
    • RCRA waste no. U353
    • paratoluidine
    • pAminotoluene
    • pMethylaniline
    • pToluidyna
    • pTolylamine
    • CI 37107
    • pToluidin
    • Tolyamine
    • 4Aminotoluene
    • 4Aminotoluen
    • p-Tolyamine
    • 4Toluidine
    • p-tolyl-amine
    • 4-amino-toluene
    • Aniline, pmethyl
    • pMethylbenzenamine
    • Toluidine, p
    • para-methylaniline
    • 4-methyl aniline
    • 4-methyl-aniline
    • 4Methylbenzenamine
    • Naphtol ASKG
    • Naphtol ASKGLL
    • 4MN
    • p-Methylbenzeneamine
    • 1Amino4methylbenzene
    • 4Amino1methylbenzene
    • 4-methyl-phenylamine
    • Benzenamine, 4methyl
    • p-Toluidine, 99%
    • section signa-Touidine
    • Benzamine, 4-methyl-
    • p-Toluidine (ACGIH)
    • Benzolamin, 4-methyl-
    • 1-Amino-4-methylbenzol
    • p-Toluidine, 99.6%
    • 4-METHYLBENZENEAMINE
    • WLN: ZR D1
    • SCHEMBL11887
    • p-Toluidine, liquid or solid
    • Benzenamine, 4-methyl-(9CI)
    • p-Toluidine, for synthesis, 99%
    • C.I.Azoic Coupling Component 107
    • NSC15350
    • Tox21_202142
    • Tox21_300168
    • BDBM50008562
    • STL137776
    • AKOS000119134
    • GS-6708
    • p-Toluidine 100 microg/mL in Methanol
    • NCGC00247917-01
    • NCGC00247917-02
    • NCGC00247917-03
    • NCGC00254002-01
    • NCGC00259691-01
    • BP-11946
    • DB-024354
    • NS00003075
    • p-Toluidine, SAJ special grade, >=99.0%
    • T0300
    • EN300-17941
    • p-Toluidine, liquid or solid [UN1708] [Poison]
    • Q2043499
    • Z57127875

  • Applications

    p-Toluidine (CAS 106-49-0) is primarily used as an intermediate in the production of dyes and pigments for textiles, coatings, and inks (including azo dyes and pigments). It is also used as a chemical precursor for specialty polymers and rubber-related chemicals, providing building blocks for various organic syntheses in materials applications. Additionally, p-toluidine may serve as a precursor in the synthesis of epoxy resin curing agents or components for epoxy formulations, depending on the formulation. It is also used as a building block for exploratory organic syntheses in pharmaceutical and agrochemical research. Its use is subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 211.67
    methanol 208.41
    isopropanol 154.29
    water 3.16
    ethyl acetate 269.1
    n-propanol 169.35
    acetone 412.52
    n-butanol 137.22
    acetonitrile 231.49
    DMF 436.06
    toluene 32.45
    isobutanol 97.35
    1,4-dioxane 228.34
    methyl acetate 278.95
    THF 523.33
    2-butanone 315.1
    n-pentanol 94.97
    sec-butanol 107.29
    n-hexane 7.58
    ethylene glycol 54.64
    NMP 152.45
    cyclohexane 4.04
    DMSO 303.85
    n-butyl acetate 163.78
    n-octanol 60.45
    chloroform 215.94
    n-propyl acetate 117.47
    acetic acid 142.94
    dichloromethane 131.37
    cyclohexanone 149.41
    propylene glycol 90.02
    isopropyl acetate 114.34
    DMAc 333.73
    2-ethoxyethanol 154.47
    isopentanol 93.93
    n-heptane 13.02
    ethyl formate 161.68
    1,2-dichloroethane 88.15
    n-hexanol 196.68
    2-methoxyethanol 280.5
    isobutyl acetate 70.38
    tetrachloromethane 42.75
    n-pentyl acetate 65.34
    transcutol 187.99
    n-heptanol 85.23
    ethylbenzene 23.16
    MIBK 101.46
    2-propoxyethanol 309.34
    tert-butanol 161.49
    MTBE 128.86
    2-butoxyethanol 147.05
    propionic acid 160.68
    o-xylene 22.41
    formic acid 69.35
    diethyl ether 120.52
    m-xylene 29.61
    p-xylene 29.51
    chlorobenzene 60.08
    dimethyl carbonate 127.74
    n-octane 5.83
    formamide 104.37
    cyclopentanone 335.02
    2-pentanone 222.0
    anisole 86.04
    cyclopentyl methyl ether 136.01
    gamma-butyrolactone 315.4
    1-methoxy-2-propanol 238.47
    pyridine 159.78
    3-pentanone 147.22
    furfural 208.4
    n-dodecane 4.95
    diethylene glycol 177.94
    diisopropyl ether 30.15
    tert-amyl alcohol 109.76
    acetylacetone 190.84
    n-hexadecane 5.33
    acetophenone 70.03
    methyl propionate 235.92
    isopentyl acetate 105.09
    trichloroethylene 206.98
    n-nonanol 54.49
    cyclohexanol 46.24
    benzyl alcohol 62.64
    2-ethylhexanol 89.9
    isooctanol 58.34
    dipropyl ether 113.2
    1,2-dichlorobenzene 54.22
    ethyl lactate 64.07
    propylene carbonate 146.07
    n-methylformamide 247.73
    2-pentanol 76.5
    n-pentane 5.53
    1-propoxy-2-propanol 202.62
    1-methoxy-2-propyl acetate 149.2
    2-(2-methoxypropoxy) propanol 85.68
    mesitylene 17.18
    ε-caprolactone 129.59
    p-cymene 25.25
    epichlorohydrin 266.77
    1,1,1-trichloroethane 129.37
    2-aminoethanol 117.0
    morpholine-4-carbaldehyde 203.27
    sulfolane 223.42
    2,2,4-trimethylpentane 5.21
    2-methyltetrahydrofuran 221.25
    n-hexyl acetate 83.95
    isooctane 5.33
    2-(2-butoxyethoxy)ethanol 123.1
    sec-butyl acetate 61.84
    tert-butyl acetate 106.48
    decalin 5.01
    glycerin 116.2
    diglyme 230.1
    acrylic acid 121.91
    isopropyl myristate 33.75
    n-butyric acid 222.68
    acetyl acetate 115.92
    di(2-ethylhexyl) phthalate 32.49
    ethyl propionate 114.36
    nitromethane 402.01
    1,2-diethoxyethane 95.55
    benzonitrile 71.93
    trioctyl phosphate 29.21
    1-bromopropane 55.97
    gamma-valerolactone 303.71
    n-decanol 42.82
    triethyl phosphate 38.0
    4-methyl-2-pentanol 49.96
    propionitrile 188.82
    vinylene carbonate 124.55
    1,1,2-trichlorotrifluoroethane 167.73
    DMS 60.93
    cumene 21.24
    2-octanol 44.84
    2-hexanone 126.7
    octyl acetate 49.45
    limonene 33.63
    1,2-dimethoxyethane 231.85
    ethyl orthosilicate 37.59
    tributyl phosphate 29.94
    diacetone alcohol 139.79
    N,N-dimethylaniline 57.05
    acrylonitrile 218.83
    aniline 62.25
    1,3-propanediol 146.69
    bromobenzene 55.14
    dibromomethane 80.11
    1,1,2,2-tetrachloroethane 155.06
    2-methyl-cyclohexyl acetate 58.34
    tetrabutyl urea 42.88
    diisobutyl methanol 44.05
    2-phenylethanol 96.44
    styrene 28.4
    dioctyl adipate 38.44
    dimethyl sulfate 145.8
    ethyl butyrate 104.52
    methyl lactate 117.95
    butyl lactate 56.47
    diethyl carbonate 58.84
    propanediol butyl ether 80.78
    triethyl orthoformate 62.43
    p-tert-butyltoluene 26.91
    methyl 4-tert-butylbenzoate 75.2
    morpholine 240.44
    tert-butylamine 73.0
    n-dodecanol 33.09
    dimethoxymethane 258.46
    ethylene carbonate 109.04
    cyrene 74.64
    2-ethoxyethyl acetate 91.15
    2-ethylhexyl acetate 75.94
    1,2,4-trichlorobenzene 61.76
    4-methylpyridine 133.18
    dibutyl ether 53.51
    2,6-dimethyl-4-heptanol 44.05
    DEF 165.49
    dimethyl isosorbide 137.0
    tetrachloroethylene 101.07
    eugenol 82.14
    triacetin 58.03
    span 80 75.27
    1,4-butanediol 53.59
    1,1-dichloroethane 136.07
    2-methyl-1-pentanol 68.08
    methyl formate 191.2
    2-methyl-1-butanol 80.48
    n-decane 7.9
    butyronitrile 168.12
    3,7-dimethyl-1-octanol 51.09
    1-chlorooctane 34.48
    1-chlorotetradecane 13.78
    n-nonane 7.31
    undecane 6.12
    tert-butylcyclohexane 7.93
    cyclooctane 2.39
    cyclopentanol 84.49
    tetrahydropyran 165.75
    tert-amyl methyl ether 80.94
    2,5,8-trioxanonane 144.23
    1-hexene 37.72
    2-isopropoxyethanol 104.72
    2,2,2-trifluoroethanol 69.18
    methyl butyrate 140.71

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction