N-methylglutamic acid

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  • Identifiers

    CAS number
    6753-62-4

    Molecular formula
    C6H11NO4

    SMILES
    CNC(CCC(=O)O)C(=O)O

    Safety labels

  • Odor profile

    Fragrance
    Odorless 66.68%
    Savory 38.26%
    Meaty 33.44%
    Sweet 29.58%
    Milky 20.95%
    Cooked 20.8%
    Sour 19.2%
    Cheesy 18.76%
    Sulfurous 18.42%
    Buttery 17.84%

     

    Flavor
    Odorless 75.42%
    Mild 37.36%
    Very mild 31.01%
    Sour 28.81%
    Bland 28.43%
    Yeast 25.75%
    Faint 23.26%
    Acidic 22.85%
    Sweet-like 22.77%
    Stinky 20.18%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    -3.0

    pKa est.
    6.05 (neutral)

    Molecular weight
    161.16 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    340°C

    Flash point

    • 188.61 ˚C est.

  • Synonyms

    • DTXSID00986911
    • RefChem:1091951
    • DTXCID90942142
    • 6753-62-4
    • N-methylglutamic acid
    • N-Methyl-DL-glutamic acid
    • 2-(methylamino)pentanedioic acid
    • MFCD00037760
    • N-Me-DL-Glu-OH HCl
    • Glutamic acid, N-methyl-
    • 128724-80-1
    • N-Methyl-DL-Glu
    • DL-Glutamic acid, N-methyl-
    • 7-methylglutamic acid
    • N-Methylglutamic acid #
    • SCHEMBL180085
    • orb1944965
    • CHEMBL1160512
    • CHEBI:180974
    • NSC109187
    • AKOS015851053
    • CS-W016140
    • HY-W015424
    • AS-60927
    • SY398158
    • DB-010698
    • DB-013660
    • DB-014947
    • DB-055045
    • E78236
    • 795M792
    • F329854
    • L-Glutamic acid, N-methyl-, polymer with 1,2-ethanediamine (9CI)
    • 6753-62-4

  • Applications

    N-methylglutamic acid (CAS 6753-62-4) is primarily used as an intermediate and building block in organic synthesis, particularly for pharmaceutical and fine chemicals. It serves as a chiral building block for drug intermediates and peptidomimetics. It also can act as a precursor or component for specialty polymers and peptide-like materials. Additionally, it may function as a ligand or chelating agent in catalytic or coordination chemistry research. It is occasionally evaluated for cosmetic formulations as a hydrating amino acid derivative.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 12.62
    methanol 33.48
    isopropanol 5.72
    water 99.28
    ethyl acetate 3.59
    n-propanol 6.52
    acetone 6.59
    n-butanol 6.05
    acetonitrile 2.25
    DMF 306.63
    toluene 0.54
    isobutanol 4.47
    1,4-dioxane 36.8
    methyl acetate 2.52
    THF 28.36
    2-butanone 3.25
    n-pentanol 4.04
    sec-butanol 3.96
    n-hexane 0.54
    ethylene glycol 65.52
    NMP 443.85
    cyclohexane 0.75
    DMSO 297.28
    n-butyl acetate 2.5
    n-octanol 4.23
    chloroform 0.35
    n-propyl acetate 1.94
    acetic acid 47.46
    dichloromethane 1.22
    cyclohexanone 19.06
    propylene glycol 38.77
    isopropyl acetate 2.62
    DMAc 193.15
    2-ethoxyethanol 35.25
    isopentanol 4.73
    n-heptane 0.81
    ethyl formate 6.53
    1,2-dichloroethane 1.93
    n-hexanol 4.38
    2-methoxyethanol 102.04
    isobutyl acetate 0.95
    tetrachloromethane 0.18
    n-pentyl acetate 3.06
    transcutol 69.12
    n-heptanol 4.83
    ethylbenzene 0.65
    MIBK 2.77
    2-propoxyethanol 26.53
    tert-butanol 7.81
    MTBE 2.27
    2-butoxyethanol 21.33
    propionic acid 17.86
    o-xylene 1.56
    formic acid 203.46
    diethyl ether 2.47
    m-xylene 1.0
    p-xylene 1.0
    chlorobenzene 0.55
    dimethyl carbonate 7.29
    n-octane 0.42
    formamide 162.87
    cyclopentanone 25.41
    2-pentanone 4.27
    anisole 2.16
    cyclopentyl methyl ether 10.4
    gamma-butyrolactone 58.64
    1-methoxy-2-propanol 55.53
    pyridine 5.81
    3-pentanone 3.51
    furfural 55.45
    n-dodecane 0.27
    diethylene glycol 55.8
    diisopropyl ether 1.03
    tert-amyl alcohol 5.87
    acetylacetone 9.59
    n-hexadecane 0.29
    acetophenone 4.58
    methyl propionate 7.19
    isopentyl acetate 2.2
    trichloroethylene 1.72
    n-nonanol 4.25
    cyclohexanol 9.12
    benzyl alcohol 4.62
    2-ethylhexanol 2.62
    isooctanol 3.54
    dipropyl ether 3.26
    1,2-dichlorobenzene 1.0
    ethyl lactate 6.75
    propylene carbonate 17.63
    n-methylformamide 75.11
    2-pentanol 3.19
    n-pentane 0.45
    1-propoxy-2-propanol 14.42
    1-methoxy-2-propyl acetate 8.21
    2-(2-methoxypropoxy) propanol 23.33
    mesitylene 1.09
    ε-caprolactone 26.79
    p-cymene 1.15
    epichlorohydrin 20.93
    1,1,1-trichloroethane 0.33
    2-aminoethanol 59.26
    morpholine-4-carbaldehyde 251.89
    sulfolane 167.56
    2,2,4-trimethylpentane 0.29
    2-methyltetrahydrofuran 11.33
    n-hexyl acetate 4.81
    isooctane 0.17
    2-(2-butoxyethoxy)ethanol 38.1
    sec-butyl acetate 1.26
    tert-butyl acetate 3.62
    decalin 0.41
    glycerin 134.72
    diglyme 53.16
    acrylic acid 29.83
    isopropyl myristate 1.91
    n-butyric acid 15.06
    acetyl acetate 2.76
    di(2-ethylhexyl) phthalate 4.5
    ethyl propionate 2.97
    nitromethane 42.74
    1,2-diethoxyethane 5.93
    benzonitrile 2.5
    trioctyl phosphate 3.72
    1-bromopropane 0.62
    gamma-valerolactone 109.91
    n-decanol 3.34
    triethyl phosphate 3.25
    4-methyl-2-pentanol 2.05
    propionitrile 1.59
    vinylene carbonate 15.04
    1,1,2-trichlorotrifluoroethane 32.82
    DMS 6.19
    cumene 0.81
    2-octanol 2.69
    2-hexanone 2.06
    octyl acetate 3.15
    limonene 1.72
    1,2-dimethoxyethane 31.57
    ethyl orthosilicate 2.96
    tributyl phosphate 3.34
    diacetone alcohol 14.43
    N,N-dimethylaniline 4.22
    acrylonitrile 3.81
    aniline 2.75
    1,3-propanediol 47.27
    bromobenzene 0.36
    dibromomethane 0.6
    1,1,2,2-tetrachloroethane 2.08
    2-methyl-cyclohexyl acetate 3.31
    tetrabutyl urea 7.83
    diisobutyl methanol 1.89
    2-phenylethanol 4.27
    styrene 0.52
    dioctyl adipate 4.31
    dimethyl sulfate 32.3
    ethyl butyrate 2.81
    methyl lactate 24.46
    butyl lactate 8.09
    diethyl carbonate 1.84
    propanediol butyl ether 28.31
    triethyl orthoformate 3.47
    p-tert-butyltoluene 1.08
    methyl 4-tert-butylbenzoate 11.91
    morpholine 48.13
    tert-butylamine 2.8
    n-dodecanol 2.51
    dimethoxymethane 43.65
    ethylene carbonate 11.55
    cyrene 42.27
    2-ethoxyethyl acetate 6.55
    2-ethylhexyl acetate 1.85
    1,2,4-trichlorobenzene 1.5
    4-methylpyridine 5.07
    dibutyl ether 2.4
    2,6-dimethyl-4-heptanol 1.89
    DEF 32.88
    dimethyl isosorbide 31.85
    tetrachloroethylene 1.67
    eugenol 14.44
    triacetin 8.83
    span 80 23.15
    1,4-butanediol 19.25
    1,1-dichloroethane 0.43
    2-methyl-1-pentanol 3.36
    methyl formate 36.63
    2-methyl-1-butanol 4.68
    n-decane 0.43
    butyronitrile 2.2
    3,7-dimethyl-1-octanol 2.64
    1-chlorooctane 0.98
    1-chlorotetradecane 0.54
    n-nonane 0.42
    undecane 0.33
    tert-butylcyclohexane 0.3
    cyclooctane 0.52
    cyclopentanol 13.11
    tetrahydropyran 7.57
    tert-amyl methyl ether 3.11
    2,5,8-trioxanonane 45.63
    1-hexene 0.84
    2-isopropoxyethanol 13.71
    2,2,2-trifluoroethanol 24.2
    methyl butyrate 4.52

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction