N,N-Dimethylacetamide

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  • Identifiers

    CAS number
    127-19-5

    Molecular formula
    C4H9NO

    SMILES
    CC(=O)N(C)C

    Safety labels

    Irritant
    Irritant

    Health Hazard
    Health

  • Odor profile

    Fragrance
    Fruity 52.79%
    Cheesy 46.79%
    Pungent 32.11%
    Ethereal 31.05%
    Ketonic 29.64%
    Mint 25.23%
    Nutty 23.43%
    Dairy 23.22%
    Buttery 23.15%
    Herbal 22.77%

     

    Flavor
    Fruity 45.38%
    Cheese 36.91%
    Sweet 31.9%
    Oily 31.35%
    Butter 29.19%
    Pungent 28.26%
    Creamy 27.17%
    Fatty 26.12%
    Tropical 25.41%
    Buttery 24.63%

     

    Odor impact est.
    Low

    Odor threshold

    • Odor Threshold Low: 21.0 [mmHg]. Odor Threshold High: 47.0 [mmHg]. Odor threshold from "Quick Guide: The Electronic NIOSH Pocket Guide to Chemical Hazards"
    • ODOR THRESHOLD FOR 50% RESPONSE IS 21.4 PPM; FOR 100% RESPONSE, 46.8 PPM.
    • Odor low: 163.8 mg/cu m; Odor high: 163.8 mg/cu m

  • Properties

    XLogP3-AA
    -0.8

    pKa est.
    7.53 (neutral)

    Molecular weight
    87.12 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Very fast

    Melting point expt.

    • -4 °F (NTP, 1992)
    • -18.59 °C
    • -20 °C
    • -4 °F

    Boiling point

    • 329 to 331 °F at 760 mmHg (NTP, 1992)
    • 163-165 °C
    • 165 °C
    • 329 °F

    Flash point

    • 45.3 ˚C est.
    • 151 °F (NTP, 1992)
    • 70 °C
    • 70 °C (OPEN CUP)
    • 63 °C c.c.
    • 158 °F (open cup)
    • (oc) 158 °F

    Solubility expt.

    • greater than or equal to 100 mg/mL at 72 °F (NTP, 1992)
    • SOL IN BENZENE
    • Soluble in alcohol, acetone, ether
    • Miscible with most org solvents
    • MISCIBLE WITH AROMATIC CMPD, ESTERS, KETONES, ETHERS
    • Miscible in water.
    • Solubility in water: miscible
    • Miscible

  • Synonyms

    • N,N-DIMETHYLACETAMIDE
    • 127-19-5
    • Dimethylacetamide
    • Acetamide, N,N-dimethyl-
    • DMAc
    • Acetdimethylamide
    • Dimethyl acetamide
    • N,N-Dimethyl acetamide
    • Dimethylamide acetate
    • N,N-Dimethylethanamide
    • Dimethylacetone amide
    • Acetic acid, dimethylamide
    • Acetyldimethylamine
    • NSC 3138
    • CBC 510337
    • SK 7176
    • n-n-dimethylacetamide
    • HSDB 74
    • N.N-Dimethylacetamide
    • MFCD00008686
    • Hallucinogen
    • CCRIS 4623
    • DTXSID5020499
    • JCV5VDB3HY
    • U-5954
    • UNII-JCV5VDB3HY
    • Acetic acid dimethylamide
    • Dimethylamid kyseliny octove
    • EINECS 204-826-4
    • CHEBI:84254
    • AI3-15276
    • N,N-Dimethyl-acetamide
    • NSC-3138
    • DTXCID90499
    • NSC3138
    • EC 204-826-4
    • Acetamide, N,N-dimethyl-, labeled with deuterium (9CI)
    • DIMETHYLACETAMIDE (MART.)
    • DIMETHYLACETAMIDE [MART.]
    • Dimethylacetamid
    • N,N-DIMETHYLACETAMIDE (II)
    • N,N-DIMETHYLACETAMIDE [II]
    • N,N-DIMETHYLACETAMIDE (USP-RS)
    • N,N-DIMETHYLACETAMIDE [USP-RS]
    • DIMETHYLACETAMIDE (EP MONOGRAPH)
    • DIMETHYLACETAMIDE [EP MONOGRAPH]
    • Dimethylacetamide; N,N-Dimethylacetamide
    • Acetyl dimethylamine
    • CAS-127-19-5
    • N,N-dimethylacetoamide
    • N, N-dimethylacetamide
    • Acetic acid-dimethylamide
    • Dimethylamid kyseliny octove [Czech]
    • dimethyacetamide
    • dimethylactamide
    • dimethylacteamide
    • trimethylformamide
    • dimeihyl acetamide
    • dimethyl-acetamide
    • n-dimethylacetamide
    • N,N-dimethyacetamide
    • N,N-dimethylactamide
    • N-Acetyldimethylamine
    • N,N dimethylacetamide
    • n,n,-dimethylacetamide
    • N,-N-dimethylacetamide
    • N,N -dimethylacetamide
    • N,N-di-methylacetamide
    • N,N-dimethylacet-amide
    • N, N-dimethylacetoamide
    • N,N-dimethyl acetoamide
    • n,n,-dimethyl-acetamide
    • N,N-dimethyl- acetamide
    • methane, dimethylcarbamoyl-
    • CH3CON(CH3)2
    • N, N-Dimethylacetamide, EP
    • CHEMBL11873
    • N,N-Dimethylacetamide, >=99%
    • N,N-Dimethylacetamide, anhydrous
    • Acetic acid-dimethylamide 1000 microg/mL in Acetonitrile
    • N,N-DIMETHYLACETAMIDE [MI]
    • WLN: 1VN1 & 1
    • N,N-Dimethylacetamide, HPLC Grade
    • Tox21_202174
    • Tox21_302787
    • N,N-DIMETHYLACETAMIDE [HSDB]
    • NSC820333
    • STL482892
    • N,N-DIMETHYLACETAMIDE [VANDF]
    • ACETIC ACID,AMIDE,N,N-DIMETHYL
    • AKOS000118789
    • CS-W023195
    • HY-W042416
    • NSC-820333
    • N,N-Dimethylacetamide, p.a., 99.5%
    • N,N-Dimethylacetamide, AR, >=99.5%
    • NCGC00159401-02
    • NCGC00159401-03
    • NCGC00256375-01
    • NCGC00259723-01
    • BP-31151
    • DA-65832
    • N,N-Dimethylacetamide, SAJ special grade
    • N,N-Dimethylacetamide, analytical standard
    • N,N-Dimethylacetamide, anhydrous, 99.8%
    • DB-041302
    • N,N-Dimethylacetamide, 99.5%, Extra Dry
    • D0641
    • NS00006036
    • N,N-Dimethylacetamide, for HPLC, >=99.7%
    • N,N-Dimethylacetamide, for HPLC, >=99.9%
    • N,N-Dimethylacetamide, ReagentPlus(R), 99%
    • C20339
    • N,N-Dimethylacetamide, ReagentPlus(R), >=99%
    • InChI=1/C4H9NO/c1-4(6)5(2)3/h1-3H
    • N,N-Dimethylacetamide, anhydrous, water < 50ppm
    • Q411452
    • Residual Solvent Class 2 - N,N-Dimethylacetamide
    • N,N-Dimethylacetamide, SAJ first grade, >=99.0%
    • N,N-Dimethylacetamide, UV HPLC spectroscopic, 99%
    • N,N-Dimethylacetamide, anhydrous, ZerO2(TM), 99.8%
    • N,N-Dimethylacetamide, Vetec(TM) reagent grade, 98%
    • F0001-0392
    • N,N-Dimethylacetamide, puriss. p.a., >=99.5% (GC)
    • N,N-Dimethylacetamide, spectrophotometric grade, >=99%
    • N,N-Dimethylacetamide, for peptide synthesis, >=99.8% (GC)
    • 204-826-4
    • 5Y9

  • Applications

    Commonly used as a high-boiling, polar aprotic solvent in polymer processing and resin manufacture, N,N-Dimethylacetamide (CAS 127-19-5) dissolves polymers such as polyacrylonitrile, polyurethane, and polysulfones, enabling fiber spinning, film casting, and coatings. It also serves as a solvent in coatings, inks, and adhesive formulations due to its solvency for resins and additives. In pharmaceutical and agrochemical manufacturing, it acts as a reaction and purification solvent, often used during synthesis and formulation steps under appropriate regulations. In electronics and semiconductor industries, DMAC is applied in photoresist processing and in polymer electrolyte or thin-film formulations. It is also used as an industrial cleaning/degreasing solvent and as an intermediate or processing solvent in chemical synthesis. Usage is subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 2178.42
    methanol 3833.5
    isopropanol 1483.2
    water 1569.8
    ethyl acetate 296.28
    n-propanol 1305.83
    acetone 637.13
    n-butanol 923.37
    acetonitrile 989.25
    DMF 1233.52
    toluene 96.61
    isobutanol 862.53
    1,4-dioxane 484.07
    methyl acetate 514.91
    THF 558.46
    2-butanone 512.31
    n-pentanol 395.85
    sec-butanol 1084.96
    n-hexane 37.65
    ethylene glycol 758.72
    NMP 835.95
    cyclohexane 37.46
    DMSO 561.52
    n-butyl acetate 58.36
    n-octanol 99.17
    chloroform 1226.65
    n-propyl acetate 75.82
    acetic acid 1801.38
    dichloromethane 949.94
    cyclohexanone 326.29
    propylene glycol 850.03
    isopropyl acetate 117.67
    DMAc 1043.53
    2-ethoxyethanol 590.77
    isopentanol 502.51
    n-heptane 16.97
    ethyl formate 417.14
    1,2-dichloroethane 355.43
    n-hexanol 194.77
    2-methoxyethanol 1502.87
    isobutyl acetate 39.93
    tetrachloromethane 352.38
    n-pentyl acetate 78.15
    transcutol 378.29
    n-heptanol 125.71
    ethylbenzene 41.1
    MIBK 88.36
    2-propoxyethanol 297.46
    tert-butanol 1030.46
    MTBE 359.99
    2-butoxyethanol 229.47
    propionic acid 1016.54
    o-xylene 86.21
    formic acid 2288.65
    diethyl ether 332.36
    m-xylene 55.74
    p-xylene 71.75
    chlorobenzene 145.57
    dimethyl carbonate 93.51
    n-octane 8.1
    formamide 2292.64
    cyclopentanone 461.9
    2-pentanone 240.38
    anisole 109.72
    cyclopentyl methyl ether 195.09
    gamma-butyrolactone 527.83
    1-methoxy-2-propanol 761.29
    pyridine 536.95
    3-pentanone 186.04
    furfural 607.13
    n-dodecane 5.06
    diethylene glycol 290.09
    diisopropyl ether 43.98
    tert-amyl alcohol 871.0
    acetylacetone 149.44
    n-hexadecane 5.24
    acetophenone 99.96
    methyl propionate 285.92
    isopentyl acetate 50.97
    trichloroethylene 725.25
    n-nonanol 83.85
    cyclohexanol 415.21
    benzyl alcohol 205.34
    2-ethylhexanol 76.04
    isooctanol 82.26
    dipropyl ether 56.53
    1,2-dichlorobenzene 122.9
    ethyl lactate 77.47
    propylene carbonate 219.57
    n-methylformamide 1358.1
    2-pentanol 455.24
    n-pentane 63.66
    1-propoxy-2-propanol 170.18
    1-methoxy-2-propyl acetate 66.69
    2-(2-methoxypropoxy) propanol 102.86
    mesitylene 26.85
    ε-caprolactone 304.13
    p-cymene 25.4
    epichlorohydrin 523.2
    1,1,1-trichloroethane 436.86
    2-aminoethanol 1442.29
    morpholine-4-carbaldehyde 608.29
    sulfolane 400.77
    2,2,4-trimethylpentane 26.75
    2-methyltetrahydrofuran 473.45
    n-hexyl acetate 98.1
    isooctane 8.27
    2-(2-butoxyethoxy)ethanol 149.0
    sec-butyl acetate 47.17
    tert-butyl acetate 79.52
    decalin 12.37
    glycerin 843.41
    diglyme 254.14
    acrylic acid 868.17
    isopropyl myristate 23.55
    n-butyric acid 707.98
    acetyl acetate 120.03
    di(2-ethylhexyl) phthalate 38.8
    ethyl propionate 78.38
    nitromethane 1459.25
    1,2-diethoxyethane 88.93
    benzonitrile 187.01
    trioctyl phosphate 22.73
    1-bromopropane 258.17
    gamma-valerolactone 596.86
    n-decanol 52.59
    triethyl phosphate 28.23
    4-methyl-2-pentanol 143.72
    propionitrile 549.49
    vinylene carbonate 229.41
    1,1,2-trichlorotrifluoroethane 623.36
    DMS 64.59
    cumene 31.1
    2-octanol 76.3
    2-hexanone 95.66
    octyl acetate 40.14
    limonene 37.47
    1,2-dimethoxyethane 423.02
    ethyl orthosilicate 29.69
    tributyl phosphate 25.74
    diacetone alcohol 192.01
    N,N-dimethylaniline 85.24
    acrylonitrile 691.34
    aniline 334.64
    1,3-propanediol 1280.81
    bromobenzene 99.42
    dibromomethane 566.59
    1,1,2,2-tetrachloroethane 574.08
    2-methyl-cyclohexyl acetate 39.24
    tetrabutyl urea 37.48
    diisobutyl methanol 31.43
    2-phenylethanol 118.36
    styrene 52.88
    dioctyl adipate 36.44
    dimethyl sulfate 139.71
    ethyl butyrate 46.15
    methyl lactate 217.39
    butyl lactate 77.41
    diethyl carbonate 31.73
    propanediol butyl ether 179.72
    triethyl orthoformate 37.84
    p-tert-butyltoluene 23.84
    methyl 4-tert-butylbenzoate 89.53
    morpholine 814.57
    tert-butylamine 616.82
    n-dodecanol 33.68
    dimethoxymethane 380.09
    ethylene carbonate 166.73
    cyrene 118.73
    2-ethoxyethyl acetate 104.98
    2-ethylhexyl acetate 37.6
    1,2,4-trichlorobenzene 175.3
    4-methylpyridine 465.6
    dibutyl ether 50.11
    2,6-dimethyl-4-heptanol 31.43
    DEF 374.25
    dimethyl isosorbide 105.34
    tetrachloroethylene 520.68
    eugenol 99.73
    triacetin 76.76
    span 80 104.2
    1,4-butanediol 395.38
    1,1-dichloroethane 607.14
    2-methyl-1-pentanol 275.71
    methyl formate 657.36
    2-methyl-1-butanol 622.41
    n-decane 9.93
    butyronitrile 472.54
    3,7-dimethyl-1-octanol 65.75
    1-chlorooctane 37.16
    1-chlorotetradecane 11.86
    n-nonane 9.88
    undecane 6.68
    tert-butylcyclohexane 14.45
    cyclooctane 9.45
    cyclopentanol 583.47
    tetrahydropyran 387.27
    tert-amyl methyl ether 251.71
    2,5,8-trioxanonane 142.38
    1-hexene 106.96
    2-isopropoxyethanol 259.26
    2,2,2-trifluoroethanol 808.13
    methyl butyrate 121.26

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction