N-Methylacetanilide

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  • Identifiers

    CAS number
    579-10-2

    Molecular formula
    C9H11NO

    SMILES
    CC(=O)N(C)C1=CC=CC=C1

    Safety labels

    Acute Toxic
    Acute Toxic

  • Odor profile

    Fragrance
    Floral 64.87%
    Grape 44.5%
    Fruity 41.48%
    Citrus 39.65%
    Grapefruit 38.01%
    Sweet 35.03%
    Fresh 32.23%
    Neroli 30.89%
    Woody 30.42%
    Honey 28.84%

     

    Flavor
    Fruity 52.52%
    Sweet 36.11%
    Floral 35.46%
    Musty 25.2%
    Tropical 23.47%
    Mild 23.14%
    Powdery 21.8%
    Grape 21.52%
    Honey 20.7%
    Orange flower 20.61%

     

    Odor impact est.
    Medium

  • Properties

    XLogP3-AA
    1.1

    pKa est.
    5.51 (weak acid)

    Molecular weight
    149.19 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Slow

    Boiling point est.
    247°C

    Flash point

    • 110.69 ˚C est.

  • Synonyms

    • N-Methylacetanilide
    • N-Methyl-N-phenylacetamide
    • 579-10-2
    • Methylazol
    • Methylantifebrin
    • Acetomethylanilide
    • Exalgin
    • Oxalgin
    • Acetamide, N-methyl-N-phenyl-
    • Phenylmethylacetamide
    • ACETANILIDE, N-METHYL-
    • N-Acetyl-methylaniline
    • N-Acetyl-N-methylaniline
    • NSC 2140
    • EINECS 209-436-8
    • MFCD00026181
    • BRN 2207686
    • 6MR085F8DW
    • AI3-05816
    • NSC-2140
    • N-methyl-N-phenyl-acetamide
    • METHYLACETANILIDE, N-
    • DTXSID8060373
    • N-METHYLACETANILIDE [MI]
    • UNII-6MR085F8DW
    • n-methyl-acetanilide
    • N-Acetylmethylaniline
    • aniline, N-acetyl-N-methyl-
    • SCHEMBL208445
    • WLN: 1VN1&R
    • CHEMBL481312
    • DTXCID7042279
    • NSC2140
    • AC9550
    • AKOS006229545
    • LS-13627
    • SY053096
    • CS-0155055
    • M0134
    • NS00005621
    • EN300-6769057
    • AD-266/40232951
    • Q27265173
    • Z31506242
    • InChI=1/C9H11NO/c1-8(11)10(2)9-6-4-3-5-7-9/h3-7H,1-2H
    • 209-436-8

  • Applications

    N-Methylacetanilide (CAS 579-10-2) is primarily used as an aromatic amide building block in organic synthesis. In industry, it is commonly employed as an intermediate for pharmaceutical compounds and for the preparation of dyes and pigments. It also serves as a starting material or modifier in polymer and plastics chemistry. In coatings and ink formulations, it can function as a processing intermediate or additive, supporting resin synthesis and formulation compatibility. Additionally, it is evaluated for use in various specialty chemical syntheses, including agrochemical or other aromatic amide applications, depending on regulatory constraints and formulation needs.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 519.71
    methanol 760.24
    isopropanol 371.73
    water 38.18
    ethyl acetate 202.68
    n-propanol 395.78
    acetone 275.71
    n-butanol 279.62
    acetonitrile 550.05
    DMF 674.47
    toluene 175.51
    isobutanol 279.1
    1,4-dioxane 542.01
    methyl acetate 291.18
    THF 358.52
    2-butanone 260.4
    n-pentanol 178.36
    sec-butanol 300.73
    n-hexane 23.43
    ethylene glycol 240.8
    NMP 511.43
    cyclohexane 49.58
    DMSO 529.66
    n-butyl acetate 97.22
    n-octanol 97.43
    chloroform 1310.79
    n-propyl acetate 94.94
    acetic acid 356.57
    dichloromethane 1352.17
    cyclohexanone 355.8
    propylene glycol 221.29
    isopropyl acetate 93.83
    DMAc 619.24
    2-ethoxyethanol 243.94
    isopentanol 173.45
    n-heptane 21.76
    ethyl formate 230.98
    1,2-dichloroethane 496.35
    n-hexanol 147.26
    2-methoxyethanol 461.57
    isobutyl acetate 62.21
    tetrachloromethane 176.54
    n-pentyl acetate 81.18
    transcutol 337.87
    n-heptanol 82.47
    ethylbenzene 101.51
    MIBK 95.68
    2-propoxyethanol 225.27
    tert-butanol 328.05
    MTBE 168.73
    2-butoxyethanol 134.38
    propionic acid 320.46
    o-xylene 136.64
    formic acid 254.06
    diethyl ether 200.15
    m-xylene 107.59
    p-xylene 131.51
    chlorobenzene 229.81
    dimethyl carbonate 107.0
    n-octane 13.09
    formamide 356.42
    cyclopentanone 343.66
    2-pentanone 160.43
    anisole 198.31
    cyclopentyl methyl ether 174.73
    gamma-butyrolactone 404.47
    1-methoxy-2-propanol 267.5
    pyridine 421.63
    3-pentanone 165.85
    furfural 443.68
    n-dodecane 13.14
    diethylene glycol 219.11
    diisopropyl ether 47.89
    tert-amyl alcohol 260.17
    acetylacetone 171.94
    n-hexadecane 14.55
    acetophenone 174.74
    methyl propionate 207.54
    isopentyl acetate 87.1
    trichloroethylene 845.84
    n-nonanol 82.49
    cyclohexanol 223.78
    benzyl alcohol 179.55
    2-ethylhexanol 86.62
    isooctanol 66.96
    dipropyl ether 86.59
    1,2-dichlorobenzene 219.47
    ethyl lactate 83.15
    propylene carbonate 242.67
    n-methylformamide 433.89
    2-pentanol 148.28
    n-pentane 27.31
    1-propoxy-2-propanol 137.63
    1-methoxy-2-propyl acetate 109.11
    2-(2-methoxypropoxy) propanol 129.06
    mesitylene 60.13
    ε-caprolactone 268.55
    p-cymene 56.63
    epichlorohydrin 485.8
    1,1,1-trichloroethane 442.33
    2-aminoethanol 349.64
    morpholine-4-carbaldehyde 471.77
    sulfolane 464.07
    2,2,4-trimethylpentane 17.01
    2-methyltetrahydrofuran 293.19
    n-hexyl acetate 126.38
    isooctane 9.6
    2-(2-butoxyethoxy)ethanol 163.46
    sec-butyl acetate 64.67
    tert-butyl acetate 93.15
    decalin 25.47
    glycerin 253.89
    diglyme 300.32
    acrylic acid 291.95
    isopropyl myristate 56.62
    n-butyric acid 269.27
    acetyl acetate 130.48
    di(2-ethylhexyl) phthalate 67.18
    ethyl propionate 107.06
    nitromethane 502.17
    1,2-diethoxyethane 128.22
    benzonitrile 239.09
    trioctyl phosphate 47.19
    1-bromopropane 279.59
    gamma-valerolactone 439.09
    n-decanol 64.19
    triethyl phosphate 70.06
    4-methyl-2-pentanol 71.99
    propionitrile 372.53
    vinylene carbonate 284.72
    1,1,2-trichlorotrifluoroethane 347.87
    DMS 121.8
    cumene 72.65
    2-octanol 61.5
    2-hexanone 112.0
    octyl acetate 75.69
    limonene 75.45
    1,2-dimethoxyethane 338.98
    ethyl orthosilicate 64.82
    tributyl phosphate 54.72
    diacetone alcohol 134.72
    N,N-dimethylaniline 146.56
    acrylonitrile 451.98
    aniline 229.92
    1,3-propanediol 311.82
    bromobenzene 231.24
    dibromomethane 770.43
    1,1,2,2-tetrachloroethane 621.87
    2-methyl-cyclohexyl acetate 89.64
    tetrabutyl urea 78.78
    diisobutyl methanol 50.33
    2-phenylethanol 139.39
    styrene 125.63
    dioctyl adipate 81.77
    dimethyl sulfate 177.03
    ethyl butyrate 100.48
    methyl lactate 131.77
    butyl lactate 77.55
    diethyl carbonate 88.93
    propanediol butyl ether 122.73
    triethyl orthoformate 74.08
    p-tert-butyltoluene 52.42
    methyl 4-tert-butylbenzoate 137.22
    morpholine 520.72
    tert-butylamine 209.66
    n-dodecanol 51.31
    dimethoxymethane 282.87
    ethylene carbonate 221.3
    cyrene 150.13
    2-ethoxyethyl acetate 113.41
    2-ethylhexyl acetate 69.69
    1,2,4-trichlorobenzene 245.23
    4-methylpyridine 378.22
    dibutyl ether 88.54
    2,6-dimethyl-4-heptanol 50.33
    DEF 270.17
    dimethyl isosorbide 205.13
    tetrachloroethylene 402.73
    eugenol 145.89
    triacetin 127.5
    span 80 113.62
    1,4-butanediol 150.63
    1,1-dichloroethane 533.79
    2-methyl-1-pentanol 145.87
    methyl formate 305.33
    2-methyl-1-butanol 204.13
    n-decane 19.4
    butyronitrile 307.42
    3,7-dimethyl-1-octanol 80.73
    1-chlorooctane 67.87
    1-chlorotetradecane 31.27
    n-nonane 18.93
    undecane 15.72
    tert-butylcyclohexane 23.28
    cyclooctane 13.63
    cyclopentanol 272.89
    tetrahydropyran 330.24
    tert-amyl methyl ether 136.39
    2,5,8-trioxanonane 223.04
    1-hexene 87.33
    2-isopropoxyethanol 149.65
    2,2,2-trifluoroethanol 176.13
    methyl butyrate 148.3

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction