p-Methoxymethylanisole

Overview IFRA Request a quote

  • Identifiers

    CAS number
    1515-81-7

    Molecular formula
    C9H12O2

    SMILES
    COCC1=CC=C(C=C1)OC

    Safety labels

    Corrosive
    Corrosive

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Floral 84.36%
    Anisic 66.3%
    Green 59.75%
    Sweet 59.11%
    Earthy 48.22%
    Rose 44.13%
    Fruity 43.37%
    Spicy 42.76%
    Aromatic 40.46%
    Vanilla 37.08%

     

    Flavor
    Fruity 74.06%
    Sweet 66.85%
    Floral 58.35%
    Rose 41.3%
    Earthy 37.17%
    Spicy 36.28%
    Almond 36.13%
    Chocolate 35.92%
    Cherry 34.63%
    Vanilla 34.01%

     

    Odor impact est.
    High

  • Properties

    XLogP3-AA
    1.6

    pKa est.
    6.25 (neutral)

    Molecular weight
    152.19 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Moderately slow

    Boiling point est.
    225°C

    Flash point

    • 85.97 ˚C est.

  • Synonyms

    • 1-methoxy-4-(methoxymethyl)benzene
    • 1515-81-7
    • p-(Methoxymethyl)anisole
    • Benzene, 1-methoxy-4-(methoxymethyl)-
    • p-Methoxymethylanisole
    • 4-(Methoxymethyl)anisole
    • (4-Methoxybenzyl) Methyl Ether
    • p,alpha-Dimethoxytoluene
    • 4-methoxybenzyl methyl ether
    • 563PH7T92V
    • EINECS 216-161-7
    • MFCD00155135
    • NSC 37490
    • NSC-37490
    • 4-METHOXYMETHYLANISOLE
    • Toluene, p,.alpha.-dimethoxy-
    • DTXSID0061743
    • P-METHOXYBENZYL METHYL ETHER
    • METHYL-4-METHOXYBENZYL ETHER
    • UNII-563PH7T92V
    • NSC37490
    • para-alpha-dimethoxytoluene
    • 4-(methoxymethyl)-anisole
    • p,.alpha.-Dimethoxytoluene
    • SCHEMBL31270
    • SCHEMBL1151673
    • SCHEMBL5321146
    • DTXCID8034902
    • SCHEMBL10205414
    • TOLUENE, P,ALPHA-DIMETHOXY-
    • 1-methoxy-4-(methoxymethyl)-benzene
    • 4-Methoxybenzyl alcohol, methyl ether
    • AKOS015995151
    • AS-63148
    • SY022059
    • CS-0150191
    • M2305
    • NS00021683
    • S10552
    • Q27261368
    • 216-161-7

  • Applications

    Chemical name: p-Methoxymethylanisole; CAS 1515-81-7. p-Methoxymethylanisole is primarily employed in fragrance and flavor applications as an odorant and fragrance intermediate; in perfumery and cosmetics it often serves as a fragrance ingredient and may contribute as a fixative in formulations. It is also used as a chemical intermediate in organic synthesis for downstream products in polymers, coatings, and specialty chemicals. In industrial manufacturing it can function as a solvent or co-solvent in certain processes, and in household products it may be used as an odorant additive in cleaners, air fresheners, and related formulations. Use is subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 1019.26
    methanol 899.69
    isopropanol 694.52
    water 4.5
    ethyl acetate 1149.75
    n-propanol 757.07
    acetone 1387.61
    n-butanol 615.39
    acetonitrile 1538.43
    DMF 1319.16
    toluene 319.43
    isobutanol 461.1
    1,4-dioxane 1665.02
    methyl acetate 1158.28
    THF 1426.08
    2-butanone 939.46
    n-pentanol 403.75
    sec-butanol 587.45
    n-hexane 66.72
    ethylene glycol 398.21
    NMP 969.78
    cyclohexane 137.51
    DMSO 2716.49
    n-butyl acetate 576.35
    n-octanol 126.3
    chloroform 2776.76
    n-propyl acetate 576.25
    acetic acid 1611.93
    dichloromethane 3114.08
    cyclohexanone 896.64
    propylene glycol 472.49
    isopropyl acetate 441.1
    DMAc 892.53
    2-ethoxyethanol 967.82
    isopentanol 450.88
    n-heptane 51.06
    ethyl formate 702.75
    1,2-dichloroethane 2069.41
    n-hexanol 341.87
    2-methoxyethanol 1366.63
    isobutyl acetate 253.53
    tetrachloromethane 562.09
    n-pentyl acetate 201.21
    transcutol 2342.28
    n-heptanol 124.02
    ethylbenzene 157.44
    MIBK 323.27
    2-propoxyethanol 652.48
    tert-butanol 952.92
    MTBE 750.44
    2-butoxyethanol 292.86
    propionic acid 913.13
    o-xylene 204.14
    formic acid 780.64
    diethyl ether 994.15
    m-xylene 187.92
    p-xylene 181.84
    chlorobenzene 603.36
    dimethyl carbonate 366.98
    n-octane 14.67
    formamide 1347.35
    cyclopentanone 1078.29
    2-pentanone 650.58
    anisole 511.35
    cyclopentyl methyl ether 705.79
    gamma-butyrolactone 1368.27
    1-methoxy-2-propanol 818.73
    pyridine 1201.88
    3-pentanone 553.42
    furfural 1331.39
    n-dodecane 10.68
    diethylene glycol 659.85
    diisopropyl ether 192.78
    tert-amyl alcohol 687.48
    acetylacetone 773.59
    n-hexadecane 12.55
    acetophenone 385.51
    methyl propionate 779.85
    isopentyl acetate 399.0
    trichloroethylene 3390.52
    n-nonanol 107.49
    cyclohexanol 522.85
    benzyl alcohol 365.49
    2-ethylhexanol 216.22
    isooctanol 102.66
    dipropyl ether 335.05
    1,2-dichlorobenzene 531.1
    ethyl lactate 257.87
    propylene carbonate 679.29
    n-methylformamide 1069.45
    2-pentanol 400.61
    n-pentane 75.75
    1-propoxy-2-propanol 466.12
    1-methoxy-2-propyl acetate 506.44
    2-(2-methoxypropoxy) propanol 350.49
    mesitylene 123.07
    ε-caprolactone 748.53
    p-cymene 116.03
    epichlorohydrin 1938.85
    1,1,1-trichloroethane 1592.69
    2-aminoethanol 620.91
    morpholine-4-carbaldehyde 1106.0
    sulfolane 1593.69
    2,2,4-trimethylpentane 43.83
    2-methyltetrahydrofuran 1162.8
    n-hexyl acetate 280.18
    isooctane 30.32
    2-(2-butoxyethoxy)ethanol 480.37
    sec-butyl acetate 301.53
    tert-butyl acetate 494.16
    decalin 56.94
    glycerin 592.03
    diglyme 1091.77
    acrylic acid 872.97
    isopropyl myristate 104.26
    n-butyric acid 919.58
    acetyl acetate 648.19
    di(2-ethylhexyl) phthalate 107.11
    ethyl propionate 465.22
    nitromethane 2944.37
    1,2-diethoxyethane 681.94
    benzonitrile 471.5
    trioctyl phosphate 74.46
    1-bromopropane 889.82
    gamma-valerolactone 1278.16
    n-decanol 79.74
    triethyl phosphate 196.57
    4-methyl-2-pentanol 177.79
    propionitrile 812.86
    vinylene carbonate 694.72
    1,1,2-trichlorotrifluoroethane 1471.1
    DMS 354.5
    cumene 108.69
    2-octanol 76.01
    2-hexanone 442.68
    octyl acetate 130.43
    limonene 181.27
    1,2-dimethoxyethane 1211.03
    ethyl orthosilicate 189.64
    tributyl phosphate 115.45
    diacetone alcohol 542.88
    N,N-dimethylaniline 280.22
    acrylonitrile 1012.97
    aniline 621.93
    1,3-propanediol 756.55
    bromobenzene 622.7
    dibromomethane 1882.68
    1,1,2,2-tetrachloroethane 2280.63
    2-methyl-cyclohexyl acetate 259.92
    tetrabutyl urea 131.58
    diisobutyl methanol 124.92
    2-phenylethanol 293.48
    styrene 239.63
    dioctyl adipate 181.49
    dimethyl sulfate 611.31
    ethyl butyrate 414.24
    methyl lactate 365.18
    butyl lactate 181.6
    diethyl carbonate 318.41
    propanediol butyl ether 287.66
    triethyl orthoformate 286.4
    p-tert-butyltoluene 110.66
    methyl 4-tert-butylbenzoate 259.91
    morpholine 1812.25
    tert-butylamine 570.42
    n-dodecanol 61.32
    dimethoxymethane 800.06
    ethylene carbonate 575.19
    cyrene 329.8
    2-ethoxyethyl acetate 413.42
    2-ethylhexyl acetate 312.33
    1,2,4-trichlorobenzene 696.02
    4-methylpyridine 863.19
    dibutyl ether 212.8
    2,6-dimethyl-4-heptanol 124.92
    DEF 780.82
    dimethyl isosorbide 533.26
    tetrachloroethylene 1488.86
    eugenol 267.17
    triacetin 378.95
    span 80 247.43
    1,4-butanediol 322.7
    1,1-dichloroethane 1622.45
    2-methyl-1-pentanol 328.64
    methyl formate 823.98
    2-methyl-1-butanol 445.16
    n-decane 19.29
    butyronitrile 678.49
    3,7-dimethyl-1-octanol 152.74
    1-chlorooctane 103.46
    1-chlorotetradecane 37.75
    n-nonane 19.72
    undecane 13.65
    tert-butylcyclohexane 51.58
    cyclooctane 45.64
    cyclopentanol 531.86
    tetrahydropyran 1259.9
    tert-amyl methyl ether 491.51
    2,5,8-trioxanonane 664.96
    1-hexene 225.71
    2-isopropoxyethanol 565.93
    2,2,2-trifluoroethanol 620.77
    methyl butyrate 592.18

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction