Oleanolic Acid

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  • Identifiers

    CAS number
    508-02-1

    Molecular formula
    C30H48O3

    SMILES
    C[C@]12CC[C@@H](C([C@@H]1CC[C@@]3([C@@H]2CC=C4[C@]3(CC[C@@]5([C@H]4CC(CC5)(C)C)C(=O)O)C)C)(C)C)O

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  • Odor profile

    Fragrance
    Woody 88.15%
    Amber 59.99%
    Dry 54.85%
    Cedar 53.61%
    Balsamic 47.0%
    Musk 43.55%
    Sandalwood 42.16%
    Camphoreous 38.8%
    Vetiver 37.74%
    Spicy 36.64%

     

    Flavor
    Woody 69.36%
    Camphor 52.43%
    Sweet 49.06%
    Pine 48.32%
    Balsam 43.34%
    Herbal 37.76%
    Earthy 37.32%
    Dry 37.13%
    Spicy 34.48%
    Fresh 31.67%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    7.5

    pKa est.
    6.41 (neutral)

    Molecular weight
    456.7 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Moderately fast

    Boiling point est.
    392°C

    Melting point expt.

    • 310 °C

    Flash point

    • 261.46 ˚C est.

  • Synonyms

    • OLEANOLIC ACID
    • Oleanic acid
    • 508-02-1
    • Caryophyllin
    • Astrantiagenin C
    • Giganteumgenin C
    • Virgaureagenin B
    • 3beta-Hydroxyolean-12-en-28-oic acid
    • Oleanol
    • oleonolic acid
    • (4aS,6aR,6aS,6bR,8aR,10S,12aR,14bS)-10-hydroxy-2,2,6a,6b,9,9,12a-heptamethyl-1,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carboxylic acid
    • 6SMK8R7TGJ
    • NSC-114945
    • Olean-12-en-28-oic acid, 3-hydroxy-, (3beta)-
    • DTXSID50858790
    • CHEBI:37659
    • Triterpenes, Oleanane
    • RefChem:6084
    • DTXCID701474453
    • 208-081-6
    • OLEANOLIC_ACID
    • 3-beta-Hydroxyolean-12-en-28-oic acid
    • MFCD00064914
    • (3-beta)-3-Hydroxyolean-12-en-28-oic acid
    • NSC114945
    • OleanolicAcid
    • NSC 114945
    • Oleanoic Acid Hydrate
    • (4aS,6aS,6bR,8aR,10S,12aR,12bR,14bS)-10-hydroxy-2,2,6a,6b,9,9,12a-heptamethyl-1,3,4,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-octadecahydropicene-4a(2H)-carboxylic acid
    • (2S,5S,10S,18S,1R,14R,15R,20R)-18-hydroxy-1,2,8,8,15,19,19-heptamethylpentacyc lo[12.8.0.0<2,11>.0<5,10>.0<15,20>]docos-11-ene-5-carboxylic acid
    • (4aS,5S,6aS,6bR,8R,8aR,10S,12aR,12bR,14bS)-10-Hydroxy-2,2,6a,6b,9,9,12a-heptamethyl-1,3,4,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-octadecahydro-2H-picene-4a-carboxylic acid
    • SMR000445561
    • CCRIS 6493
    • CHEMBL168
    • (3.beta.)-3-Hydroxyolean-12-en-28-oic acid
    • EINECS 208-081-6
    • UNII-6SMK8R7TGJ
    • Olean-12-en-28-oic acid, 3-hydroxy-, (3.beta.)-
    • oleanolic-acid
    • Gledigenin 1
    • Oleanolic acid CRS
    • OleanolsA currencyure
    • Olean-12-en-28-oic acid, 3.beta.-hydroxy-
    • Olean-12-en-28-oic acid, 3beta-hydroxy-
    • Olean-12-en-28-oic acid, 3-beta-hydroxy-
    • Oleanolic acid (Standard)
    • Oleanolic acid, >=97%
    • OLEANOLIC ACID [MI]
    • SCHEMBL71070
    • MLS000697656
    • MLS002207133
    • Olean-12-en-28-oic acid, 3-hydroxy-, (3-beta)-
    • GTPL3306
    • OLEANOLIC ACID [USP-RS]
    • OLEANOLIC ACID [WHO-DD]
    • HY-N0156R
    • GLXC-06699
    • HMS2232D15
    • Oleanolic acid (OA)(Compound 1)
    • Oleanolic acid, analytical standard
    • EX-A1991
    • HY-N0156
    • MSK40102
    • BDBM50346601
    • EBC-13066
    • olean-12-en-3beta-ol-28-oic acid
    • 3-beta-Hydroxyolean-12-en-28-oate
    • 3beta-hydroxy-Olean-12-en-28-oate
    • AKOS015951416
    • AC-8026
    • CCG-208530
    • CS-3800
    • FO71102
    • LMPR0106150004
    • 3.beta.-hydroxy-Olean-12-en-28-oate
    • 3beta-hydroxy-olea-12-en-28-oic acid
    • 3beta-hydroxy-Olean-12-en-28-oic acid
    • NCGC00017222-10
    • NCGC00017222-13
    • (4aS,6aS,6bR,8aR,10S,12aR,12bR,14bS)-10-hydroxy-2,2,6a,6b,9,9,12a-heptamethyl-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-4a-carboxylic acid
    • AS-35338
    • BP-25410
    • ST057162
    • SY056722
    • (3-beta)-3-Hydroxyolean-12-en-28-oate
    • 3.beta.-hydroxy-Olean-12-en-28-oic acid
    • (3beta)-3-hydroxyolean-12-en-28-oic acid
    • NS00019728
    • (3.beta.)-3-hydroxy-Olean-12-en-28-oate
    • C17148
    • EN300-342251
    • (3.beta.)-3-hydroxy-Olean-12-en-28-oic acid
    • (3.beta.)-3-beta-hydroxy-Olean-12-en-28-oate
    • 3.BETA.-HYDROXYOLEAN-12-EN-28-OIC ACID
    • 508O021
    • Q418628
    • (3.beta.)-3-beta-hydroxy-Olean-12-en-28-oic acid
    • BRD-K90647725-001-06-5
    • BRD-K90647725-001-07-3
    • Oleanolic acid, primary pharmaceutical reference standard
    • C7EE6ACC-7175-4947-B524-FF8479525DA1
    • OLEANOLIC ACID (CONSTITUENT OF BANABA LEAF) [DSC]
    • OLEANOLIC ACID (CONSTITUENT OF HOLY BASIL LEAF) [DSC]
    • Oleanolic acid, United States Pharmacopeia (USP) Reference Standard
    • (4aS,6aR,6aS,6bR,8aR,10S,12aR,14bS)-10-hydroxy-2,2,6a,6b,9,9,12a-heptamethyl-1,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carboxylicacid
    • 508-02-1

  • Applications

    Oleanolic acid (CAS 508-02-1) is primarily used as a building block and chemical intermediate for the synthesis of triterpenoid derivatives in pharmaceutical research. In cosmetics and personal care, it is evaluated as a skin-conditioning agent and antioxidant in formulations derived from natural sources. In industrial manufacturing, it is studied as a precursor for specialty polymers, resins, and coatings based on triterpenoid chemistry. In agricultural development, oleanolic acid derivatives are studied as lead structures for plant-protection products and as elicitors of plant defense responses. Its use is subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 8.1
    methanol 5.42
    isopropanol 7.6
    water 0.0
    ethyl acetate 7.3
    n-propanol 15.23
    acetone 6.01
    n-butanol 14.71
    acetonitrile 1.59
    DMF 63.63
    toluene 13.15
    isobutanol 10.36
    1,4-dioxane 43.09
    methyl acetate 5.57
    THF 88.5
    2-butanone 11.92
    n-pentanol 11.73
    sec-butanol 8.59
    n-hexane 0.57
    ethylene glycol 0.69
    NMP 42.66
    cyclohexane 0.53
    DMSO 9.33
    n-butyl acetate 8.94
    n-octanol 5.37
    chloroform 22.81
    n-propyl acetate 5.43
    acetic acid 3.93
    dichloromethane 10.65
    cyclohexanone 19.32
    propylene glycol 2.47
    isopropyl acetate 8.02
    DMAc 43.84
    2-ethoxyethanol 18.14
    isopentanol 10.25
    n-heptane 0.53
    ethyl formate 2.8
    1,2-dichloroethane 6.84
    n-hexanol 13.98
    2-methoxyethanol 26.09
    isobutyl acetate 5.92
    tetrachloromethane 2.88
    n-pentyl acetate 12.51
    transcutol 48.82
    n-heptanol 10.29
    ethylbenzene 5.94
    MIBK 9.12
    2-propoxyethanol 55.11
    tert-butanol 6.3
    MTBE 9.54
    2-butoxyethanol 29.71
    propionic acid 4.52
    o-xylene 6.25
    formic acid 1.59
    diethyl ether 13.05
    m-xylene 8.53
    p-xylene 5.49
    chlorobenzene 8.75
    dimethyl carbonate 6.96
    n-octane 0.18
    formamide 2.59
    cyclopentanone 28.81
    2-pentanone 12.33
    anisole 14.49
    cyclopentyl methyl ether 26.38
    gamma-butyrolactone 21.61
    1-methoxy-2-propanol 36.43
    pyridine 29.58
    3-pentanone 9.94
    furfural 17.11
    n-dodecane 0.07
    diethylene glycol 15.76
    diisopropyl ether 3.34
    tert-amyl alcohol 6.47
    acetylacetone 11.36
    n-hexadecane 0.1
    acetophenone 10.6
    methyl propionate 10.98
    isopentyl acetate 10.57
    trichloroethylene 19.38
    n-nonanol 6.29
    cyclohexanol 8.4
    benzyl alcohol 12.13
    2-ethylhexanol 6.36
    isooctanol 7.83
    dipropyl ether 9.78
    1,2-dichlorobenzene 7.33
    ethyl lactate 5.01
    propylene carbonate 8.26
    n-methylformamide 9.45
    2-pentanol 8.51
    n-pentane 0.61
    1-propoxy-2-propanol 36.65
    1-methoxy-2-propyl acetate 23.78
    2-(2-methoxypropoxy) propanol 18.81
    mesitylene 4.15
    ε-caprolactone 18.27
    p-cymene 3.51
    epichlorohydrin 32.12
    1,1,1-trichloroethane 6.34
    2-aminoethanol 4.32
    morpholine-4-carbaldehyde 63.94
    sulfolane 23.97
    2,2,4-trimethylpentane 0.45
    2-methyltetrahydrofuran 27.06
    n-hexyl acetate 12.94
    isooctane 0.4
    2-(2-butoxyethoxy)ethanol 28.64
    sec-butyl acetate 5.43
    tert-butyl acetate 10.12
    decalin 0.58
    glycerin 4.33
    diglyme 45.18
    acrylic acid 3.8
    isopropyl myristate 3.79
    n-butyric acid 9.04
    acetyl acetate 4.5
    di(2-ethylhexyl) phthalate 6.62
    ethyl propionate 6.1
    nitromethane 6.4
    1,2-diethoxyethane 15.06
    benzonitrile 6.53
    trioctyl phosphate 4.44
    1-bromopropane 5.54
    gamma-valerolactone 52.61
    n-decanol 3.29
    triethyl phosphate 4.59
    4-methyl-2-pentanol 5.63
    propionitrile 4.2
    vinylene carbonate 8.68
    1,1,2-trichlorotrifluoroethane 18.26
    DMS 9.66
    cumene 3.73
    2-octanol 4.74
    2-hexanone 8.58
    octyl acetate 5.57
    limonene 3.98
    1,2-dimethoxyethane 27.82
    ethyl orthosilicate 5.49
    tributyl phosphate 3.66
    diacetone alcohol 13.55
    N,N-dimethylaniline 12.35
    acrylonitrile 4.58
    aniline 13.4
    1,3-propanediol 8.61
    bromobenzene 8.67
    dibromomethane 7.26
    1,1,2,2-tetrachloroethane 17.51
    2-methyl-cyclohexyl acetate 8.49
    tetrabutyl urea 5.95
    diisobutyl methanol 3.8
    2-phenylethanol 16.98
    styrene 6.12
    dioctyl adipate 6.82
    dimethyl sulfate 10.8
    ethyl butyrate 6.83
    methyl lactate 8.77
    butyl lactate 13.15
    diethyl carbonate 3.82
    propanediol butyl ether 18.81
    triethyl orthoformate 8.63
    p-tert-butyltoluene 3.87
    methyl 4-tert-butylbenzoate 17.61
    morpholine 67.76
    tert-butylamine 3.7
    n-dodecanol 1.65
    dimethoxymethane 47.51
    ethylene carbonate 6.95
    cyrene 20.07
    2-ethoxyethyl acetate 19.4
    2-ethylhexyl acetate 8.49
    1,2,4-trichlorobenzene 10.95
    4-methylpyridine 23.68
    dibutyl ether 3.63
    2,6-dimethyl-4-heptanol 3.8
    DEF 18.11
    dimethyl isosorbide 33.99
    tetrachloroethylene 10.99
    eugenol 19.09
    triacetin 11.87
    span 80 17.51
    1,4-butanediol 3.14
    1,1-dichloroethane 6.58
    2-methyl-1-pentanol 7.84
    methyl formate 4.87
    2-methyl-1-butanol 10.86
    n-decane 0.23
    butyronitrile 5.12
    3,7-dimethyl-1-octanol 4.84
    1-chlorooctane 1.63
    1-chlorotetradecane 0.35
    n-nonane 0.19
    undecane 0.12
    tert-butylcyclohexane 0.6
    cyclooctane 0.32
    cyclopentanol 10.05
    tetrahydropyran 31.7
    tert-amyl methyl ether 7.91
    2,5,8-trioxanonane 25.51
    1-hexene 2.65
    2-isopropoxyethanol 13.56
    2,2,2-trifluoroethanol 1.67
    methyl butyrate 6.91

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction