Norcorydine

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  • Identifiers

    CAS number
    26931-78-2

    Molecular formula
    C19H21NO4

    SMILES
    COC1=C(C2=C(C[C@H]3C4=C2C(=C(C=C4CCN3)OC)O)C=C1)OC

    Safety labels

  • Odor profile

    Fragrance
    Phenolic 41.97%
    Vanilla 40.54%
    Spicy 37.28%
    Odorless 32.16%
    Smoky 31.41%
    Sweet 30.9%
    Powdery 28.86%
    Balsamic 27.84%
    Burnt 26.67%
    Animal 25.0%

     

    Flavor
    Bitter 93.49%
    Bland 24.23%
    Sweet-like 20.78%
    Cedarleaf 20.11%
    Parsley 19.99%
    Eugenol 18.82%
    Very strong 18.59%
    Indole 18.52%
    Cereal 18.38%
    Lovage 18.31%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    2.6

    pKa est.
    7.35 (neutral)

    Molecular weight
    327.4 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    786°C

    Flash point

    • 218.87 ˚C est.

  • Synonyms

    • Norcorydine
    • (+)-Norcorydine
    • 26931-78-2
    • DTXSID40181428
    • (6aS)-2,10,11-trimethoxy-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinolin-1-ol
    • (6aS)-2,10,11-trimethoxy-5,6,6a,7-tetrahydro-4H-dibenzo(de,g)quinolin-1-ol
    • 1-Hydroxy-2,10,11-trimethoxynoraporphine
    • RefChem:166581
    • DTXCID50103919
    • CHEMBL494053
    • SCHEMBL31504460
    • CHEBI:175183
    • NS00094699
    • 26931-78-2

  • Applications

    Norcorydine, CAS 26931-78-2, is primarily treated as an organic synthesis intermediate and a core scaffold for isoquinoline-derived compounds; it is also used as a precursor for pharmaceutical lead compounds and employed as a reference material in analytical chemistry for related alkaloids; in research and development, it is evaluated as a starting point for medicinal chemistry and alkaloid synthesis studies; depending on local regulations, it may be considered an ingredient for materials science research or related chemical applications.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 4.69
    methanol 5.82
    isopropanol 3.05
    water 0.2
    ethyl acetate 12.05
    n-propanol 4.35
    acetone 8.08
    n-butanol 4.5
    acetonitrile 3.81
    DMF 35.39
    toluene 1.31
    isobutanol 3.54
    1,4-dioxane 8.69
    methyl acetate 8.95
    THF 13.3
    2-butanone 7.18
    n-pentanol 3.77
    sec-butanol 2.23
    n-hexane 0.2
    ethylene glycol 7.12
    NMP 38.0
    cyclohexane 0.45
    DMSO 34.36
    n-butyl acetate 12.66
    n-octanol 3.52
    chloroform 25.53
    n-propyl acetate 10.38
    acetic acid 31.07
    dichloromethane 27.04
    cyclohexanone 18.99
    propylene glycol 2.42
    isopropyl acetate 9.27
    DMAc 42.94
    2-ethoxyethanol 15.66
    isopentanol 5.14
    n-heptane 0.39
    ethyl formate 12.74
    1,2-dichloroethane 18.0
    n-hexanol 6.09
    2-methoxyethanol 22.86
    isobutyl acetate 7.61
    tetrachloromethane 6.1
    n-pentyl acetate 12.34
    transcutol 29.68
    n-heptanol 5.98
    ethylbenzene 1.55
    MIBK 7.39
    2-propoxyethanol 24.07
    tert-butanol 4.16
    MTBE 2.51
    2-butoxyethanol 19.09
    propionic acid 11.57
    o-xylene 2.15
    formic acid 23.25
    diethyl ether 3.95
    m-xylene 1.95
    p-xylene 2.06
    chlorobenzene 5.42
    dimethyl carbonate 18.8
    n-octane 0.31
    formamide 31.64
    cyclopentanone 19.74
    2-pentanone 8.13
    anisole 4.14
    cyclopentyl methyl ether 6.3
    gamma-butyrolactone 32.29
    1-methoxy-2-propanol 15.23
    pyridine 9.27
    3-pentanone 7.25
    furfural 40.88
    n-dodecane 0.32
    diethylene glycol 32.94
    diisopropyl ether 1.89
    tert-amyl alcohol 3.49
    acetylacetone 15.36
    n-hexadecane 0.38
    acetophenone 10.93
    methyl propionate 13.35
    isopentyl acetate 12.56
    trichloroethylene 36.29
    n-nonanol 4.27
    cyclohexanol 5.24
    benzyl alcohol 7.76
    2-ethylhexanol 5.24
    isooctanol 5.46
    dipropyl ether 4.66
    1,2-dichlorobenzene 9.46
    ethyl lactate 12.2
    propylene carbonate 24.87
    n-methylformamide 19.62
    2-pentanol 2.75
    n-pentane 0.25
    1-propoxy-2-propanol 13.56
    1-methoxy-2-propyl acetate 20.64
    2-(2-methoxypropoxy) propanol 15.54
    mesitylene 1.75
    ε-caprolactone 22.32
    p-cymene 3.77
    epichlorohydrin 28.65
    1,1,1-trichloroethane 10.72
    2-aminoethanol 6.31
    morpholine-4-carbaldehyde 45.65
    sulfolane 50.61
    2,2,4-trimethylpentane 0.29
    2-methyltetrahydrofuran 6.09
    n-hexyl acetate 10.27
    isooctane 0.22
    2-(2-butoxyethoxy)ethanol 18.21
    sec-butyl acetate 7.16
    tert-butyl acetate 9.47
    decalin 0.5
    glycerin 13.35
    diglyme 35.07
    acrylic acid 18.74
    isopropyl myristate 4.97
    n-butyric acid 16.4
    acetyl acetate 16.26
    di(2-ethylhexyl) phthalate 8.77
    ethyl propionate 9.55
    nitromethane 42.05
    1,2-diethoxyethane 10.31
    benzonitrile 8.5
    trioctyl phosphate 6.81
    1-bromopropane 4.57
    gamma-valerolactone 39.06
    n-decanol 3.27
    triethyl phosphate 10.86
    4-methyl-2-pentanol 2.85
    propionitrile 4.91
    vinylene carbonate 31.05
    1,1,2-trichlorotrifluoroethane 56.52
    DMS 17.67
    cumene 1.94
    2-octanol 3.21
    2-hexanone 6.88
    octyl acetate 6.57
    limonene 4.62
    1,2-dimethoxyethane 19.2
    ethyl orthosilicate 9.42
    tributyl phosphate 7.84
    diacetone alcohol 14.16
    N,N-dimethylaniline 5.29
    acrylonitrile 9.49
    aniline 4.72
    1,3-propanediol 10.63
    bromobenzene 4.64
    dibromomethane 12.88
    1,1,2,2-tetrachloroethane 29.66
    2-methyl-cyclohexyl acetate 11.83
    tetrabutyl urea 10.2
    diisobutyl methanol 3.73
    2-phenylethanol 11.37
    styrene 1.71
    dioctyl adipate 9.13
    dimethyl sulfate 36.63
    ethyl butyrate 10.69
    methyl lactate 18.44
    butyl lactate 12.84
    diethyl carbonate 10.73
    propanediol butyl ether 10.57
    triethyl orthoformate 10.21
    p-tert-butyltoluene 3.4
    methyl 4-tert-butylbenzoate 16.63
    morpholine 11.19
    tert-butylamine 2.04
    n-dodecanol 2.55
    dimethoxymethane 24.33
    ethylene carbonate 24.91
    cyrene 25.08
    2-ethoxyethyl acetate 20.97
    2-ethylhexyl acetate 10.73
    1,2,4-trichlorobenzene 11.92
    4-methylpyridine 7.13
    dibutyl ether 3.54
    2,6-dimethyl-4-heptanol 3.73
    DEF 18.5
    dimethyl isosorbide 29.19
    tetrachloroethylene 29.02
    eugenol 17.83
    triacetin 17.18
    span 80 12.1
    1,4-butanediol 5.43
    1,1-dichloroethane 7.55
    2-methyl-1-pentanol 4.39
    methyl formate 19.51
    2-methyl-1-butanol 4.1
    n-decane 0.49
    butyronitrile 4.71
    3,7-dimethyl-1-octanol 4.11
    1-chlorooctane 2.33
    1-chlorotetradecane 1.19
    n-nonane 0.36
    undecane 0.39
    tert-butylcyclohexane 0.38
    cyclooctane 0.26
    cyclopentanol 4.93
    tetrahydropyran 5.0
    tert-amyl methyl ether 2.97
    2,5,8-trioxanonane 26.63
    1-hexene 0.82
    2-isopropoxyethanol 11.51
    2,2,2-trifluoroethanol 29.76
    methyl butyrate 12.03

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction