Naphazoline Hydrochloride

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  • Identifiers

    CAS number
    550-99-2

    Molecular formula
    C14H15ClN2

    SMILES
    C1CN=C(N1)CC2=CC=CC3=CC=CC=C32.Cl

    Safety labels

    Acute Toxic
    Acute Toxic

  • Odor profile

    Odorless 33.79%
    Animal 33.22%
    Nutty 28.37%
    Musty 27.78%
    Phenolic 26.62%
    Sweet 25.66%
    Honey 24.1%
    Bitter 24.06%
    Roasted 23.82%
    Fishy 22.62%

    Scent© AI

  • Properties

    Molecular weight
    246.73 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    479°C

    Melting point expt.

    • 255-260 °C

    Flash point est.
    136.3 ˚C

    Solubility expt.

    • >37 [ug/mL] (The mean of the results at pH 7.4)
    • Soluble in ethanol; slightly soluble in chlorform; insoluble in benzene and ether
    • In water, 4.0X10+5 mg/L at 25 °C

  • Synonyms

    • NAPHAZOLINE HYDROCHLORIDE
    • 550-99-2
    • NAPHAZOLINE HCL
    • Albalon
    • Opcon
    • Albalon Liquifilm
    • Naphcon
    • Rhinantin
    • Rhinoperd
    • Rinofug
    • Stricylon
    • Vasocon
    • Niazol
    • Clera hydrochloride
    • Naphazoline chloride
    • Coldan
    • Sanorin
    • Privine hydrochloride
    • Prizole hydrochloride
    • Naphcon forte
    • 2-(1-Naphthylmethyl)-2-imidazoline hydrochloride
    • Naphazoliniumchlorid
    • Naphazolini chloridum
    • Naphthasolium chloride
    • 2-(1-Naphthylmethyl)imidazoline hydrochloride
    • NAFAZAIR
    • HSDB 2174
    • Naphthylmethylimidazolinhydrochlorid
    • Naphazoline (hydrochloride)
    • EINECS 208-989-2
    • MFCD00012554
    • NSC 35711
    • NSC-35711
    • DTXSID7045788
    • UNII-MZ1131787D
    • 2-(1-Naphthylmethyl)-2-imidazoline monohydrochloride
    • MZ1131787D
    • 1H-Imidazole, 4,5-dihydro-2-(1-naphthalenylmethyl)-, monohydrochloride
    • 2-Imidazoline, 2-(1-naphthylmethyl)-, monohydrochloride
    • MLS000028434
    • CHEBI:7470
    • 2-(naphthalen-1-ylmethyl)-4,5-dihydro-1H-imidazole hydrochloride
    • DTXCID801011874
    • Naphazoline hydrochloride (Naphcon)
    • NSC35711
    • Naphazoline hydrochloride [USP:JAN]
    • SMR000058292
    • Vasoclear
    • 2-(naphthalen-1-ylmethyl)-4,5-dihydro-1H-imidazole;hydrochloride
    • Comfort Eye Drops
    • Degest-2
    • OPCON-A COMPONENT NAPHAZOLINE HYDROCHLORIDE
    • VISINE-A COMPONENT NAPHAZOLINE HYDROCHLORIDE
    • NAPHCON-A COMPONENT NAPHAZOLINE HYDROCHLORIDE
    • VASOCON-A COMPONENT NAPHAZOLINE HYDROCHLORIDE
    • Strictylon
    • 4,5-Dihydro-2-(1-naphthylmethyl)-1H-imidazole Hydrochloride
    • CHEMBL1706
    • Sanorin-Spofa
    • Naphazoline hydrochloride (USP:JAN)
    • Clear Eyes
    • NAPHAZOLINE HYDROCHLORIDE (MART.)
    • NAPHAZOLINE HYDROCHLORIDE [MART.]
    • NAPHAZOLINE HYDROCHLORIDE (USP-RS)
    • NAPHAZOLINE HYDROCHLORIDE [USP-RS]
    • Naphazoline hydrochloride [JAN]
    • NAPHAZOLINE HYDROCHLORIDE (EP IMPURITY)
    • NAPHAZOLINE HYDROCHLORIDE (EP MONOGRAPH)
    • NAPHAZOLINE HYDROCHLORIDE [EP IMPURITY]
    • NAPHAZOLINE HYDROCHLORIDE [EP MONOGRAPH]
    • NAPHAZOLINE HYDROCHLORIDE (USP MONOGRAPH)
    • NAPHAZOLINE HYDROCHLORIDE [USP MONOGRAPH]
    • CAS-550-99-2
    • Albacon
    • Nazal
    • SR-01000000067
    • Sato Clear
    • Pi Yuan Chin
    • Prestwick_507
    • Albalon (TN)
    • Vasocon (TN)
    • component of Nasocon
    • NAFASOLINA
    • Opera_ID_230
    • AC1LCWB1
    • Hydrochloride, Naphazoline
    • Naphazoline Monohydrochloride
    • SureCN1649580
    • SCHEMBL24153
    • MLS001148448
    • MLS002222217
    • Monohydrochloride, Naphazoline
    • NAPHAZOLINEHYDROCHLORIDE
    • SPECTRUM1500424
    • 2-Imidazoline, monohydrochloride
    • HY-B0446R
    • MolPort-000-703-064
    • HMS1568I13
    • HMS1920P11
    • Pharmakon1600-01500424
    • EX-A4103
    • HY-B0446
    • Tox21_111255
    • CCG-40122
    • NSC757110
    • s2519
    • NAPHAZOLINE HYDROCHLORIDE [MI]
    • AKOS015908797
    • Naphazoline hydrochloride (JP18/USP)
    • Tox21_111255_1
    • FD11448
    • Naphazoline (hydrochloride) (Standard)
    • NC00523
    • NSC-757110
    • NAPHAZOLINE HYDROCHLORIDE [HSDB]
    • NAPHAZOLINE HYDROCHLORIDE [VANDF]
    • NCGC00016506-07
    • NCGC00094732-01
    • NCGC00094732-02
    • NCGC00094732-03
    • NCGC00094732-04
    • AS-16861
    • NAPHAZOLINE HYDROCHLORIDE [WHO-DD]
    • WLN: L66J B1- BT5M CN BUTJ &GH
    • LT00114215
    • LT00233108
    • N0542
    • NS00076392

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 58.56
    methanol 300.72
    isopropanol 9.29
    water 70.79
    ethyl acetate 3.08
    n-propanol 29.96
    acetone 3.91
    n-butanol 14.47
    acetonitrile 4.59
    DMF 151.58
    toluene 0.2
    isobutanol 11.08
    1,4-dioxane 8.76
    methyl acetate 3.63
    THF 5.41
    2-butanone 2.53
    n-pentanol 13.18
    sec-butanol 5.64
    n-hexane 0.11
    ethylene glycol 389.12
    NMP 64.04
    cyclohexane 0.09
    DMSO 119.86
    n-butyl acetate 3.58
    n-octanol 3.27
    chloroform 13.78
    n-propyl acetate 4.32
    acetic acid 75.34
    dichloromethane 19.64
    cyclohexanone 6.81
    propylene glycol 60.93
    isopropyl acetate 1.63
    DMAc 100.42
    2-ethoxyethanol 75.2
    isopentanol 8.1
    n-heptane 0.16
    ethyl formate 11.34
    1,2-dichloroethane 9.4
    n-hexanol 6.99
    2-methoxyethanol 162.15
    isobutyl acetate 2.85
    tetrachloromethane 1.77
    n-pentyl acetate 3.68
    transcutol 71.78
    n-heptanol 6.36
    ethylbenzene 0.42
    MIBK 1.92
    2-propoxyethanol 43.72
    tert-butanol 4.54
    MTBE 0.65
    2-butoxyethanol 27.76
    propionic acid 24.44
    o-xylene 0.51
    formic acid 500.84
    diethyl ether 1.58
    m-xylene 0.55
    p-xylene 0.65
    chlorobenzene 1.09
    dimethyl carbonate 6.47
    n-octane 0.12
    formamide 456.22
    cyclopentanone 7.41
    2-pentanone 2.24
    anisole 2.09
    cyclopentyl methyl ether 2.2
    gamma-butyrolactone 17.46
    1-methoxy-2-propanol 41.59
    pyridine 6.35
    3-pentanone 1.96
    furfural 32.95
    n-dodecane 0.11
    diethylene glycol 109.44
    diisopropyl ether 0.35
    tert-amyl alcohol 3.72
    acetylacetone 4.12
    n-hexadecane 0.12
    acetophenone 5.1
    methyl propionate 5.8
    isopentyl acetate 3.52
    trichloroethylene 15.85
    n-nonanol 3.56
    cyclohexanol 4.11
    benzyl alcohol 8.81
    2-ethylhexanol 3.27
    isooctanol 4.81
    dipropyl ether 2.12
    1,2-dichlorobenzene 2.38
    ethyl lactate 11.24
    propylene carbonate 9.15
    n-methylformamide 136.19
    2-pentanol 3.07
    n-pentane 0.1
    1-propoxy-2-propanol 16.31
    1-methoxy-2-propyl acetate 7.22
    2-(2-methoxypropoxy) propanol 19.02
    mesitylene 0.45
    ε-caprolactone 9.63
    p-cymene 0.96
    epichlorohydrin 17.72
    1,1,1-trichloroethane 1.83
    2-aminoethanol 239.03
    morpholine-4-carbaldehyde 60.43
    sulfolane 35.09
    2,2,4-trimethylpentane 0.07
    2-methyltetrahydrofuran 2.25
    n-hexyl acetate 3.95
    isooctane 0.05
    2-(2-butoxyethoxy)ethanol 26.76
    sec-butyl acetate 1.91
    tert-butyl acetate 1.66
    decalin 0.11
    glycerin 190.39
    diglyme 44.82
    acrylic acid 40.68
    isopropyl myristate 1.66
    n-butyric acid 17.41
    acetyl acetate 2.82
    di(2-ethylhexyl) phthalate 5.65
    ethyl propionate 3.66
    nitromethane 67.35
    1,2-diethoxyethane 6.42
    benzonitrile 4.31
    trioctyl phosphate 3.64
    1-bromopropane 1.79
    gamma-valerolactone 28.85
    n-decanol 2.58
    triethyl phosphate 4.17
    4-methyl-2-pentanol 1.98
    propionitrile 4.65
    vinylene carbonate 13.4
    1,1,2-trichlorotrifluoroethane 71.28
    DMS 6.21
    cumene 0.68
    2-octanol 2.38
    2-hexanone 3.12
    octyl acetate 2.75
    limonene 0.98
    1,2-dimethoxyethane 35.08
    ethyl orthosilicate 3.79
    tributyl phosphate 4.03
    diacetone alcohol 7.37
    N,N-dimethylaniline 3.24
    acrylonitrile 12.14
    aniline 2.76
    1,3-propanediol 109.24
    bromobenzene 0.72
    dibromomethane 6.41
    1,1,2,2-tetrachloroethane 13.8
    2-methyl-cyclohexyl acetate 4.48
    tetrabutyl urea 6.45
    diisobutyl methanol 1.55
    2-phenylethanol 7.69
    styrene 0.43
    dioctyl adipate 4.26
    dimethyl sulfate 16.82
    ethyl butyrate 3.44
    methyl lactate 20.56
    butyl lactate 9.94
    diethyl carbonate 3.45
    propanediol butyl ether 23.21
    triethyl orthoformate 3.88
    p-tert-butyltoluene 0.8
    methyl 4-tert-butylbenzoate 9.5
    morpholine 18.54
    tert-butylamine 1.66
    n-dodecanol 1.86
    dimethoxymethane 30.0
    ethylene carbonate 9.64
    cyrene 24.65
    2-ethoxyethyl acetate 8.03
    2-ethylhexyl acetate 2.8
    1,2,4-trichlorobenzene 3.34
    4-methylpyridine 2.82
    dibutyl ether 1.57
    2,6-dimethyl-4-heptanol 1.55
    DEF 12.93
    dimethyl isosorbide 22.02
    tetrachloroethylene 15.29
    eugenol 18.25
    triacetin 8.68
    span 80 14.72
    1,4-butanediol 57.97
    1,1-dichloroethane 2.14
    2-methyl-1-pentanol 7.48
    methyl formate 52.57
    2-methyl-1-butanol 8.42
    n-decane 0.17
    butyronitrile 3.72
    3,7-dimethyl-1-octanol 2.71
    1-chlorooctane 0.75
    1-chlorotetradecane 0.37
    n-nonane 0.13
    undecane 0.14
    tert-butylcyclohexane 0.11
    cyclooctane 0.05
    cyclopentanol 5.87
    tetrahydropyran 2.08
    tert-amyl methyl ether 0.98
    2,5,8-trioxanonane 30.68
    1-hexene 0.53
    2-isopropoxyethanol 24.86
    2,2,2-trifluoroethanol 49.9
    methyl butyrate 5.58

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction