p-Ethoxyacetophenone

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  • Identifiers

    CAS number
    1676-63-7

    Molecular formula
    C10H12O2

    SMILES
    CCOC1=CC=C(C=C1)C(=O)C

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Sweet 83.28%
    Floral 83.09%
    Anisic 62.58%
    Vanilla 61.22%
    Hawthorn 58.01%
    Powdery 57.95%
    Hay 51.33%
    Cherry 47.99%
    Balsamic 46.04%
    Coumarinic 45.89%

     

    Flavor
    Sweet 94.96%
    Vanilla 63.89%
    Hawthorn 59.08%
    Floral 56.26%
    Powdery 54.78%
    Balsam 50.38%
    Bitter 49.89%
    Cherry 44.5%
    Almond 39.83%
    Creamy 39.48%

     

    Odor impact est.
    Medium

  • Properties

    XLogP3-AA
    2.1

    pKa est.
    7.58 (neutral)

    Molecular weight
    164.2 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Slow

    Boiling point est.
    259°C

    Flash point

    • 100.21 ˚C est.

  • Synonyms

    • 4'-Ethoxyacetophenone
    • 1676-63-7
    • 1-(4-Ethoxyphenyl)ethanone
    • p-Ethoxyacetophenone
    • Ethanone, 1-(4-ethoxyphenyl)-
    • 4-Ethoxyacetophenone
    • 1-(4-Ethoxyphenyl)ethan-1-one
    • Acetophenone, p-ethoxy-
    • Acetophenone, 4'-ethoxy-
    • 4'-Ethoxy acetophenone
    • MFCD00009095
    • EWR02SWC14
    • NSC 403850
    • EINECS 216-825-6
    • NSC 406258
    • NSC-403850
    • NSC-406258
    • AI3-01029
    • 4-Acetylphenetole
    • 4-Ethoxyphenylethanone
    • UNII-EWR02SWC14
    • 4\'-Ethoxyacetophenone
    • 4'-Ethoxyacetophenone, 98%
    • SCHEMBL166144
    • CHEMBL5290014
    • DTXSID5061873
    • CK1149
    • NSC403850
    • NSC406258
    • STL163384
    • AKOS000120844
    • CS-W013245
    • FE35357
    • FS-1543
    • SY011487
    • DB-043709
    • E0458
    • NS00025505
    • EN300-16105
    • 4 inverted exclamation mark -Ethoxyacetophenone
    • 4'-Ethoxyacetophenone, Vetec(TM) reagent grade, 98%
    • Q27277399
    • Z53832961
    • F0001-0614

  • Applications

    p-Ethoxyacetophenone (CAS 1676-63-7) is primarily used as an intermediate in organic synthesis. In the fragrance and flavor/aroma industries, it is commonly employed as a precursor to shape aroma profiles and may function as an odorant or fixative in perfumery; in cosmetics and personal care, it can serve as a fragrance ingredient or scent component; in the pharmaceutical and agrochemical sectors, it acts as a building block for the synthesis of more complex active compounds; in general industrial manufacturing, it serves as a versatile synthetic building block for preparing related acetophenone derivatives. Use is subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 146.31
    methanol 190.73
    isopropanol 111.04
    water 2.19
    ethyl acetate 266.37
    n-propanol 130.09
    acetone 438.59
    n-butanol 137.76
    acetonitrile 327.16
    DMF 778.74
    toluene 152.94
    isobutanol 106.07
    1,4-dioxane 607.46
    methyl acetate 295.4
    THF 625.97
    2-butanone 326.29
    n-pentanol 116.76
    sec-butanol 116.85
    n-hexane 43.35
    ethylene glycol 96.84
    NMP 835.31
    cyclohexane 42.78
    DMSO 1032.69
    n-butyl acetate 204.94
    n-octanol 56.9
    chloroform 1027.49
    n-propyl acetate 166.12
    acetic acid 388.34
    dichloromethane 1042.84
    cyclohexanone 456.27
    propylene glycol 85.3
    isopropyl acetate 176.99
    DMAc 890.32
    2-ethoxyethanol 296.84
    isopentanol 154.62
    n-heptane 15.92
    ethyl formate 152.36
    1,2-dichloroethane 703.58
    n-hexanol 100.58
    2-methoxyethanol 437.84
    isobutyl acetate 118.83
    tetrachloromethane 144.18
    n-pentyl acetate 103.95
    transcutol 1503.05
    n-heptanol 45.3
    ethylbenzene 97.62
    MIBK 163.23
    2-propoxyethanol 261.23
    tert-butanol 252.6
    MTBE 312.47
    2-butoxyethanol 125.47
    propionic acid 220.54
    o-xylene 121.24
    formic acid 194.45
    diethyl ether 285.42
    m-xylene 107.01
    p-xylene 122.51
    chlorobenzene 309.3
    dimethyl carbonate 197.05
    n-octane 6.84
    formamide 340.15
    cyclopentanone 555.79
    2-pentanone 233.23
    anisole 293.25
    cyclopentyl methyl ether 297.11
    gamma-butyrolactone 652.12
    1-methoxy-2-propanol 297.07
    pyridine 412.11
    3-pentanone 251.08
    furfural 660.37
    n-dodecane 7.25
    diethylene glycol 281.64
    diisopropyl ether 91.89
    tert-amyl alcohol 219.77
    acetylacetone 390.02
    n-hexadecane 8.49
    acetophenone 249.25
    methyl propionate 245.58
    isopentyl acetate 206.45
    trichloroethylene 1245.73
    n-nonanol 53.74
    cyclohexanol 151.68
    benzyl alcohol 180.36
    2-ethylhexanol 81.55
    isooctanol 43.7
    dipropyl ether 115.63
    1,2-dichlorobenzene 329.7
    ethyl lactate 104.34
    propylene carbonate 311.74
    n-methylformamide 284.78
    2-pentanol 98.81
    n-pentane 26.32
    1-propoxy-2-propanol 170.46
    1-methoxy-2-propyl acetate 256.31
    2-(2-methoxypropoxy) propanol 262.64
    mesitylene 76.4
    ε-caprolactone 386.15
    p-cymene 59.52
    epichlorohydrin 812.71
    1,1,1-trichloroethane 557.9
    2-aminoethanol 137.52
    morpholine-4-carbaldehyde 813.52
    sulfolane 898.24
    2,2,4-trimethylpentane 24.81
    2-methyltetrahydrofuran 412.26
    n-hexyl acetate 176.35
    isooctane 15.89
    2-(2-butoxyethoxy)ethanol 300.61
    sec-butyl acetate 133.94
    tert-butyl acetate 263.54
    decalin 40.48
    glycerin 198.38
    diglyme 618.9
    acrylic acid 255.62
    isopropyl myristate 81.18
    n-butyric acid 230.47
    acetyl acetate 263.4
    di(2-ethylhexyl) phthalate 92.59
    ethyl propionate 173.4
    nitromethane 870.07
    1,2-diethoxyethane 362.78
    benzonitrile 233.18
    trioctyl phosphate 54.83
    1-bromopropane 296.89
    gamma-valerolactone 721.86
    n-decanol 41.6
    triethyl phosphate 122.68
    4-methyl-2-pentanol 72.0
    propionitrile 211.41
    vinylene carbonate 315.73
    1,1,2-trichlorotrifluoroethane 580.47
    DMS 292.64
    cumene 74.28
    2-octanol 35.24
    2-hexanone 195.62
    octyl acetate 92.94
    limonene 90.49
    1,2-dimethoxyethane 551.67
    ethyl orthosilicate 117.39
    tributyl phosphate 96.08
    diacetone alcohol 259.7
    N,N-dimethylaniline 198.25
    acrylonitrile 305.88
    aniline 214.26
    1,3-propanediol 173.11
    bromobenzene 352.34
    dibromomethane 603.18
    1,1,2,2-tetrachloroethane 956.31
    2-methyl-cyclohexyl acetate 162.36
    tetrabutyl urea 119.09
    diisobutyl methanol 57.23
    2-phenylethanol 146.84
    styrene 144.61
    dioctyl adipate 142.22
    dimethyl sulfate 420.78
    ethyl butyrate 152.07
    methyl lactate 159.87
    butyl lactate 99.07
    diethyl carbonate 140.44
    propanediol butyl ether 142.07
    triethyl orthoformate 138.29
    p-tert-butyltoluene 60.71
    methyl 4-tert-butylbenzoate 186.95
    morpholine 604.91
    tert-butylamine 163.77
    n-dodecanol 33.94
    dimethoxymethane 401.0
    ethylene carbonate 258.07
    cyrene 252.57
    2-ethoxyethyl acetate 219.53
    2-ethylhexyl acetate 171.72
    1,2,4-trichlorobenzene 423.17
    4-methylpyridine 393.78
    dibutyl ether 118.62
    2,6-dimethyl-4-heptanol 57.23
    DEF 379.83
    dimethyl isosorbide 403.47
    tetrachloroethylene 557.5
    eugenol 187.77
    triacetin 257.09
    span 80 165.05
    1,4-butanediol 84.57
    1,1-dichloroethane 522.79
    2-methyl-1-pentanol 139.72
    methyl formate 224.17
    2-methyl-1-butanol 146.06
    n-decane 10.87
    butyronitrile 180.73
    3,7-dimethyl-1-octanol 75.43
    1-chlorooctane 53.68
    1-chlorotetradecane 26.28
    n-nonane 9.96
    undecane 8.62
    tert-butylcyclohexane 36.32
    cyclooctane 16.22
    cyclopentanol 147.58
    tetrahydropyran 373.34
    tert-amyl methyl ether 245.04
    2,5,8-trioxanonane 474.42
    1-hexene 109.76
    2-isopropoxyethanol 199.15
    2,2,2-trifluoroethanol 201.01
    methyl butyrate 207.79

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction