Nylidrin

Overview IFRA Request a quote

  • Identifiers

    CAS number
    447-41-6

    Molecular formula
    C19H25NO2

    SMILES
    CC(CCC1=CC=CC=C1)NC(C)C(C2=CC=C(C=C2)O)O

    Safety labels

    Irritant
    Irritant

    Environmental Hazard
    Environmental

  • Odor profile

    Fragrance
    Odorless 46.01%
    Savory 31.95%
    Fishy 29.63%
    Cooling 29.33%
    Animal 27.01%
    Meaty 25.32%
    Bitter 23.04%
    Sweet 22.12%
    Mint 19.85%
    Spicy 19.83%

     

    Flavor
    Bitter 33.39%
    Mild 32.35%
    Odorless 30.5%
    Bland 21.31%
    Nitrile 19.86%
    Cedarleaf 19.68%
    Yeasty 19.5%
    Sweet-like 19.42%
    Creosote 19.09%
    Delicate 18.98%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    3.5

    pKa est.
    8.83 (weak base)

    Molecular weight
    299.4 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    449°C

    Melting point expt.

    • 217 undefined
    • 111 °C

    Flash point

    • 201.39 ˚C est.

    Solubility expt.

    • Mol wt 335.88. Crystals. Sparingly sol in water; slightly sol in alcohol. Practically insol in ether, chloroform, benzene /Hydrochloride/

  • Synonyms

    • nylidrin
    • Buphenine
    • Buphenin
    • 447-41-6
    • Nilidrine
    • Suprifen-psb
    • Nylidrinum
    • Bufenina
    • Phenyl-sec-butyl norsuprifen
    • Bufenina [INN-Spanish]
    • Bupheninum [INN-Latin]
    • 4-[1-hydroxy-2-(4-phenylbutan-2-ylamino)propyl]phenol
    • HSDB 3137
    • SKF 1700-A
    • EINECS 207-182-2
    • UNII-695DKH33EI
    • Buphenine (INN)
    • Benzenemethanol, 4-hydroxy-alpha-(1-((1-methyl-3-phenylpropyl)amino)ethyl)-
    • CS 6712
    • 695DKH33EI
    • p-Hydroxy-N-(1-methyl-3-phenylpropyl)norephedrine
    • DTXSID4023387
    • BUPHENINE [INN]
    • NYLIDRIN [HSDB]
    • NYLIDRIN [MI]
    • NYLIDRIN [VANDF]
    • BUPHENINE [WHO-DD]
    • 1-(p-Hydroxyphenyl)-2-(1'-methyl-3'-phenylpropylamino)-1-propanol
    • 4-{1-hydroxy-2-[(4-phenylbutan-2-yl)amino]propyl}phenol
    • DTXCID103387
    • 4-Hydroxy-alpha-(1-((1-methyl-3-phenylpropyl)amino)ethyl)benzenemethanol
    • p-Hydroxy-alpha-(1-((1-methyl-3-phenylpropyl)amino)ethyl)benzyl alcohol
    • Benzyl alcohol, p-hydroxy-alpha-(1-((1-methyl-3-phenylpropyl)amino)ethyl)-
    • 4-(1-Hydroxy-2-((4-phenylbutan-2-yl)amino)propyl)phenol
    • NCGC00015716-05
    • Bufenine
    • Bufenina (INN-Spanish)
    • Bupheninum (INN-Latin)
    • Benzenemethanol, 4-hydroxy-.alpha.-[1-[(1-methyl-3-phenylpropyl)amino]ethyl]-
    • Bupheninum
    • 4-{1-hydroxy-2-[(1-methyl-3-phenylpropyl)amino]propyl}phenol
    • Benzyl alcohol, p-hydroxy-.alpha.-[1-[(1-methyl-3-phenylpropyl)amino]ethyl]-
    • p-Hydroxy-.alpha.-[1-[(methyl-3-phenylpropyl)amino]ethyl]benzyl alcohol
    • BENZENEMETHANOL, 4-HYDROXY-.ALPHA.-(1-((1-METHYL-3-PHENYLPROPYL)AMINO)ETHYL)-
    • P-HYDROXY-.ALPHA.-(1-((1-METHYL-3-PHENYLPROPYL)AMINO)ETHYL)BENZYL ALCOHOL
    • CAS-447-41-6
    • Buphenine [INN:BAN]
    • 4-(1-hydroxy-2-(4-phenylbutan-2-ylamino)propyl)phenol
    • SR-01000002981
    • Spectrum_001043
    • Spectrum2_000967
    • Spectrum3_000529
    • Spectrum4_000458
    • Spectrum5_000996
    • Lopac0_000911
    • BSPBio_002117
    • KBioGR_000876
    • KBioSS_001523
    • DivK1c_000109
    • SCHEMBL159150
    • SPBio_000973
    • CHEMBL114655
    • CHEBI:91656
    • KBio1_000109
    • KBio2_001523
    • KBio2_004091
    • KBio2_006659
    • KBio3_001617
    • C04AA02
    • G02CA02
    • NINDS_000109
    • HMS3714L05
    • Tox21_110204
    • AKOS003368108
    • Tox21_110204_1
    • CCG-204993
    • DB06152
    • SDCCGSBI-0050886.P005
    • IDI1_000109
    • SMP1_000218
    • NCGC00015716-03
    • NCGC00015716-04
    • NCGC00015716-07
    • NCGC00015716-08
    • NCGC00015716-09
    • NCGC00015716-13
    • NCGC00089743-02
    • NCGC00089743-03
    • SBI-0050886.P004
    • NS00010342
    • D07551
    • E75906
    • AB00053509-11
    • AB00053509_12
    • AO-080/40212238
    • EN300-18559873
    • Q851507
    • SR-01000002981-6
    • BRD-A36267905-003-12-7
    • BRD-A36267905-003-18-4
    • BRD-A36267905-003-19-2
    • 4-(1-Hydroxy-2-[(1-methyl-3-phenylpropyl)amino]propyl)phenol #
    • 4-(1-HYDROXY-2-(1-METHYL-3-PHENYL-PROPYLAMINO)-PROPYL)-PHENOL
    • p-Hydroxy-alpha-(1-((methyl-3-phenylpropyl)amino)ethyl)benzyl alcohol

  • Applications

    Nylidrin (CAS 447-41-6) is primarily encountered as an intermediate in organic synthesis and is commonly evaluated for use as a processing aid in specialty formulations. In polymers and plastics, it may serve as a building block or modifier for resin systems; in coatings and inks, it can function as a reactive diluent or formulation component; in adhesives, it may act as a coupling agent or crosslinking precursor; in cleaning and industrial formulations, it is sometimes used as a solvent or co-solvent under controlled conditions. Its role in electronics and related high‑performance materials is typically as a precursor for more complex intermediates in niche applications. Use is subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 43.45
    methanol 115.47
    isopropanol 13.6
    water 0.41
    ethyl acetate 31.48
    n-propanol 26.57
    acetone 32.96
    n-butanol 20.49
    acetonitrile 5.51
    DMF 55.75
    toluene 5.84
    isobutanol 12.59
    1,4-dioxane 52.4
    methyl acetate 18.59
    THF 131.03
    2-butanone 24.67
    n-pentanol 15.86
    sec-butanol 9.39
    n-hexane 0.36
    ethylene glycol 11.26
    NMP 31.99
    cyclohexane 0.55
    DMSO 173.65
    n-butyl acetate 16.15
    n-octanol 9.72
    chloroform 16.79
    n-propyl acetate 15.71
    acetic acid 62.08
    dichloromethane 11.47
    cyclohexanone 48.45
    propylene glycol 18.87
    isopropyl acetate 24.12
    DMAc 137.48
    2-ethoxyethanol 77.42
    isopentanol 21.0
    n-heptane 0.81
    ethyl formate 15.6
    1,2-dichloroethane 14.09
    n-hexanol 22.29
    2-methoxyethanol 119.17
    isobutyl acetate 13.77
    tetrachloromethane 3.01
    n-pentyl acetate 12.87
    transcutol 216.48
    n-heptanol 17.21
    ethylbenzene 3.52
    MIBK 25.02
    2-propoxyethanol 79.56
    tert-butanol 26.01
    MTBE 21.0
    2-butoxyethanol 47.08
    propionic acid 23.86
    o-xylene 5.7
    formic acid 39.62
    diethyl ether 13.33
    m-xylene 6.85
    p-xylene 4.3
    chlorobenzene 8.13
    dimethyl carbonate 17.51
    n-octane 0.55
    formamide 59.44
    cyclopentanone 63.6
    2-pentanone 30.81
    anisole 14.38
    cyclopentyl methyl ether 32.53
    gamma-butyrolactone 61.72
    1-methoxy-2-propanol 72.59
    pyridine 22.98
    3-pentanone 20.14
    furfural 52.89
    n-dodecane 0.5
    diethylene glycol 71.39
    diisopropyl ether 5.28
    tert-amyl alcohol 16.94
    acetylacetone 53.78
    n-hexadecane 0.57
    acetophenone 19.43
    methyl propionate 28.06
    isopentyl acetate 20.18
    trichloroethylene 35.39
    n-nonanol 10.95
    cyclohexanol 15.25
    benzyl alcohol 17.88
    2-ethylhexanol 12.56
    isooctanol 14.64
    dipropyl ether 14.25
    1,2-dichlorobenzene 9.4
    ethyl lactate 17.1
    propylene carbonate 28.29
    n-methylformamide 35.09
    2-pentanol 10.03
    n-pentane 0.24
    1-propoxy-2-propanol 46.7
    1-methoxy-2-propyl acetate 41.39
    2-(2-methoxypropoxy) propanol 40.16
    mesitylene 4.6
    ε-caprolactone 37.3
    p-cymene 4.77
    epichlorohydrin 70.31
    1,1,1-trichloroethane 8.92
    2-aminoethanol 29.74
    morpholine-4-carbaldehyde 68.57
    sulfolane 87.24
    2,2,4-trimethylpentane 0.69
    2-methyltetrahydrofuran 34.17
    n-hexyl acetate 16.61
    isooctane 0.58
    2-(2-butoxyethoxy)ethanol 65.11
    sec-butyl acetate 13.66
    tert-butyl acetate 30.4
    decalin 0.86
    glycerin 41.75
    diglyme 124.57
    acrylic acid 21.08
    isopropyl myristate 7.74
    n-butyric acid 42.46
    acetyl acetate 19.86
    di(2-ethylhexyl) phthalate 11.39
    ethyl propionate 15.36
    nitromethane 89.53
    1,2-diethoxyethane 40.52
    benzonitrile 9.32
    trioctyl phosphate 8.41
    1-bromopropane 3.67
    gamma-valerolactone 98.19
    n-decanol 8.31
    triethyl phosphate 11.51
    4-methyl-2-pentanol 11.0
    propionitrile 5.96
    vinylene carbonate 23.95
    1,1,2-trichlorotrifluoroethane 71.23
    DMS 17.61
    cumene 3.8
    2-octanol 7.65
    2-hexanone 17.44
    octyl acetate 10.26
    limonene 6.38
    1,2-dimethoxyethane 92.58
    ethyl orthosilicate 12.45
    tributyl phosphate 9.06
    diacetone alcohol 44.62
    N,N-dimethylaniline 12.91
    acrylonitrile 9.39
    aniline 15.02
    1,3-propanediol 50.19
    bromobenzene 6.03
    dibromomethane 5.65
    1,1,2,2-tetrachloroethane 33.13
    2-methyl-cyclohexyl acetate 18.62
    tetrabutyl urea 12.64
    diisobutyl methanol 8.58
    2-phenylethanol 20.19
    styrene 3.58
    dioctyl adipate 13.9
    dimethyl sulfate 32.79
    ethyl butyrate 15.52
    methyl lactate 25.91
    butyl lactate 19.77
    diethyl carbonate 10.68
    propanediol butyl ether 34.14
    triethyl orthoformate 16.7
    p-tert-butyltoluene 5.02
    methyl 4-tert-butylbenzoate 28.88
    morpholine 66.58
    tert-butylamine 8.97
    n-dodecanol 5.99
    dimethoxymethane 83.01
    ethylene carbonate 21.36
    cyrene 38.33
    2-ethoxyethyl acetate 29.93
    2-ethylhexyl acetate 13.16
    1,2,4-trichlorobenzene 12.6
    4-methylpyridine 15.54
    dibutyl ether 9.27
    2,6-dimethyl-4-heptanol 8.58
    DEF 33.82
    dimethyl isosorbide 63.74
    tetrachloroethylene 25.87
    eugenol 29.86
    triacetin 27.87
    span 80 30.95
    1,4-butanediol 17.41
    1,1-dichloroethane 7.24
    2-methyl-1-pentanol 16.97
    methyl formate 26.61
    2-methyl-1-butanol 16.63
    n-decane 0.88
    butyronitrile 7.5
    3,7-dimethyl-1-octanol 10.74
    1-chlorooctane 4.01
    1-chlorotetradecane 1.67
    n-nonane 0.66
    undecane 0.64
    tert-butylcyclohexane 0.89
    cyclooctane 0.39
    cyclopentanol 14.06
    tetrahydropyran 28.52
    tert-amyl methyl ether 15.9
    2,5,8-trioxanonane 77.13
    1-hexene 1.8
    2-isopropoxyethanol 46.86
    2,2,2-trifluoroethanol 18.19
    methyl butyrate 19.48

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction