N,N-Dimethylacrylamide

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  • Identifiers

    CAS number
    2680-03-7

    Molecular formula
    C5H9NO

    SMILES
    CN(C)C(=O)C=C

    Safety labels

    Corrosive
    Corrosive

    Acute Toxic
    Acute Toxic

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Pungent 39.84%
    Cheesy 27.0%
    Burnt 24.42%
    Roasted 23.54%
    Odorless 23.49%
    Cooked 21.36%
    Fruity 21.14%
    Sharp 21.12%
    Radish 20.92%
    Sulfurous 20.41%

     

    Flavor
    Fruity 34.67%
    Nutty 29.75%
    Cooked 26.08%
    Pungent 22.56%
    Roasted 21.87%
    Hazelnut 21.41%
    Matches 21.36%
    Taco 20.75%
    Filbert 20.43%
    Roasted peanuts 20.22%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    0.3

    pKa est.
    6.33 (neutral)

    Molecular weight
    99.13 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Fast

    Boiling point est.
    184°C

    Flash point

    • 46.97 ˚C est.

  • Synonyms

    • N,N-Dimethylacrylamide
    • 2680-03-7
    • 2-Propenamide, N,N-dimethyl-
    • ACRYLAMIDE, N,N-DIMETHYL-
    • Dimethylamid kyseliny akrylove
    • AS46JK7Q6I
    • DTXSID0051944
    • NSC-32613
    • NSC-35191
    • DTXCID3030507
    • RefChem:7875
    • DMAA-N,N
    • 220-237-5
    • N,N-dimethylprop-2-enamide
    • Acylamide, N,N-dimethyl
    • N,N-dimethyl-acrylamide
    • N,N-Dimethyl-2-propenamide
    • MFCD00008626
    • N,N-dimethyl acrylamide
    • N,N-Dimethylacrylamide (stabilized with MEHQ)
    • Acylamide,N-dimethyl
    • Acrylamide,N-dimethyl-
    • DMAA; DMAC; N,N-Dimethyl-2-propenamide
    • 2-Propenamide,N-dimethyl-
    • Propenamide, N,N-dimethyl-
    • dimethylaminoacrolein
    • EINECS 220-237-5
    • NSC 32613
    • NSC 35191
    • Dimethylamid kyseliny akrylove [Czech]
    • BRN 1742219
    • N, N-Dimethylacrylamide
    • n,n-dimethylaminoacrolein
    • AI3-15677
    • UNII-AS46JK7Q6I
    • SCHEMBL15015
    • SCHEMBL294140
    • SCHEMBL3939494
    • DIMETHYLACRYLAMIDE, N,N-
    • SCHEMBL13240596
    • YLGYACDQVQQZSW-UHFFFAOYSA-
    • N,N-Dimethylacrylamide,min. 98%
    • NSC32613
    • NSC35191
    • Tox21_303732
    • MSK001875
    • SBB008330
    • AKOS009157019
    • NCGC00357041-01
    • CAS-2680-03-7
    • CS-0016062
    • D1091
    • NS00004520
    • D70136
    • D78231
    • EC 220-237-5
    • EN300-189106
    • N,N-Dimethylacrylamide, (stabilized with MEHQ)
    • F046781
    • Q15632705
    • InChI=1/C5H9NO/c1-4-5(7)6(2)3/h4H,1H2,2-3H3
    • N,N-Dimethylacrylamide (contains 500 ppm monomethyl ether hydroquinone as inhibitor)
    • N,N-Dimethylacrylamide contains 500 ppm monomethyl ether hydroquinone as inhibitor
    • N,N-Dimethylacrylamide, 99%, contains 500 ppm monomethyl ether hydroquinone as inhibitor
    • 2680-03-7

  • Applications

    N,N-Dimethylacrylamide (CAS 2680-03-7) is primarily used as a monomer to synthesize hydrophilic polymers and hydrogel networks, supporting biomedical and healthcare-relevant material research such as biosensors, tissue engineering scaffolds, and controlled drug-delivery systems. It is commonly copolymerized with other vinyl monomers to tailor coating, adhesive, and paint formulations by adjusting hydrophilicity, swelling, and mechanical properties. In the plastics and coatings sector, DMA serves as a building block for customized, water-compatible polymer systems. It also acts as a precursor or intermediate for the synthesis of specialty monomers used in advanced polymeric materials for electronics, sensors, and related applications, depending on formulation design.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 388.72
    methanol 667.47
    isopropanol 217.58
    water 58.77
    ethyl acetate 105.5
    n-propanol 260.75
    acetone 133.39
    n-butanol 232.83
    acetonitrile 207.54
    DMF 174.39
    toluene 61.25
    isobutanol 191.04
    1,4-dioxane 175.06
    methyl acetate 137.65
    THF 226.43
    2-butanone 154.28
    n-pentanol 162.68
    sec-butanol 214.04
    n-hexane 32.36
    ethylene glycol 111.43
    NMP 225.69
    cyclohexane 33.49
    DMSO 152.68
    n-butyl acetate 84.88
    n-octanol 55.26
    chloroform 411.54
    n-propyl acetate 70.3
    acetic acid 409.61
    dichloromethane 371.09
    cyclohexanone 167.24
    propylene glycol 90.6
    isopropyl acetate 57.46
    DMAc 200.52
    2-ethoxyethanol 201.32
    isopentanol 169.6
    n-heptane 20.75
    ethyl formate 132.76
    1,2-dichloroethane 171.08
    n-hexanol 123.53
    2-methoxyethanol 294.78
    isobutyl acetate 44.93
    tetrachloromethane 155.01
    n-pentyl acetate 62.43
    transcutol 241.35
    n-heptanol 67.45
    ethylbenzene 41.18
    MIBK 61.1
    2-propoxyethanol 159.65
    tert-butanol 234.7
    MTBE 150.83
    2-butoxyethanol 105.28
    propionic acid 205.4
    o-xylene 58.78
    formic acid 365.82
    diethyl ether 146.99
    m-xylene 43.69
    p-xylene 65.57
    chlorobenzene 101.53
    dimethyl carbonate 32.61
    n-octane 9.13
    formamide 285.98
    cyclopentanone 180.86
    2-pentanone 101.31
    anisole 79.59
    cyclopentyl methyl ether 112.48
    gamma-butyrolactone 197.47
    1-methoxy-2-propanol 144.19
    pyridine 184.29
    3-pentanone 87.74
    furfural 230.05
    n-dodecane 6.2
    diethylene glycol 129.37
    diisopropyl ether 37.81
    tert-amyl alcohol 227.16
    acetylacetone 75.65
    n-hexadecane 6.63
    acetophenone 79.2
    methyl propionate 83.77
    isopentyl acetate 81.18
    trichloroethylene 343.75
    n-nonanol 50.56
    cyclohexanol 144.09
    benzyl alcohol 90.89
    2-ethylhexanol 72.47
    isooctanol 53.75
    dipropyl ether 66.23
    1,2-dichlorobenzene 102.78
    ethyl lactate 43.58
    propylene carbonate 113.51
    n-methylformamide 180.33
    2-pentanol 131.67
    n-pentane 37.31
    1-propoxy-2-propanol 97.37
    1-methoxy-2-propyl acetate 66.65
    2-(2-methoxypropoxy) propanol 83.71
    mesitylene 30.45
    ε-caprolactone 153.78
    p-cymene 38.62
    epichlorohydrin 214.88
    1,1,1-trichloroethane 218.97
    2-aminoethanol 192.41
    morpholine-4-carbaldehyde 181.62
    sulfolane 194.07
    2,2,4-trimethylpentane 25.26
    2-methyltetrahydrofuran 212.57
    n-hexyl acetate 77.36
    isooctane 12.36
    2-(2-butoxyethoxy)ethanol 101.46
    sec-butyl acetate 48.17
    tert-butyl acetate 68.02
    decalin 18.04
    glycerin 115.63
    diglyme 166.1
    acrylic acid 188.29
    isopropyl myristate 30.9
    n-butyric acid 213.73
    acetyl acetate 67.44
    di(2-ethylhexyl) phthalate 44.25
    ethyl propionate 58.34
    nitromethane 292.89
    1,2-diethoxyethane 96.63
    benzonitrile 111.82
    trioctyl phosphate 28.98
    1-bromopropane 135.87
    gamma-valerolactone 208.88
    n-decanol 36.65
    triethyl phosphate 43.53
    4-methyl-2-pentanol 65.13
    propionitrile 150.56
    vinylene carbonate 117.54
    1,1,2-trichlorotrifluoroethane 205.14
    DMS 55.32
    cumene 36.65
    2-octanol 46.29
    2-hexanone 84.78
    octyl acetate 42.18
    limonene 52.62
    1,2-dimethoxyethane 206.03
    ethyl orthosilicate 45.02
    tributyl phosphate 35.48
    diacetone alcohol 89.88
    N,N-dimethylaniline 66.95
    acrylonitrile 167.33
    aniline 104.19
    1,3-propanediol 219.46
    bromobenzene 87.24
    dibromomethane 260.87
    1,1,2,2-tetrachloroethane 254.37
    2-methyl-cyclohexyl acetate 66.55
    tetrabutyl urea 42.8
    diisobutyl methanol 41.65
    2-phenylethanol 81.87
    styrene 48.68
    dioctyl adipate 46.38
    dimethyl sulfate 53.61
    ethyl butyrate 67.89
    methyl lactate 50.45
    butyl lactate 54.49
    diethyl carbonate 48.78
    propanediol butyl ether 74.25
    triethyl orthoformate 54.19
    p-tert-butyltoluene 34.87
    methyl 4-tert-butylbenzoate 72.16
    morpholine 210.88
    tert-butylamine 170.85
    n-dodecanol 27.6
    dimethoxymethane 98.57
    ethylene carbonate 89.13
    cyrene 96.53
    2-ethoxyethyl acetate 78.05
    2-ethylhexyl acetate 66.29
    1,2,4-trichlorobenzene 129.78
    4-methylpyridine 165.84
    dibutyl ether 51.04
    2,6-dimethyl-4-heptanol 41.65
    DEF 120.91
    dimethyl isosorbide 128.71
    tetrachloroethylene 230.95
    eugenol 80.23
    triacetin 66.81
    span 80 74.22
    1,4-butanediol 107.52
    1,1-dichloroethane 206.76
    2-methyl-1-pentanol 137.42
    methyl formate 126.34
    2-methyl-1-butanol 192.21
    n-decane 10.35
    butyronitrile 174.67
    3,7-dimethyl-1-octanol 57.07
    1-chlorooctane 35.22
    1-chlorotetradecane 14.99
    n-nonane 10.23
    undecane 7.68
    tert-butylcyclohexane 20.02
    cyclooctane 12.23
    cyclopentanol 166.58
    tetrahydropyran 169.03
    tert-amyl methyl ether 130.37
    2,5,8-trioxanonane 120.5
    1-hexene 75.71
    2-isopropoxyethanol 118.37
    2,2,2-trifluoroethanol 180.27
    methyl butyrate 86.82

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction