N-Methylpiperidine

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  • Identifiers

    CAS number
    626-67-5

    Molecular formula
    C6H13N

    SMILES
    CN1CCCCC1

    Safety labels

    Flammable
    Flammable

    Corrosive
    Corrosive

    Acute Toxic
    Acute Toxic

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Fishy 75.59%
    Cheesy 63.15%
    Animal 51.47%
    Ripe 43.43%
    Musty 29.12%
    Nutty 26.28%
    Oily 25.78%
    Sweet 25.44%
    Popcorn 23.21%
    Solvent 23.07%

     

    Flavor
    Sweet 44.07%
    Animal 36.97%
    Bitter 36.76%
    Floral 36.56%
    Spicy 28.19%
    Ammoniacal 27.98%
    Alkaline 27.19%
    Earthy 26.48%
    Amine 26.16%
    Shrimp 24.39%

     

    Odor impact est.
    High

  • Properties

    XLogP3-AA
    1.3

    pKa est.
    8.41 (weak base)

    Molecular weight
    99.17 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra fast

    Boiling point est.
    105°C

    Flash point

    • 2.8 ˚C est.

  • Synonyms

    • 1-Methylpiperidine
    • N-METHYLPIPERIDINE
    • 626-67-5
    • Piperidine, 1-methyl-
    • methylpiperidine
    • 1-Methyl-piperidine
    • LK 20
    • EINECS 210-959-9
    • piperidine, 1-methyl
    • AI3-25263
    • 617374QZN4
    • DTXSID8060822
    • UNII-617374QZN4
    • EC 210-959-9
    • UN 2399
    • N-methyl piperidine
    • UN2399
    • methylpiperdine
    • 1-methylpiperadine
    • N-methyl-piperidine
    • 1-methyl piperidine
    • MFCD00006491
    • N-Methylpiperidine, 99%
    • 1-Methylpiperidine, >=98%
    • CHEMBL281417
    • GTPL5522
    • SCHEMBL1220995
    • DTXCID0043420
    • STR03153
    • PDSP1_001476
    • PDSP2_001460
    • AKOS015950624
    • FM36440
    • DB-002021
    • M0403
    • NS00007867
    • 1-Methylpiperidine [UN2399] [Flammable liquid]
    • Q24004759

  • Applications

    N-Methylpiperidine (CAS 626-67-5) is a tertiary amine widely used as a chemical intermediate and building block for the synthesis of piperidine-containing compounds, including pharmaceuticals and agrochemicals. It functions as a non-nucleophilic base and reagent in organic synthesis, supporting processes such as acylations and condensations and serving as an acid scavenger in reaction media. It may be used as a solvent or reaction medium in certain specialized synthetic steps. In addition, it provides a starting point for preparing N-substituted piperidine derivatives and related heterocycles for pharmaceutical and specialty chemical applications.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 766.35
    methanol 761.47
    isopropanol 394.36
    water 4.99
    ethyl acetate 596.33
    n-propanol 615.37
    acetone 378.89
    n-butanol 609.42
    acetonitrile 423.49
    DMF 251.63
    toluene 225.25
    isobutanol 309.85
    1,4-dioxane 668.92
    methyl acetate 446.05
    THF 963.5
    2-butanone 433.12
    n-pentanol 295.15
    sec-butanol 371.95
    n-hexane 104.11
    ethylene glycol 133.74
    NMP 395.41
    cyclohexane 204.77
    DMSO 329.88
    n-butyl acetate 867.34
    n-octanol 133.79
    chloroform 2095.26
    n-propyl acetate 251.51
    acetic acid 948.88
    dichloromethane 1463.33
    cyclohexanone 575.7
    propylene glycol 172.71
    isopropyl acetate 246.24
    DMAc 206.07
    2-ethoxyethanol 340.89
    isopentanol 322.17
    n-heptane 176.61
    ethyl formate 463.46
    1,2-dichloroethane 636.4
    n-hexanol 563.49
    2-methoxyethanol 622.91
    isobutyl acetate 125.83
    tetrachloromethane 551.48
    n-pentyl acetate 241.91
    transcutol 859.03
    n-heptanol 181.76
    ethylbenzene 67.64
    MIBK 133.32
    2-propoxyethanol 713.67
    tert-butanol 306.68
    MTBE 259.33
    2-butoxyethanol 301.91
    propionic acid 604.15
    o-xylene 113.04
    formic acid 319.43
    diethyl ether 535.54
    m-xylene 108.46
    p-xylene 83.36
    chlorobenzene 363.04
    dimethyl carbonate 71.99
    n-octane 44.61
    formamide 273.91
    cyclopentanone 589.27
    2-pentanone 333.72
    anisole 125.68
    cyclopentyl methyl ether 418.49
    gamma-butyrolactone 830.18
    1-methoxy-2-propanol 348.41
    pyridine 667.33
    3-pentanone 272.33
    furfural 650.51
    n-dodecane 24.5
    diethylene glycol 420.53
    diisopropyl ether 98.64
    tert-amyl alcohol 263.36
    acetylacetone 246.31
    n-hexadecane 26.4
    acetophenone 108.9
    methyl propionate 299.94
    isopentyl acetate 439.24
    trichloroethylene 1161.2
    n-nonanol 125.08
    cyclohexanol 388.57
    benzyl alcohol 147.28
    2-ethylhexanol 332.81
    isooctanol 125.44
    dipropyl ether 458.2
    1,2-dichlorobenzene 270.9
    ethyl lactate 97.49
    propylene carbonate 443.11
    n-methylformamide 321.96
    2-pentanol 293.75
    n-pentane 151.61
    1-propoxy-2-propanol 554.49
    1-methoxy-2-propyl acetate 362.73
    2-(2-methoxypropoxy) propanol 172.11
    mesitylene 60.35
    ε-caprolactone 572.1
    p-cymene 111.05
    epichlorohydrin 695.53
    1,1,1-trichloroethane 774.99
    2-aminoethanol 302.06
    morpholine-4-carbaldehyde 401.35
    sulfolane 484.85
    2,2,4-trimethylpentane 47.32
    2-methyltetrahydrofuran 767.62
    n-hexyl acetate 238.33
    isooctane 28.9
    2-(2-butoxyethoxy)ethanol 275.92
    sec-butyl acetate 137.46
    tert-butyl acetate 176.01
    decalin 43.57
    glycerin 196.9
    diglyme 440.45
    acrylic acid 475.97
    isopropyl myristate 83.78
    n-butyric acid 867.06
    acetyl acetate 318.96
    di(2-ethylhexyl) phthalate 80.64
    ethyl propionate 193.25
    nitromethane 712.96
    1,2-diethoxyethane 499.15
    benzonitrile 260.71
    trioctyl phosphate 63.66
    1-bromopropane 609.28
    gamma-valerolactone 672.22
    n-decanol 93.83
    triethyl phosphate 121.18
    4-methyl-2-pentanol 116.89
    propionitrile 459.37
    vinylene carbonate 410.12
    1,1,2-trichlorotrifluoroethane 564.06
    DMS 128.12
    cumene 46.52
    2-octanol 100.37
    2-hexanone 206.01
    octyl acetate 121.33
    limonene 195.29
    1,2-dimethoxyethane 359.3
    ethyl orthosilicate 128.64
    tributyl phosphate 92.89
    diacetone alcohol 173.6
    N,N-dimethylaniline 68.68
    acrylonitrile 438.56
    aniline 352.18
    1,3-propanediol 408.61
    bromobenzene 349.09
    dibromomethane 1077.71
    1,1,2,2-tetrachloroethane 884.47
    2-methyl-cyclohexyl acetate 183.01
    tetrabutyl urea 95.53
    diisobutyl methanol 134.66
    2-phenylethanol 237.93
    styrene 101.34
    dioctyl adipate 109.45
    dimethyl sulfate 86.15
    ethyl butyrate 398.86
    methyl lactate 123.57
    butyl lactate 168.45
    diethyl carbonate 209.67
    propanediol butyl ether 165.59
    triethyl orthoformate 255.11
    p-tert-butyltoluene 100.91
    methyl 4-tert-butylbenzoate 114.8
    morpholine 767.06
    tert-butylamine 244.85
    n-dodecanol 73.67
    dimethoxymethane 209.36
    ethylene carbonate 353.7
    cyrene 107.49
    2-ethoxyethyl acetate 283.81
    2-ethylhexyl acetate 382.26
    1,2,4-trichlorobenzene 321.78
    4-methylpyridine 436.8
    dibutyl ether 246.06
    2,6-dimethyl-4-heptanol 134.66
    DEF 329.33
    dimethyl isosorbide 256.56
    tetrachloroethylene 749.56
    eugenol 116.05
    triacetin 165.66
    span 80 188.36
    1,4-butanediol 132.11
    1,1-dichloroethane 767.59
    2-methyl-1-pentanol 196.23
    methyl formate 220.15
    2-methyl-1-butanol 328.62
    n-decane 46.18
    butyronitrile 510.7
    3,7-dimethyl-1-octanol 148.39
    1-chlorooctane 120.1
    1-chlorotetradecane 45.74
    n-nonane 48.76
    undecane 32.2
    tert-butylcyclohexane 39.17
    cyclooctane 62.26
    cyclopentanol 407.94
    tetrahydropyran 812.22
    tert-amyl methyl ether 202.13
    2,5,8-trioxanonane 272.04
    1-hexene 231.25
    2-isopropoxyethanol 203.44
    2,2,2-trifluoroethanol 280.26
    methyl butyrate 246.44

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction