Norwogonin

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  • Identifiers

    CAS number
    4443-09-8

    Molecular formula
    C15H10O5

    SMILES
    C1=CC=C(C=C1)C2=CC(=O)C3=C(O2)C(=C(C=C3O)O)O

    Safety labels

  • Odor profile

    Fragrance
    Odorless 55.99%
    Phenolic 53.29%
    Burnt 37.67%
    Smoky 24.16%
    Medicinal 23.81%
    Spicy 22.97%
    Bitter 20.29%
    Balsamic 20.29%
    Savory 19.45%
    Animal 18.23%

     

    Flavor
    Bitter 93.89%
    Very strong 20.6%
    Odorless 20.47%
    Sweet-like 20.43%
    Indole 20.26%
    Cedarleaf 20.24%
    Nitrile 20.16%
    Lovage 20.05%
    Curry 19.83%
    Eugenol 19.57%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    2.7

    pKa est.
    9.3 (weak base)

    Molecular weight
    270.24 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    796°C

    Flash point

    • 204.18 ˚C est.

  • Synonyms

    • Norwogonin
    • 5,7,8-Trihydroxyflavone
    • 4443-09-8
    • 5,7,8-trihydroxy-2-phenylchromen-4-one
    • FLAVONE, 5,7,8-TRIHYDROXY-
    • 70U0WT21IB
    • NSC-128304
    • 2-Phenyl-5,7,8-trihydroxy-4H-1-benzopyran-4-one
    • CHEBI:7642
    • DTXSID20196171
    • nor-wogonin
    • RefChem:166733
    • DTXCID30118662
    • 5,7,8-hydroxyflavone
    • 5,7,8-Trihydroxy-2-phenyl-4H-chromen-4-one
    • MFCD00016946
    • NSC128304
    • 5,7,8-trihydroxy-2-phenyl-chromen-4-one
    • 5,7,8-TRIHYDROXY-2-PHENYL-4H-1-BENZOPYRAN-4-ONE
    • NSC 128304
    • BRN 0272168
    • 5,7,8-trihydroxy flavone
    • UNII-70U0WT21IB
    • SCHEMBL760431
    • 4H-1-Benzopyran-4-one, 2-phenyl-5,7,8-trihydroxy-
    • CHEMBL485250
    • orb1299124
    • SCHEMBL30485998
    • HY-N2562
    • TRIHYDROXYFLAVONE, 5,7,8-
    • LMPK12111329
    • AKOS027381297
    • EBC-616551
    • FT65533
    • AC-34633
    • MS-23814
    • CS-0022894
    • NS00094649
    • ST50309217
    • E80692
    • Q15425306
    • NCGC00385188-01!5,7,8-trihydroxy-2-phenylchromen-4-one
    • 4443-09-8

  • Applications

    Norwogonin (CAS 4443-09-8) is used as an intermediate in the synthesis of flavonoid derivatives and as a building block for industrial production of related compounds in research settings. It also serves as an analytical standard or reference material in natural products analysis to support LC/MS and NMR workflows. In perfumery and cosmetics, it may be evaluated as a fragrance component or odorant within regulated formulations. Additionally, it is employed as a laboratory-scale building block for flavonoid-based molecules in pharmaceutical research, with use governed by local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 5.85
    methanol 3.47
    isopropanol 5.86
    water 0.0
    ethyl acetate 4.93
    n-propanol 7.47
    acetone 2.45
    n-butanol 7.16
    acetonitrile 1.34
    DMF 43.78
    toluene 0.42
    isobutanol 4.54
    1,4-dioxane 7.85
    methyl acetate 5.89
    THF 79.29
    2-butanone 10.31
    n-pentanol 3.15
    sec-butanol 8.51
    n-hexane 0.0
    ethylene glycol 8.88
    NMP 43.85
    cyclohexane 0.01
    DMSO 266.47
    n-butyl acetate 4.22
    n-octanol 1.68
    chloroform 0.0
    n-propyl acetate 3.69
    acetic acid 6.43
    dichloromethane 0.01
    cyclohexanone 11.38
    propylene glycol 9.68
    isopropyl acetate 4.76
    DMAc 75.12
    2-ethoxyethanol 21.24
    isopentanol 6.85
    n-heptane 0.02
    ethyl formate 2.28
    1,2-dichloroethane 0.14
    n-hexanol 2.93
    2-methoxyethanol 80.21
    isobutyl acetate 1.69
    tetrachloromethane 0.01
    n-pentyl acetate 3.11
    transcutol 83.64
    n-heptanol 2.25
    ethylbenzene 0.28
    MIBK 5.36
    2-propoxyethanol 26.4
    tert-butanol 9.33
    MTBE 3.35
    2-butoxyethanol 11.79
    propionic acid 6.66
    o-xylene 0.51
    formic acid 5.32
    diethyl ether 1.39
    m-xylene 0.4
    p-xylene 0.3
    chlorobenzene 0.16
    dimethyl carbonate 5.44
    n-octane 0.01
    formamide 16.11
    cyclopentanone 28.9
    2-pentanone 6.68
    anisole 2.47
    cyclopentyl methyl ether 9.77
    gamma-butyrolactone 30.74
    1-methoxy-2-propanol 58.68
    pyridine 6.73
    3-pentanone 3.36
    furfural 16.14
    n-dodecane 0.04
    diethylene glycol 32.61
    diisopropyl ether 0.51
    tert-amyl alcohol 9.99
    acetylacetone 12.46
    n-hexadecane 0.04
    acetophenone 4.26
    methyl propionate 8.21
    isopentyl acetate 5.01
    trichloroethylene 0.25
    n-nonanol 2.08
    cyclohexanol 5.68
    benzyl alcohol 4.1
    2-ethylhexanol 2.2
    isooctanol 2.13
    dipropyl ether 2.19
    1,2-dichlorobenzene 0.23
    ethyl lactate 6.12
    propylene carbonate 6.93
    n-methylformamide 12.63
    2-pentanol 5.15
    n-pentane 0.01
    1-propoxy-2-propanol 18.95
    1-methoxy-2-propyl acetate 15.7
    2-(2-methoxypropoxy) propanol 18.1
    mesitylene 0.24
    ε-caprolactone 13.8
    p-cymene 0.7
    epichlorohydrin 30.23
    1,1,1-trichloroethane 0.06
    2-aminoethanol 13.81
    morpholine-4-carbaldehyde 39.22
    sulfolane 80.06
    2,2,4-trimethylpentane 0.04
    2-methyltetrahydrofuran 20.16
    n-hexyl acetate 4.27
    isooctane 0.02
    2-(2-butoxyethoxy)ethanol 24.15
    sec-butyl acetate 3.11
    tert-butyl acetate 7.65
    decalin 0.02
    glycerin 34.84
    diglyme 41.15
    acrylic acid 6.87
    isopropyl myristate 2.3
    n-butyric acid 7.14
    acetyl acetate 2.51
    di(2-ethylhexyl) phthalate 2.79
    ethyl propionate 4.13
    nitromethane 16.19
    1,2-diethoxyethane 8.87
    benzonitrile 2.08
    trioctyl phosphate 2.13
    1-bromopropane 0.09
    gamma-valerolactone 43.65
    n-decanol 1.63
    triethyl phosphate 3.25
    4-methyl-2-pentanol 3.04
    propionitrile 2.53
    vinylene carbonate 4.05
    1,1,2-trichlorotrifluoroethane 23.16
    DMS 6.42
    cumene 0.27
    2-octanol 1.45
    2-hexanone 4.22
    octyl acetate 2.87
    limonene 0.93
    1,2-dimethoxyethane 26.48
    ethyl orthosilicate 2.91
    tributyl phosphate 2.56
    diacetone alcohol 28.04
    N,N-dimethylaniline 2.13
    acrylonitrile 4.56
    aniline 3.65
    1,3-propanediol 27.04
    bromobenzene 0.08
    dibromomethane 0.01
    1,1,2,2-tetrachloroethane 0.38
    2-methyl-cyclohexyl acetate 3.54
    tetrabutyl urea 4.23
    diisobutyl methanol 2.13
    2-phenylethanol 5.02
    styrene 0.24
    dioctyl adipate 4.04
    dimethyl sulfate 17.11
    ethyl butyrate 4.01
    methyl lactate 17.15
    butyl lactate 6.13
    diethyl carbonate 2.53
    propanediol butyl ether 13.12
    triethyl orthoformate 4.5
    p-tert-butyltoluene 0.77
    methyl 4-tert-butylbenzoate 7.56
    morpholine 27.87
    tert-butylamine 2.02
    n-dodecanol 1.21
    dimethoxymethane 24.67
    ethylene carbonate 3.19
    cyrene 15.7
    2-ethoxyethyl acetate 7.7
    2-ethylhexyl acetate 3.16
    1,2,4-trichlorobenzene 0.64
    4-methylpyridine 5.28
    dibutyl ether 2.19
    2,6-dimethyl-4-heptanol 2.13
    DEF 13.74
    dimethyl isosorbide 28.41
    tetrachloroethylene 0.19
    eugenol 8.39
    triacetin 7.65
    span 80 10.4
    1,4-butanediol 4.26
    1,1-dichloroethane 0.04
    2-methyl-1-pentanol 4.07
    methyl formate 5.51
    2-methyl-1-butanol 6.82
    n-decane 0.04
    butyronitrile 2.22
    3,7-dimethyl-1-octanol 2.44
    1-chlorooctane 0.33
    1-chlorotetradecane 0.2
    n-nonane 0.02
    undecane 0.04
    tert-butylcyclohexane 0.03
    cyclooctane 0.01
    cyclopentanol 8.82
    tetrahydropyran 5.2
    tert-amyl methyl ether 4.74
    2,5,8-trioxanonane 30.59
    1-hexene 0.04
    2-isopropoxyethanol 12.34
    2,2,2-trifluoroethanol 2.39
    methyl butyrate 5.24

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction