Nordihydrocapsiate

Overview IFRA Request a quote

  • Identifiers

    CAS number
    220012-53-3

    Molecular formula
    C17H26O4

    SMILES
    CC(C)CCCCCC(=O)OCC1=CC(=C(C=C1)O)OC

    Safety labels

  • Odor profile

    Fragrance
    Sweet 46.7%
    Balsamic 43.46%
    Spicy 40.06%
    Floral 38.82%
    Vanilla 36.63%
    Fruity 33.63%
    Odorless 29.99%
    Woody 29.97%
    Warm 29.0%
    Herbal 28.69%

     

    Flavor
    Herbal 44.63%
    Woody 39.52%
    Warm 33.11%
    Spicy 30.58%
    Oily 30.01%
    Mild 28.56%
    Spice 27.54%
    Bland 26.72%
    Soapy 26.32%
    Parsley 23.58%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    4.5

    pKa est.
    9.85 (weak base)

    Molecular weight
    294.4 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    382°C

    Flash point

    • 161.65 ˚C est.

  • Synonyms

    • Nordihydrocapsiate
    • 220012-53-3
    • (4-HYDROXY-3-METHOXYPHENYL)METHYL 7-METHYLOCTANOATE
    • 4S73H45T4T
    • DTXSID80176439
    • Octanoic acid, 7-methyl-, (4-hydroxy-3-methoxyphenyl)methyl ester
    • RefChem:166590
    • DTXCID4098930
    • 879-035-6
    • 4-Hydroxy-3-methoxybenzyl 7-methyloctanoate
    • MFCD28137841
    • UNII-4S73H45T4T
    • (4-hydroxy-3-methoxy-phenyl)methyl 7-methyloctanoate
    • SCHEMBL1586484
    • CHEMBL5396122
    • CHEBI:174795
    • Nordihydrocapsiate, analytical standard
    • FN71846
    • 4-Hydroxy-3-methoxybenzyl7-methyloctanoate
    • G63781
    • Q27260415
    • 220012-53-3

  • Applications

    Nordihydrocapsiate, CAS 220012-53-3, is used in food and beverage applications as a chili-derived flavor and heat-modulating ingredient, often added to control the level of spiciness and as a component of pepper extracts or spice blends. It is also employed in cosmetics and personal care as a heat sensation element and fragrance note in formulations. In food science and product development, it can function as a component in flavor systems and in formulation optimization studies. It is also considered for inclusion in dietary supplements or functional foods in pepper-derived extracts, depending on local regulations.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 2824.51
    methanol 4077.31
    isopropanol 1414.61
    water 0.15
    ethyl acetate 3272.59
    n-propanol 1450.72
    acetone 3293.67
    n-butanol 819.04
    acetonitrile 1712.63
    DMF 1212.73
    toluene 149.63
    isobutanol 670.94
    1,4-dioxane 1529.71
    methyl acetate 1875.93
    THF 2209.12
    2-butanone 1567.02
    n-pentanol 402.48
    sec-butanol 745.3
    n-hexane 2.1
    ethylene glycol 118.28
    NMP 399.11
    cyclohexane 10.52
    DMSO 2740.51
    n-butyl acetate 527.3
    n-octanol 81.89
    chloroform 1233.3
    n-propyl acetate 755.54
    acetic acid 1403.58
    dichloromethane 1512.88
    cyclohexanone 1077.15
    propylene glycol 319.67
    isopropyl acetate 1119.03
    DMAc 936.6
    2-ethoxyethanol 1236.71
    isopentanol 546.52
    n-heptane 2.21
    ethyl formate 816.36
    1,2-dichloroethane 1269.95
    n-hexanol 244.98
    2-methoxyethanol 2576.64
    isobutyl acetate 361.19
    tetrachloromethane 86.09
    n-pentyl acetate 256.24
    transcutol 2056.5
    n-heptanol 88.77
    ethylbenzene 71.18
    MIBK 533.18
    2-propoxyethanol 736.2
    tert-butanol 1441.15
    MTBE 1071.83
    2-butoxyethanol 299.94
    propionic acid 778.77
    o-xylene 94.85
    formic acid 367.96
    diethyl ether 882.25
    m-xylene 105.88
    p-xylene 99.62
    chlorobenzene 265.99
    dimethyl carbonate 329.65
    n-octane 2.78
    formamide 982.93
    cyclopentanone 1332.31
    2-pentanone 1325.84
    anisole 275.85
    cyclopentyl methyl ether 566.77
    gamma-butyrolactone 1461.45
    1-methoxy-2-propanol 1438.59
    pyridine 601.22
    3-pentanone 599.23
    furfural 795.68
    n-dodecane 3.69
    diethylene glycol 563.85
    diisopropyl ether 122.23
    tert-amyl alcohol 810.21
    acetylacetone 1453.08
    n-hexadecane 4.25
    acetophenone 289.69
    methyl propionate 1251.21
    isopentyl acetate 426.78
    trichloroethylene 1688.12
    n-nonanol 76.31
    cyclohexanol 419.12
    benzyl alcohol 260.62
    2-ethylhexanol 98.36
    isooctanol 83.09
    dipropyl ether 104.35
    1,2-dichlorobenzene 232.91
    ethyl lactate 216.42
    propylene carbonate 657.82
    n-methylformamide 1062.63
    2-pentanol 406.77
    n-pentane 2.07
    1-propoxy-2-propanol 414.27
    1-methoxy-2-propyl acetate 560.58
    2-(2-methoxypropoxy) propanol 275.34
    mesitylene 62.51
    ε-caprolactone 919.83
    p-cymene 43.9
    epichlorohydrin 2006.06
    1,1,1-trichloroethane 780.11
    2-aminoethanol 526.33
    morpholine-4-carbaldehyde 734.92
    sulfolane 1069.52
    2,2,4-trimethylpentane 7.22
    2-methyltetrahydrofuran 1106.04
    n-hexyl acetate 278.8
    isooctane 5.97
    2-(2-butoxyethoxy)ethanol 458.23
    sec-butyl acetate 437.47
    tert-butyl acetate 872.07
    decalin 9.13
    glycerin 327.22
    diglyme 944.23
    acrylic acid 431.79
    isopropyl myristate 89.2
    n-butyric acid 1483.61
    acetyl acetate 939.61
    di(2-ethylhexyl) phthalate 91.01
    ethyl propionate 553.28
    nitromethane 3220.77
    1,2-diethoxyethane 577.88
    benzonitrile 281.62
    trioctyl phosphate 65.46
    1-bromopropane 397.7
    gamma-valerolactone 1583.2
    n-decanol 56.01
    triethyl phosphate 110.83
    4-methyl-2-pentanol 177.1
    propionitrile 703.42
    vinylene carbonate 504.6
    1,1,2-trichlorotrifluoroethane 781.31
    DMS 298.95
    cumene 48.11
    2-octanol 66.03
    2-hexanone 470.03
    octyl acetate 121.65
    limonene 63.9
    1,2-dimethoxyethane 1304.01
    ethyl orthosilicate 105.44
    tributyl phosphate 91.03
    diacetone alcohol 831.33
    N,N-dimethylaniline 124.96
    acrylonitrile 803.33
    aniline 274.37
    1,3-propanediol 1024.67
    bromobenzene 258.28
    dibromomethane 823.28
    1,1,2,2-tetrachloroethane 1229.21
    2-methyl-cyclohexyl acetate 187.63
    tetrabutyl urea 105.32
    diisobutyl methanol 68.64
    2-phenylethanol 220.06
    styrene 96.85
    dioctyl adipate 151.74
    dimethyl sulfate 407.29
    ethyl butyrate 304.42
    methyl lactate 343.86
    butyl lactate 199.89
    diethyl carbonate 201.78
    propanediol butyl ether 269.6
    triethyl orthoformate 164.24
    p-tert-butyltoluene 44.9
    methyl 4-tert-butylbenzoate 218.49
    morpholine 2088.21
    tert-butylamine 383.25
    n-dodecanol 42.09
    dimethoxymethane 1311.27
    ethylene carbonate 509.95
    cyrene 233.19
    2-ethoxyethyl acetate 496.6
    2-ethylhexyl acetate 264.21
    1,2,4-trichlorobenzene 269.51
    4-methylpyridine 558.64
    dibutyl ether 119.25
    2,6-dimethyl-4-heptanol 68.64
    DEF 803.43
    dimethyl isosorbide 439.67
    tetrachloroethylene 661.47
    eugenol 216.42
    triacetin 325.44
    span 80 196.44
    1,4-butanediol 284.18
    1,1-dichloroethane 1188.51
    2-methyl-1-pentanol 290.1
    methyl formate 748.63
    2-methyl-1-butanol 448.18
    n-decane 5.89
    butyronitrile 706.98
    3,7-dimethyl-1-octanol 106.52
    1-chlorooctane 48.91
    1-chlorotetradecane 18.11
    n-nonane 4.88
    undecane 4.49
    tert-butylcyclohexane 8.83
    cyclooctane 2.96
    cyclopentanol 456.6
    tetrahydropyran 1252.44
    tert-amyl methyl ether 452.32
    2,5,8-trioxanonane 551.65
    1-hexene 30.75
    2-isopropoxyethanol 638.06
    2,2,2-trifluoroethanol 349.81
    methyl butyrate 769.07

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction