N-isopropyl-N'-phenyl-p-phenylenediamine

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  • Identifiers

    CAS number
    101-72-4

    Molecular formula
    C15H18N2

    SMILES
    CC(C)NC1=CC=C(C=C1)NC2=CC=CC=C2

    Safety labels

    Irritant
    Irritant

    Environmental Hazard
    Environmental

  • Odor profile

    Fragrance
    Animal 39.27%
    Cheesy 33.53%
    Meaty 32.81%
    Floral 32.34%
    Grape 30.98%
    Fruity 30.97%
    Ripe 29.93%
    Burnt 29.63%
    Fishy 28.18%
    Roasted 27.36%

     

    Flavor
    Mild 28.05%
    Green 24.27%
    Floral 22.87%
    Meaty 21.78%
    Fruity 20.88%
    Bitter 20.22%
    Nitrile 19.76%
    Creosote 19.37%
    Very strong 19.24%
    Green pepper 19.22%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    4.0

    pKa est.
    5.85 (weak acid)

    Molecular weight
    226.32 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Melting point expt.

    • 162 to 169 °F (NTP, 1992)
    • 75 °C
    • 72-76 °C

    Boiling point

    • 322 °F at 1 mmHg (NTP, 1992)

    Flash point

    • 197.44 ˚C est.
    • 303 °F (NTP, 1992)

    Solubility expt.

    • less than 1 mg/mL at 64 °F (NTP, 1992)
    • Soluble in benzene and gasoline; insoluble in water.
    • Insoluble water; soluble in aromatic solvents
    • Solubility in water: none

  • Synonyms

    • 101-72-4
    • N-Isopropyl-N'-phenyl-p-phenylenediamine
    • IPPD
    • N-isopropyl-N'-phenyl-1,4-phenylenediamine
    • Cyzone
    • N1-Isopropyl-N4-phenylbenzene-1,4-diamine
    • 4-Anilino-N-isopropylaniline
    • 4-Isopropylaminodiphenylamine
    • Antigen 3c
    • Nonox ZA
    • Antioxidant 4010NA
    • Antioxidant IP
    • Santoflex IP
    • 4-(ISOPROPYLAMINO)DIPHENYLAMINE
    • Diaphen FP
    • Cyzone IP
    • Diafen FP
    • Orflex PP
    • Antigene 3C
    • Flexzone 3C
    • Elastozone 34
    • 1,4-Benzenediamine, N-(1-methylethyl)-N'-phenyl-
    • Santoflex 36
    • Antioxidant 40NA
    • Ozonon 3C
    • Ipognox 44
    • Permanax 115
    • Nocrack 810NA
    • N-isopropyl-N'-phenylbenzene-1,4-diamine
    • Antioxidant 4010 NA
    • Nocrac 810NA
    • S-IP
    • ASM 4010MA
    • N-(1-Methylethyl)-N'-phenyl-1,4-benzenediamine
    • 4010 NA
    • NCI-C56304
    • N-2-Propyl-N'-phenyl-p-phenylenediamine
    • 4010NA
    • p-Phenylenediamine, N-isopropyl-N'-phenyl-
    • N-Phenyl-N'-isopropyl-p-phenylenediamine
    • N-Fenyl-N'-isopropyl-p-fenylendiamin
    • N-Isopropyl-N'-fenyl-p-fenylendiamin
    • N-Phenyl-N'-isopropyl-1,4-phenylenediamine
    • NSC 41029
    • para-Isopropylaminodiphenylamine
    • CCRIS 4833
    • Akrochem antioxidant pd1
    • NA 4010
    • CHEBI:63569
    • HSDB 5342
    • Santoflex IPPD
    • Dusantox IPPD
    • Permanax IPPD
    • Permanex IPPD
    • N-Isopropyl-N'-phenyl-para-phenylenediamine
    • EINECS 202-969-7
    • 1-N-phenyl-4-N-propan-2-ylbenzene-1,4-diamine
    • BRN 2213195
    • Vulkanox 4010NA
    • DTXSID1025485
    • 0M7PSL4100
    • N-Fenyl-N'-isopropyl-p-fenylendiamin [Czech]
    • N-Isopropyl-N'-fenyl-p-fenylendiamin [Czech]
    • NSC-41029
    • N-Isopropyl-N'-phenyl-4-phenylenediamine
    • p-(Isopropylamino)diphenylamine
    • DTXCID705485
    • EC 202-969-7
    • 1,4-Benzenediamine, N1-(1-methylethyl)-N4-phenyl-
    • NCGC00091826-01
    • p-Phenylenediamine, N-isopropyl-N'-phenyl
    • 4-(ISOPROPYLAMINO)DIPHENYLAMINE [HSDB]
    • N-ISOPROPYL-N'-PHENYL PARAPHENYLENEDIAMINE
    • N1-phenyl-N4-(propan-2-yl)benzene-1,4-diamine
    • CAS-101-72-4
    • SMR000826283
    • N-Fenyl-N'-isopropyl-p-fenylendiamin (czech)
    • N-ISOPROPYL-N'-FENYL-P-FENYLENDIAMIN (CZECH)
    • UNII-0M7PSL4100
    • Flexizone GH
    • Black rubber mix
    • Flexone 3c
    • lsopropyl 0 PPD
    • Anto H
    • Vanox 3C
    • Phenylcyclohexyl PPD
    • ACCINOX ZA
    • DIAFEN PP
    • AO-CD
    • 4AnilinoNisopropylaniline
    • Enamine_001818
    • NAUGARD I 4
    • ANTO "H
    • WLN: 1YMR DMR
    • N-Isopropyl-N/'-phenyl-1,4-phenylenediamine
    • 4Isopropylaminodiphenylamine
    • Epitope ID:161749
    • VULKANOX 4020NA
    • N,N`Diphenylpphenylenediamine
    • Oprea1_357975
    • SCHEMBL38820
    • VULKANOX 4010 NA
    • paraIsopropylaminodiphenylamine
    • 4-isopropylamino-diphenylamine
    • MLS002152911
    • MLS006011580
    • 4(Isopropylamino)diphenylamine
    • NFenylN'isopropylpfenylendiamin
    • NIsopropylN'fenylpfenylendiamin
    • Benzenediamine, N-(1-methylethyl)-N'-phenyl-, 1,4-
    • SCHEMBL8585221
    • CHEMBL1449018
    • N2PropylN'phenylpphenylenediamine
    • OUBMGJOQLXMSNT-UHFFFAOYSA-
    • NIsopropylNphenyl4phenylenediamine
    • NPhenylN'isopropylpphenylenediamine
    • 810NA
    • HMS1399C14
    • HMS3016N21
    • NCI C56304
    • NIsopropylN'phenyl4phenylenediamine
    • NPhenylN`cyclohexylpphenylenediamine
    • ALBB-024373
    • NSC41029
    • Tox21_111169
    • Tox21_201424
    • Tox21_303202
    • 1, N-(1-methylethyl)-N'-phenyl-

  • Applications

    N-isopropyl-N'-phenyl-p-phenylenediamine (CAS 101-72-4) is primarily used as an antioxidant and processing stabilizer for rubber and various plastics, helping to inhibit thermo-oxidative degradation and ozone cracking during compounding, extrusion, and molding. It is also employed as a stabilizer in coatings, inks, and adhesive formulations to extend service life under environmental and processing conditions. As a diarylamine with aryl substituents, it can serve as a dye intermediate or pigment precursor in colorant chemistry and may be considered in cosmetic color systems under controlled conditions. In polymer systems such as polyolefins and polyurethanes, it can function as a stabilizing additive to improve long-term material durability. Its use is subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 72.76
    methanol 68.3
    isopropanol 46.54
    water 0.06
    ethyl acetate 238.02
    n-propanol 76.47
    acetone 610.03
    n-butanol 77.7
    acetonitrile 111.04
    DMF 552.79
    toluene 62.94
    isobutanol 52.72
    1,4-dioxane 291.61
    methyl acetate 231.25
    THF 985.79
    2-butanone 382.0
    n-pentanol 76.15
    sec-butanol 56.44
    n-hexane 18.11
    ethylene glycol 19.9
    NMP 452.9
    cyclohexane 12.51
    DMSO 897.18
    n-butyl acetate 193.31
    n-octanol 42.75
    chloroform 467.49
    n-propyl acetate 139.15
    acetic acid 116.02
    dichloromethane 415.39
    cyclohexanone 360.03
    propylene glycol 46.77
    isopropyl acetate 127.95
    DMAc 717.44
    2-ethoxyethanol 143.73
    isopentanol 67.6
    n-heptane 12.43
    ethyl formate 100.7
    1,2-dichloroethane 336.48
    n-hexanol 89.91
    2-methoxyethanol 188.27
    isobutyl acetate 111.65
    tetrachloromethane 39.41
    n-pentyl acetate 78.68
    transcutol 581.05
    n-heptanol 39.28
    ethylbenzene 34.85
    MIBK 128.84
    2-propoxyethanol 211.4
    tert-butanol 68.85
    MTBE 157.22
    2-butoxyethanol 94.76
    propionic acid 95.78
    o-xylene 37.76
    formic acid 23.11
    diethyl ether 190.1
    m-xylene 39.41
    p-xylene 50.56
    chlorobenzene 122.96
    dimethyl carbonate 138.53
    n-octane 5.19
    formamide 44.02
    cyclopentanone 775.18
    2-pentanone 282.44
    anisole 122.26
    cyclopentyl methyl ether 282.64
    gamma-butyrolactone 619.0
    1-methoxy-2-propanol 170.62
    pyridine 232.43
    3-pentanone 254.87
    furfural 323.22
    n-dodecane 4.73
    diethylene glycol 121.04
    diisopropyl ether 48.89
    tert-amyl alcohol 69.13
    acetylacetone 347.83
    n-hexadecane 5.48
    acetophenone 117.85
    methyl propionate 245.73
    isopentyl acetate 150.33
    trichloroethylene 577.05
    n-nonanol 41.97
    cyclohexanol 69.18
    benzyl alcohol 80.77
    2-ethylhexanol 67.55
    isooctanol 33.45
    dipropyl ether 144.92
    1,2-dichlorobenzene 108.6
    ethyl lactate 76.94
    propylene carbonate 240.33
    n-methylformamide 131.44
    2-pentanol 51.64
    n-pentane 8.06
    1-propoxy-2-propanol 164.77
    1-methoxy-2-propyl acetate 204.43
    2-(2-methoxypropoxy) propanol 111.94
    mesitylene 23.97
    ε-caprolactone 231.07
    p-cymene 31.45
    epichlorohydrin 583.99
    1,1,1-trichloroethane 227.3
    2-aminoethanol 44.21
    morpholine-4-carbaldehyde 337.47
    sulfolane 741.05
    2,2,4-trimethylpentane 7.43
    2-methyltetrahydrofuran 395.09
    n-hexyl acetate 124.33
    isooctane 5.05
    2-(2-butoxyethoxy)ethanol 157.67
    sec-butyl acetate 92.6
    tert-butyl acetate 139.84
    decalin 11.09
    glycerin 68.53
    diglyme 308.06
    acrylic acid 88.11
    isopropyl myristate 50.83
    n-butyric acid 134.92
    acetyl acetate 148.24
    di(2-ethylhexyl) phthalate 53.19
    ethyl propionate 128.03
    nitromethane 306.23
    1,2-diethoxyethane 209.7
    benzonitrile 86.86
    trioctyl phosphate 37.47
    1-bromopropane 156.65
    gamma-valerolactone 491.91
    n-decanol 33.14
    triethyl phosphate 68.37
    4-methyl-2-pentanol 37.15
    propionitrile 94.26
    vinylene carbonate 167.57
    1,1,2-trichlorotrifluoroethane 305.76
    DMS 132.72
    cumene 28.6
    2-octanol 25.85
    2-hexanone 165.11
    octyl acetate 67.11
    limonene 48.54
    1,2-dimethoxyethane 277.24
    ethyl orthosilicate 65.27
    tributyl phosphate 52.59
    diacetone alcohol 146.04
    N,N-dimethylaniline 75.51
    acrylonitrile 112.44
    aniline 95.93
    1,3-propanediol 59.47
    bromobenzene 128.84
    dibromomethane 248.22
    1,1,2,2-tetrachloroethane 488.73
    2-methyl-cyclohexyl acetate 103.18
    tetrabutyl urea 66.72
    diisobutyl methanol 37.46
    2-phenylethanol 85.99
    styrene 50.4
    dioctyl adipate 79.0
    dimethyl sulfate 258.66
    ethyl butyrate 128.55
    methyl lactate 114.39
    butyl lactate 72.03
    diethyl carbonate 88.76
    propanediol butyl ether 85.67
    triethyl orthoformate 99.68
    p-tert-butyltoluene 31.51
    methyl 4-tert-butylbenzoate 92.47
    morpholine 330.94
    tert-butylamine 40.69
    n-dodecanol 26.91
    dimethoxymethane 384.65
    ethylene carbonate 148.71
    cyrene 125.48
    2-ethoxyethyl acetate 137.19
    2-ethylhexyl acetate 123.34
    1,2,4-trichlorobenzene 140.69
    4-methylpyridine 193.4
    dibutyl ether 97.57
    2,6-dimethyl-4-heptanol 37.46
    DEF 256.87
    dimethyl isosorbide 210.47
    tetrachloroethylene 229.81
    eugenol 84.1
    triacetin 131.69
    span 80 91.88
    1,4-butanediol 36.48
    1,1-dichloroethane 254.64
    2-methyl-1-pentanol 72.44
    methyl formate 123.22
    2-methyl-1-butanol 68.92
    n-decane 8.34
    butyronitrile 103.58
    3,7-dimethyl-1-octanol 48.81
    1-chlorooctane 40.45
    1-chlorotetradecane 16.63
    n-nonane 7.94
    undecane 6.06
    tert-butylcyclohexane 11.19
    cyclooctane 5.33
    cyclopentanol 105.31
    tetrahydropyran 314.2
    tert-amyl methyl ether 117.68
    2,5,8-trioxanonane 205.37
    1-hexene 72.64
    2-isopropoxyethanol 113.19
    2,2,2-trifluoroethanol 43.07
    methyl butyrate 158.35

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction