Octisalate

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  • Identifiers

    CAS number
    118-60-5

    Molecular formula
    C15H22O3

    SMILES
    CCCCC(CC)COC(=O)C1=CC=CC=C1O

    Safety labels

    Irritant
    Irritant

    Environmental Hazard
    Environmental

  • Odor profile

    Fragrance
    Floral 71.43%
    Sweet 65.72%
    Balsamic 64.77%
    Fruity 59.29%
    Herbal 51.89%
    Spicy 43.88%
    Woody 35.56%
    Fresh 34.55%
    Jasmin 31.7%
    Green 30.27%

     

    Flavor
    Herbal 54.05%
    Woody 38.37%
    Spicy 28.1%
    Warm 27.0%
    Balsam 26.08%
    Mild 25.02%
    Oily 24.72%
    Floral 24.49%
    Bitter 22.13%
    Lovage 21.45%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    5.7

    pKa est.
    8.0 (neutral)

    Molecular weight
    250.33 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    308°C

    Flash point

    • 147.01 ˚C est.

  • Synonyms

    • 2-ETHYLHEXYL SALICYLATE
    • Octisalate
    • 118-60-5
    • 2-Ethylhexyl 2-hydroxybenzoate
    • Ethylhexyl salicylate
    • Ethyl hexyl salicylate
    • Sunarome O
    • Benzoic acid, 2-hydroxy-, 2-ethylhexyl ester
    • Sunarome WMO
    • Escalol
    • Uvinul
    • Octisalate [USAN]
    • USAF DO-11
    • Neo Heliopan
    • Salicylic acid, 2-ethylhexyl ester
    • Octisalato
    • Salicylic Acid 2-Ethylhexyl Ester
    • NSC 46151
    • NSC-46151
    • DTXSID7040734
    • OCTISALATE [II]
    • OCTISALATE [INN]
    • MFCD00053300
    • OCTISALATE [VANDF]
    • 4X49Y0596W
    • OCTISALATE [MART.]
    • OCTISALATE [USP-RS]
    • OCTISALATE [WHO-DD]
    • WMO
    • DTXCID5020734
    • CHEBI:88639
    • OCTISALATE [USP MONOGRAPH]
    • ETHYLHEXYL SALICYLATE [VANDF]
    • NCGC00159324-02
    • Octyl salicylate;2-Ethylhexyl salicylate
    • OCTISALATE (II)
    • OCTISALATE (MART.)
    • OCTISALATE (USP-RS)
    • OCTISALATE (USP MONOGRAPH)
    • CAS-118-60-5
    • OCTYLSALICYLATE
    • EINECS 204-263-4
    • BRN 2730664
    • octisalatum
    • Octisalate [USAN:USP:INN]
    • Dermoblock OS
    • Tanning Oil
    • UNII-4X49Y0596W
    • Neo Heliopan OS
    • Uvinul (TN)
    • Escalol 587
    • Salicylic acid-2-ethyl-1-hexyl ester
    • Uvinul O-18
    • Octisalate (Standard)
    • 2-Hydroxybenzoic acid 2-ethylhexyl ester
    • Octisalate (USP/INN)
    • Ethylhexyl salicylic acid
    • Salicylic Acid Octyl Ester
    • EC 204-263-4
    • SCHEMBL39594
    • 2-Ethylhexyl2-hydroxybenzoate
    • 2-Ethylhexyl salicylate, 99%
    • Arizona Sun Tanning Oil SPF 3
    • CHEMBL1329203
    • HY-B0929R
    • MSK3405
    • WLN: QR BVO1Y4 & 2
    • 2-Ethylhexyl salicylate, >=99%
    • HY-B0929
    • NSC46151
    • ETHYLHEXYL SALICYLATE [INCI]
    • Tox21_111573
    • s6405
    • STL570066
    • AKOS015890505
    • Tox21_111573_1
    • CS-4398
    • DB11062
    • NCGC00159324-03
    • NCGC00159324-04
    • AC-12458
    • LS-14437
    • SY052290
    • 2-hydroxy benzoic acid 2-ethylhexyl ester
    • DB-041415
    • 2-Ethylhexyl salicylate, analytical standard
    • NS00011474
    • S0387
    • D05226
    • F85195
    • EN300-7381990
    • Q27160526
    • Octisalate, United States Pharmacopeia (USP) Reference Standard
    • Octisalate, Pharmaceutical Secondary Standard; Certified Reference Material
    • 204-263-4

  • Applications

    2-Ethylhexyl salicylate (INCI: Ethylhexyl Salicylate, Octyl Salicylate) is an oil-soluble UVB filter widely employed in cosmetics, especially sunscreens, lotions, sprays and lip balms, where it absorbs 280-320 nm radiation to shield skin against sunburn, photo-aging and skin cancer; it also acts as an emollient that enhances spreadability, boosts water resistance, and photostabilizes complementary UVA filters like avobenzone; beyond skin care it serves as a fragrance carrier, polymer stabilizer and surface-protective additive in coatings, complying with EU, FDA and ASEAN regulations, exhibiting low irritation and high formulation compatibility, making it suitable for high-SPF systems as well as hair-care products or tropical climate preparations.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 8797.02
    methanol 8220.68
    isopropanol 5315.31
    water 0.08
    ethyl acetate 6587.15
    n-propanol 7582.32
    acetone 10153.39
    n-butanol 5550.5
    acetonitrile 5681.93
    DMF 9747.73
    toluene 1508.3
    isobutanol 4489.48
    1,4-dioxane 4286.25
    methyl acetate 4914.94
    THF 6489.25
    2-butanone 7742.52
    n-pentanol 2090.63
    sec-butanol 4518.48
    n-hexane 89.19
    ethylene glycol 361.72
    NMP 4464.99
    cyclohexane 231.86
    DMSO 8674.7
    n-butyl acetate 2134.5
    n-octanol 320.16
    chloroform 5133.56
    n-propyl acetate 2085.09
    acetic acid 2279.82
    dichloromethane 6439.43
    cyclohexanone 6232.69
    propylene glycol 997.42
    isopropyl acetate 2823.41
    DMAc 4517.75
    2-ethoxyethanol 2373.56
    isopentanol 3191.61
    n-heptane 24.04
    ethyl formate 2164.49
    1,2-dichloroethane 7487.0
    n-hexanol 1593.86
    2-methoxyethanol 6249.38
    isobutyl acetate 966.48
    tetrachloromethane 408.64
    n-pentyl acetate 857.03
    transcutol 5303.05
    n-heptanol 409.98
    ethylbenzene 458.43
    MIBK 2007.23
    2-propoxyethanol 2534.93
    tert-butanol 4353.16
    MTBE 4124.53
    2-butoxyethanol 936.06
    propionic acid 2380.62
    o-xylene 598.11
    formic acid 480.14
    diethyl ether 5478.49
    m-xylene 697.84
    p-xylene 556.95
    chlorobenzene 2169.7
    dimethyl carbonate 1094.38
    n-octane 13.48
    formamide 1657.9
    cyclopentanone 6543.97
    2-pentanone 5889.64
    anisole 1239.33
    cyclopentyl methyl ether 3193.64
    gamma-butyrolactone 5829.42
    1-methoxy-2-propanol 4109.87
    pyridine 5068.41
    3-pentanone 3379.59
    furfural 3028.01
    n-dodecane 13.72
    diethylene glycol 1306.45
    diisopropyl ether 828.82
    tert-amyl alcohol 3226.27
    acetylacetone 3957.45
    n-hexadecane 17.22
    acetophenone 1073.38
    methyl propionate 4640.41
    isopentyl acetate 1693.92
    trichloroethylene 9081.55
    n-nonanol 282.86
    cyclohexanol 3076.23
    benzyl alcohol 1015.88
    2-ethylhexanol 574.2
    isooctanol 337.75
    dipropyl ether 711.12
    1,2-dichlorobenzene 1347.03
    ethyl lactate 555.2
    propylene carbonate 2214.89
    n-methylformamide 4694.5
    2-pentanol 2828.69
    n-pentane 103.58
    1-propoxy-2-propanol 1467.63
    1-methoxy-2-propyl acetate 1708.91
    2-(2-methoxypropoxy) propanol 701.5
    mesitylene 352.28
    ε-caprolactone 4243.03
    p-cymene 173.76
    epichlorohydrin 8614.23
    1,1,1-trichloroethane 4015.13
    2-aminoethanol 1707.29
    morpholine-4-carbaldehyde 3338.47
    sulfolane 5349.25
    2,2,4-trimethylpentane 64.14
    2-methyltetrahydrofuran 5667.27
    n-hexyl acetate 1018.07
    isooctane 56.01
    2-(2-butoxyethoxy)ethanol 1253.5
    sec-butyl acetate 1265.8
    tert-butyl acetate 2326.42
    decalin 84.67
    glycerin 789.36
    diglyme 2475.97
    acrylic acid 1407.66
    isopropyl myristate 313.56
    n-butyric acid 4228.72
    acetyl acetate 1821.05
    di(2-ethylhexyl) phthalate 253.62
    ethyl propionate 1669.01
    nitromethane 5829.78
    1,2-diethoxyethane 1928.72
    benzonitrile 1474.79
    trioctyl phosphate 195.32
    1-bromopropane 3686.77
    gamma-valerolactone 6405.87
    n-decanol 199.84
    triethyl phosphate 294.57
    4-methyl-2-pentanol 870.13
    propionitrile 4214.14
    vinylene carbonate 1741.07
    1,1,2-trichlorotrifluoroethane 2708.57
    DMS 933.52
    cumene 229.4
    2-octanol 271.84
    2-hexanone 2150.76
    octyl acetate 400.31
    limonene 333.46
    1,2-dimethoxyethane 3494.59
    ethyl orthosilicate 274.69
    tributyl phosphate 272.91
    diacetone alcohol 2224.1
    N,N-dimethylaniline 497.68
    acrylonitrile 4509.27
    aniline 2160.89
    1,3-propanediol 2848.15
    bromobenzene 2195.11
    dibromomethane 4300.31
    1,1,2,2-tetrachloroethane 6903.33
    2-methyl-cyclohexyl acetate 592.31
    tetrabutyl urea 335.22
    diisobutyl methanol 281.39
    2-phenylethanol 820.94
    styrene 763.45
    dioctyl adipate 430.56
    dimethyl sulfate 1404.78
    ethyl butyrate 1003.05
    methyl lactate 1133.35
    butyl lactate 631.44
    diethyl carbonate 554.27
    propanediol butyl ether 827.53
    triethyl orthoformate 492.7
    p-tert-butyltoluene 172.84
    methyl 4-tert-butylbenzoate 589.4
    morpholine 7869.51
    tert-butylamine 2034.85
    n-dodecanol 142.57
    dimethoxymethane 4611.65
    ethylene carbonate 1675.6
    cyrene 624.06
    2-ethoxyethyl acetate 1320.5
    2-ethylhexyl acetate 1097.02
    1,2,4-trichlorobenzene 1536.02
    4-methylpyridine 4984.86
    dibutyl ether 555.78
    2,6-dimethyl-4-heptanol 281.39
    DEF 5272.2
    dimethyl isosorbide 1177.0
    tetrachloroethylene 3239.77
    eugenol 588.16
    triacetin 712.52
    span 80 563.43
    1,4-butanediol 648.54
    1,1-dichloroethane 6854.4
    2-methyl-1-pentanol 1519.91
    methyl formate 2285.27
    2-methyl-1-butanol 3527.23
    n-decane 23.02
    butyronitrile 4138.67
    3,7-dimethyl-1-octanol 412.22
    1-chlorooctane 221.66
    1-chlorotetradecane 74.68
    n-nonane 20.32
    undecane 17.31
    tert-butylcyclohexane 67.11
    cyclooctane 44.55
    cyclopentanol 3060.79
    tetrahydropyran 6747.2
    tert-amyl methyl ether 2129.03
    2,5,8-trioxanonane 1281.51
    1-hexene 737.36
    2-isopropoxyethanol 1357.14
    2,2,2-trifluoroethanol 506.17
    methyl butyrate 2546.2

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction