O-Methyltyramine

Overview IFRA Request a quote

  • Identifiers

    CAS number
    55-81-2

    Molecular formula
    C9H13NO

    SMILES
    COC1=CC=C(C=C1)CCN

    Safety labels

    Corrosive
    Corrosive

  • Odor profile

    Fragrance
    Fishy 47.8%
    Cheesy 41.35%
    Animal 39.62%
    Ripe 29.59%
    Meaty 28.43%
    Phenolic 27.9%
    Smoky 27.89%
    Sweet 26.3%
    Floral 25.08%
    Musty 24.0%

     

    Flavor
    Sweet 58.63%
    Phenolic 48.9%
    Spicy 39.54%
    Meaty 38.76%
    Mild 35.67%
    Medicinal 33.15%
    Floral 32.03%
    Spice 29.03%
    Fishy 27.53%
    Anise 27.03%

     

    Odor impact est.
    Medium

  • Properties

    XLogP3-AA
    1.6

    pKa est.
    5.75 (weak acid)

    Molecular weight
    151.21 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Slow

    Boiling point est.
    251°C

    Flash point

    • 110.72 ˚C est.

  • Synonyms

    • 4-Methoxyphenethylamine
    • 55-81-2
    • 2-(4-Methoxyphenyl)ethylamine
    • 2-(4-Methoxyphenyl)ethanamine
    • Homoanisylamine
    • p-Methoxyphenethylamine
    • 4-Methoxyphenylethylamine
    • 4-Methoxybenzeneethanamine
    • O-Methyltyramine
    • Benzeneethanamine, 4-methoxy-
    • P-METHOXYPHENYLETHYLAMINE
    • Tyramine, O-methyl-
    • 4-Methoxy-2-phenethylamine
    • 2-(p-Methoxyphenyl)ethylamine
    • USAF EL-52
    • 2-(4-Methoxyphenyl)Ethan-1-Amine
    • 4-Methoxy-beta-phenylethylamine
    • PHENETHYLAMINE, p-METHOXY-
    • NSC 43687
    • 2-(4-Methoxy-phenyl)-ethylamine
    • EINECS 200-245-5
    • MFCD00008192
    • BRN 0508967
    • CHEBI:266039
    • NSC-43687
    • UCE8P23XWF
    • CHEMBL101036
    • 2-(4-methoxyphenyl)-ethylamine
    • DTXSID6058764
    • 4-Methoxy-.beta.-phenylethylamine
    • 4-13-00-01789 (Beilstein Handbook Reference)
    • 4-Methoxyphenethyl amine
    • UNII-UCE8P23XWF
    • 2-(4-methoxyphenyl) ethylamine
    • p-methoxyphenethyl amine
    • 4-methoxy phenethylamine
    • 4-methoxyphenethyl-amine
    • 4-Methoxy-phenethylamine
    • 4-methoxybenzenethanamine
    • para-methoxyphenethylamine
    • 4-methoxylphenylethylamine
    • 4-Methoxybenzylmethylamine
    • 4-(2-Aminoethyl)anisole
    • 4-methoxyphenylethyl amine
    • para-Methoxyphenylethylamine
    • 4-Methoxy-benzeneethanamine
    • SCHEMBL4634
    • (4-methoxybenzyl)methylamine
    • WLN: Z2R DO1
    • 4-methoxy-2-phenylethylamine
    • 2-(4-methoxyphenyl)ethaneamine
    • SCHEMBL4779445
    • 2-( 4-methoxyphenyl)ethylamine
    • 2-(4-methoxy-phenyl)ethylamine
    • DTXCID3096903
    • DTXCID8041822
    • 2-(4-Methoxyphenyl)ethanamine #
    • 4-Methoxyphenethylamine, >=98%
    • 2-(4-methoxy-phenyl)-ethyl-amine
    • NSC43687
    • STR05874
    • BBL027694
    • BDBM50240697
    • STL371947
    • {2-[4-(methyloxy)phenyl]ethyl}amine
    • AKOS000119749
    • FM06003
    • NCGC00163353-01
    • SY001720
    • DB-052803
    • A8057
    • M0795
    • NS00033404
    • EN300-20025
    • 10.14272/LTPVSOCPYWDIFU-UHFFFAOYSA-N.1
    • doi:10.14272/LTPVSOCPYWDIFU-UHFFFAOYSA-N.1
    • Q27225715
    • F2190-0399
    • Z104476454
    • 200-245-5
    • ZHH

  • Applications

    O-Methyltyramine is primarily used as an intermediate in the organic synthesis of phenethylamine derivatives and can serve as a building block for more complex aromatic amines. In fragrance and flavor applications, it is considered a potential fragrance intermediate or odor-active precursor. In cosmetics and personal care, it is studied as a building block for aroma-related compounds. In pharmaceutical research, it is used as a starting material for synthesizing related phenethylamines and as a reference substrate for metabolism studies. In industrial chemical manufacturing, it can function as a building block for specialty compounds.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 1064.74
    methanol 1601.88
    isopropanol 427.24
    water 17.17
    ethyl acetate 629.83
    n-propanol 727.49
    acetone 590.68
    n-butanol 528.38
    acetonitrile 700.02
    DMF 1036.15
    toluene 118.12
    isobutanol 318.22
    1,4-dioxane 1071.04
    methyl acetate 528.56
    THF 638.61
    2-butanone 345.38
    n-pentanol 258.8
    sec-butanol 251.28
    n-hexane 5.88
    ethylene glycol 648.66
    NMP 437.47
    cyclohexane 20.49
    DMSO 1981.0
    n-butyl acetate 210.98
    n-octanol 40.34
    chloroform 1023.07
    n-propyl acetate 176.13
    acetic acid 1522.89
    dichloromethane 1018.54
    cyclohexanone 464.58
    propylene glycol 465.35
    isopropyl acetate 158.31
    DMAc 514.86
    2-ethoxyethanol 712.35
    isopentanol 271.78
    n-heptane 8.13
    ethyl formate 553.97
    1,2-dichloroethane 652.54
    n-hexanol 230.87
    2-methoxyethanol 1552.63
    isobutyl acetate 83.84
    tetrachloromethane 174.73
    n-pentyl acetate 63.09
    transcutol 918.06
    n-heptanol 59.08
    ethylbenzene 30.13
    MIBK 98.47
    2-propoxyethanol 491.89
    tert-butanol 527.39
    MTBE 224.56
    2-butoxyethanol 157.75
    propionic acid 754.41
    o-xylene 65.16
    formic acid 1102.85
    diethyl ether 296.38
    m-xylene 64.06
    p-xylene 36.79
    chlorobenzene 255.8
    dimethyl carbonate 173.43
    n-octane 2.78
    formamide 1321.1
    cyclopentanone 500.34
    2-pentanone 248.09
    anisole 134.79
    cyclopentyl methyl ether 246.68
    gamma-butyrolactone 738.07
    1-methoxy-2-propanol 600.64
    pyridine 661.1
    3-pentanone 193.62
    furfural 739.24
    n-dodecane 2.53
    diethylene glycol 644.98
    diisopropyl ether 36.24
    tert-amyl alcohol 257.9
    acetylacetone 312.35
    n-hexadecane 2.89
    acetophenone 113.24
    methyl propionate 401.42
    isopentyl acetate 132.44
    trichloroethylene 1262.34
    n-nonanol 35.95
    cyclohexanol 259.48
    benzyl alcohol 168.5
    2-ethylhexanol 84.01
    isooctanol 41.98
    dipropyl ether 94.3
    1,2-dichlorobenzene 191.94
    ethyl lactate 110.64
    propylene carbonate 374.07
    n-methylformamide 1067.53
    2-pentanol 169.16
    n-pentane 10.04
    1-propoxy-2-propanol 232.33
    1-methoxy-2-propyl acetate 220.54
    2-(2-methoxypropoxy) propanol 121.38
    mesitylene 34.47
    ε-caprolactone 398.98
    p-cymene 28.12
    epichlorohydrin 863.97
    1,1,1-trichloroethane 486.71
    2-aminoethanol 871.51
    morpholine-4-carbaldehyde 644.44
    sulfolane 746.34
    2,2,4-trimethylpentane 7.63
    2-methyltetrahydrofuran 420.66
    n-hexyl acetate 76.91
    isooctane 5.06
    2-(2-butoxyethoxy)ethanol 198.68
    sec-butyl acetate 76.34
    tert-butyl acetate 152.77
    decalin 8.45
    glycerin 691.52
    diglyme 431.36
    acrylic acid 708.9
    isopropyl myristate 25.85
    n-butyric acid 866.52
    acetyl acetate 313.34
    di(2-ethylhexyl) phthalate 43.49
    ethyl propionate 141.87
    nitromethane 1988.83
    1,2-diethoxyethane 222.04
    benzonitrile 204.0
    trioctyl phosphate 29.61
    1-bromopropane 207.93
    gamma-valerolactone 829.1
    n-decanol 27.75
    triethyl phosphate 67.36
    4-methyl-2-pentanol 69.31
    propionitrile 423.42
    vinylene carbonate 406.3
    1,1,2-trichlorotrifluoroethane 841.28
    DMS 107.44
    cumene 22.6
    2-octanol 26.21
    2-hexanone 122.82
    octyl acetate 37.98
    limonene 45.85
    1,2-dimethoxyethane 653.43
    ethyl orthosilicate 67.46
    tributyl phosphate 40.43
    diacetone alcohol 216.39
    N,N-dimethylaniline 69.04
    acrylonitrile 588.51
    aniline 335.64
    1,3-propanediol 962.02
    bromobenzene 210.34
    dibromomethane 523.19
    1,1,2,2-tetrachloroethane 841.82
    2-methyl-cyclohexyl acetate 80.3
    tetrabutyl urea 45.65
    diisobutyl methanol 39.62
    2-phenylethanol 145.14
    styrene 51.44
    dioctyl adipate 51.31
    dimethyl sulfate 253.13
    ethyl butyrate 137.61
    methyl lactate 237.67
    butyl lactate 72.42
    diethyl carbonate 102.98
    propanediol butyl ether 127.32
    triethyl orthoformate 99.03
    p-tert-butyltoluene 28.36
    methyl 4-tert-butylbenzoate 83.22
    morpholine 1192.94
    tert-butylamine 215.77
    n-dodecanol 22.06
    dimethoxymethane 516.98
    ethylene carbonate 366.65
    cyrene 134.05
    2-ethoxyethyl acetate 143.45
    2-ethylhexyl acetate 95.57
    1,2,4-trichlorobenzene 239.37
    4-methylpyridine 425.4
    dibutyl ether 47.4
    2,6-dimethyl-4-heptanol 39.62
    DEF 401.89
    dimethyl isosorbide 195.07
    tetrachloroethylene 666.39
    eugenol 96.8
    triacetin 103.03
    span 80 99.84
    1,4-butanediol 325.2
    1,1-dichloroethane 484.16
    2-methyl-1-pentanol 144.72
    methyl formate 723.99
    2-methyl-1-butanol 248.49
    n-decane 4.1
    butyronitrile 374.82
    3,7-dimethyl-1-octanol 43.89
    1-chlorooctane 23.71
    1-chlorotetradecane 9.14
    n-nonane 3.67
    undecane 3.05
    tert-butylcyclohexane 7.65
    cyclooctane 6.29
    cyclopentanol 285.32
    tetrahydropyran 582.91
    tert-amyl methyl ether 127.62
    2,5,8-trioxanonane 267.4
    1-hexene 31.66
    2-isopropoxyethanol 279.33
    2,2,2-trifluoroethanol 502.51
    methyl butyrate 218.73

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction