N-Methyldiethanolamine

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  • Identifiers

    CAS number
    105-59-9

    Molecular formula
    C5H13NO2

    SMILES
    CN(CCO)CCO

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Fishy 55.62%
    Odorless 43.39%
    Sweet 41.0%
    Alcoholic 29.96%
    Oily 21.33%
    Ripe 20.69%
    Cheesy 20.25%
    Solvent 15.72%
    Savory 15.68%
    Cooling 15.11%

     

    Flavor
    Odorless 54.48%
    Sweet 31.28%
    Mild 28.15%
    Sulfurous 27.89%
    Sweet-like 25.78%
    Very slight 23.43%
    Fishy 23.06%
    Bitter 22.47%
    Cauliflower 21.43%
    Soup 21.41%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    -1.1

    pKa est.
    7.46 (neutral)

    Molecular weight
    119.16 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Slow

    Melting point expt.

    • -6 °F (NTP, 1992)
    • -21 °C

    Boiling point

    • 477 °F at 760 mmHg (NTP, 1992)
    • 245 °C
    • 247 °C

    Flash point

    • 126.88 ˚C est.
    • 260 °F (NTP, 1992)
    • 127 °C (261 °F) - closed cup
    • 260 °F (127 °C) (Open Cup)
    • 136 °C c.c.

    Solubility expt.

    • Very soluble (NTP, 1992)
    • In water, 1.0X10+6 mg/L, temp not specified (miscible)
    • Miscible with water
    • Very soluble in water
    • Miscible with benzene
    • Solubility in water, g/100ml at 25 °C: 100

  • Synonyms

    • N-METHYLDIETHANOLAMINE
    • 105-59-9
    • Bis(hydroxyethyl)methylamine
    • Methyldiethanolamine
    • Methyl diethanolamine
    • Ethanol, 2,2'-(methylimino)bis-
    • 2,2'-(Methylimino)diethanol
    • 591248-66-7
    • N-Methylaminodiglycol
    • N-Methyldiethanolimine
    • N-Methyliminodiethanol
    • 2,2'-Methyliminodiethanol
    • N-Methyl-2,2'-iminodiethanol
    • 2-[2-hydroxyethyl(methyl)amino]ethanol
    • USAF DO-52
    • N-methyl diethanolamine
    • N,N-Bis(2-hydroxyethyl)methylamine
    • Bis(2-hydroxyethyl)methylamine
    • Methylbis(2-hydroxyethyl)amine
    • Diethanolmethylamine
    • Methyliminodiethanol
    • Bis(2-hydroxyethyl) methyl amine
    • Ethanol, 2,2'-(methylimino)di-
    • NSC 11690
    • CCRIS 4843
    • N,N-Di(2-hydroxyethyl)-N-methylamine
    • 2-(N-2-Hydroxyethyl-N-methylamino)ethanol
    • EINECS 203-312-7
    • UNII-3IG3K131QJ
    • BRN 1734441
    • N-Methylimino-2,2'-diethanol
    • DTXSID8025591
    • HSDB 6804
    • n-methyl-diethanol amine
    • AMINO ALCOHOL MDA
    • NSC-11690
    • N-Methyl-2,2-iminodiethanol
    • 3IG3K131QJ
    • DTXCID605591
    • METHYLDIETHANOLAMINE, N-
    • 2-[(2-hydroxyethyl)(methyl)amino]ethan-1-ol
    • EC 203-312-7
    • 2-Hydroxy-1-[(2-hydroxyethyl)methylamino]-ethyl
    • 4-04-00-01517 (Beilstein Handbook Reference)
    • N-METHYLDIETHANOLAMINE [HSDB]
    • N-(2-Hydroxyethyl)-N-methylethanolam
    • n-methyl-n,n-bis(2-hydroxyethyl)amine
    • 2,2'-(METHYLIMINO)BIS(ETHANOL)
    • Ethanol,2'-(methylimino)di-
    • Ethanol,2'-(methylimino)bis-
    • WLN: Q2N1 & 2Q
    • N-methyl-diethanolamine
    • bis-(Hydroxyethyl)methylamine
    • methyldiethanolamin
    • MDEA amine
    • Mdea (diol)
    • NMethylaminodiglycol
    • Amietol M12
    • n-methyldiethanolamin
    • NMethyldiethanolimine
    • NMethyliminodiethanol
    • methyl diethanol amine
    • N-methyl diethanol-amine
    • 2,2'Methyliminodiethanol
    • di(hydroxyethyl)methylamine
    • NMethyl2,2'iminodiethanol
    • 2,2'(Methylimino)diethanol
    • SCHEMBL17605
    • 2,2`(Methylimino)bisethanol
    • Bis(2hydroxyethyl)methylamine
    • Methylbis(2hydroxyethyl)amine
    • N-Methyldiethanolamine, 99%
    • NMethylbis(2hydroxyethyl)amine
    • Ethanol, 2,2'(methylimino)di
    • Bis(2hydroxyethyl) methyl amine
    • 2,2`-(Methylimino)bis-ethanol
    • CHEMBL3185149
    • Ethanol, 2,2'(methylimino)bis
    • N-Methyldiethanolamine, >=99%
    • N,NBis(2hydroxyethyl)methylamine
    • N,NDi(2hydroxyethyl)Nmethylamine
    • N(2hydroxyethyl)Nmethylethanolamine
    • NSC11690
    • NSC49131
    • NSC51500
    • 2(N2HydroxyethylNmethylamino)ethanol
    • METHYL DIETHANOLAMINE [INCI]
    • Tox21_201199
    • MFCD00002848
    • NSC-49131
    • NSC-51500
    • STL281951
    • 2,2'-METHYLIMINODIETHANOLAMINE
    • AKOS009031354
    • N,N-bis-(2-hydroxyethyl)-methylamine
    • AT34020
    • FB18727
    • N-METHYLBIS(2-HYDROXYETHYL)AMINE
    • NCGC00248955-01
    • NCGC00258751-01
    • CAS-105-59-9
    • LS-13102
    • 2-[(2-hydroxy-ethyl)methyl-amino]-ethanol
    • DB-297071
    • M0505
    • NS00004394
    • N-(2-HYDROXYETHYL)-N-METHYLETHANOLAMINE
    • 2,2'-(METHYLAZANEDIYL)BIS(ETHAN-1-OL)
    • ethane, 1-hydroxy-2-(2-hydroxyethylmethyl)amino-
    • Q252344
    • ethane, 1-hydroxy-2-(2-hydroxyethyl-N-methyl)amino-
    • N-Methyldiethanolamine 1000 microg/mL in Ammonium Hydroxide

  • Applications

    N-Methyldiethanolamine (CAS 105-59-9) is widely used as a solvent and acid-gas absorber in gas treating, removing CO2 and H2S from natural gas and refinery gas; it serves as a key intermediate in the manufacture of surfactants and corrosion inhibitors for oilfield and industrial formulations; it functions as a solvent and processing aid in polymer and resin production, acting as a building block for epoxy and polyurethane systems; it also serves as a neutralizer and pH adjuster in industrial cleaners and coatings formulations; and can be used as a building block for specialty coatings and adhesive additives.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 48.32
    methanol 190.39
    isopropanol 10.87
    water 627.74
    ethyl acetate 2.75
    n-propanol 30.24
    acetone 1.46
    n-butanol 15.06
    acetonitrile 4.12
    DMF 37.74
    toluene 0.27
    isobutanol 11.48
    1,4-dioxane 14.79
    methyl acetate 4.05
    THF 12.9
    2-butanone 1.93
    n-pentanol 5.38
    sec-butanol 10.24
    n-hexane 0.21
    ethylene glycol 271.33
    NMP 105.01
    cyclohexane 0.81
    DMSO 56.67
    n-butyl acetate 2.89
    n-octanol 3.87
    chloroform 6.83
    n-propyl acetate 1.76
    acetic acid 211.03
    dichloromethane 8.71
    cyclohexanone 9.61
    propylene glycol 120.07
    isopropyl acetate 0.98
    DMAc 29.59
    2-ethoxyethanol 27.15
    isopentanol 4.45
    n-heptane 0.84
    ethyl formate 8.58
    1,2-dichloroethane 3.88
    n-hexanol 8.97
    2-methoxyethanol 95.82
    isobutyl acetate 1.04
    tetrachloromethane 3.02
    n-pentyl acetate 2.11
    transcutol 36.06
    n-heptanol 6.16
    ethylbenzene 0.27
    MIBK 0.53
    2-propoxyethanol 29.0
    tert-butanol 6.87
    MTBE 1.06
    2-butoxyethanol 17.84
    propionic acid 72.39
    o-xylene 0.65
    formic acid 575.53
    diethyl ether 1.3
    m-xylene 0.37
    p-xylene 0.41
    chlorobenzene 1.11
    dimethyl carbonate 2.14
    n-octane 0.28
    formamide 232.25
    cyclopentanone 11.42
    2-pentanone 0.99
    anisole 0.94
    cyclopentyl methyl ether 3.62
    gamma-butyrolactone 36.95
    1-methoxy-2-propanol 25.52
    pyridine 6.11
    3-pentanone 1.33
    furfural 46.25
    n-dodecane 0.22
    diethylene glycol 65.74
    diisopropyl ether 0.32
    tert-amyl alcohol 7.91
    acetylacetone 1.59
    n-hexadecane 0.24
    acetophenone 1.96
    methyl propionate 4.16
    isopentyl acetate 2.06
    trichloroethylene 7.01
    n-nonanol 3.5
    cyclohexanol 14.43
    benzyl alcohol 4.34
    2-ethylhexanol 4.08
    isooctanol 3.87
    dipropyl ether 2.21
    1,2-dichlorobenzene 2.16
    ethyl lactate 7.03
    propylene carbonate 16.15
    n-methylformamide 62.43
    2-pentanol 3.55
    n-pentane 0.33
    1-propoxy-2-propanol 14.57
    1-methoxy-2-propyl acetate 4.5
    2-(2-methoxypropoxy) propanol 13.24
    mesitylene 0.38
    ε-caprolactone 17.58
    p-cymene 1.14
    epichlorohydrin 12.65
    1,1,1-trichloroethane 1.77
    2-aminoethanol 215.78
    morpholine-4-carbaldehyde 69.47
    sulfolane 80.2
    2,2,4-trimethylpentane 0.3
    2-methyltetrahydrofuran 6.7
    n-hexyl acetate 3.23
    isooctane 0.12
    2-(2-butoxyethoxy)ethanol 17.99
    sec-butyl acetate 0.88
    tert-butyl acetate 1.03
    decalin 0.33
    glycerin 247.9
    diglyme 22.53
    acrylic acid 105.79
    isopropyl myristate 1.25
    n-butyric acid 31.83
    acetyl acetate 2.38
    di(2-ethylhexyl) phthalate 4.65
    ethyl propionate 1.82
    nitromethane 49.53
    1,2-diethoxyethane 2.66
    benzonitrile 3.02
    trioctyl phosphate 3.31
    1-bromopropane 1.23
    gamma-valerolactone 36.12
    n-decanol 2.57
    triethyl phosphate 3.84
    4-methyl-2-pentanol 1.24
    propionitrile 4.19
    vinylene carbonate 18.38
    1,1,2-trichlorotrifluoroethane 65.57
    DMS 4.28
    cumene 0.42
    2-octanol 2.36
    2-hexanone 0.86
    octyl acetate 2.22
    limonene 1.83
    1,2-dimethoxyethane 10.96
    ethyl orthosilicate 3.39
    tributyl phosphate 3.43
    diacetone alcohol 3.95
    N,N-dimethylaniline 1.45
    acrylonitrile 8.25
    aniline 3.18
    1,3-propanediol 116.39
    bromobenzene 0.65
    dibromomethane 4.03
    1,1,2,2-tetrachloroethane 7.53
    2-methyl-cyclohexyl acetate 3.69
    tetrabutyl urea 5.11
    diisobutyl methanol 1.84
    2-phenylethanol 5.42
    styrene 0.28
    dioctyl adipate 3.35
    dimethyl sulfate 8.34
    ethyl butyrate 2.51
    methyl lactate 14.53
    butyl lactate 7.38
    diethyl carbonate 2.29
    propanediol butyl ether 20.38
    triethyl orthoformate 3.32
    p-tert-butyltoluene 1.19
    methyl 4-tert-butylbenzoate 5.8
    morpholine 27.64
    tert-butylamine 3.11
    n-dodecanol 1.97
    dimethoxymethane 5.78
    ethylene carbonate 13.04
    cyrene 23.36
    2-ethoxyethyl acetate 3.5
    2-ethylhexyl acetate 2.0
    1,2,4-trichlorobenzene 3.44
    4-methylpyridine 2.47
    dibutyl ether 1.28
    2,6-dimethyl-4-heptanol 1.84
    DEF 7.39
    dimethyl isosorbide 18.88
    tetrachloroethylene 9.03
    eugenol 10.37
    triacetin 6.19
    span 80 19.17
    1,4-butanediol 36.67
    1,1-dichloroethane 1.4
    2-methyl-1-pentanol 2.75
    methyl formate 24.55
    2-methyl-1-butanol 7.6
    n-decane 0.32
    butyronitrile 3.02
    3,7-dimethyl-1-octanol 2.75
    1-chlorooctane 0.97
    1-chlorotetradecane 0.51
    n-nonane 0.3
    undecane 0.26
    tert-butylcyclohexane 0.26
    cyclooctane 0.31
    cyclopentanol 25.31
    tetrahydropyran 5.81
    tert-amyl methyl ether 1.39
    2,5,8-trioxanonane 20.16
    1-hexene 0.38
    2-isopropoxyethanol 8.99
    2,2,2-trifluoroethanol 101.62
    methyl butyrate 2.9

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction