N,N,N',N'-Tetramethylethylenediamine

Overview IFRA Request a quote

  • Identifiers

    CAS number
    110-18-9

    Molecular formula
    C6H16N2

    SMILES
    CN(C)CCN(C)C

    Safety labels

    Flammable
    Flammable

    Corrosive
    Corrosive

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Fishy 75.46%
    Cheesy 59.77%
    Ripe 53.29%
    Odorless 27.58%
    Oily 25.44%
    Sweet 20.66%
    Animal 20.58%
    Pungent 19.62%
    Alcoholic 18.14%
    Cooling 17.72%

     

    Flavor
    Fishy 26.62%
    Fruity 24.71%
    Mild 23.63%
    Green 22.84%
    Sulfurous 22.13%
    Yeasty 20.86%
    Bloody 20.62%
    Glue 20.25%
    Sulfury 20.23%
    Skunky 19.7%

     

    Odor impact est.
    Medium

    Odor threshold

    • Odor Threshold Low: 0.1 [mmHg]. Odor threshold (unspecified) from CHEMINFO

  • Properties

    XLogP3-AA
    0.3

    pKa est.
    7.68 (neutral)

    Molecular weight
    116.2 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra fast

    Melting point expt.

    • -67.2 °F (NTP, 1992)
    • FP: -55 °C

    Boiling point

    • 250 to 252 °F at 760 mmHg (NTP, 1992)
    • 121 °C

    Flash point

    • 28.32 ˚C est.
    • 50 °F (NTP, 1992)

    Solubility expt.

    • Soluble (NTP, 1992)
    • Sol in water and most organic solvents

  • Synonyms

    • N,N,N',N'-Tetramethylethylenediamine
    • 110-18-9
    • Temed
    • TMEDA
    • Tetramethylethylenediamine
    • N,N,N',N'-tetramethylethane-1,2-diamine
    • 1,2-Bis(dimethylamino)ethane
    • Tetramethyldiaminoethane
    • Tetrameen
    • Propamine D
    • 1,2-Ethanediamine, N,N,N',N'-tetramethyl-
    • N1,N1,N2,N2-Tetramethylethane-1,2-diamine
    • Tetramethyl ethylene diamine
    • N,N,N',N'-TETRAMETHYL-1,2-ETHANEDIAMINE
    • [2-(dimethylamino)ethyl]dimethylamine
    • MFCD00008335
    • tmen
    • 1,2-Bis-(dimethylamino)ethane
    • Ethylenediamine, N,N,N',N'-tetramethyl-
    • N,N,N',N'-Tetramethylethanediamine
    • N,N,N',N'-Tetramethyl-1,2-diaminoethane
    • N,N,N',N'-tetramethylethylendiamine
    • Dimethyl(2-(dimethylamino)ethyl)amine
    • 1,2-Di-(dimethylamino)ethane
    • N,N,N',N'-tetramethyl-ethane-1,2-diamine
    • DTXSID5026122
    • CHEBI:32850
    • K90JUB7941
    • Dimethyl[2-(dimethylamino)ethyl]amine
    • 1,2-Ethanediamine, N1,N1,N2,N2-tetramethyl-
    • CCRIS 4870
    • HSDB 5396
    • N,N,N,N-Tetramethylethylenediamine
    • EINECS 203-744-6
    • UN2372
    • UNII-K90JUB7941
    • AI3-26631
    • 9U3
    • pentafluorophenylglycine
    • N,N,N',N'-tetramethyl ethylene diamine
    • tetramethylethlenediamine
    • Tetramethylethyenediamine
    • tetramethylethylendiamine
    • tetramethyl ethylenediamine
    • tetramethyl-ethylenediamine
    • tetramethylethylene diamine
    • tetramethylethylene-diamine
    • TEMED [MI]
    • N,N,N',N'-TETRAMETHYL-ETHYLENEDIAMINE
    • N,N,N
    • SCHEMBL15334
    • 1,2-di(dimethylamino) ethane
    • N,N'-tetramethylethylenediamine
    • 1,2-bis(dimethyl-amino)ethane
    • DTXCID206122
    • ethane, 1,2-bisdimethylamino-
    • CHEMBL3181913
    • N,N,N',N'-Tetramethylenediamine
    • HMS1787N22
    • BCP25463
    • ethane, 1,2-bis-(dimethylamino)-
    • n,n,n'n'-tetramethylethylenediamine
    • n,n,n,n,-tetramethylethylenediamine
    • n,n,n,n-tetramethylethylene diamine
    • (CH3)2NCH2CH2N(CH3)2
    • N,N,N',N'-Tetramethylethenediamine
    • N,N,N',N'tetramethylethylenediamine
    • Tox21_200241
    • BBL011565
    • N,N,N',N'-tetramethylethlenediamine
    • N,N,N',N'-tetramethyletylenediamine
    • n,n,n,n -tetramethylethylene diamine
    • STL146736
    • N,N,N',N' tetramethylethylenediamine
    • N,N,N',N'-tetramethyl-ethylendiamin
    • N,N,N`,N`-Tetramethylethylenediamine
    • N,N,N1,N1-Tetramethylethylenediamine
    • AKOS000119849
    • n,n,n',n',-tetramethylethylenediamine
    • n,n,n',n'- tetramethylethylenediamine
    • n,n,n',n'-tetra-methylethylenediamine
    • N,N,N',N'-tetramethyl ethylendiamine
    • N,N,N',N'-tetramethyl-ethylendiamine
    • FT00547
    • N,N, N',N'-tetramethylethylenediamine
    • N,N,N', N'-Tetramethylethylenediamine
    • N,N,N',N'-Tetramethyl ethylenediamine
    • N,N,N',N'-Tetramethylethylene diamine
    • N,N,N',N'-tetramethylethylene-diamine
    • UN 2372
    • n,n,n',n'-tetramethyl-ethylene diamine
    • N, N, N',N'-tetramethylethylenediamine
    • N,N, N', N'-tetramethylethylenediamine
    • N,N,N', N'-tetramethyl-ethylenediamine
    • N,N,N', N'-tetramethylethylene diamine
    • N,N,N',N'-tetra methyl ethylenediamine
    • NCGC00248573-01
    • NCGC00257795-01
    • BP-30082
    • CAS-110-18-9
    • N, N, N', N'-tetramethylethylenediamine
    • N,N,N',N'-tetra methyl ethylene diamine
    • N,N,N',N'-tetramethyletane-1,2-diamine
    • VS-02982
    • N,N,N',N' tetramethyl-1,2-ethanediamine
    • N,N,N2,N2-tetramethylethane-1,2-diamine
    • N, N, N', N'-Tetra-methylethylenediamine
    • N, N, N', N'-Tetramethylethylene diamine
    • N,N,N',N'-tetramethyl-1,2-ethylenediamine
    • N,N,N',N'-Tetramethylethylenediamine, 99%
    • NS00019866
    • T0147
    • T2515
    • 1,2-Diaminoethane, N,N,N',N'-tetramethyl-
    • EN300-16690
    • D97674
    • N1, N1,N2,N2-tetramethylethane-1,2-diamine
    • TETRAMETHYLETHYLENEDIAMINE, N,N,N',N'-
    • A802159
    • N,N,N',N'-Tetramethylethylenediamine, >=99.0%
    • N,N,N',N'-Tetramethylethylenediamine, redistilled
    • doi:10.14272/KWYHDKDOAIKMQN-UHFFFAOYSA-N.1
    • Z56755629
    • F0001-0217
    • N,N,N',N'-TETRAMETHYL-1,2-ETHANEDIAMINE [HSDB]
    • N~1~,N~1~,N~2~,N~2~-tetramethylethane-1,2-diamine
    • N,N,N',N'-Tetramethylethylenediamine, Electrophoresis Grade
    • 1,2-Di-(dimethylamino)ethane [UN2372] [Flammable liquid]

  • Applications

    N,N,N',N'-Tetramethylethylenediamine (TMEDA; CAS 110-18-9) is widely used in chemical synthesis as a coordinating solvent and ligand for organomagnesium and organolithium reagents, stabilizing reactive species and enhancing rate and selectivity in Grignard and related transformations. It serves as a chelating/ligand for transition-metal catalysts used in polymerization and cross-coupling reactions, influencing catalyst performance and polymer architecture. In coatings and adhesives, TMEDA is employed as a catalyst/accelerator for epoxy resin curing, helping to accelerate cure and tune network properties. It also functions as an intermediate and building block in the manufacture of specialty chemicals and pharmaceutical precursors.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 26.42
    methanol 50.43
    isopropanol 14.7
    water 25.17
    ethyl acetate 10.36
    n-propanol 25.94
    acetone 7.21
    n-butanol 15.61
    acetonitrile 10.51
    DMF 23.7
    toluene 2.59
    isobutanol 16.91
    1,4-dioxane 18.14
    methyl acetate 18.11
    THF 21.06
    2-butanone 10.92
    n-pentanol 7.03
    sec-butanol 17.96
    n-hexane 1.48
    ethylene glycol 53.18
    NMP 63.67
    cyclohexane 4.02
    DMSO 18.64
    n-butyl acetate 14.34
    n-octanol 9.26
    chloroform 73.07
    n-propyl acetate 6.86
    acetic acid 97.28
    dichloromethane 36.77
    cyclohexanone 19.6
    propylene glycol 55.08
    isopropyl acetate 4.85
    DMAc 33.66
    2-ethoxyethanol 17.79
    isopentanol 7.68
    n-heptane 4.65
    ethyl formate 16.94
    1,2-dichloroethane 13.34
    n-hexanol 20.98
    2-methoxyethanol 43.4
    isobutyl acetate 5.09
    tetrachloromethane 27.41
    n-pentyl acetate 8.39
    transcutol 33.53
    n-heptanol 14.2
    ethylbenzene 2.08
    MIBK 2.64
    2-propoxyethanol 35.88
    tert-butanol 14.5
    MTBE 5.16
    2-butoxyethanol 25.49
    propionic acid 73.74
    o-xylene 4.13
    formic acid 84.75
    diethyl ether 3.93
    m-xylene 2.23
    p-xylene 3.41
    chlorobenzene 8.66
    dimethyl carbonate 8.2
    n-octane 1.76
    formamide 43.04
    cyclopentanone 26.9
    2-pentanone 4.59
    anisole 4.65
    cyclopentyl methyl ether 10.46
    gamma-butyrolactone 50.49
    1-methoxy-2-propanol 26.08
    pyridine 17.75
    3-pentanone 6.78
    furfural 60.4
    n-dodecane 1.38
    diethylene glycol 45.15
    diisopropyl ether 1.44
    tert-amyl alcohol 18.86
    acetylacetone 6.85
    n-hexadecane 1.42
    acetophenone 8.3
    methyl propionate 14.65
    isopentyl acetate 11.92
    trichloroethylene 42.65
    n-nonanol 8.78
    cyclohexanol 19.92
    benzyl alcohol 9.82
    2-ethylhexanol 14.54
    isooctanol 10.17
    dipropyl ether 7.98
    1,2-dichlorobenzene 13.95
    ethyl lactate 15.48
    propylene carbonate 35.69
    n-methylformamide 32.01
    2-pentanol 7.89
    n-pentane 1.66
    1-propoxy-2-propanol 29.42
    1-methoxy-2-propyl acetate 16.82
    2-(2-methoxypropoxy) propanol 24.79
    mesitylene 1.79
    ε-caprolactone 28.4
    p-cymene 6.53
    epichlorohydrin 25.01
    1,1,1-trichloroethane 20.88
    2-aminoethanol 58.17
    morpholine-4-carbaldehyde 44.46
    sulfolane 69.17
    2,2,4-trimethylpentane 2.1
    2-methyltetrahydrofuran 17.25
    n-hexyl acetate 12.01
    isooctane 0.71
    2-(2-butoxyethoxy)ethanol 24.83
    sec-butyl acetate 4.29
    tert-butyl acetate 5.2
    decalin 2.03
    glycerin 94.08
    diglyme 30.09
    acrylic acid 90.19
    isopropyl myristate 5.26
    n-butyric acid 39.77
    acetyl acetate 11.25
    di(2-ethylhexyl) phthalate 12.6
    ethyl propionate 7.47
    nitromethane 54.67
    1,2-diethoxyethane 5.81
    benzonitrile 10.92
    trioctyl phosphate 9.52
    1-bromopropane 6.77
    gamma-valerolactone 38.91
    n-decanol 7.23
    triethyl phosphate 13.78
    4-methyl-2-pentanol 3.87
    propionitrile 12.94
    vinylene carbonate 37.58
    1,1,2-trichlorotrifluoroethane 98.56
    DMS 15.87
    cumene 2.65
    2-octanol 6.97
    2-hexanone 3.88
    octyl acetate 8.7
    limonene 9.54
    1,2-dimethoxyethane 11.97
    ethyl orthosilicate 11.73
    tributyl phosphate 10.76
    diacetone alcohol 12.32
    N,N-dimethylaniline 5.36
    acrylonitrile 20.8
    aniline 12.51
    1,3-propanediol 36.93
    bromobenzene 6.7
    dibromomethane 22.65
    1,1,2,2-tetrachloroethane 45.61
    2-methyl-cyclohexyl acetate 15.56
    tetrabutyl urea 11.61
    diisobutyl methanol 6.78
    2-phenylethanol 16.6
    styrene 2.27
    dioctyl adipate 10.38
    dimethyl sulfate 19.51
    ethyl butyrate 11.46
    methyl lactate 26.94
    butyl lactate 19.81
    diethyl carbonate 10.99
    propanediol butyl ether 26.87
    triethyl orthoformate 12.87
    p-tert-butyltoluene 7.06
    methyl 4-tert-butylbenzoate 18.68
    morpholine 24.85
    tert-butylamine 9.48
    n-dodecanol 6.04
    dimethoxymethane 8.9
    ethylene carbonate 25.64
    cyrene 29.63
    2-ethoxyethyl acetate 11.64
    2-ethylhexyl acetate 11.76
    1,2,4-trichlorobenzene 22.72
    4-methylpyridine 10.42
    dibutyl ether 4.34
    2,6-dimethyl-4-heptanol 6.78
    DEF 11.49
    dimethyl isosorbide 37.52
    tetrachloroethylene 48.87
    eugenol 22.96
    triacetin 21.99
    span 80 32.57
    1,4-butanediol 15.35
    1,1-dichloroethane 14.39
    2-methyl-1-pentanol 5.3
    methyl formate 24.56
    2-methyl-1-butanol 12.53
    n-decane 1.96
    butyronitrile 7.91
    3,7-dimethyl-1-octanol 8.27
    1-chlorooctane 5.02
    1-chlorotetradecane 2.82
    n-nonane 1.92
    undecane 1.59
    tert-butylcyclohexane 2.18
    cyclooctane 1.43
    cyclopentanol 33.26
    tetrahydropyran 12.81
    tert-amyl methyl ether 6.46
    2,5,8-trioxanonane 27.19
    1-hexene 2.57
    2-isopropoxyethanol 10.99
    2,2,2-trifluoroethanol 75.02
    methyl butyrate 9.37

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction