p-(Dimethoxymethyl)anisole

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  • Identifiers

    CAS number
    2186-92-7

    Molecular formula
    C10H14O3

    SMILES
    COC1=CC=C(C=C1)C(OC)OC

  • Odor profile

    Fragrance
    Floral 78.44%
    Green 75.35%
    Sweet 56.12%
    Anisic 55.27%
    Spicy 54.45%
    Earthy 51.67%
    Herbal 47.83%
    Fresh 37.35%
    Aromatic 37.22%
    Almond 36.68%

     

    Flavor
    Fruity 76.43%
    Green 62.5%
    Floral 59.63%
    Sweet 46.52%
    Earthy 39.61%
    Wine 34.08%
    Bitter 32.64%
    Musty 29.45%
    Mushroom 28.78%
    Spicy 27.05%

     

    Odor impact est.
    Medium

  • Properties

    XLogP3-AA
    1.5

    pKa est.
    5.67 (weak acid)

    Molecular weight
    182.22 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Slow

    Boiling point est.
    250°C

    Flash point

    • 101.26 ˚C est.

  • Synonyms

    • 2186-92-7
    • 1-(Dimethoxymethyl)-4-methoxybenzene
    • p-Anisaldehyde dimethyl acetal
    • Anisaldehyde dimethyl acetal
    • 4-Methoxybenzaldehyde dimethyl acetal
    • p-(Dimethoxymethyl)anisole
    • Benzene, 1-(dimethoxymethyl)-4-methoxy-
    • Anisicaldehyde dimethylacetal
    • p-anisaldehyde dimethylacetal
    • XTE77A5ET4
    • p-methoxybenzaldehyde dimethyl acetal
    • MFCD00036507
    • alpha,alpha,4-Trimethoxytoluene
    • DTXSID3062239
    • 4-Methoxybenzaldehyddimethylacetal
    • dimethoxy(4-methoxyphenyl)methane
    • 4-ANISALDEHYDDIMETHYLACETAL
    • EINECS 218-577-4
    • 4-ANISALDEHYDE DIMETHYL ACETAL
    • ANISIC ALDEHYDE DIMETHYL ACETAL
    • P-ANISALDEHYDE, DIMETHYL ACETAL
    • (P-METHOXYPHENYL)DIMETHOXYMETHANE
    • EC 218-577-4
    • TOLUENE, P,.ALPHA.,.ALPHA.-TRIMETHOXY-
    • P-ANISALDEHYDEDIMETHYLACETAL
    • a,a,4-Trimethoxytoluene
    • anisaldehyde-dimethylacetal
    • Dimethylacetal anisaldehyde
    • UNII-XTE77A5ET4
    • SCHEMBL192165
    • DTXCID9036565
    • para-anisaldehyde dimethyl acetal
    • 4-methoxybenzaldehyde dimethylacetal
    • ALBB-033139
    • CS-M1998
    • AKOS009031188
    • FA55064
    • 1-(Dimethoxymethyl)-4-methoxybenzene #
    • AS-49359
    • SY012039
    • TOLUENE, P,ALPHA,ALPHA-TRIMETHOXY-
    • A1247
    • NS00007837
    • EN300-20830
    • Anisaldehyde dimethyl acetal, >=98.5% (GC)
    • H11271
    • Q27293986
    • 1-(dimethoxymethyl)-4-methoxybenzene;4-Anisaldehyde dimethylacetal
    • 218-577-4

  • Applications

    p-(Dimethoxymethyl)anisole (CAS 2186-92-7) is primarily used as an organic synthesis intermediate, enabling the construction of para-substituted anisole derivatives and providing an acetal-protected handle via the dimethoxymethyl group in multi-step routes. In industry, it may serve as a building block or precursor for applications in the fragrance and cosmetics sectors (as a fragrance ingredient or intermediate), as well as for polymer chemistry, coatings, and inks. It is also considered as an intermediate for pharmaceutical or agrochemical synthesis. The use is typically subject to formulation limits and local regulations.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 288.98
    methanol 301.36
    isopropanol 223.17
    water 7.57
    ethyl acetate 521.56
    n-propanol 223.23
    acetone 1009.66
    n-butanol 206.76
    acetonitrile 789.37
    DMF 1345.2
    toluene 169.47
    isobutanol 171.99
    1,4-dioxane 733.92
    methyl acetate 531.85
    THF 1025.94
    2-butanone 518.61
    n-pentanol 184.78
    sec-butanol 211.14
    n-hexane 65.74
    ethylene glycol 153.58
    NMP 1275.78
    cyclohexane 105.83
    DMSO 2417.9
    n-butyl acetate 416.29
    n-octanol 90.15
    chloroform 2409.58
    n-propyl acetate 388.23
    acetic acid 1029.43
    dichloromethane 2764.7
    cyclohexanone 653.18
    propylene glycol 143.07
    isopropyl acetate 315.26
    DMAc 960.37
    2-ethoxyethanol 543.63
    isopentanol 198.89
    n-heptane 43.26
    ethyl formate 447.22
    1,2-dichloroethane 1681.77
    n-hexanol 161.42
    2-methoxyethanol 665.5
    isobutyl acetate 193.3
    tetrachloromethane 583.04
    n-pentyl acetate 188.41
    transcutol 1421.55
    n-heptanol 80.59
    ethylbenzene 135.9
    MIBK 282.71
    2-propoxyethanol 381.77
    tert-butanol 404.83
    MTBE 462.06
    2-butoxyethanol 212.83
    propionic acid 458.65
    o-xylene 160.44
    formic acid 591.22
    diethyl ether 471.81
    m-xylene 137.47
    p-xylene 160.0
    chlorobenzene 484.74
    dimethyl carbonate 394.78
    n-octane 13.84
    formamide 1160.4
    cyclopentanone 973.03
    2-pentanone 447.57
    anisole 437.77
    cyclopentyl methyl ether 519.07
    gamma-butyrolactone 1230.07
    1-methoxy-2-propanol 455.11
    pyridine 679.08
    3-pentanone 394.57
    furfural 1228.02
    n-dodecane 9.26
    diethylene glycol 390.66
    diisopropyl ether 161.29
    tert-amyl alcohol 359.11
    acetylacetone 663.79
    n-hexadecane 10.97
    acetophenone 403.11
    methyl propionate 459.46
    isopentyl acetate 333.53
    trichloroethylene 3229.53
    n-nonanol 79.86
    cyclohexanol 240.92
    benzyl alcohol 269.78
    2-ethylhexanol 131.69
    isooctanol 74.02
    dipropyl ether 236.67
    1,2-dichlorobenzene 594.75
    ethyl lactate 208.23
    propylene carbonate 703.66
    n-methylformamide 785.49
    2-pentanol 177.9
    n-pentane 60.19
    1-propoxy-2-propanol 297.52
    1-methoxy-2-propyl acetate 414.65
    2-(2-methoxypropoxy) propanol 295.62
    mesitylene 110.44
    ε-caprolactone 575.37
    p-cymene 112.97
    epichlorohydrin 1587.08
    1,1,1-trichloroethane 1458.76
    2-aminoethanol 233.28
    morpholine-4-carbaldehyde 991.36
    sulfolane 1943.28
    2,2,4-trimethylpentane 45.5
    2-methyltetrahydrofuran 710.48
    n-hexyl acetate 250.76
    isooctane 28.27
    2-(2-butoxyethoxy)ethanol 343.04
    sec-butyl acetate 234.26
    tert-butyl acetate 437.08
    decalin 59.69
    glycerin 300.85
    diglyme 903.77
    acrylic acid 581.04
    isopropyl myristate 98.08
    n-butyric acid 483.3
    acetyl acetate 509.05
    di(2-ethylhexyl) phthalate 107.6
    ethyl propionate 345.91
    nitromethane 2332.03
    1,2-diethoxyethane 430.57
    benzonitrile 398.08
    trioctyl phosphate 77.8
    1-bromopropane 603.06
    gamma-valerolactone 995.33
    n-decanol 56.96
    triethyl phosphate 224.08
    4-methyl-2-pentanol 111.6
    propionitrile 394.18
    vinylene carbonate 690.09
    1,1,2-trichlorotrifluoroethane 1477.05
    DMS 348.56
    cumene 105.62
    2-octanol 57.68
    2-hexanone 335.79
    octyl acetate 122.49
    limonene 168.54
    1,2-dimethoxyethane 859.81
    ethyl orthosilicate 199.05
    tributyl phosphate 122.04
    diacetone alcohol 413.74
    N,N-dimethylaniline 302.05
    acrylonitrile 586.18
    aniline 323.54
    1,3-propanediol 295.49
    bromobenzene 558.47
    dibromomethane 1636.55
    1,1,2,2-tetrachloroethane 2270.92
    2-methyl-cyclohexyl acetate 263.24
    tetrabutyl urea 151.01
    diisobutyl methanol 93.02
    2-phenylethanol 225.21
    styrene 194.47
    dioctyl adipate 185.74
    dimethyl sulfate 831.66
    ethyl butyrate 345.71
    methyl lactate 274.19
    butyl lactate 169.88
    diethyl carbonate 295.13
    propanediol butyl ether 202.96
    triethyl orthoformate 262.84
    p-tert-butyltoluene 110.53
    methyl 4-tert-butylbenzoate 295.86
    morpholine 793.81
    tert-butylamine 272.94
    n-dodecanol 43.55
    dimethoxymethane 723.62
    ethylene carbonate 523.56
    cyrene 361.49
    2-ethoxyethyl acetate 321.05
    2-ethylhexyl acetate 288.7
    1,2,4-trichlorobenzene 672.05
    4-methylpyridine 554.18
    dibutyl ether 163.9
    2,6-dimethyl-4-heptanol 93.02
    DEF 603.44
    dimethyl isosorbide 558.64
    tetrachloroethylene 1532.38
    eugenol 261.66
    triacetin 357.91
    span 80 205.25
    1,4-butanediol 159.63
    1,1-dichloroethane 1168.78
    2-methyl-1-pentanol 185.7
    methyl formate 727.61
    2-methyl-1-butanol 198.71
    n-decane 16.86
    butyronitrile 371.72
    3,7-dimethyl-1-octanol 103.68
    1-chlorooctane 90.59
    1-chlorotetradecane 33.44
    n-nonane 16.89
    undecane 11.93
    tert-butylcyclohexane 51.5
    cyclooctane 41.87
    cyclopentanol 296.64
    tetrahydropyran 540.24
    tert-amyl methyl ether 372.57
    2,5,8-trioxanonane 556.6
    1-hexene 163.63
    2-isopropoxyethanol 336.96
    2,2,2-trifluoroethanol 668.7
    methyl butyrate 455.89

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction