Oxacyclononadec-10-en-2-one

Overview IFRA Botanical Request a quote

  • Identifiers

    CAS number
    80060-76-0

    Molecular formula
    C18H32O2

    SMILES
    C1CCCCOC(=O)CCCCCCC/C=C\CCC1

  • Odor profile

    Musk 89.99%
    Sweet 71.75%
    Animal 60.81%
    Powdery 57.73%
    Waxy 54.16%
    Fruity 52.45%
    Amber 51.06%
    Dry 39.21%
    Fatty 36.93%
    Clean 35.27%

    Scent© AI

  • Properties

    XLogP3-AA
    6.6

    Molecular weight
    280.4 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    362°C

    Flash point est.
    171.82 ˚C

  • Synonyms

    • oxacyclononadec-10-en-2-one
    • UNII-85Z1B0U5ZM
    • 85Z1B0U5ZM
    • 74992-69-1
    • 18-hydroxyoleic acid lactone
    • (10Z)-1-oxacyclononadec-10-en-2-one
    • (Z)-18-Octadec-9-enolide
    • (z)-octadec-9-en-18-olide
    • SCHEMBL18281091
    • SCHEMBL18281092
    • GODWWTDBDJRXIU-UPHRSURJSA-N
    • (Z)-Oxacyclononadec-10-en-2-one
    • Oxacyclononadec-10-en-2-one, (Z)-
    • Oxacyclononadec-10-en-2-one, (10Z)-
    • Q27269681

  • Applications

    Oxacyclononadec-10-en-2-one (CAS 80060-76-0) is a macrocyclic lactone with a clean, warm, ambrette-like musk profile, used mainly in fine fragrance, personal care, detergents and fabric care as a long-lasting base note and fixative that boosts diffusion and rounds floral, woody, amber and fruity accords; it shows strong substantivity on skin and textiles, making it suitable as a musk heart for eau de parfum, body mists, shampoos, shower gels, air care and candles, typically dosed from trace to a few percent depending on matrix and cost-in-use; it is also valuable in fragrance R&D (musk reference, microencapsulation to enhance performance in alkaline/wash systems, and studies of surfactant interactions) and is often selected as a more sustainable alternative to nitro/polycyclic musks due to its more natural odor character and generally better biodegradability, while still requiring case-by-case checks for formula compatibility, pH stability and IFRA/local regulatory compliance.

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 191.27
    methanol 119.68
    isopropanol 230.13
    water 0.01
    ethyl acetate 754.18
    n-propanol 231.97
    acetone 595.76
    n-butanol 286.94
    acetonitrile 257.55
    DMF 591.28
    toluene 596.59
    isobutanol 222.0
    1,4-dioxane 794.41
    methyl acetate 417.63
    THF 1628.98
    2-butanone 613.19
    n-pentanol 228.1
    sec-butanol 263.38
    n-hexane 182.55
    ethylene glycol 11.9
    NMP 875.2
    cyclohexane 473.79
    DMSO 740.33
    n-butyl acetate 736.73
    n-octanol 170.71
    chloroform 2227.16
    n-propyl acetate 662.54
    acetic acid 219.33
    dichloromethane 2202.4
    cyclohexanone 1435.3
    propylene glycol 41.22
    isopropyl acetate 631.82
    DMAc 706.43
    2-ethoxyethanol 296.38
    isopentanol 327.66
    n-heptane 134.81
    ethyl formate 271.88
    1,2-dichloroethane 1437.73
    n-hexanol 266.21
    2-methoxyethanol 329.54
    isobutyl acetate 456.93
    tetrachloromethane 321.48
    n-pentyl acetate 641.04
    transcutol 1908.44
    n-heptanol 159.91
    ethylbenzene 330.04
    MIBK 560.14
    2-propoxyethanol 400.61
    tert-butanol 340.28
    MTBE 549.32
    2-butoxyethanol 337.45
    propionic acid 228.5
    o-xylene 361.69
    formic acid 31.29
    diethyl ether 738.5
    m-xylene 380.81
    p-xylene 387.05
    chlorobenzene 779.66
    dimethyl carbonate 170.41
    n-octane 46.17
    formamide 68.69
    cyclopentanone 1362.82
    2-pentanone 756.29
    anisole 505.14
    cyclopentyl methyl ether 981.1
    gamma-butyrolactone 1229.35
    1-methoxy-2-propanol 382.93
    pyridine 1089.68
    3-pentanone 566.64
    furfural 914.84
    n-dodecane 27.55
    diethylene glycol 152.25
    diisopropyl ether 303.75
    tert-amyl alcohol 331.71
    acetylacetone 772.49
    n-hexadecane 33.97
    acetophenone 515.31
    methyl propionate 476.68
    isopentyl acetate 651.31
    trichloroethylene 2288.73
    n-nonanol 167.93
    cyclohexanol 510.73
    benzyl alcohol 309.31
    2-ethylhexanol 252.63
    isooctanol 169.94
    dipropyl ether 580.23
    1,2-dichlorobenzene 756.35
    ethyl lactate 203.43
    propylene carbonate 703.55
    n-methylformamide 184.63
    2-pentanol 292.92
    n-pentane 134.32
    1-propoxy-2-propanol 422.77
    1-methoxy-2-propyl acetate 573.58
    2-(2-methoxypropoxy) propanol 356.43
    mesitylene 270.87
    ε-caprolactone 1092.81
    p-cymene 202.86
    epichlorohydrin 1399.11
    1,1,1-trichloroethane 1215.38
    2-aminoethanol 55.02
    morpholine-4-carbaldehyde 764.5
    sulfolane 1479.28
    2,2,4-trimethylpentane 68.04
    2-methyltetrahydrofuran 1245.83
    n-hexyl acetate 669.89
    isooctane 55.68
    2-(2-butoxyethoxy)ethanol 528.97
    sec-butyl acetate 512.02
    tert-butyl acetate 648.63
    decalin 158.55
    glycerin 64.74
    diglyme 1033.77
    acrylic acid 162.77
    isopropyl myristate 254.02
    n-butyric acid 553.61
    acetyl acetate 453.65
    di(2-ethylhexyl) phthalate 193.83
    ethyl propionate 569.15
    nitromethane 467.67
    1,2-diethoxyethane 883.22
    benzonitrile 500.49
    trioctyl phosphate 138.52
    1-bromopropane 962.07
    gamma-valerolactone 1335.79
    n-decanol 116.98
    triethyl phosphate 262.21
    4-methyl-2-pentanol 196.49
    propionitrile 349.97
    vinylene carbonate 551.15
    1,1,2-trichlorotrifluoroethane 760.61
    DMS 418.39
    cumene 213.32
    2-octanol 142.05
    2-hexanone 586.1
    octyl acetate 298.08
    limonene 352.65
    1,2-dimethoxyethane 717.07
    ethyl orthosilicate 253.19
    tributyl phosphate 196.26
    diacetone alcohol 478.52
    N,N-dimethylaniline 340.05
    acrylonitrile 356.84
    aniline 463.02
    1,3-propanediol 128.13
    bromobenzene 1029.99
    dibromomethane 1534.86
    1,1,2,2-tetrachloroethane 2026.53
    2-methyl-cyclohexyl acetate 452.16
    tetrabutyl urea 266.47
    diisobutyl methanol 196.3
    2-phenylethanol 286.42
    styrene 433.23
    dioctyl adipate 374.73
    dimethyl sulfate 302.74
    ethyl butyrate 618.73
    methyl lactate 171.5
    butyl lactate 346.72
    diethyl carbonate 370.67
    propanediol butyl ether 281.66
    triethyl orthoformate 432.35
    p-tert-butyltoluene 186.07
    methyl 4-tert-butylbenzoate 444.62
    morpholine 990.68
    tert-butylamine 269.1
    n-dodecanol 90.46
    dimethoxymethane 475.78
    ethylene carbonate 519.53
    cyrene 318.8
    2-ethoxyethyl acetate 656.7
    2-ethylhexyl acetate 542.41
    1,2,4-trichlorobenzene 845.83
    4-methylpyridine 999.47
    dibutyl ether 537.31
    2,6-dimethyl-4-heptanol 196.3
    DEF 749.39
    dimethyl isosorbide 702.99
    tetrachloroethylene 1212.03
    eugenol 346.95
    triacetin 607.15
    span 80 383.44
    1,4-butanediol 53.08
    1,1-dichloroethane 1241.95
    2-methyl-1-pentanol 252.4
    methyl formate 134.73
    2-methyl-1-butanol 290.69
    n-decane 56.57
    butyronitrile 478.81
    3,7-dimethyl-1-octanol 218.71
    1-chlorooctane 245.73
    1-chlorotetradecane 86.26
    n-nonane 57.71
    undecane 37.01
    tert-butylcyclohexane 111.54
    cyclooctane 141.13
    cyclopentanol 432.43
    tetrahydropyran 1382.65
    tert-amyl methyl ether 469.42
    2,5,8-trioxanonane 650.58
    1-hexene 417.08
    2-isopropoxyethanol 281.21
    2,2,2-trifluoroethanol 76.9
    methyl butyrate 746.04

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction

Botanical

Name CAS Botanical Proportion
Ambrette seed 1 8015-62-1 Hibiscus abelmoschus L. (Abelmoschus moschatus Moench), fam. Malvaceae 1.05%
Ambrette seed 2 8015-62-1 Hibiscus abelmoschus L. (Abelmoschus moschatus Moench), fam. Malvaceae 1.0%
Ambrette seed 4 8015-62-1 Hibiscus abelmoschus L. (Abelmoschus moschatus Moench), fam. Malvaceae 5.0%
Ambrette seed 3 8015-62-1 Hibiscus abelmoschus L. (Abelmoschus moschatus Moench), fam. Malvaceae 2.1%