Neomycin Sulfate

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  • Identifiers

    CAS number
    1405-10-3

    Molecular formula
    C23H48N6O17S

    SMILES
    C1[C@H]([C@@H]([C@H]([C@@H]([C@H]1N)O[C@@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CN)O)O)N)O[C@H]3[C@@H]([C@@H]([C@H](O3)CO)O[C@@H]4[C@@H]([C@H]([C@@H]([C@@H](O4)CN)O)O)N)O)O)N.OS(=O)(=O)O

    Safety labels

    Irritant
    Irritant

    Health Hazard
    Health

  • Odor profile

    Fragrance
    Odorless 79.76%
    Fishy 29.68%
    Sweet 22.65%
    Savory 20.66%
    Cooling 19.2%
    Alcoholic 17.38%
    Meaty 14.26%
    Smoky 12.72%
    Bitter 12.67%
    Animal 11.63%

     

    Flavor
    Sweet 47.96%
    Odorless 47.75%
    Bitter 44.97%
    Sweet-like 29.61%
    Bland 20.91%
    Cauliflower 20.81%
    Alkaline 20.79%
    Fatty 20.72%
    Very slight 20.42%
    Bouillon 19.8%

     

    Odor impact est.
    Low

  • Properties

    pKa est.
    3.72 (weak acid)

    Molecular weight
    712.7 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Fast

    Boiling point est.
    3931°C

    Flash point

    • 263.24 ˚C est.

  • Synonyms

    • NEOMYCIN SULFATE
    • Neomycin B sulfate
    • 1405-10-3
    • Neomycin sulphate
    • Mycifradin
    • Bykomycin
    • Neomix
    • Fradiomycin sulfate
    • Neo-Rx
    • Myciguent
    • Neobiotic
    • Neo-Fradin
    • CHEBI:53636
    • DTXSID10948247
    • USAF CB-19
    • Tuttomycin
    • Endomixin
    • Fraquinol
    • Myacine
    • Neosulf
    • Neomycin b, sulphate (salt)
    • Neo-sol 50
    • (1R,2R,3S,4R,6S)-4,6-diamino-2-{[3-O-(2,6-diamino-2,6-dideoxy-beta-L-idopyranosyl)-beta-D-ribofuranosyl]oxy}-3-hydroxycyclohexyl 2,6-diamino-2,6-dideoxy-alpha-D-glucopyranoside sulfate
    • Sulfate, Framycetin
    • Neomycin sulfate (USP)
    • Sulfate, Neomycin B
    • NEOMED 325
    • Vitacilina
    • Cicatrene
    • Graneodin
    • Neobacrin
    • Neoplex
    • Neovet
    • Neomycin Liquid
    • Biosol Liquid
    • Neosol-Oral
    • Gppe nsl gel
    • Neomycin Ointment
    • NSC-757240
    • Neo-Sol
    • Antibiotic Ointment
    • First Aid Ointment
    • (1R,2R,3S,4R,6S)-4,6-diamino-2-((3-O-(2,6-diamino-2,6-dideoxy-beta-L-idopyranosyl)-beta-D-ribofuranosyl)oxy)-3-hydroxycyclohexyl 2,6-diamino-2,6-dideoxy-alpha-D-glucopyranoside sulfate
    • NEOSOL
    • Neosol Soluble Powder
    • NeoMed Soluble Powder
    • Family Care Antibiotic
    • Neomycin Oral Solution
    • Neomycin Sulfate 325
    • RefChem:55696
    • Neo 200 Oral Solution
    • First Aid Only Antibiotic
    • Roosin Neomycin Antibiotic
    • 057Y626693
    • Water-jel Neomycin Antibiotic
    • Single Antibiotic With Neomycin
    • DTXSID4041074
    • CHEBI:31635
    • DTXCID501768698
    • First Aid Only Neomycin Antibiotic
    • POMADA SULFA FIRST AID ANTIBIOTIC
    • Family Care Triple Antibiotic Pain Relief
    • First Aid Only Antibiotic Neomycin Sulfate
    • Vitacilina Neomycin Sulfate First Aid Antibiotic
    • Biosol Sterile Solution, Biosol Sterile Solution 50 mg
    • Neomix 325 Soluble Powder, Neomix AG 325 Soluble Powder
    • Neomix Ag 325 Medicated Premix, Neomix 325 Medicated Premix
    • 215-773-1
    • Neomycin, sulfate (salt)
    • Framycetin sulfate
    • 28002-70-2
    • Framycin sulfate
    • Neomycin B sulphate
    • Neomycin trisulfate salt hydrate
    • Neomycin B, sulfate (salt)
    • Neomycin sulfate 100 microg/mL in Water
    • (2S,3S,4R,5R,6R)-5-Amino-2-(aminomethyl)-6-(((2R,3S,4R,5S)-5-(((1R,2R,3S,5R,6S)-3,5-diamino-2-(((2R,3R,4R,5S,6R)-3-amino-6-(aminomethyl)-4,5-dihydroxytetrahydro-2H-pyran-2-yl)oxy)-6-hydroxycyclohexyl)oxy)-4-hydroxy-2-(hydroxymethyl)tetrahydrofuran-3-yl)oxy)tetrahydro-2H-pyran-3,4-diol xsulfate
    • C23H48N6O17S
    • Neomycin Trisulfate Hydrate
    • MFCD00150827
    • (2R,3S,4R,5R,6R)-5-amino-2-(aminomethyl)-6-[(1R,2R,3S,4R,6S)-4,6-diamino-2-[(2S,3R,4S,5R)-4-[(2R,3R,4R,5S,6S)-3-amino-6-(aminomethyl)-4,5-dihydroxyoxan-2-yl]oxy-3-hydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy-3-hydroxycyclohexyl]oxyoxane-3,4-diol;sulfuric acid
    • 4146-30-9
    • (2S,3S,4R,5R,6R)-5-Amino-2-(aminomethyl)-6-(((2R,3S,4R,5S)-5-(((1R,2R,3S,5R,6S)-3,5-diamino-2-(((2R,3R,4R,5S,6R)-3-amino-6-(aminomethyl)-4,5-dihydroxytetrahydro-2H-pyran-2-yl)oxy)-6-hydroxycyclohexyl)oxy)-4-hydroxy-2-(hydroxymethyl)tetrahydrofuran-3-yl)oxy)tetrahydro-2H-pyran-3,4-diol sulfate
    • EINECS 248-770-9
    • MFCD00077833
    • O-2,6-Diamino-2,6-dideoxy-ss-L-idopyranosyl-(1?3)-O-ss-D-ribofuranosyl-(1?5)-O-[2,6-diamino-2,6-dideoxy-a-D-glucopyranosyl-(1?4)]-2-deoxy-D-streptamine sulfate (salt) (9CI); Neomycin B, sulfate (salt) (8CI); Framycetin sulfate; Framycin sulfate
    • Isofra (TN)
    • Neomycin sulfate CRS
    • Fradiomycin Sulfate RS
    • Framycetin sulfate CRS
    • starbld0006229
    • (2R,3S,4R,5R,6R)-5-amino-2-(aminomethyl)-6-[(1R,2R,3S,4R,6S)-4,6-diamino-2-[(2S,3R,4S,5R)-4-[(2R,3R,4R,5S,6S)-3-amino-6-(aminomethyl)-4,5-dihydroxy-tetrahydropyran-2-yl]oxy-3-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]oxy-3-hydroxy-cyclohexoxy]tetrahydropyran-3,4-diol;sulfuric acid
    • SCHEMBL373681
    • MSK7710B
    • MSK7710B-100AW
    • MSK7710B-100MW
    • HMS2095O18
    • HMS3712O18
    • MSK7710B-1000AW
    • MSK7710B-1000MW
    • EBC-98150
    • AKOS016340327
    • AN10534
    • CCG-220158
    • KS-1358
    • 2nd International Standard for Neomycin B
    • D-Streptamine, O-2,6-diamino-2,6-dideoxy-beta-L-idopyranosyl-(1-3)-O-beta-D-ribofuranosyl-(1-5)-O-(2,6-diamino-2,6-dideoxy-alpha-D-glucopyranosyl-(1-4))-2-deoxy-, sulfate (salt)
    • Neomycin sulfate for microbiological assay
    • SY072627
    • Third International Standard for Neomycin
    • Framycetin sulfate (Neomycin B sulfate) RS
    • F0649
    • NS00083866
    • Neomycin sulfate for microbiological assay CRS
    • WHO Third International Standard for Neomycin
    • D07994
    • N-2515
    • 405N103
    • Q27124126
    • Neomycin sulfate Solution in Methanol/Water, 1000ug/mL
    • Neomycin sulfate Solution in Methanol/Water, 100ug/mL
    • Neomycin sulfate Solution in Acetonitrile/Water, 1000ug/mL
    • Neomycin sulfate Solution in Acetonitrile/Water, 100ug/mL
    • Neomycin trisulfate, Antibiotic for Culture Media Use Only
    • Neomycin Sulfate, gamma-Irradiated, Tissue Culture Grade - CAS 1405-10-3
    • Sulfuric acid--(1R,2R,3S,4R,6S)-4,6-diamino-2-{[3-O-(2,6-diamino-2,6-dideoxy-beta-L-idopyranosyl)-beta-D-ribofuranosyl]oxy}-3-hydroxycyclohexyl 2,6-diamino-2,6-dideoxy-alpha-D-glucopyranoside (1/1)
    • 1405-10-3

  • Applications

    Neomycin sulfate (CAS 1405-10-3) is a broad-spectrum aminoglycoside antibiotic used primarily in pharmaceutical and veterinary products; it is commonly formulated in topical ointments and creams for skin infections, included in ophthalmic and otic preparations, and prescribed orally or rectally for bowel decontamination or certain gastrointestinal bacterial conditions under medical supervision; it also appears in combination products for wound care and dermatology, and is used in veterinary medicines for animal health applications. Usage is subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 4.71
    methanol 10.42
    isopropanol 0.85
    water 46.17
    ethyl acetate 0.55
    n-propanol 1.38
    acetone 1.27
    n-butanol 0.91
    acetonitrile 0.61
    DMF 8.9
    toluene 0.15
    isobutanol 0.37
    1,4-dioxane 2.06
    methyl acetate 0.51
    THF 3.22
    2-butanone 0.77
    n-pentanol 0.39
    sec-butanol 0.49
    n-hexane 0.02
    ethylene glycol 12.36
    NMP 19.74
    cyclohexane 0.06
    DMSO 49.27
    n-butyl acetate 0.21
    n-octanol 0.23
    chloroform 0.36
    n-propyl acetate 0.2
    acetic acid 32.14
    dichloromethane 0.5
    cyclohexanone 1.55
    propylene glycol 7.06
    isopropyl acetate 0.26
    DMAc 8.59
    2-ethoxyethanol 4.73
    isopentanol 0.3
    n-heptane 0.04
    ethyl formate 1.17
    1,2-dichloroethane 0.36
    n-hexanol 0.3
    2-methoxyethanol 16.64
    isobutyl acetate 0.07
    tetrachloromethane 0.13
    n-pentyl acetate 0.34
    transcutol 5.65
    n-heptanol 0.43
    ethylbenzene 0.05
    MIBK 0.22
    2-propoxyethanol 2.93
    tert-butanol 0.27
    MTBE 0.1
    2-butoxyethanol 2.97
    propionic acid 2.46
    o-xylene 0.1
    formic acid 128.9
    diethyl ether 0.32
    m-xylene 0.08
    p-xylene 0.05
    chlorobenzene 0.09
    dimethyl carbonate 1.25
    n-octane 0.03
    formamide 69.11
    cyclopentanone 2.78
    2-pentanone 0.68
    anisole 0.13
    cyclopentyl methyl ether 0.79
    gamma-butyrolactone 4.3
    1-methoxy-2-propanol 5.86
    pyridine 1.6
    3-pentanone 0.49
    furfural 6.72
    n-dodecane 0.01
    diethylene glycol 7.71
    diisopropyl ether 0.05
    tert-amyl alcohol 0.26
    acetylacetone 1.26
    n-hexadecane 0.01
    acetophenone 0.33
    methyl propionate 0.93
    isopentyl acetate 0.12
    trichloroethylene 0.7
    n-nonanol 0.23
    cyclohexanol 0.64
    benzyl alcohol 0.5
    2-ethylhexanol 0.11
    isooctanol 0.18
    dipropyl ether 0.22
    1,2-dichlorobenzene 0.08
    ethyl lactate 0.69
    propylene carbonate 1.5
    n-methylformamide 8.74
    2-pentanol 0.33
    n-pentane 0.03
    1-propoxy-2-propanol 1.41
    1-methoxy-2-propyl acetate 0.74
    2-(2-methoxypropoxy) propanol 1.05
    mesitylene 0.04
    ε-caprolactone 1.77
    p-cymene 0.04
    epichlorohydrin 2.33
    1,1,1-trichloroethane 0.1
    2-aminoethanol 9.72
    morpholine-4-carbaldehyde 15.37
    sulfolane 13.46
    2,2,4-trimethylpentane 0.01
    2-methyltetrahydrofuran 0.91
    n-hexyl acetate 0.26
    isooctane 0.0
    2-(2-butoxyethoxy)ethanol 2.51
    sec-butyl acetate 0.1
    tert-butyl acetate 0.19
    decalin 0.01
    glycerin 28.33
    diglyme 4.23
    acrylic acid 5.67
    isopropyl myristate 0.07
    n-butyric acid 2.49
    acetyl acetate 0.59
    di(2-ethylhexyl) phthalate 0.16
    ethyl propionate 0.21
    nitromethane 15.22
    1,2-diethoxyethane 0.5
    benzonitrile 0.22
    trioctyl phosphate 0.15
    1-bromopropane 0.12
    gamma-valerolactone 10.73
    n-decanol 0.15
    triethyl phosphate 0.18
    4-methyl-2-pentanol 0.1
    propionitrile 0.23
    vinylene carbonate 1.6
    1,1,2-trichlorotrifluoroethane 10.42
    DMS 0.39
    cumene 0.03
    2-octanol 0.17
    2-hexanone 0.23
    octyl acetate 0.17
    limonene 0.07
    1,2-dimethoxyethane 2.08
    ethyl orthosilicate 0.15
    tributyl phosphate 0.12
    diacetone alcohol 1.02
    N,N-dimethylaniline 0.15
    acrylonitrile 0.58
    aniline 0.54
    1,3-propanediol 8.83
    bromobenzene 0.06
    dibromomethane 0.26
    1,1,2,2-tetrachloroethane 0.57
    2-methyl-cyclohexyl acetate 0.15
    tetrabutyl urea 0.26
    diisobutyl methanol 0.05
    2-phenylethanol 0.37
    styrene 0.05
    dioctyl adipate 0.17
    dimethyl sulfate 4.37
    ethyl butyrate 0.21
    methyl lactate 3.47
    butyl lactate 0.73
    diethyl carbonate 0.13
    propanediol butyl ether 2.91
    triethyl orthoformate 0.23
    p-tert-butyltoluene 0.04
    methyl 4-tert-butylbenzoate 0.55
    morpholine 3.84
    tert-butylamine 0.08
    n-dodecanol 0.09
    dimethoxymethane 3.35
    ethylene carbonate 1.03
    cyrene 3.14
    2-ethoxyethyl acetate 0.9
    2-ethylhexyl acetate 0.1
    1,2,4-trichlorobenzene 0.13
    4-methylpyridine 0.67
    dibutyl ether 0.12
    2,6-dimethyl-4-heptanol 0.05
    DEF 1.7
    dimethyl isosorbide 1.75
    tetrachloroethylene 0.62
    eugenol 0.78
    triacetin 0.67
    span 80 1.46
    1,4-butanediol 2.22
    1,1-dichloroethane 0.14
    2-methyl-1-pentanol 0.17
    methyl formate 5.45
    2-methyl-1-butanol 0.34
    n-decane 0.02
    butyronitrile 0.27
    3,7-dimethyl-1-octanol 0.07
    1-chlorooctane 0.06
    1-chlorotetradecane 0.02
    n-nonane 0.02
    undecane 0.02
    tert-butylcyclohexane 0.01
    cyclooctane 0.03
    cyclopentanol 1.06
    tetrahydropyran 0.79
    tert-amyl methyl ether 0.14
    2,5,8-trioxanonane 2.67
    1-hexene 0.04
    2-isopropoxyethanol 1.32
    2,2,2-trifluoroethanol 13.98
    methyl butyrate 0.33

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction