Norcapsaicin

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  • Identifiers

    CAS number
    61229-08-1

    Molecular formula
    C17H25NO3

    SMILES
    CC(C)/C=C/CCCC(=O)NCC1=CC(=C(C=C1)O)OC

    Safety labels

  • Odor profile

    Fragrance
    Spicy 41.46%
    Herbal 41.37%
    Savory 38.52%
    Cooling 37.09%
    Meaty 35.7%
    Odorless 32.97%
    Mint 31.23%
    Roasted 23.61%
    Warm 22.91%
    Animal 21.61%

     

    Flavor
    Herbal 53.22%
    Mild 29.88%
    Odorless 29.71%
    Spicy 28.17%
    Warm 26.25%
    Bland 25.17%
    Woody 24.38%
    Spice 20.23%
    Creosote 19.9%
    Lovage 19.89%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    3.0

    pKa est.
    10.12 (weak base)

    Molecular weight
    291.4 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    431°C

    Melting point expt.

    • 42.5 - 44 °C

    Flash point

    • 183.67 ˚C est.

  • Synonyms

    • norcapsaicin
    • 61229-08-1
    • (E)-N-(4-Hydroxy-3-methoxybenzyl)-7-methyloct-5-enamide
    • (E)-N-[(4-hydroxy-3-methoxyphenyl)methyl]-7-methyloct-5-enamide
    • (5E)-N-[(4-HYDROXY-3-METHOXYPHENYL)METHYL]-7-METHYLOCT-5-ENAMIDE
    • SCHEMBL8163896
    • SCHEMBL29371033
    • CHEBI:174089
    • 7-Methyl-N-vanillyl-5-octenamide
    • DTXSID901317984
    • (E)-N-[(4-hydroxy-3-methoxy-phenyl)methyl]-7-methyl-oct-5-enamide
    • N-[(4-Hydroxy-3-methoxyphenyl)methyl]-7-methyl-5-octenamide, 9CI
    • 5-Octenamide, N-((4-hydroxy-3-methoxyphenyl)methyl)-7-methyl-, (E)-
    • 61229-08-1

  • Applications

    Norcapsaicin (CAS 61229-08-1) is a capsaicinoid derived from pepper extracts and is primarily used in research and development related to pungency and flavor components. In industry, it serves as an analytical reference material (HPLC/GC) for quantifying capsaicinoids in pepper extracts and spice products; it is also used to evaluate sensory pungency and model flavor profiles in product development. In cosmetics and personal care, it is studied for dermal irritation potential and warming sensation effects at permitted concentrations to support formulation research. In pharmaceutical research, it may be used in formulation studies and dermal safety assessments at limited levels, but not claimed as a therapeutic. It also functions as an intermediate or reference compound in the synthesis and development of capsaicinoid analogs and related analytical systems. All applications are subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 372.98
    methanol 477.68
    isopropanol 204.1
    water 0.13
    ethyl acetate 256.56
    n-propanol 181.25
    acetone 412.68
    n-butanol 120.85
    acetonitrile 95.99
    DMF 192.97
    toluene 27.8
    isobutanol 90.73
    1,4-dioxane 263.46
    methyl acetate 160.51
    THF 492.86
    2-butanone 187.55
    n-pentanol 83.28
    sec-butanol 118.85
    n-hexane 0.77
    ethylene glycol 30.74
    NMP 98.6
    cyclohexane 2.21
    DMSO 676.3
    n-butyl acetate 62.82
    n-octanol 27.04
    chloroform 194.12
    n-propyl acetate 81.45
    acetic acid 255.33
    dichloromethane 193.28
    cyclohexanone 174.53
    propylene glycol 107.04
    isopropyl acetate 105.24
    DMAc 303.43
    2-ethoxyethanol 225.49
    isopentanol 86.72
    n-heptane 0.97
    ethyl formate 84.94
    1,2-dichloroethane 142.19
    n-hexanol 56.5
    2-methoxyethanol 388.64
    isobutyl acetate 55.69
    tetrachloromethane 14.01
    n-pentyl acetate 45.04
    transcutol 471.76
    n-heptanol 31.29
    ethylbenzene 16.21
    MIBK 79.71
    2-propoxyethanol 158.67
    tert-butanol 220.87
    MTBE 114.39
    2-butoxyethanol 86.78
    propionic acid 112.17
    o-xylene 20.77
    formic acid 74.99
    diethyl ether 73.47
    m-xylene 22.48
    p-xylene 21.02
    chlorobenzene 42.63
    dimethyl carbonate 52.88
    n-octane 1.17
    formamide 126.01
    cyclopentanone 232.78
    2-pentanone 148.27
    anisole 54.71
    cyclopentyl methyl ether 87.92
    gamma-butyrolactone 217.8
    1-methoxy-2-propanol 256.19
    pyridine 100.23
    3-pentanone 81.11
    furfural 153.64
    n-dodecane 1.66
    diethylene glycol 150.25
    diisopropyl ether 16.77
    tert-amyl alcohol 129.2
    acetylacetone 191.42
    n-hexadecane 1.82
    acetophenone 62.87
    methyl propionate 125.4
    isopentyl acetate 65.23
    trichloroethylene 221.99
    n-nonanol 26.79
    cyclohexanol 76.25
    benzyl alcohol 66.13
    2-ethylhexanol 27.66
    isooctanol 27.69
    dipropyl ether 21.22
    1,2-dichlorobenzene 42.33
    ethyl lactate 52.79
    propylene carbonate 102.52
    n-methylformamide 105.23
    2-pentanol 64.36
    n-pentane 0.61
    1-propoxy-2-propanol 97.69
    1-methoxy-2-propyl acetate 99.23
    2-(2-methoxypropoxy) propanol 86.67
    mesitylene 13.99
    ε-caprolactone 133.27
    p-cymene 12.27
    epichlorohydrin 276.08
    1,1,1-trichloroethane 89.15
    2-aminoethanol 96.43
    morpholine-4-carbaldehyde 162.77
    sulfolane 246.3
    2,2,4-trimethylpentane 2.38
    2-methyltetrahydrofuran 168.82
    n-hexyl acetate 56.89
    isooctane 1.69
    2-(2-butoxyethoxy)ethanol 124.66
    sec-butyl acetate 55.84
    tert-butyl acetate 106.61
    decalin 2.74
    glycerin 112.31
    diglyme 220.23
    acrylic acid 81.51
    isopropyl myristate 24.32
    n-butyric acid 176.71
    acetyl acetate 100.07
    di(2-ethylhexyl) phthalate 32.38
    ethyl propionate 60.55
    nitromethane 351.92
    1,2-diethoxyethane 104.75
    benzonitrile 54.44
    trioctyl phosphate 22.6
    1-bromopropane 44.01
    gamma-valerolactone 270.22
    n-decanol 20.64
    triethyl phosphate 30.09
    4-methyl-2-pentanol 37.37
    propionitrile 63.07
    vinylene carbonate 81.59
    1,1,2-trichlorotrifluoroethane 170.24
    DMS 60.52
    cumene 13.45
    2-octanol 20.53
    2-hexanone 73.41
    octyl acetate 31.77
    limonene 16.82
    1,2-dimethoxyethane 215.43
    ethyl orthosilicate 29.9
    tributyl phosphate 26.97
    diacetone alcohol 141.82
    N,N-dimethylaniline 37.22
    acrylonitrile 77.41
    aniline 56.82
    1,3-propanediol 176.72
    bromobenzene 38.32
    dibromomethane 107.33
    1,1,2,2-tetrachloroethane 187.51
    2-methyl-cyclohexyl acetate 45.34
    tetrabutyl urea 35.83
    diisobutyl methanol 19.87
    2-phenylethanol 57.39
    styrene 19.12
    dioctyl adipate 42.16
    dimethyl sulfate 88.36
    ethyl butyrate 46.82
    methyl lactate 77.06
    butyl lactate 52.21
    diethyl carbonate 36.52
    propanediol butyl ether 90.96
    triethyl orthoformate 38.65
    p-tert-butyltoluene 12.5
    methyl 4-tert-butylbenzoate 63.12
    morpholine 309.53
    tert-butylamine 60.32
    n-dodecanol 15.97
    dimethoxymethane 221.06
    ethylene carbonate 74.94
    cyrene 86.79
    2-ethoxyethyl acetate 91.16
    2-ethylhexyl acetate 43.05
    1,2,4-trichlorobenzene 53.96
    4-methylpyridine 85.98
    dibutyl ether 26.16
    2,6-dimethyl-4-heptanol 19.87
    DEF 98.86
    dimethyl isosorbide 128.85
    tetrachloroethylene 101.42
    eugenol 68.09
    triacetin 81.3
    span 80 67.99
    1,4-butanediol 71.28
    1,1-dichloroethane 121.43
    2-methyl-1-pentanol 68.15
    methyl formate 91.92
    2-methyl-1-butanol 72.71
    n-decane 2.45
    butyronitrile 72.67
    3,7-dimethyl-1-octanol 29.75
    1-chlorooctane 13.71
    1-chlorotetradecane 6.1
    n-nonane 1.91
    undecane 1.97
    tert-butylcyclohexane 2.76
    cyclooctane 0.88
    cyclopentanol 81.27
    tetrahydropyran 173.69
    tert-amyl methyl ether 65.71
    2,5,8-trioxanonane 153.64
    1-hexene 6.5
    2-isopropoxyethanol 132.98
    2,2,2-trifluoroethanol 58.93
    methyl butyrate 82.46

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction