Norpseudoephedrine, hydrochloride

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  • Identifiers

    CAS number
    2153-98-2

    Molecular formula
    C9H14ClNO

    SMILES
    C[C@@H]([C@H](C1=CC=CC=C1)O)N.Cl

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Odorless 43.48%
    Sweet 34.79%
    Fishy 34.25%
    Bitter 27.3%
    Cooling 25.69%
    Savory 22.68%
    Mint 20.7%
    Animal 19.34%
    Ripe 18.47%
    Cheesy 18.16%

     

    Flavor
    Mild 35.21%
    Odorless 32.96%
    Sulfurous 29.82%
    Sweet 27.51%
    Meaty 22.91%
    Bitter 20.96%
    Sweet-like 20.21%
    Bloody 19.56%
    Nitrile 19.48%
    Yeasty 19.46%

     

    Odor impact est.
    Low

  • Properties

    pKa est.
    5.37 (weak acid)

    Molecular weight
    187.66 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    265°C

    Flash point

    • 122.9 ˚C est.

  • Synonyms

    • Cathine hydrochloride
    • 2153-98-2
    • Norpseudoephedrine hydrochloride
    • Amorphan
    • Minusin
    • (+)-Norpseudoephedrine hydrochloride
    • d-Norpseudoephedrine hydrochloride
    • IX73851J3P
    • DTXSID70891149
    • RefChem:854749
    • Norpseudoephedrine, hydrochloride
    • DTXCID101362878
    • norpseudoephedrine hydrochloride, (+)-
    • 218-446-1
    • d-Cathine.HCl
    • Fugoa
    • Adiposettin
    • (1S,2S)-2-amino-1-phenylpropan-1-ol;hydrochloride
    • (+)-Norpseudoephedrine Hydrochloride (Cathine Hydrochloride)
    • Reduform
    • fasupond
    • EINECS 218-446-1
    • Norpseudoephedrine HCl
    • CATHINE HCL
    • Cathine (hydrochloride)
    • UNII-IX73851J3P
    • Antiadipositum X-112 (TN)
    • SCHEMBL20553236
    • DYWNLSQWJMTVGJ-DKXTVVGFSA-N
    • Benzenemethanol, alpha-((1S)-1-aminoethyl)-, hydrochloride, (alphaS)-
    • CATHINE HYDROCHLORIDE [WHO-DD]
    • FN159735
    • (+)-Norpseudoephedrine hydrochloride solution
    • NORPSEUDOEPHEDRINE HYDROCHLORIDE [MI]
    • 45P788
    • D07628
    • (+)-Norpseudoephedrine HCl (Cathinhydrochlorid)
    • d-Cathine.HCl, 1mg/ml in Methanol (as free base)
    • Q27280935
    • (+)-Norpseudoephedrine Hydrochloride (Cathinhydrochlorid)
    • (1S,2S)-2-Amino-1-phenylpropan-1-ol--hydrogen chloride (1/1)
    • Benzenemethanol, .alpha.-[(1S)-1-aminoethyl]-, hydrochloride, (.alpha.S)-
    • BENZENEMETHANOL, .ALPHA.-((1S)-1-AMINOETHYL)-, HYDROCHLORIDE (1:1), (.ALPHA.S)-
    • Benzenemethanol, alpha-((1S)-1-aminoethyl)-, hydrochloride (1:1), (alphaS)-
    • (+)-Norpseudoephedrine Hydrochloride (Cathine Hydrochloride) 0.1 mg/ml in Methanol (as free base)
    • 2153-98-2

  • Applications

    Norpseudoephedrine hydrochloride is primarily used as an intermediate in organic synthesis, notably in the production of active pharmaceutical ingredients. It is also regarded as a chiral building block for amine synthesis and related derivatives in chemical research and development. In industrial manufacturing, it can serve as a precursor for downstream steps in the synthesis of amine-containing compounds and other intermediates. In R&D settings, it may be used as a reference material to optimize formulation and synthetic processes. Its use and handling are subject to local regulations and should comply with applicable safety and regulatory limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 85.9
    methanol 143.51
    isopropanol 42.67
    water 16.08
    ethyl acetate 10.11
    n-propanol 49.11
    acetone 24.96
    n-butanol 35.47
    acetonitrile 32.09
    DMF 108.43
    toluene 5.63
    isobutanol 36.15
    1,4-dioxane 76.49
    methyl acetate 11.66
    THF 77.53
    2-butanone 14.34
    n-pentanol 31.0
    sec-butanol 25.62
    n-hexane 0.98
    ethylene glycol 70.26
    NMP 102.5
    cyclohexane 1.94
    DMSO 240.42
    n-butyl acetate 18.99
    n-octanol 18.55
    chloroform 54.41
    n-propyl acetate 13.85
    acetic acid 124.26
    dichloromethane 55.15
    cyclohexanone 48.41
    propylene glycol 50.48
    isopropyl acetate 7.0
    DMAc 71.66
    2-ethoxyethanol 76.35
    isopentanol 28.93
    n-heptane 3.17
    ethyl formate 28.09
    1,2-dichloroethane 24.09
    n-hexanol 44.44
    2-methoxyethanol 118.32
    isobutyl acetate 11.13
    tetrachloromethane 7.84
    n-pentyl acetate 12.15
    transcutol 108.43
    n-heptanol 28.05
    ethylbenzene 5.9
    MIBK 11.77
    2-propoxyethanol 82.67
    tert-butanol 44.91
    MTBE 12.98
    2-butoxyethanol 51.02
    propionic acid 47.32
    o-xylene 8.06
    formic acid 118.29
    diethyl ether 7.88
    m-xylene 7.75
    p-xylene 7.31
    chlorobenzene 15.32
    dimethyl carbonate 9.68
    n-octane 1.61
    formamide 106.09
    cyclopentanone 65.43
    2-pentanone 12.22
    anisole 18.26
    cyclopentyl methyl ether 24.78
    gamma-butyrolactone 89.32
    1-methoxy-2-propanol 63.68
    pyridine 40.91
    3-pentanone 8.22
    furfural 103.42
    n-dodecane 1.37
    diethylene glycol 98.72
    diisopropyl ether 3.5
    tert-amyl alcohol 28.73
    acetylacetone 18.77
    n-hexadecane 1.48
    acetophenone 23.0
    methyl propionate 11.4
    isopentyl acetate 18.27
    trichloroethylene 60.04
    n-nonanol 16.47
    cyclohexanol 25.64
    benzyl alcohol 29.86
    2-ethylhexanol 23.26
    isooctanol 22.04
    dipropyl ether 16.61
    1,2-dichlorobenzene 18.87
    ethyl lactate 21.32
    propylene carbonate 50.73
    n-methylformamide 82.55
    2-pentanol 16.09
    n-pentane 0.96
    1-propoxy-2-propanol 51.39
    1-methoxy-2-propyl acetate 24.03
    2-(2-methoxypropoxy) propanol 38.41
    mesitylene 6.3
    ε-caprolactone 42.73
    p-cymene 8.81
    epichlorohydrin 69.53
    1,1,1-trichloroethane 14.42
    2-aminoethanol 91.24
    morpholine-4-carbaldehyde 97.1
    sulfolane 140.01
    2,2,4-trimethylpentane 1.3
    2-methyltetrahydrofuran 37.82
    n-hexyl acetate 16.53
    isooctane 1.26
    2-(2-butoxyethoxy)ethanol 51.54
    sec-butyl acetate 7.36
    tert-butyl acetate 11.14
    decalin 2.05
    glycerin 93.98
    diglyme 93.32
    acrylic acid 55.45
    isopropyl myristate 8.05
    n-butyric acid 56.7
    acetyl acetate 9.7
    di(2-ethylhexyl) phthalate 17.12
    ethyl propionate 9.85
    nitromethane 113.95
    1,2-diethoxyethane 22.34
    benzonitrile 28.43
    trioctyl phosphate 13.2
    1-bromopropane 8.78
    gamma-valerolactone 96.7
    n-decanol 13.34
    triethyl phosphate 12.78
    4-methyl-2-pentanol 12.75
    propionitrile 20.02
    vinylene carbonate 48.59
    1,1,2-trichlorotrifluoroethane 92.04
    DMS 12.38
    cumene 6.94
    2-octanol 13.35
    2-hexanone 14.8
    octyl acetate 11.75
    limonene 12.53
    1,2-dimethoxyethane 75.91
    ethyl orthosilicate 13.33
    tributyl phosphate 11.47
    diacetone alcohol 30.19
    N,N-dimethylaniline 19.12
    acrylonitrile 34.19
    aniline 17.95
    1,3-propanediol 85.44
    bromobenzene 13.06
    dibromomethane 29.03
    1,1,2,2-tetrachloroethane 45.03
    2-methyl-cyclohexyl acetate 20.62
    tetrabutyl urea 17.83
    diisobutyl methanol 12.98
    2-phenylethanol 32.65
    styrene 5.88
    dioctyl adipate 15.3
    dimethyl sulfate 25.3
    ethyl butyrate 16.26
    methyl lactate 23.81
    butyl lactate 20.7
    diethyl carbonate 12.04
    propanediol butyl ether 45.25
    triethyl orthoformate 15.26
    p-tert-butyltoluene 8.25
    methyl 4-tert-butylbenzoate 32.42
    morpholine 76.02
    tert-butylamine 21.08
    n-dodecanol 10.62
    dimethoxymethane 37.3
    ethylene carbonate 36.85
    cyrene 56.04
    2-ethoxyethyl acetate 17.84
    2-ethylhexyl acetate 13.19
    1,2,4-trichlorobenzene 23.18
    4-methylpyridine 25.79
    dibutyl ether 9.68
    2,6-dimethyl-4-heptanol 12.98
    DEF 22.84
    dimethyl isosorbide 58.02
    tetrachloroethylene 35.59
    eugenol 36.3
    triacetin 23.73
    span 80 40.35
    1,4-butanediol 45.56
    1,1-dichloroethane 14.99
    2-methyl-1-pentanol 24.32
    methyl formate 52.75
    2-methyl-1-butanol 27.35
    n-decane 2.09
    butyronitrile 22.78
    3,7-dimethyl-1-octanol 15.09
    1-chlorooctane 7.01
    1-chlorotetradecane 3.27
    n-nonane 1.9
    undecane 1.64
    tert-butylcyclohexane 2.05
    cyclooctane 1.25
    cyclopentanol 41.24
    tetrahydropyran 30.24
    tert-amyl methyl ether 10.48
    2,5,8-trioxanonane 71.04
    1-hexene 3.58
    2-isopropoxyethanol 43.17
    2,2,2-trifluoroethanol 45.36
    methyl butyrate 17.82

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction