p-CRESIDINE

Overview IFRA Request a quote

  • Identifiers

    CAS number
    120-71-8

    Molecular formula
    C8H11NO

    SMILES
    CC1=CC(=C(C=C1)OC)N

    Safety labels

    Irritant
    Irritant

    Health Hazard
    Health

  • Odor profile

    Fragrance
    Phenolic 53.19%
    Sweet 48.48%
    Smoky 42.42%
    Spicy 41.2%
    Leathery 35.09%
    Animal 34.5%
    Woody 34.34%
    Burnt 33.2%
    Earthy 32.97%
    Medicinal 31.59%

     

    Flavor
    Sweet 58.96%
    Phenolic 51.32%
    Spicy 49.45%
    Powdery 40.68%
    Medicinal 38.2%
    Smoky 38.0%
    Woody 37.51%
    Floral 36.88%
    Vanilla 34.6%
    Spice 34.1%

     

    Odor impact est.
    Medium

  • Properties

    XLogP3-AA
    1.7

    pKa est.
    5.15 (weak acid)

    Molecular weight
    137.18 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Moderately slow

    Melting point expt.

    • 126 to 129 °F (NTP, 1992)
    • 51.5 °C

    Boiling point

    • 455 °F at 760 mmHg (NTP, 1992)
    • 235 °C

    Flash point

    • 107.28 ˚C est.
    • greater than 230 °F (NTP, 1992)
    • 111 °C

    Solubility expt.

    • less than 1 mg/mL at 72 °F (NTP, 1992)
    • Slightly soluble in water, chloroform. Soluble in ether, benzene, petroleum ether, and ethanol.
    • Solubility in water: poor

  • Synonyms

    • 2-Methoxy-5-methylaniline
    • 120-71-8
    • P-CRESIDINE
    • Cresidine
    • para-Cresidine
    • 5-Methyl-o-anisidine
    • Benzenamine, 2-methoxy-5-methyl-
    • Krezidin
    • 2-Amino-4-methylanisole
    • 6-Methoxy-m-toluidine
    • 3-Amino-4-methoxytoluene
    • 4-Methoxy-m-toluidine
    • Krezidine
    • 4-Methyl-2-aminoanisole
    • Azoic Red 36
    • 2-Methoxy-5-methylbenzenamine
    • 1-Amino-2-methoxy-5-methylbenzene
    • o-Anisidine, 5-methyl-
    • C.I. Azoic Red 83
    • 3-Amino-p-cresol methyl ether
    • p-Kresidin
    • p-Kresidin [Czech]
    • NCI-C02982
    • m-Amino-p-cresol, methyl ester
    • ortho-Anisidine, 5-methyl-
    • CCRIS 183
    • NSC 406904
    • HSDB 4107
    • 3-Amino-para-cresol, methyl ether
    • EINECS 204-419-1
    • meta-Amino-para-cresol, methyl ether
    • BRN 0637071
    • DTXSID1020350
    • NSC6162
    • 4C11L78UR3
    • NSC-6162
    • NSC-406904
    • P-CRESIDINE [HSDB]
    • DTXCID30350
    • PARA-CRESIDINE [IARC]
    • CHEBI:82307
    • EC 204-419-1
    • 3-13-00-01577 (Beilstein Handbook Reference)
    • M-AMINO-P-CRESOL METHYL ESTER
    • MFCD00007815
    • NSC406904
    • 2-METHOXY-5-METHYLBENZENEAMINE
    • WLN: ZR C1 FO1
    • PARA-CRESIDINE (IARC)
    • CAS-120-71-8
    • 2-methoxy-5-methyl-aniline
    • pKresidin
    • UNII-4C11L78UR3
    • 2-Amino-p-cresol methyl ether
    • 5Methyloanisidine
    • 4Methoxymtoluidine
    • 6Methoxymtoluidine
    • ZZT
    • 2Amino4methylanisole
    • 4Methyl2aminoanisole
    • oAnisidine, 5methyl
    • 3Amino4methoxytoluene
    • 2Methoxy5methylaniline
    • orthoAnisidine, 5methyl
    • 4-Methoxy-meta-toluidine
    • 5-Methyl-ortho-anisidine
    • 2Methoxy5methylbenzenamine
    • 3Aminopcresol methyl ether
    • 2-amino -4-methylanisole
    • 5-methyl-2-methoxyaniline
    • mAminopcresol, methyl ester
    • 1Amino2methoxy5methylbenzene
    • Benzenamine, 2methoxy5methyl
    • SCHEMBL55544
    • MLS002152926
    • BIDD:GT0303
    • 3Aminoparacresol, methyl ether
    • 2-methoxy-5-methyl-benzenamine
    • CHEMBL398755
    • o-Anisidine, 5-methyl-(8CI)
    • metaAminoparacresol, methyl ether
    • 3-Amino-para-cresol methyl ether
    • 2-Methoxy-5-methylaniline, 99%
    • 1-amino-3-methyl-6-methoxybenzene
    • Tox21_201907
    • Tox21_300012
    • STL196541
    • M-AMINO-P-CRESOL METHYL ETHER
    • AKOS000119398
    • NCGC00090863-01
    • NCGC00090863-02
    • NCGC00090863-03
    • NCGC00254113-01
    • NCGC00259456-01
    • AC-23656
    • AS-30235
    • SMR001224526
    • DB-041574
    • M0115
    • NS00011442
    • EN300-20247
    • 2-Methoxy-5-methylaniline, analytical standard
    • C19216
    • Q309528
    • 2-Methoxy-5-methylaniline 100 microg/mL in Acetonitrile
    • F2190-0481
    • Z104477476
    • 204-419-1

  • Applications

    p-Cresidine is an aromatic amine mainly used as an intermediate in the production of colorants and pigments, particularly in the synthesis of azo dyes and industrial pigments. It is also used as a precursor in the manufacture of polymers and plastics to enable color development and as an intermediate in polymer and rubber formulations. In coatings, inks, and related applications, p-Cresidine is commonly considered as an intermediate for making pigments and colorants used in coatings and printing systems. Additionally, it is used in research and development as a reagent for organic synthesis and for custom chemical transformations. Its use is contingent on local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 621.84
    methanol 904.25
    isopropanol 294.69
    water 8.96
    ethyl acetate 234.03
    n-propanol 393.45
    acetone 251.74
    n-butanol 318.52
    acetonitrile 783.26
    DMF 269.14
    toluene 63.08
    isobutanol 190.04
    1,4-dioxane 1034.17
    methyl acetate 239.8
    THF 742.16
    2-butanone 167.75
    n-pentanol 207.11
    sec-butanol 191.43
    n-hexane 7.99
    ethylene glycol 154.07
    NMP 117.61
    cyclohexane 25.43
    DMSO 412.43
    n-butyl acetate 142.57
    n-octanol 68.88
    chloroform 526.76
    n-propyl acetate 120.71
    acetic acid 662.12
    dichloromethane 566.07
    cyclohexanone 200.57
    propylene glycol 131.9
    isopropyl acetate 69.77
    DMAc 127.98
    2-ethoxyethanol 392.4
    isopentanol 165.27
    n-heptane 19.81
    ethyl formate 375.96
    1,2-dichloroethane 256.17
    n-hexanol 211.16
    2-methoxyethanol 731.93
    isobutyl acetate 57.01
    tetrachloromethane 90.36
    n-pentyl acetate 61.79
    transcutol 435.38
    n-heptanol 81.43
    ethylbenzene 28.48
    MIBK 58.23
    2-propoxyethanol 344.57
    tert-butanol 282.97
    MTBE 143.91
    2-butoxyethanol 159.43
    propionic acid 231.92
    o-xylene 34.33
    formic acid 498.67
    diethyl ether 246.36
    m-xylene 34.73
    p-xylene 35.22
    chlorobenzene 113.14
    dimethyl carbonate 57.73
    n-octane 7.15
    formamide 645.77
    cyclopentanone 212.12
    2-pentanone 115.08
    anisole 99.66
    cyclopentyl methyl ether 149.62
    gamma-butyrolactone 335.03
    1-methoxy-2-propanol 278.84
    pyridine 355.08
    3-pentanone 78.01
    furfural 375.58
    n-dodecane 5.5
    diethylene glycol 289.24
    diisopropyl ether 28.73
    tert-amyl alcohol 157.78
    acetylacetone 124.08
    n-hexadecane 6.11
    acetophenone 71.97
    methyl propionate 120.98
    isopentyl acetate 93.84
    trichloroethylene 386.65
    n-nonanol 60.0
    cyclohexanol 148.93
    benzyl alcohol 106.22
    2-ethylhexanol 92.56
    isooctanol 55.15
    dipropyl ether 118.54
    1,2-dichlorobenzene 87.59
    ethyl lactate 57.41
    propylene carbonate 190.23
    n-methylformamide 413.17
    2-pentanol 118.99
    n-pentane 12.66
    1-propoxy-2-propanol 171.43
    1-methoxy-2-propyl acetate 106.0
    2-(2-methoxypropoxy) propanol 95.46
    mesitylene 19.9
    ε-caprolactone 183.63
    p-cymene 28.37
    epichlorohydrin 461.31
    1,1,1-trichloroethane 198.35
    2-aminoethanol 280.9
    morpholine-4-carbaldehyde 273.72
    sulfolane 219.39
    2,2,4-trimethylpentane 6.91
    2-methyltetrahydrofuran 354.07
    n-hexyl acetate 79.03
    isooctane 5.38
    2-(2-butoxyethoxy)ethanol 160.44
    sec-butyl acetate 49.47
    tert-butyl acetate 72.47
    decalin 9.18
    glycerin 197.09
    diglyme 335.24
    acrylic acid 207.31
    isopropyl myristate 30.9
    n-butyric acid 385.18
    acetyl acetate 133.86
    di(2-ethylhexyl) phthalate 38.0
    ethyl propionate 78.3
    nitromethane 881.86
    1,2-diethoxyethane 175.16
    benzonitrile 141.18
    trioctyl phosphate 29.82
    1-bromopropane 133.09
    gamma-valerolactone 385.98
    n-decanol 44.43
    triethyl phosphate 47.61
    4-methyl-2-pentanol 47.78
    propionitrile 329.68
    vinylene carbonate 223.61
    1,1,2-trichlorotrifluoroethane 269.41
    DMS 53.55
    cumene 21.73
    2-octanol 41.78
    2-hexanone 95.65
    octyl acetate 44.14
    limonene 45.5
    1,2-dimethoxyethane 545.44
    ethyl orthosilicate 51.34
    tributyl phosphate 34.37
    diacetone alcohol 102.67
    N,N-dimethylaniline 51.79
    acrylonitrile 333.01
    aniline 128.38
    1,3-propanediol 447.08
    bromobenzene 95.19
    dibromomethane 313.94
    1,1,2,2-tetrachloroethane 261.69
    2-methyl-cyclohexyl acetate 64.15
    tetrabutyl urea 40.24
    diisobutyl methanol 41.58
    2-phenylethanol 107.61
    styrene 38.82
    dioctyl adipate 48.73
    dimethyl sulfate 63.93
    ethyl butyrate 108.98
    methyl lactate 70.55
    butyl lactate 50.09
    diethyl carbonate 82.59
    propanediol butyl ether 93.48
    triethyl orthoformate 80.7
    p-tert-butyltoluene 27.15
    methyl 4-tert-butylbenzoate 62.83
    morpholine 909.76
    tert-butylamine 146.79
    n-dodecanol 34.28
    dimethoxymethane 261.09
    ethylene carbonate 197.57
    cyrene 95.81
    2-ethoxyethyl acetate 97.52
    2-ethylhexyl acetate 69.66
    1,2,4-trichlorobenzene 94.17
    4-methylpyridine 205.86
    dibutyl ether 67.62
    2,6-dimethyl-4-heptanol 41.58
    DEF 126.03
    dimethyl isosorbide 148.21
    tetrachloroethylene 188.65
    eugenol 77.82
    triacetin 69.49
    span 80 84.88
    1,4-butanediol 147.81
    1,1-dichloroethane 213.75
    2-methyl-1-pentanol 118.65
    methyl formate 331.0
    2-methyl-1-butanol 147.46
    n-decane 9.72
    butyronitrile 336.97
    3,7-dimethyl-1-octanol 50.75
    1-chlorooctane 35.93
    1-chlorotetradecane 14.09
    n-nonane 9.29
    undecane 7.06
    tert-butylcyclohexane 8.37
    cyclooctane 7.45
    cyclopentanol 179.23
    tetrahydropyran 549.64
    tert-amyl methyl ether 77.53
    2,5,8-trioxanonane 212.79
    1-hexene 35.19
    2-isopropoxyethanol 175.57
    2,2,2-trifluoroethanol 190.17
    methyl butyrate 124.36

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction