Nervonic Acid

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  • Identifiers

    CAS number
    506-37-6

    Molecular formula
    C24H46O2

    SMILES
    CCCCCCCC/C=C\CCCCCCCCCCCCCC(=O)O

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Waxy 75.06%
    Fatty 74.64%
    Oily 48.36%
    Odorless 27.7%
    Creamy 21.47%
    Meaty 20.69%
    Savory 20.31%
    Dairy 20.22%
    Fishy 19.83%
    Sweet 19.19%

     

    Flavor
    Fatty 44.31%
    Waxy 42.14%
    Faint 34.58%
    Mild 30.22%
    Bland 28.36%
    Fat 25.97%
    Slightly waxy 24.39%
    Odorless 23.07%
    Bay oil 22.08%
    Delicate 21.59%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    9.8

    pKa est.
    7.3 (neutral)

    Molecular weight
    366.6 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    440°C

    Flash point

    • 224.46 ˚C est.

  • Synonyms

    • Nervonic acid
    • 506-37-6
    • (Z)-tetracos-15-enoic acid
    • cis-15-tetracosenoic acid
    • (Z)-15-Tetracosenoic acid
    • (15Z)-Tetracosenoic acid
    • Nevonic acid
    • 15Z-tetracosenoic acid
    • 91OQS788BE
    • CHEBI:44247
    • DTXSID801009308
    • 24:1(N-9)
    • DTXSID40862068
    • RefChem:43200
    • Fatty Acid 24:1 n-9
    • DTXCID60810889
    • DTXCID001436135
    • 610-549-3
    • Tetracos-15-enoic acid
    • selacholeic acid
    • (15Z)-tetracos-15-enoic acid
    • cis-selacholeic acid
    • MFCD00010507
    • 15-Tetracosenoic acid, (15Z)-
    • (15e)-Tetracos-15-Enoic Acid
    • FA 24:1
    • C24:1n-9
    • selacholeate
    • UNII-91OQS788BE
    • Nervonsaeure
    • cis-selacholeate
    • 15-Tetracosenoate
    • 15Z-tetracosenoate
    • NERVONICACID
    • cis-15-Teracosenoate
    • cis-15-Tetracosenate
    • 15cis-tetracosenoic acid
    • z-15-Tetracosenoic acid
    • cis-15-Teracosenoic acid
    • cis-15-Tetracosenic acid
    • (Z)-tetracos-15-enoicacid
    • NERVONIC ACID [DSC]
    • SCHEMBL21103
    • orb1302431
    • SCHEMBL4344540
    • NERVONIC ACID [WHO-DD]
    • Tetracosenoic acid, 15-(Z)-
    • CHEMBL1173379
    • MSK1775
    • cis-Delta(15)-tetracosenoic acid
    • Nervonic acid, analytical standard
    • HY-N2526
    • 15-TETRACOSENOIC ACID, CIS-
    • LMFA01030092
    • s6430
    • TETRACOSENOIC ACID, (15Z)-
    • AKOS027320479
    • 15-TETRACOSENOIC ACID, (Z)-
    • EBC-616135
    • FD10484
    • Nervonic acid, >=99% (capillary GC)
    • NCGC00484930-01
    • AC-33771
    • AS-59819
    • BP-40917
    • FA(24:1)
    • FN145192
    • SY105993
    • FA(24:1(15Z))
    • Nervonic acid, analytical reference material
    • CS-0022797
    • NS00015174
    • T1642
    • C08323
    • 506N376
    • F535733
    • Q414231
    • 3F0366A4-A342-402E-B731-D54879FC86E7
    • 506-37-6

  • Applications

    Nervonic acid (CAS 506-37-6) is used in cosmetics and personal care as an emollient and skin-conditioning lipid, contributing to moisturization and creamy slip in creams, lotions, and hair-care formulations. It also serves as a long-chain fatty acid feedstock for the synthesis of esters, amides, and other specialty lubricants. In polymers and coatings, nervonic acid-derived esters can function as wax-like additives or plasticizers to improve texture, gloss, and compatibility of coatings and polymer blends. In general industrial manufacturing, it is employed as an intermediate for lipid-based specialty chemicals such as surfactants and stabilizers. As a precursor to fatty acid esters, nervonic acid can form surfactants and emulsifiers used in cleaning formulations and household products, subject to formulation constraints. In pharmaceutical or topical applications, nervonic acid may be evaluated as an excipient or lipid component in lipid-based delivery systems, subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 4.68
    methanol 5.24
    isopropanol 5.17
    water 0.01
    ethyl acetate 21.23
    n-propanol 6.25
    acetone 14.67
    n-butanol 8.56
    acetonitrile 3.21
    DMF 33.35
    toluene 10.95
    isobutanol 6.72
    1,4-dioxane 32.5
    methyl acetate 13.45
    THF 145.28
    2-butanone 23.43
    n-pentanol 10.11
    sec-butanol 8.74
    n-hexane 6.32
    ethylene glycol 0.4
    NMP 133.8
    cyclohexane 20.48
    DMSO 64.2
    n-butyl acetate 46.17
    n-octanol 20.06
    chloroform 74.61
    n-propyl acetate 44.03
    acetic acid 8.35
    dichloromethane 71.51
    cyclohexanone 97.64
    propylene glycol 1.85
    isopropyl acetate 31.94
    DMAc 100.6
    2-ethoxyethanol 23.77
    isopentanol 14.21
    n-heptane 7.97
    ethyl formate 10.47
    1,2-dichloroethane 52.86
    n-hexanol 11.97
    2-methoxyethanol 19.57
    isobutyl acetate 36.03
    tetrachloromethane 21.86
    n-pentyl acetate 82.44
    transcutol 211.39
    n-heptanol 17.55
    ethylbenzene 15.25
    MIBK 41.8
    2-propoxyethanol 31.78
    tert-butanol 17.09
    MTBE 31.99
    2-butoxyethanol 47.09
    propionic acid 9.03
    o-xylene 15.22
    formic acid 1.91
    diethyl ether 16.58
    m-xylene 12.98
    p-xylene 20.27
    chlorobenzene 20.48
    dimethyl carbonate 7.79
    n-octane 4.73
    formamide 3.88
    cyclopentanone 101.54
    2-pentanone 30.02
    anisole 30.3
    cyclopentyl methyl ether 69.73
    gamma-butyrolactone 79.59
    1-methoxy-2-propanol 27.63
    pyridine 30.3
    3-pentanone 25.99
    furfural 55.29
    n-dodecane 2.74
    diethylene glycol 9.57
    diisopropyl ether 15.12
    tert-amyl alcohol 21.85
    acetylacetone 42.68
    n-hexadecane 3.31
    acetophenone 44.81
    methyl propionate 18.53
    isopentyl acetate 57.08
    trichloroethylene 88.47
    n-nonanol 22.6
    cyclohexanol 22.49
    benzyl alcohol 15.37
    2-ethylhexanol 18.79
    isooctanol 22.27
    dipropyl ether 42.76
    1,2-dichlorobenzene 33.44
    ethyl lactate 20.77
    propylene carbonate 50.84
    n-methylformamide 8.1
    2-pentanol 9.36
    n-pentane 3.15
    1-propoxy-2-propanol 44.67
    1-methoxy-2-propyl acetate 59.79
    2-(2-methoxypropoxy) propanol 62.35
    mesitylene 14.01
    ε-caprolactone 89.6
    p-cymene 17.38
    epichlorohydrin 87.87
    1,1,1-trichloroethane 63.18
    2-aminoethanol 2.29
    morpholine-4-carbaldehyde 73.8
    sulfolane 203.24
    2,2,4-trimethylpentane 6.42
    2-methyltetrahydrofuran 87.4
    n-hexyl acetate 80.61
    isooctane 4.06
    2-(2-butoxyethoxy)ethanol 74.59
    sec-butyl acetate 41.75
    tert-butyl acetate 66.86
    decalin 12.57
    glycerin 4.13
    diglyme 165.18
    acrylic acid 5.77
    isopropyl myristate 32.64
    n-butyric acid 24.91
    acetyl acetate 17.92
    di(2-ethylhexyl) phthalate 23.54
    ethyl propionate 36.32
    nitromethane 18.65
    1,2-diethoxyethane 81.22
    benzonitrile 16.57
    trioctyl phosphate 18.77
    1-bromopropane 32.58
    gamma-valerolactone 128.17
    n-decanol 14.44
    triethyl phosphate 40.29
    4-methyl-2-pentanol 12.44
    propionitrile 5.76
    vinylene carbonate 30.85
    1,1,2-trichlorotrifluoroethane 63.66
    DMS 30.75
    cumene 15.21
    2-octanol 17.97
    2-hexanone 44.09
    octyl acetate 34.59
    limonene 30.41
    1,2-dimethoxyethane 71.4
    ethyl orthosilicate 44.02
    tributyl phosphate 25.06
    diacetone alcohol 63.24
    N,N-dimethylaniline 32.31
    acrylonitrile 5.46
    aniline 11.04
    1,3-propanediol 5.67
    bromobenzene 25.96
    dibromomethane 49.61
    1,1,2,2-tetrachloroethane 111.56
    2-methyl-cyclohexyl acetate 67.04
    tetrabutyl urea 45.28
    diisobutyl methanol 19.96
    2-phenylethanol 18.1
    styrene 14.34
    dioctyl adipate 56.21
    dimethyl sulfate 27.32
    ethyl butyrate 55.87
    methyl lactate 12.48
    butyl lactate 55.38
    diethyl carbonate 28.77
    propanediol butyl ether 38.71
    triethyl orthoformate 59.64
    p-tert-butyltoluene 17.93
    methyl 4-tert-butylbenzoate 78.33
    morpholine 49.66
    tert-butylamine 12.98
    n-dodecanol 9.87
    dimethoxymethane 26.06
    ethylene carbonate 28.71
    cyrene 59.64
    2-ethoxyethyl acetate 81.14
    2-ethylhexyl acetate 51.29
    1,2,4-trichlorobenzene 41.9
    4-methylpyridine 30.99
    dibutyl ether 55.88
    2,6-dimethyl-4-heptanol 19.96
    DEF 44.52
    dimethyl isosorbide 147.48
    tetrachloroethylene 62.73
    eugenol 54.45
    triacetin 88.75
    span 80 56.83
    1,4-butanediol 2.91
    1,1-dichloroethane 37.89
    2-methyl-1-pentanol 16.54
    methyl formate 5.73
    2-methyl-1-butanol 12.1
    n-decane 6.6
    butyronitrile 9.41
    3,7-dimethyl-1-octanol 26.62
    1-chlorooctane 26.07
    1-chlorotetradecane 8.15
    n-nonane 6.23
    undecane 3.96
    tert-butylcyclohexane 10.07
    cyclooctane 7.09
    cyclopentanol 22.75
    tetrahydropyran 56.41
    tert-amyl methyl ether 37.88
    2,5,8-trioxanonane 102.67
    1-hexene 12.67
    2-isopropoxyethanol 25.59
    2,2,2-trifluoroethanol 4.97
    methyl butyrate 53.4

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction