Oxacyclopentadecan-2-one

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  • Identifiers

    CAS number
    3537-83-5

    Molecular formula
    C14H26O2

    SMILES
    C1CCCCCCC(=O)OCCCCCC1

  • Odor profile

    Fragrance
    Musk 90.41%
    Sweet 79.36%
    Animal 65.62%
    Powdery 57.3%
    Fruity 56.83%
    Waxy 55.5%
    Amber 52.16%
    Fatty 40.81%
    Woody 37.17%
    Dry 35.33%

     

    Flavor
    Fruity 64.81%
    Animal 35.94%
    Natural 29.23%
    Musk 26.3%
    Powdery 26.17%
    Fruit 23.02%
    Minty 22.32%
    Cheese 20.94%
    Musky 20.9%
    Shrimp 20.76%

     

    Odor impact est.
    High

  • Properties

    XLogP3-AA
    5.2

    pKa est.
    12.29 (strong base)

    Molecular weight
    226.35 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    319°C

    Flash point

    • 148.61 ˚C est.

  • Synonyms

    • Oxacyclopentadecan-2-one
    • Cyclotetradecanolide
    • 3537-83-5
    • DTXSID6063064
    • tetradecanolide
    • Tetradecanolactone
    • tetradecano-14-lactone
    • 1-oxacyclopentadecan-2-one
    • SCHEMBL918482
    • DTXCID6039001

  • Applications

    Oxacyclopentadecan-2-one, CAS 3537-83-5, is primarily used as a fragrance ingredient and fixative in perfumery, leveraging its macrocyclic musk-like aroma; it is often considered a scent component in cosmetics and personal care products to extend fragrance longevity; it also appears in household formulations such as cleaners and detergents as an additional fragrance; in industrial manufacturing it can serve as an intermediate or precursor in the synthesis of macrocyclic lactones and related specialty chemicals for specific applications; it may be used as a precursor or component for specialty polymers in the polymers/plastics sector, depending on regulatory requirements and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 864.66
    methanol 710.93
    isopropanol 999.12
    water 0.05
    ethyl acetate 2093.53
    n-propanol 922.75
    acetone 2439.34
    n-butanol 903.95
    acetonitrile 1254.82
    DMF 2805.3
    toluene 1310.95
    isobutanol 807.99
    1,4-dioxane 2147.51
    methyl acetate 1300.01
    THF 3946.88
    2-butanone 1874.52
    n-pentanol 612.63
    sec-butanol 914.45
    n-hexane 497.32
    ethylene glycol 86.98
    NMP 2613.67
    cyclohexane 1004.64
    DMSO 2483.61
    n-butyl acetate 1815.76
    n-octanol 414.74
    chloroform 5722.66
    n-propyl acetate 1555.51
    acetic acid 1110.24
    dichloromethane 5126.76
    cyclohexanone 3752.9
    propylene glycol 222.62
    isopropyl acetate 1622.55
    DMAc 1895.91
    2-ethoxyethanol 781.42
    isopentanol 953.49
    n-heptane 288.09
    ethyl formate 995.19
    1,2-dichloroethane 3451.79
    n-hexanol 693.67
    2-methoxyethanol 1242.49
    isobutyl acetate 1007.63
    tetrachloromethane 955.2
    n-pentyl acetate 1416.2
    transcutol 3726.99
    n-heptanol 379.73
    ethylbenzene 647.54
    MIBK 1282.03
    2-propoxyethanol 1048.64
    tert-butanol 1244.06
    MTBE 1625.0
    2-butoxyethanol 803.9
    propionic acid 1016.54
    o-xylene 744.17
    formic acid 192.64
    diethyl ether 1854.87
    m-xylene 794.15
    p-xylene 850.27
    chlorobenzene 1894.02
    dimethyl carbonate 549.29
    n-octane 102.43
    formamide 417.11
    cyclopentanone 3823.45
    2-pentanone 1999.87
    anisole 1065.11
    cyclopentyl methyl ether 2285.71
    gamma-butyrolactone 3612.06
    1-methoxy-2-propanol 1177.37
    pyridine 3203.06
    3-pentanone 1499.28
    furfural 2732.64
    n-dodecane 60.8
    diethylene glycol 514.45
    diisopropyl ether 720.4
    tert-amyl alcohol 1054.15
    acetylacetone 2109.95
    n-hexadecane 75.19
    acetophenone 1057.13
    methyl propionate 1364.47
    isopentyl acetate 1501.25
    trichloroethylene 5738.32
    n-nonanol 378.72
    cyclohexanol 1456.64
    benzyl alcohol 722.48
    2-ethylhexanol 584.04
    isooctanol 385.45
    dipropyl ether 1242.82
    1,2-dichlorobenzene 1749.15
    ethyl lactate 462.2
    propylene carbonate 2005.0
    n-methylformamide 1081.02
    2-pentanol 844.41
    n-pentane 351.07
    1-propoxy-2-propanol 1029.64
    1-methoxy-2-propyl acetate 1335.81
    2-(2-methoxypropoxy) propanol 723.19
    mesitylene 552.42
    ε-caprolactone 2760.24
    p-cymene 406.43
    epichlorohydrin 3434.18
    1,1,1-trichloroethane 3243.7
    2-aminoethanol 303.72
    morpholine-4-carbaldehyde 2235.79
    sulfolane 4005.05
    2,2,4-trimethylpentane 145.49
    2-methyltetrahydrofuran 2835.49
    n-hexyl acetate 1487.4
    isooctane 127.6
    2-(2-butoxyethoxy)ethanol 1111.41
    sec-butyl acetate 1112.16
    tert-butyl acetate 1557.54
    decalin 326.2
    glycerin 309.38
    diglyme 2213.5
    acrylic acid 791.26
    isopropyl myristate 519.88
    n-butyric acid 1925.14
    acetyl acetate 1298.92
    di(2-ethylhexyl) phthalate 380.36
    ethyl propionate 1303.25
    nitromethane 2109.17
    1,2-diethoxyethane 1697.88
    benzonitrile 1366.86
    trioctyl phosphate 285.1
    1-bromopropane 2168.72
    gamma-valerolactone 3769.85
    n-decanol 261.63
    triethyl phosphate 514.31
    4-methyl-2-pentanol 524.6
    propionitrile 1350.67
    vinylene carbonate 1670.28
    1,1,2-trichlorotrifluoroethane 2084.68
    DMS 972.97
    cumene 419.65
    2-octanol 341.29
    2-hexanone 1359.53
    octyl acetate 615.26
    limonene 680.16
    1,2-dimethoxyethane 1870.75
    ethyl orthosilicate 495.98
    tributyl phosphate 421.27
    diacetone alcohol 1198.86
    N,N-dimethylaniline 680.47
    acrylonitrile 1597.98
    aniline 1320.93
    1,3-propanediol 599.53
    bromobenzene 2358.15
    dibromomethane 3558.48
    1,1,2,2-tetrachloroethane 4930.02
    2-methyl-cyclohexyl acetate 868.84
    tetrabutyl urea 530.8
    diisobutyl methanol 429.12
    2-phenylethanol 637.45
    styrene 933.61
    dioctyl adipate 745.18
    dimethyl sulfate 936.29
    ethyl butyrate 1262.56
    methyl lactate 553.44
    butyl lactate 805.39
    diethyl carbonate 770.13
    propanediol butyl ether 687.69
    triethyl orthoformate 859.45
    p-tert-butyltoluene 389.93
    methyl 4-tert-butylbenzoate 887.94
    morpholine 2660.79
    tert-butylamine 941.79
    n-dodecanol 200.31
    dimethoxymethane 1409.01
    ethylene carbonate 1563.98
    cyrene 600.34
    2-ethoxyethyl acetate 1404.95
    2-ethylhexyl acetate 1227.07
    1,2,4-trichlorobenzene 1848.47
    4-methylpyridine 2744.58
    dibutyl ether 1164.22
    2,6-dimethyl-4-heptanol 429.12
    DEF 2256.75
    dimethyl isosorbide 1292.31
    tetrachloroethylene 3314.5
    eugenol 678.26
    triacetin 1231.74
    span 80 788.69
    1,4-butanediol 218.62
    1,1-dichloroethane 3387.34
    2-methyl-1-pentanol 597.88
    methyl formate 719.92
    2-methyl-1-butanol 844.63
    n-decane 124.87
    butyronitrile 1588.88
    3,7-dimethyl-1-octanol 515.78
    1-chlorooctane 527.64
    1-chlorotetradecane 184.01
    n-nonane 131.16
    undecane 82.25
    tert-butylcyclohexane 247.55
    cyclooctane 302.39
    cyclopentanol 1480.14
    tetrahydropyran 3198.21
    tert-amyl methyl ether 1183.06
    2,5,8-trioxanonane 1249.02
    1-hexene 1105.17
    2-isopropoxyethanol 694.2
    2,2,2-trifluoroethanol 406.04
    methyl butyrate 1801.58

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction