p-Methoxyphenetole

Overview IFRA Request a quote

  • Identifiers

    CAS number
    5076-72-2

    Molecular formula
    C9H12O2

    SMILES
    CCOC1=CC=C(C=C1)OC

  • Odor profile

    Fragrance
    Sweet 87.75%
    Nutty 65.55%
    Anisic 63.09%
    Phenolic 63.08%
    Vanilla 53.46%
    Earthy 48.65%
    Aromatic 40.59%
    Musty 37.22%
    Spicy 36.58%
    Smoky 35.77%

     

    Flavor
    Sweet 63.35%
    Bitter 58.02%
    Green 48.85%
    Vanilla 43.34%
    Fruity 38.23%
    Phenolic 36.05%
    Musty 35.4%
    Anise 34.68%
    Creamy 32.72%
    New mown hay 30.09%

     

    Odor impact est.
    High

  • Properties

    XLogP3-AA
    2.1

    pKa est.
    7.34 (neutral)

    Molecular weight
    152.19 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Moderately slow

    Boiling point est.
    227°C

    Flash point

    • 83.15 ˚C est.

  • Synonyms

    • 1-Ethoxy-4-methoxybenzene
    • p-Ethoxyanisole
    • p-Methoxyphenetole
    • 5076-72-2
    • 4-Ethoxyanisole
    • Benzene, 1-ethoxy-4-methoxy-
    • Ethyl p-methoxyphenyl ether
    • EINECS 225-786-4
    • I9389X2T25
    • DTXSID60198795
    • UNII-I9389X2T25
    • 1-methoxy-4-ethoxybenzene
    • 1-Ethoxy-4-methoxybenzene #
    • SCHEMBL354674
    • CHEMBL2252609
    • DTXCID20121286
    • NS00022258
    • Q27280598
    • 225-786-4

  • Applications

    p-Methoxyphenetole is primarily used as an aromatic ether intermediate and solvent in organic synthesis, commonly serving as a precursor for fragrance compounds such as anisaldehyde and related anisole derivatives; in industrial manufacturing it may function as a solvent for coatings, inks, and surface-treatment formulations; in perfumery and cosmetics it can act as a fragrance ingredient or precursor contributing anisole-like notes; it may also be evaluated as a chemical intermediate for the synthesis of pharmaceutical or polymer-related intermediates under appropriate safety and regulatory controls.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 154.55
    methanol 149.74
    isopropanol 114.63
    water 1.16
    ethyl acetate 540.26
    n-propanol 143.36
    acetone 596.47
    n-butanol 149.62
    acetonitrile 581.98
    DMF 623.29
    toluene 221.26
    isobutanol 112.68
    1,4-dioxane 923.84
    methyl acetate 547.24
    THF 973.35
    2-butanone 507.3
    n-pentanol 122.82
    sec-butanol 135.25
    n-hexane 68.37
    ethylene glycol 81.52
    NMP 858.13
    cyclohexane 98.31
    DMSO 1384.9
    n-butyl acetate 393.89
    n-octanol 69.48
    chloroform 1857.97
    n-propyl acetate 321.59
    acetic acid 471.04
    dichloromethane 2169.67
    cyclohexanone 653.16
    propylene glycol 71.39
    isopropyl acetate 292.34
    DMAc 764.97
    2-ethoxyethanol 332.89
    isopentanol 160.06
    n-heptane 36.96
    ethyl formate 265.4
    1,2-dichloroethane 1480.07
    n-hexanol 123.43
    2-methoxyethanol 449.48
    isobutyl acetate 188.57
    tetrachloromethane 335.97
    n-pentyl acetate 162.97
    transcutol 1571.71
    n-heptanol 53.1
    ethylbenzene 140.87
    MIBK 210.85
    2-propoxyethanol 305.21
    tert-butanol 265.67
    MTBE 431.38
    2-butoxyethanol 147.6
    propionic acid 256.72
    o-xylene 164.78
    formic acid 181.79
    diethyl ether 460.19
    m-xylene 134.82
    p-xylene 176.99
    chlorobenzene 502.92
    dimethyl carbonate 283.16
    n-octane 13.45
    formamide 370.44
    cyclopentanone 798.4
    2-pentanone 340.94
    anisole 416.83
    cyclopentyl methyl ether 450.52
    gamma-butyrolactone 1027.16
    1-methoxy-2-propanol 290.45
    pyridine 659.41
    3-pentanone 396.3
    furfural 948.86
    n-dodecane 12.3
    diethylene glycol 288.77
    diisopropyl ether 134.4
    tert-amyl alcohol 248.86
    acetylacetone 606.25
    n-hexadecane 14.43
    acetophenone 346.18
    methyl propionate 388.89
    isopentyl acetate 343.18
    trichloroethylene 2580.59
    n-nonanol 66.11
    cyclohexanol 193.98
    benzyl alcohol 199.35
    2-ethylhexanol 114.49
    isooctanol 54.54
    dipropyl ether 216.08
    1,2-dichlorobenzene 556.39
    ethyl lactate 137.18
    propylene carbonate 501.88
    n-methylformamide 289.09
    2-pentanol 113.95
    n-pentane 44.69
    1-propoxy-2-propanol 214.05
    1-methoxy-2-propyl acetate 404.03
    2-(2-methoxypropoxy) propanol 302.45
    mesitylene 99.75
    ε-caprolactone 561.31
    p-cymene 103.04
    epichlorohydrin 1417.95
    1,1,1-trichloroethane 1192.54
    2-aminoethanol 122.13
    morpholine-4-carbaldehyde 890.87
    sulfolane 1369.56
    2,2,4-trimethylpentane 36.45
    2-methyltetrahydrofuran 705.1
    n-hexyl acetate 242.8
    isooctane 22.67
    2-(2-butoxyethoxy)ethanol 339.64
    sec-butyl acetate 228.49
    tert-butyl acetate 382.24
    decalin 67.42
    glycerin 162.53
    diglyme 782.77
    acrylic acid 294.04
    isopropyl myristate 117.97
    n-butyric acid 306.65
    acetyl acetate 537.42
    di(2-ethylhexyl) phthalate 117.51
    ethyl propionate 331.79
    nitromethane 1278.61
    1,2-diethoxyethane 555.19
    benzonitrile 334.77
    trioctyl phosphate 73.68
    1-bromopropane 574.84
    gamma-valerolactone 916.1
    n-decanol 50.71
    triethyl phosphate 213.35
    4-methyl-2-pentanol 77.75
    propionitrile 338.26
    vinylene carbonate 490.39
    1,1,2-trichlorotrifluoroethane 926.58
    DMS 429.31
    cumene 100.65
    2-octanol 43.6
    2-hexanone 286.97
    octyl acetate 130.87
    limonene 154.09
    1,2-dimethoxyethane 737.23
    ethyl orthosilicate 199.51
    tributyl phosphate 135.34
    diacetone alcohol 290.69
    N,N-dimethylaniline 251.87
    acrylonitrile 459.94
    aniline 276.67
    1,3-propanediol 173.91
    bromobenzene 644.19
    dibromomethane 1279.58
    1,1,2,2-tetrachloroethane 1938.71
    2-methyl-cyclohexyl acetate 260.52
    tetrabutyl urea 161.99
    diisobutyl methanol 79.83
    2-phenylethanol 176.52
    styrene 207.62
    dioctyl adipate 213.7
    dimethyl sulfate 598.09
    ethyl butyrate 315.14
    methyl lactate 175.72
    butyl lactate 127.96
    diethyl carbonate 291.71
    propanediol butyl ether 144.13
    triethyl orthoformate 245.62
    p-tert-butyltoluene 99.01
    methyl 4-tert-butylbenzoate 251.83
    morpholine 797.1
    tert-butylamine 183.46
    n-dodecanol 43.04
    dimethoxymethane 474.04
    ethylene carbonate 411.24
    cyrene 279.95
    2-ethoxyethyl acetate 317.04
    2-ethylhexyl acetate 304.12
    1,2,4-trichlorobenzene 678.9
    4-methylpyridine 543.49
    dibutyl ether 194.45
    2,6-dimethyl-4-heptanol 79.83
    DEF 474.04
    dimethyl isosorbide 570.88
    tetrachloroethylene 1133.3
    eugenol 224.04
    triacetin 368.68
    span 80 191.77
    1,4-butanediol 79.12
    1,1-dichloroethane 999.96
    2-methyl-1-pentanol 147.64
    methyl formate 273.25
    2-methyl-1-butanol 151.13
    n-decane 19.71
    butyronitrile 289.28
    3,7-dimethyl-1-octanol 96.21
    1-chlorooctane 87.97
    1-chlorotetradecane 41.26
    n-nonane 19.22
    undecane 14.82
    tert-butylcyclohexane 55.87
    cyclooctane 37.56
    cyclopentanol 196.12
    tetrahydropyran 600.83
    tert-amyl methyl ether 324.71
    2,5,8-trioxanonane 573.72
    1-hexene 151.02
    2-isopropoxyethanol 233.67
    2,2,2-trifluoroethanol 255.7
    methyl butyrate 377.06

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction