N-Methylformamide

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  • Identifiers

    CAS number
    123-39-7

    Molecular formula
    C2H5NO

    SMILES
    CNC=O

    Safety labels

    Irritant
    Irritant

    Health Hazard
    Health

  • Odor profile

    Fragrance
    Pungent 49.99%
    Cheesy 46.36%
    Odorless 38.93%
    Fruity 32.42%
    Sharp 30.77%
    Sulfurous 25.79%
    Radish 25.26%
    Ripe 24.23%
    Green 24.14%
    Fishy 23.37%

     

    Flavor
    Pungent 63.19%
    Mustard 43.54%
    Garlic 27.04%
    Vinegar 26.19%
    Odorless 25.65%
    Formyl 24.59%
    Rancid 23.07%
    Sulfur 23.04%
    Soy 23.01%
    Ethereal 23.0%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    -1.0

    pKa est.
    6.0 (weak acid)

    Molecular weight
    59.07 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Moderately fast

    Melting point expt.

    • -40 °F (NTP, 1992)
    • -5.4 °C
    • -3.8 °C
    • -3 °C

    Boiling point

    • 356 to 365 °F at 760 mmHg (NTP, 1992)
    • 180-185 °C
    • 182.5 °C

    Flash point

    • 58.57 ˚C est.
    • 208 °F (NTP, 1992)
    • 98 °C
    • 98 °C c.c.

    Solubility expt.

    • greater than or equal to 100 mg/mL at 68 °F (NTP, 1992)
    • Very soluble in acetone, ethanol.
    • Miscible in water
    • 1000 mg/mL at 25 °C
    • Solubility in water: good
    • Water miscible
    • Ethanol miscible
    • Ether immiscible

  • Synonyms

    • N-METHYLFORMAMIDE
    • 123-39-7
    • Methylformamide
    • Formamide, N-methyl-
    • Monomethylformamide
    • n-methyl-Formamide
    • N-Formylmethylamine
    • N-Monomethylformamide
    • NSC 3051
    • EK 7011
    • HCONHCH3
    • Formamide, methyl-
    • Formic acid amide, N-methyl-
    • X 188
    • HSDB 100
    • EINECS 204-624-6
    • BRN 1098352
    • CHEBI:7438
    • methylimidoformic acid
    • XPE4G7Y986
    • AI3-26076
    • NSC3051
    • N-METHYL-FORMIC ACID-AMIDE
    • N-Methyl-formimidic acid
    • NSC-3051
    • NMF
    • (E)-methylimidoformic acid
    • (Z)-methylimidoformic acid
    • N-METHYLFORMAMIDE [MI]
    • DTXSID0025608
    • N-METHYLFORMAMIDE [HSDB]
    • EC 204-624-6
    • 4-04-00-00170 (Beilstein Handbook Reference)
    • N-Methylformamide, 99%
    • methanimidic acid, methyl-
    • N-Methyl formamide
    • formylmethylamine
    • UNII-XPE4G7Y986
    • NMethyl formamide
    • n-methylcarboxamide
    • N-methylmethanamide
    • Formamide, Nmethyl
    • Methylformamide; Monomethylformamide; N-Methylformimidic Acid; N-Monomethylformamide; NSC 3051
    • Formamide, N-methyl
    • MFCD00003280
    • N-methylformimidic acid
    • methyl-Methanimidic acid
    • n-methyl Formic acid amide
    • WLN: VHM1
    • Formic acid amide, Nmethyl
    • CHEMBL9240
    • Formamide, N-methyl- ( )
    • DTXCID905608
    • BBL027430
    • STL146549
    • AKOS000118787
    • SB85388
    • NCI60_002574
    • DB-046834
    • F0059
    • NS00006200
    • EN300-19419
    • A805066
    • Q138742
    • BRD-K33445938-001-01-8
    • F0001-0365
    • Z104473766
    • 204-624-6

  • Applications

    N-Methylformamide (CAS 123-39-7) is a polar aprotic amide solvent used as a general reaction medium in chemical synthesis. In industry, it serves as a processing solvent for polymers and resins, aiding polymerization and formulation for coatings and adhesives. It is also employed as a solvent in coatings, inks, and specialty formulations, and as a processing medium for electronics-related materials such as photoresists and related chemistries. Additionally, it can act as an intermediate or building block in the manufacture of specialty chemicals and pharmaceutical precursors, and may be used in R&D as a versatile solvent for organic reactions.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 165.39
    methanol 472.8
    isopropanol 58.88
    water 992.37
    ethyl acetate 8.63
    n-propanol 79.69
    acetone 27.43
    n-butanol 59.62
    acetonitrile 36.12
    DMF 209.96
    toluene 2.16
    isobutanol 50.57
    1,4-dioxane 24.76
    methyl acetate 17.76
    THF 27.8
    2-butanone 16.39
    n-pentanol 27.79
    sec-butanol 40.35
    n-hexane 1.09
    ethylene glycol 194.73
    NMP 169.36
    cyclohexane 1.44
    DMSO 141.68
    n-butyl acetate 9.14
    n-octanol 8.84
    chloroform 29.79
    n-propyl acetate 7.14
    acetic acid 557.38
    dichloromethane 34.05
    cyclohexanone 29.66
    propylene glycol 113.14
    isopropyl acetate 4.24
    DMAc 138.83
    2-ethoxyethanol 63.2
    isopentanol 31.67
    n-heptane 1.3
    ethyl formate 36.93
    1,2-dichloroethane 15.06
    n-hexanol 18.18
    2-methoxyethanol 164.06
    isobutyl acetate 4.17
    tetrachloromethane 7.88
    n-pentyl acetate 7.61
    transcutol 72.93
    n-heptanol 12.02
    ethylbenzene 1.61
    MIBK 5.2
    2-propoxyethanol 40.16
    tert-butanol 44.6
    MTBE 8.37
    2-butoxyethanol 31.83
    propionic acid 126.55
    o-xylene 3.24
    formic acid 920.06
    diethyl ether 6.1
    m-xylene 1.99
    p-xylene 3.11
    chlorobenzene 7.01
    dimethyl carbonate 8.5
    n-octane 0.6
    formamide 542.35
    cyclopentanone 38.4
    2-pentanone 9.12
    anisole 6.08
    cyclopentyl methyl ether 9.41
    gamma-butyrolactone 65.05
    1-methoxy-2-propanol 58.52
    pyridine 33.4
    3-pentanone 7.01
    furfural 108.51
    n-dodecane 0.47
    diethylene glycol 65.15
    diisopropyl ether 1.53
    tert-amyl alcohol 39.22
    acetylacetone 10.64
    n-hexadecane 0.47
    acetophenone 10.45
    methyl propionate 11.9
    isopentyl acetate 8.13
    trichloroethylene 38.05
    n-nonanol 7.28
    cyclohexanol 27.51
    benzyl alcohol 18.52
    2-ethylhexanol 8.76
    isooctanol 8.98
    dipropyl ether 4.95
    1,2-dichlorobenzene 8.03
    ethyl lactate 13.0
    propylene carbonate 32.49
    n-methylformamide 198.25
    2-pentanol 17.77
    n-pentane 1.46
    1-propoxy-2-propanol 22.36
    1-methoxy-2-propyl acetate 9.05
    2-(2-methoxypropoxy) propanol 24.07
    mesitylene 1.59
    ε-caprolactone 30.33
    p-cymene 2.69
    epichlorohydrin 38.86
    1,1,1-trichloroethane 8.63
    2-aminoethanol 206.89
    morpholine-4-carbaldehyde 102.31
    sulfolane 90.43
    2,2,4-trimethylpentane 1.2
    2-methyltetrahydrofuran 18.56
    n-hexyl acetate 9.41
    isooctane 0.55
    2-(2-butoxyethoxy)ethanol 31.5
    sec-butyl acetate 3.4
    tert-butyl acetate 4.5
    decalin 0.76
    glycerin 177.59
    diglyme 50.67
    acrylic acid 188.36
    isopropyl myristate 3.29
    n-butyric acid 89.22
    acetyl acetate 8.84
    di(2-ethylhexyl) phthalate 9.83
    ethyl propionate 5.29
    nitromethane 229.83
    1,2-diethoxyethane 8.96
    benzonitrile 17.86
    trioctyl phosphate 6.35
    1-bromopropane 6.22
    gamma-valerolactone 69.41
    n-decanol 5.29
    triethyl phosphate 6.09
    4-methyl-2-pentanol 8.0
    propionitrile 23.5
    vinylene carbonate 41.57
    1,1,2-trichlorotrifluoroethane 100.11
    DMS 8.92
    cumene 1.9
    2-octanol 6.22
    2-hexanone 6.73
    octyl acetate 5.71
    limonene 3.96
    1,2-dimethoxyethane 38.51
    ethyl orthosilicate 5.67
    tributyl phosphate 7.34
    diacetone alcohol 17.46
    N,N-dimethylaniline 7.31
    acrylonitrile 51.6
    aniline 17.16
    1,3-propanediol 170.46
    bromobenzene 4.02
    dibromomethane 16.18
    1,1,2,2-tetrachloroethane 26.49
    2-methyl-cyclohexyl acetate 7.46
    tetrabutyl urea 11.02
    diisobutyl methanol 4.46
    2-phenylethanol 12.7
    styrene 2.39
    dioctyl adipate 7.77
    dimethyl sulfate 22.9
    ethyl butyrate 7.24
    methyl lactate 26.45
    butyl lactate 15.96
    diethyl carbonate 5.84
    propanediol butyl ether 38.04
    triethyl orthoformate 6.61
    p-tert-butyltoluene 2.49
    methyl 4-tert-butylbenzoate 14.63
    morpholine 48.82
    tert-butylamine 21.66
    n-dodecanol 3.92
    dimethoxymethane 27.59
    ethylene carbonate 24.48
    cyrene 32.07
    2-ethoxyethyl acetate 11.01
    2-ethylhexyl acetate 6.14
    1,2,4-trichlorobenzene 11.37
    4-methylpyridine 22.73
    dibutyl ether 4.11
    2,6-dimethyl-4-heptanol 4.46
    DEF 30.41
    dimethyl isosorbide 28.79
    tetrachloroethylene 30.34
    eugenol 21.11
    triacetin 13.13
    span 80 25.06
    1,4-butanediol 68.85
    1,1-dichloroethane 10.29
    2-methyl-1-pentanol 20.19
    methyl formate 106.49
    2-methyl-1-butanol 38.66
    n-decane 0.68
    butyronitrile 22.63
    3,7-dimethyl-1-octanol 7.61
    1-chlorooctane 2.32
    1-chlorotetradecane 1.08
    n-nonane 0.67
    undecane 0.54
    tert-butylcyclohexane 0.84
    cyclooctane 0.49
    cyclopentanol 44.21
    tetrahydropyran 14.28
    tert-amyl methyl ether 7.43
    2,5,8-trioxanonane 37.12
    1-hexene 3.1
    2-isopropoxyethanol 25.56
    2,2,2-trifluoroethanol 214.61
    methyl butyrate 11.06

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction