Oxyphenbutazone

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  • Identifiers

    CAS number
    129-20-4

    Molecular formula
    C19H20N2O3

    SMILES
    CCCCC1C(=O)N(N(C1=O)C2=CC=C(C=C2)O)C3=CC=CC=C3

    Safety labels

    Irritant
    Irritant

    Environmental Hazard
    Environmental

  • Odor profile

    Odorless 45.69%
    Spicy 27.07%
    Herbal 23.98%
    Bitter 23.3%
    Animal 22.21%
    Phenolic 21.85%
    Cooling 20.8%
    Fruity 19.93%
    Sweet 19.29%
    Savory 18.17%

    Scent© AI

  • Properties

    XLogP3-AA
    2.7

    Molecular weight
    324.4 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    586°C

    Melting point expt.

    • 96 °C

    Flash point est.
    213.07 ˚C

    Solubility expt.

    • 60 mg/L (at 30 °C)
    • ANHYDROUS CRYSTALS FROM ETHER & PETROLEUM ETHER WITH MP 124-125 °C; ACIDIC REACTION; MP 96 °C; FORMS WATER-SOL SODIUM SALT; SOL IN ETHANOL, METHANOL, CHLOROFORM, BENZENE, ETHER /MONOHYDRATE/
    • VERY SLIGHTLY SOL IN WATER; FREELY SOL IN ACETONE

  • Synonyms

    • oxyphenbutazone
    • 129-20-4
    • Oxyphenylbutazone
    • Tandearil
    • Crovaril
    • Flogitolo
    • Flogoril
    • Visubutina
    • Frabel
    • Oxalid
    • Neo-Farmadol
    • Oxifenylbutazon
    • Oxiphenbutazone
    • Butapirone
    • Californit
    • Oxazolidin
    • Flamaril
    • Tanderil
    • Oxyphenobutazone
    • p-Oxyphenylbutazone
    • Oxi-Fenibutol
    • Etrozolidina
    • Idrobutazina
    • Oxyphentamin
    • Artroflog
    • Butaflogin
    • Butanova
    • Butazonic
    • Butilene
    • Deflogin
    • Flanaril
    • Floghene
    • Flogistin
    • Flogodin
    • Flogostop
    • Flopirina
    • Infammil
    • Ipabutona
    • Isobutazina
    • Isobutil
    • Offitril
    • Oxibutol
    • Pirabutina
    • Piraflogin
    • Poliflogil
    • Tandacote
    • Tandalgesic
    • Tendearil
    • Flogal
    • Infamil
    • Iridil
    • Mysite
    • Neofen
    • Optimal
    • Remazin
    • Reumox
    • Rumapax
    • Telidal
    • Valioil
    • Metabolite I
    • Oxazolidin-Geigy
    • Oxybuton
    • p-Hydroxyphenylbutazone
    • Oxiphenbutazonum
    • Flegmostam
    • Hydroxyphenylbutazon
    • Oxazolioin
    • Reunabutal
    • Aradinum
    • Butanora
    • Portoril
    • Telidac
    • Usaf Ge-14
    • Genal
    • Cinophen-N
    • Oxifenbutazona
    • Oxyphenbutazone anhydrous
    • Suganril
    • Oxyphenbutazonum
    • 3,5-Pyrazolidinedione, 4-butyl-1-(4-hydroxyphenyl)-2-phenyl-
    • Ossifenbutazone
    • Tanderal
    • Reozon
    • Oxyphenbutazone [INN]
    • 1-Phenyl-2-(p-hydroxyphenyl)-3,5-dioxo-4-butylpyrazolidine
    • BM 1
    • 1-(p-Hydroxyphenyl)-2-phenyl-4-butyl-3,5-pyrazolidinedione
    • 4-Butyl-1-(4-hydroxyphenyl)-2-phenyl-3,5-pyrazolidinedione
    • 4-Butyl-1-(p-hydroxyphenyl)-2-phenyl-3,5-pyrazolidinedione
    • 4-Butyl-2-(p-hydroxyphenyl)-1-phenyl-3,5-pyrazolidinedione
    • Oxifenbutazona [INN-Spanish]
    • Oxyphenbutazonum [INN-Latin]
    • 4-Butyl-2-(4-hydroxyphenyl)-1-phenyl-3,5-dioxopyrazolidine
    • CCRIS 6717
    • 4-BUTYL-1-(4-HYDROXYPHENYL)-2-PHENYLPYRAZOLIDINE-3,5-DIONE
    • HSDB 3144
    • G 27202
    • 1-Phenyl-2-(p-hydroxyphenyl)-3,5-dioxo-4-n-butylpyrazolidine
    • 3,5-Dioxo-1-phenyl-2-(p-hydroxyphenyl)-4-N-butylpyrazolidene
    • EINECS 204-936-2
    • NSC 526053
    • NSC-526053
    • UNII-A7D84513GV
    • 1-p-Hydroxyphenyl-2-phenyl-3,5-dioxo-4-N-butylpyrazolidine
    • BRN 0307474
    • 3,5-Pyrazolidinedione, 4-butyl-1-(p-hydroxyphenyl)-2-phenyl-
    • DTXSID1045291
    • CHEBI:76258
    • AI3-26792
    • A7D84513GV
    • 3,5-Pyrazolidinedione, 4-butyl-1-(4-hydroxyphenyl)-2-phenyl
    • MLS003373849
    • DTXCID9025291
    • RO-04-4410
    • G-27202
    • G-29701
    • Oxyphenbutazone (INN)
    • (+/-)-OXYPHENBUTAZONE ANHYDROUS
    • 1-(p-Hydroxyphenyl)-2-phenyl-3,5-dioxo-4-N-butylpyrazolidine
    • OXYPHENBUTAZONE ANHYDROUS, (+/-)-
    • Ossifenbutazone [DCIT]
    • NSC-757261
    • AB00052064_08
    • Oxifenbutazona (INN-Spanish)
    • Oxyphenbutazonum (INN-Latin)
    • Hydroxyphenylbutazone
    • OXYPHENBUTAZONE (IARC)
    • OPB

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 36.57
    methanol 55.77
    isopropanol 16.02
    water 0.04
    ethyl acetate 103.31
    n-propanol 30.24
    acetone 216.67
    n-butanol 26.1
    acetonitrile 101.34
    DMF 356.55
    toluene 43.23
    isobutanol 17.89
    1,4-dioxane 109.46
    methyl acetate 119.93
    THF 234.26
    2-butanone 172.66
    n-pentanol 21.22
    sec-butanol 20.85
    n-hexane 0.16
    ethylene glycol 7.76
    NMP 275.04
    cyclohexane 0.73
    DMSO 222.34
    n-butyl acetate 53.85
    n-octanol 6.33
    chloroform 222.79
    n-propyl acetate 50.78
    acetic acid 97.76
    dichloromethane 275.02
    cyclohexanone 246.82
    propylene glycol 13.81
    isopropyl acetate 58.25
    DMAc 483.37
    2-ethoxyethanol 64.99
    isopentanol 29.23
    n-heptane 0.15
    ethyl formate 70.96
    1,2-dichloroethane 211.28
    n-hexanol 16.5
    2-methoxyethanol 135.72
    isobutyl acetate 34.14
    tetrachloromethane 6.04
    n-pentyl acetate 30.12
    transcutol 134.58
    n-heptanol 10.21
    ethylbenzene 14.77
    MIBK 57.55
    2-propoxyethanol 76.84
    tert-butanol 18.58
    MTBE 16.82
    2-butoxyethanol 43.54
    propionic acid 53.08
    o-xylene 17.62
    formic acid 36.35
    diethyl ether 19.69
    m-xylene 15.95
    p-xylene 22.93
    chlorobenzene 99.32
    dimethyl carbonate 75.16
    n-octane 0.15
    formamide 79.16
    cyclopentanone 309.01
    2-pentanone 110.54
    anisole 47.89
    cyclopentyl methyl ether 47.49
    gamma-butyrolactone 284.93
    1-methoxy-2-propanol 80.33
    pyridine 240.46
    3-pentanone 77.34
    furfural 251.74
    n-dodecane 0.34
    diethylene glycol 64.48
    diisopropyl ether 4.23
    tert-amyl alcohol 18.06
    acetylacetone 177.65
    n-hexadecane 0.42
    acetophenone 78.02
    methyl propionate 100.72
    isopentyl acetate 51.1
    trichloroethylene 451.45
    n-nonanol 7.91
    cyclohexanol 29.37
    benzyl alcohol 59.25
    2-ethylhexanol 11.53
    isooctanol 9.88
    dipropyl ether 8.07
    1,2-dichlorobenzene 75.13
    ethyl lactate 37.53
    propylene carbonate 144.47
    n-methylformamide 108.36
    2-pentanol 12.33
    n-pentane 0.15
    1-propoxy-2-propanol 40.92
    1-methoxy-2-propyl acetate 72.76
    2-(2-methoxypropoxy) propanol 50.88
    mesitylene 7.71
    ε-caprolactone 161.8
    p-cymene 8.41
    epichlorohydrin 382.23
    1,1,1-trichloroethane 83.12
    2-aminoethanol 20.26
    morpholine-4-carbaldehyde 195.22
    sulfolane 261.22
    2,2,4-trimethylpentane 0.4
    2-methyltetrahydrofuran 95.96
    n-hexyl acetate 31.43
    isooctane 0.26
    2-(2-butoxyethoxy)ethanol 62.35
    sec-butyl acetate 35.85
    tert-butyl acetate 49.44
    decalin 0.87
    glycerin 29.34
    diglyme 117.18
    acrylic acid 61.88
    isopropyl myristate 14.68
    n-butyric acid 85.21
    acetyl acetate 83.81
    di(2-ethylhexyl) phthalate 25.28
    ethyl propionate 47.9
    nitromethane 263.61
    1,2-diethoxyethane 41.24
    benzonitrile 88.3
    trioctyl phosphate 14.05
    1-bromopropane 40.03
    gamma-valerolactone 366.26
    n-decanol 6.38
    triethyl phosphate 24.08
    4-methyl-2-pentanol 10.76
    propionitrile 67.81
    vinylene carbonate 138.8
    1,1,2-trichlorotrifluoroethane 168.69
    DMS 59.47
    cumene 9.07
    2-octanol 5.83
    2-hexanone 58.49
    octyl acetate 19.41
    limonene 9.56
    1,2-dimethoxyethane 115.03
    ethyl orthosilicate 19.42
    tributyl phosphate 18.53
    diacetone alcohol 70.49
    N,N-dimethylaniline 26.39
    acrylonitrile 126.87
    aniline 66.76
    1,3-propanediol 42.15
    bromobenzene 92.78
    dibromomethane 122.18
    1,1,2,2-tetrachloroethane 255.05
    2-methyl-cyclohexyl acetate 35.46
    tetrabutyl urea 27.9
    diisobutyl methanol 7.66
    2-phenylethanol 48.31
    styrene 23.58
    dioctyl adipate 29.17
    dimethyl sulfate 110.68
    ethyl butyrate 36.5
    methyl lactate 64.06
    butyl lactate 32.53
    diethyl carbonate 31.0
    propanediol butyl ether 29.68
    triethyl orthoformate 25.31
    p-tert-butyltoluene 6.91
    methyl 4-tert-butylbenzoate 47.02
    morpholine 135.84
    tert-butylamine 6.74
    n-dodecanol 5.19
    dimethoxymethane 145.36
    ethylene carbonate 103.92
    cyrene 71.55
    2-ethoxyethyl acetate 58.43
    2-ethylhexyl acetate 35.98
    1,2,4-trichlorobenzene 98.07
    4-methylpyridine 197.16
    dibutyl ether 9.3
    2,6-dimethyl-4-heptanol 7.66
    DEF 120.41
    dimethyl isosorbide 91.34
    tetrachloroethylene 116.71
    eugenol 52.72
    triacetin 48.15
    span 80 36.99
    1,4-butanediol 14.18
    1,1-dichloroethane 124.51
    2-methyl-1-pentanol 25.93
    methyl formate 94.37
    2-methyl-1-butanol 24.2
    n-decane 0.4
    butyronitrile 60.04
    3,7-dimethyl-1-octanol 10.58
    1-chlorooctane 3.74
    1-chlorotetradecane 2.36
    n-nonane 0.26
    undecane 0.36
    tert-butylcyclohexane 0.62
    cyclooctane 0.18
    cyclopentanol 37.22
    tetrahydropyran 81.72
    tert-amyl methyl ether 15.46
    2,5,8-trioxanonane 88.18
    1-hexene 2.41
    2-isopropoxyethanol 40.15
    2,2,2-trifluoroethanol 33.68
    methyl butyrate 72.83

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction