N-Ethyl-p-toluenesulfonamide

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  • Identifiers

    CAS number
    1321-55-7

    Molecular formula
    C9H13NO2S

    SMILES
    CCNS(=O)(=O)C1=CC=C(C=C1)C

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Odorless 59.85%
    Cooked 29.21%
    Savory 27.9%
    Roasted 27.38%
    Meaty 27.22%
    Sulfurous 26.18%
    Pungent 21.34%
    Burnt 18.05%
    Bitter 17.83%
    Onion 17.81%

     

    Flavor
    Bitter 67.37%
    Odorless 26.03%
    Nitrile 21.49%
    Mild 21.13%
    Taco 19.51%
    Roasted peanuts 19.22%
    Gooseberry 19.18%
    Bread crust 19.16%
    Very strong 19.07%
    Cedarleaf 19.0%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    1.6

    pKa est.
    9.04 (weak base)

    Molecular weight
    199.27 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    340°C

    Melting point expt.

    • 147 °F (NTP, 1992)

    Flash point

    • 182.09 ˚C est.

    Solubility expt.

    • less than 1 mg/mL at 70 °F (NTP, 1992)

  • Synonyms

    • N-ETHYL-P-TOLUENESULFONAMIDE
    • N-Ethyl-4-methylbenzenesulfonamide
    • N-Ethyl-p-tolylsulfonamide
    • Benzenesulfonamide, N-ethyl-4-methyl-
    • N-Ethyl-4-toluenesulfonamide
    • Ethyl tosylamide
    • p-Tolueneethylsulfonamide
    • ethyl-p-toluenesulfonamide
    • N-Ethyltoluene-4-sulphonamide
    • NSC 68803
    • CCRIS 6037
    • N-Ethyl-4-methyl benzenesulfonamide
    • EINECS 201-275-1
    • DTXSID5025310
    • 992S798SJB
    • NSC-68803
    • DTXCID405310
    • 4-Toluenesulfonamide, N-ethyl-
    • ETHYL P-TOLUENESULFONAMIDE
    • OHPZPBNDOVQJMH-UHFFFAOYSA-
    • NTosylethylamine
    • NEthylptolylsulfonamide
    • pTolueneethylsulfonamide
    • pTolueneNethylsulfonamide
    • pToluene ethylsulfonamide
    • NEthyl4toluenesulfonamide
    • NEthyltoluene4sulphonamide
    • p-toluene ethylsulfonamide
    • RefChem:829978
    • Ethyl tosylamide [INCI]
    • N-ethyl toluenesulfonamide
    • pToluenesulfonylNethylamide
    • pToluenesulfonamide, Nethyl
    • 4Toluenesulfonamide, Nethyl
    • NEthylpmethylbenzenesulfonamide
    • NEthyl4methylbenzenesulfonamide
    • NEthyl4methyl benzenesulfonamide
    • NEthyl4methylbenzene sulfonamide
    • X3491OQT7S
    • Benzenesulfonamide, Nethyl4methyl
    • pToluenesulfonamide, Nethyl (8CI)
    • P-TOLUNESULFONAMIDE, N-ETHYL-
    • N-ETHYL-4-METHYLBENZENE SULFONAMIDE
    • 1321-55-7
    • 904-696-5
    • InChI=1/C9H13NO2S/c1-3-10-13(11,12)9-6-4-8(2)5-7-9/h4-7,10H,3H2,1-2H3
    • 80-39-7
    • Santicizer 3
    • N-Tosylethylamine
    • p-Toluenesulfonamide, N-ethyl-
    • N-Ethyl-p-methylbenzenesulfonamide
    • 1321-54-6
    • p-Toluenesulfonyl-N-ethylamide
    • N-ethyl-4-methylbenzene-1-sulfonamide
    • MFCD00048511
    • n-ethyl-p-toluene sulfonamide
    • N-PTSA
    • N-Ethyl-4-methyl-benzenesulfonamide
    • N-?Ethyl-?p-?toluenesulfonamide
    • UNII-992S798SJB
    • Unipex 108
    • Ethyl toluenesulfonamide
    • Brinzolamide Impurity 26
    • n-ethyl-p-toluensulfonamid
    • NCIOpen2_000527
    • N-ethyl-4-toluene sulfonamide
    • SCHEMBL126985
    • orb3031106
    • SCHEMBL5527861
    • SCHEMBL5886057
    • SCHEMBL8351001
    • CHEMBL1492809
    • HMS1661F02
    • n-ethyl-4-methyl-benzenesulfonamid
    • N-Ethyl-p-toluenesulfonamide, 98%
    • NSC68803
    • P-TOLUENE-N-ETHYLSULFONAMIDE
    • Tox21_200366
    • ethyl[(4-methylphenyl)sulfonyl]amine
    • MSK161676
    • STK416319
    • N-ETHYL P-TOLUENE SULPHONAMIDE
    • N-ethyl(4-methyl phenyl) sulfonamide
    • AKOS000431178
    • MSK161676-100M
    • CAS-80-39-7
    • NCGC00091206-01
    • NCGC00091206-02
    • NCGC00257920-01
    • AS-14234
    • FE172189
    • SY052260
    • DB-056430
    • DB-371542
    • CS-0151957
    • E0674
    • NS00010912
    • ST50915634
    • EN300-15862
    • F435725
    • W-104236
    • Q27272165
    • Z45528338
    • N-Ethyl-p-toluenesulfonamide Solution in Methanol, 100ug/mL
    • N-Ethyl-4-methylbenzenesulfonamide 100 microg/mL in Acetonitrile
    • 80-39-7

  • Applications

    Primarily, N-Ethyl-p-toluenesulfonamide is used as an intermediate in organic synthesis, enabling the preparation of sulfonamide-based specialty chemicals. It may function as a solvent or co-solvent in certain reaction systems. In polymer and plastic processing, it can serve as a processing aid or as a precursor for sulfonamide-containing formulations. It is also encountered as a building block in coatings and inks, contributing to the synthesis of functional additives or intermediate compounds. Use is typically governed by formulation goals and subject to local regulations and limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 188.92
    methanol 255.6
    isopropanol 166.81
    water 1.27
    ethyl acetate 249.49
    n-propanol 152.04
    acetone 504.33
    n-butanol 125.63
    acetonitrile 417.75
    DMF 1439.31
    toluene 57.33
    isobutanol 88.45
    1,4-dioxane 408.2
    methyl acetate 377.91
    THF 432.2
    2-butanone 493.7
    n-pentanol 84.61
    sec-butanol 165.41
    n-hexane 1.08
    ethylene glycol 45.99
    NMP 819.31
    cyclohexane 7.88
    DMSO 472.2
    n-butyl acetate 128.73
    n-octanol 51.08
    chloroform 322.16
    n-propyl acetate 131.72
    acetic acid 217.86
    dichloromethane 281.22
    cyclohexanone 719.01
    propylene glycol 128.72
    isopropyl acetate 122.54
    DMAc 805.09
    2-ethoxyethanol 137.68
    isopentanol 82.76
    n-heptane 1.89
    ethyl formate 192.49
    1,2-dichloroethane 227.86
    n-hexanol 78.42
    2-methoxyethanol 309.0
    isobutyl acetate 66.81
    tetrachloromethane 16.96
    n-pentyl acetate 83.8
    transcutol 306.0
    n-heptanol 42.96
    ethylbenzene 31.74
    MIBK 111.47
    2-propoxyethanol 146.98
    tert-butanol 160.54
    MTBE 98.65
    2-butoxyethanol 86.08
    propionic acid 197.19
    o-xylene 43.4
    formic acid 92.48
    diethyl ether 98.55
    m-xylene 37.29
    p-xylene 48.3
    chlorobenzene 152.75
    dimethyl carbonate 104.02
    n-octane 1.83
    formamide 306.73
    cyclopentanone 751.37
    2-pentanone 259.68
    anisole 118.94
    cyclopentyl methyl ether 125.57
    gamma-butyrolactone 641.33
    1-methoxy-2-propanol 241.88
    pyridine 392.0
    3-pentanone 219.91
    furfural 522.54
    n-dodecane 2.87
    diethylene glycol 131.06
    diisopropyl ether 23.27
    tert-amyl alcohol 137.01
    acetylacetone 324.98
    n-hexadecane 3.36
    acetophenone 153.59
    methyl propionate 220.1
    isopentyl acetate 103.5
    trichloroethylene 511.04
    n-nonanol 45.72
    cyclohexanol 141.09
    benzyl alcohol 108.94
    2-ethylhexanol 44.85
    isooctanol 34.44
    dipropyl ether 33.4
    1,2-dichlorobenzene 124.7
    ethyl lactate 73.18
    propylene carbonate 315.46
    n-methylformamide 491.83
    2-pentanol 81.21
    n-pentane 1.7
    1-propoxy-2-propanol 109.0
    1-methoxy-2-propyl acetate 137.81
    2-(2-methoxypropoxy) propanol 105.86
    mesitylene 23.65
    ε-caprolactone 407.13
    p-cymene 24.49
    epichlorohydrin 459.61
    1,1,1-trichloroethane 148.41
    2-aminoethanol 106.42
    morpholine-4-carbaldehyde 579.91
    sulfolane 649.24
    2,2,4-trimethylpentane 2.65
    2-methyltetrahydrofuran 256.43
    n-hexyl acetate 121.31
    isooctane 1.93
    2-(2-butoxyethoxy)ethanol 129.5
    sec-butyl acetate 81.27
    tert-butyl acetate 124.77
    decalin 4.26
    glycerin 137.28
    diglyme 222.84
    acrylic acid 186.44
    isopropyl myristate 47.21
    n-butyric acid 188.57
    acetyl acetate 156.36
    di(2-ethylhexyl) phthalate 52.0
    ethyl propionate 105.52
    nitromethane 730.29
    1,2-diethoxyethane 113.74
    benzonitrile 201.68
    trioctyl phosphate 39.12
    1-bromopropane 73.36
    gamma-valerolactone 813.65
    n-decanol 36.6
    triethyl phosphate 48.91
    4-methyl-2-pentanol 39.21
    propionitrile 242.11
    vinylene carbonate 319.76
    1,1,2-trichlorotrifluoroethane 249.4
    DMS 123.72
    cumene 22.5
    2-octanol 37.34
    2-hexanone 154.37
    octyl acetate 65.22
    limonene 36.58
    1,2-dimethoxyethane 259.89
    ethyl orthosilicate 42.5
    tributyl phosphate 48.3
    diacetone alcohol 170.93
    N,N-dimethylaniline 69.43
    acrylonitrile 393.74
    aniline 127.07
    1,3-propanediol 155.83
    bromobenzene 122.94
    dibromomethane 148.05
    1,1,2,2-tetrachloroethane 359.59
    2-methyl-cyclohexyl acetate 85.35
    tetrabutyl urea 72.17
    diisobutyl methanol 26.9
    2-phenylethanol 103.77
    styrene 47.16
    dioctyl adipate 71.1
    dimethyl sulfate 191.96
    ethyl butyrate 86.19
    methyl lactate 130.88
    butyl lactate 75.07
    diethyl carbonate 65.23
    propanediol butyl ether 105.52
    triethyl orthoformate 57.77
    p-tert-butyltoluene 23.38
    methyl 4-tert-butylbenzoate 103.54
    morpholine 428.58
    tert-butylamine 70.46
    n-dodecanol 28.16
    dimethoxymethane 259.55
    ethylene carbonate 240.1
    cyrene 149.03
    2-ethoxyethyl acetate 127.26
    2-ethylhexyl acetate 80.7
    1,2,4-trichlorobenzene 169.77
    4-methylpyridine 342.13
    dibutyl ether 45.39
    2,6-dimethyl-4-heptanol 26.9
    DEF 318.25
    dimethyl isosorbide 190.85
    tetrachloroethylene 168.51
    eugenol 107.46
    triacetin 130.99
    span 80 93.92
    1,4-butanediol 58.82
    1,1-dichloroethane 210.07
    2-methyl-1-pentanol 70.19
    methyl formate 321.3
    2-methyl-1-butanol 86.69
    n-decane 3.96
    butyronitrile 187.58
    3,7-dimethyl-1-octanol 45.65
    1-chlorooctane 25.63
    1-chlorotetradecane 11.79
    n-nonane 3.15
    undecane 3.39
    tert-butylcyclohexane 3.42
    cyclooctane 1.68
    cyclopentanol 172.82
    tetrahydropyran 283.15
    tert-amyl methyl ether 77.3
    2,5,8-trioxanonane 174.46
    1-hexene 11.28
    2-isopropoxyethanol 92.33
    2,2,2-trifluoroethanol 101.16
    methyl butyrate 162.2

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction