Nordihydrocapsaicin

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  • Identifiers

    CAS number
    28789-35-7

    Molecular formula
    C17H27NO3

    SMILES
    CC(C)CCCCCC(=O)NCC1=CC(=C(C=C1)O)OC

    Safety labels

    Acute Toxic
    Acute Toxic

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Cooling 42.83%
    Odorless 39.24%
    Savory 38.33%
    Spicy 31.69%
    Mint 31.12%
    Meaty 30.73%
    Herbal 29.1%
    Animal 25.04%
    Burnt 20.54%
    Warm 20.27%

     

    Flavor
    Herbal 44.23%
    Odorless 36.05%
    Bland 34.73%
    Mild 32.65%
    Warm 23.21%
    Woody 22.46%
    Spicy 22.13%
    Bitter 21.55%
    Parsley 20.48%
    Creosote 20.27%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    3.9

    pKa est.
    10.21 (weak base)

    Molecular weight
    293.4 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    448°C

    Melting point expt.

    • 60 - 61 °C

    Flash point

    • 175.17 ˚C est.

  • Synonyms

    • Nordihydrocapsaicin
    • 28789-35-7
    • N-[(4-hydroxy-3-methoxyphenyl)methyl]-7-methyloctanamide
    • Octanamide, N-[(4-hydroxy-3-methoxyphenyl)methyl]-7-methyl-
    • RF657P8DA8
    • DTXSID3042217
    • Octanamide, N-((4-hydroxy-3-methoxyphenyl)methyl)-7-methyl-
    • N-((4-hydroxy-3-methoxyphenyl)methyl)-7-methyloctanamide
    • RefChem:43815
    • DTXCID1022217
    • Nordihydrocapsacin
    • n-(4-hydroxy-3-methoxybenzyl)-7-methyloctanamide
    • Nordihydro Capsaicin
    • Norhydrocapsaicin
    • 7-methyl nordihydrocapsaicin
    • N-((4-hydroxy-3-methoxyphenyl)methyl)-7-methyl-octanamide
    • N-[(4-Hydroxy-3-methoxyphenyl)methyl]-7-methyl-octanamide
    • UNII-RF657P8DA8
    • N-[(4-Hydroxy-3-methoxyphenyl)methyl]-7-methyl-octanamide;7-Methyl-N-vanillyl-octanamide; Norhydrocapsaicin
    • EPA Pesticide Chemical Code 070707
    • Nordihydrocapsaicin (Standard)
    • SCHEMBL117622
    • 7-methyl-N-vanillyl-octanamide
    • orb1304216
    • SCHEMBL29425544
    • HY-N0449R
    • CHEBI:174101
    • VQEONGKQWIFHMN-UHFFFAOYSA-N
    • CS-D1183
    • HY-N0449
    • MFCD06796690
    • MSK157807
    • AKOS026673998
    • EBC-617762
    • FN74342
    • AC-34346
    • DA-56253
    • MS-24202
    • OCTANAMIDE, 7-METHYL-N-VANILLYL-
    • NS00021103
    • C20216
    • Q2286631
    • N-[(4-hydroxy-3-methoxy-phenyl)methyl]-7-methyl-octanamide
    • NORDIHYDROCAPSAICIN (CONSTITUENT OF CAPSICUM) [DSC]
    • N-((4-H ydroxy-3-methoxyphenyl)methyl)-7-methyl-octanamide
    • N-[(4-Hydroxy-3-methoxyphenyl)methyl]-7-methyloctanamide, 9CI
    • 28789-35-7

  • Applications

    Nordihydrocapsaicin (CAS 28789-35-7) is a capsaicinoid derived from chili peppers and is used in several real-world applications: as a key irritant component in pepper spray/self-defense formulations; as a heat-contributing flavor component in low concentrations for spice-focused food formulations; in agriculture and pest management as a deterrent or component of pepper-based repellents; as an analytical standard or reference material for profiling capsaicinoids in foods and pepper extracts; and in research settings for studying the activation of the TRPV1 receptor and related sensory mechanisms, informing formulation development under local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 1136.48
    methanol 1841.35
    isopropanol 450.36
    water 0.22
    ethyl acetate 801.81
    n-propanol 457.74
    acetone 1126.07
    n-butanol 267.15
    acetonitrile 270.31
    DMF 444.03
    toluene 32.74
    isobutanol 204.54
    1,4-dioxane 491.22
    methyl acetate 416.65
    THF 779.79
    2-butanone 435.48
    n-pentanol 142.28
    sec-butanol 195.14
    n-hexane 0.38
    ethylene glycol 71.53
    NMP 162.36
    cyclohexane 1.85
    DMSO 1299.7
    n-butyl acetate 140.76
    n-octanol 35.99
    chloroform 313.05
    n-propyl acetate 186.83
    acetic acid 676.19
    dichloromethane 340.81
    cyclohexanone 382.19
    propylene glycol 191.52
    isopropyl acetate 288.64
    DMAc 439.93
    2-ethoxyethanol 485.7
    isopentanol 173.5
    n-heptane 0.62
    ethyl formate 261.56
    1,2-dichloroethane 273.03
    n-hexanol 90.13
    2-methoxyethanol 1106.49
    isobutyl acetate 112.58
    tetrachloromethane 21.39
    n-pentyl acetate 82.71
    transcutol 866.99
    n-heptanol 42.58
    ethylbenzene 17.78
    MIBK 161.76
    2-propoxyethanol 314.42
    tert-butanol 411.29
    MTBE 196.62
    2-butoxyethanol 146.38
    propionic acid 261.94
    o-xylene 25.19
    formic acid 219.58
    diethyl ether 108.01
    m-xylene 28.83
    p-xylene 25.48
    chlorobenzene 70.77
    dimethyl carbonate 89.39
    n-octane 0.87
    formamide 401.08
    cyclopentanone 498.48
    2-pentanone 359.65
    anisole 77.18
    cyclopentyl methyl ether 135.13
    gamma-butyrolactone 503.33
    1-methoxy-2-propanol 557.62
    pyridine 180.45
    3-pentanone 141.18
    furfural 317.94
    n-dodecane 1.36
    diethylene glycol 286.12
    diisopropyl ether 21.12
    tert-amyl alcohol 206.79
    acetylacetone 500.55
    n-hexadecane 1.53
    acetophenone 95.84
    methyl propionate 303.41
    isopentyl acetate 132.29
    trichloroethylene 438.15
    n-nonanol 34.44
    cyclohexanol 130.19
    benzyl alcohol 102.63
    2-ethylhexanol 36.06
    isooctanol 38.11
    dipropyl ether 23.45
    1,2-dichlorobenzene 68.64
    ethyl lactate 89.74
    propylene carbonate 229.67
    n-methylformamide 359.83
    2-pentanol 96.68
    n-pentane 0.32
    1-propoxy-2-propanol 167.34
    1-methoxy-2-propyl acetate 196.01
    2-(2-methoxypropoxy) propanol 124.54
    mesitylene 17.8
    ε-caprolactone 305.0
    p-cymene 14.82
    epichlorohydrin 619.35
    1,1,1-trichloroethane 160.21
    2-aminoethanol 255.0
    morpholine-4-carbaldehyde 313.25
    sulfolane 448.21
    2,2,4-trimethylpentane 1.86
    2-methyltetrahydrofuran 273.14
    n-hexyl acetate 96.02
    isooctane 1.47
    2-(2-butoxyethoxy)ethanol 209.51
    sec-butyl acetate 115.41
    tert-butyl acetate 239.42
    decalin 2.19
    glycerin 216.59
    diglyme 393.89
    acrylic acid 170.14
    isopropyl myristate 32.41
    n-butyric acid 539.28
    acetyl acetate 258.83
    di(2-ethylhexyl) phthalate 44.05
    ethyl propionate 125.6
    nitromethane 1070.96
    1,2-diethoxyethane 178.83
    benzonitrile 96.79
    trioctyl phosphate 29.93
    1-bromopropane 60.23
    gamma-valerolactone 688.63
    n-decanol 25.61
    triethyl phosphate 41.88
    4-methyl-2-pentanol 55.13
    propionitrile 133.56
    vinylene carbonate 169.17
    1,1,2-trichlorotrifluoroethane 330.69
    DMS 97.55
    cumene 14.88
    2-octanol 27.78
    2-hexanone 136.72
    octyl acetate 44.52
    limonene 19.13
    1,2-dimethoxyethane 473.65
    ethyl orthosilicate 39.86
    tributyl phosphate 37.65
    diacetone alcohol 294.79
    N,N-dimethylaniline 42.61
    acrylonitrile 178.49
    aniline 87.24
    1,3-propanediol 516.92
    bromobenzene 59.85
    dibromomethane 158.68
    1,1,2,2-tetrachloroethane 339.06
    2-methyl-cyclohexyl acetate 68.71
    tetrabutyl urea 47.03
    diisobutyl methanol 24.85
    2-phenylethanol 89.65
    styrene 22.51
    dioctyl adipate 58.84
    dimethyl sulfate 139.94
    ethyl butyrate 85.63
    methyl lactate 138.13
    butyl lactate 87.09
    diethyl carbonate 60.02
    propanediol butyl ether 148.99
    triethyl orthoformate 57.03
    p-tert-butyltoluene 14.96
    methyl 4-tert-butylbenzoate 91.74
    morpholine 652.2
    tert-butylamine 88.37
    n-dodecanol 19.26
    dimethoxymethane 408.02
    ethylene carbonate 167.55
    cyrene 117.52
    2-ethoxyethyl acetate 180.08
    2-ethylhexyl acetate 81.29
    1,2,4-trichlorobenzene 83.87
    4-methylpyridine 156.59
    dibutyl ether 34.75
    2,6-dimethyl-4-heptanol 24.85
    DEF 217.71
    dimethyl isosorbide 194.78
    tetrachloroethylene 183.04
    eugenol 100.43
    triacetin 126.64
    span 80 98.71
    1,4-butanediol 143.28
    1,1-dichloroethane 231.35
    2-methyl-1-pentanol 107.18
    methyl formate 262.4
    2-methyl-1-butanol 132.71
    n-decane 1.99
    butyronitrile 160.25
    3,7-dimethyl-1-octanol 41.61
    1-chlorooctane 15.53
    1-chlorotetradecane 6.32
    n-nonane 1.56
    undecane 1.6
    tert-butylcyclohexane 2.22
    cyclooctane 0.65
    cyclopentanol 141.84
    tetrahydropyran 294.53
    tert-amyl methyl ether 94.13
    2,5,8-trioxanonane 234.72
    1-hexene 4.81
    2-isopropoxyethanol 248.87
    2,2,2-trifluoroethanol 145.83
    methyl butyrate 195.01

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction