N-Acetyl-L-glutamic acid

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  • Identifiers

    CAS number
    1188-37-0

    Molecular formula
    C7H11NO5

    SMILES
    CC(=O)N[C@@H](CCC(=O)O)C(=O)O

    Safety labels

  • Odor profile

    Fragrance
    Odorless 61.47%
    Savory 39.35%
    Sweet 35.88%
    Meaty 33.11%
    Cooked 23.46%
    Milky 23.0%
    Roasted 21.26%
    Sour 21.23%
    Buttery 19.94%
    Burnt 19.69%

     

    Flavor
    Odorless 72.57%
    Very mild 35.7%
    Mild 34.51%
    Sour 30.85%
    Bland 26.13%
    Yeast 25.36%
    Sweet-like 21.99%
    Nutty 21.97%
    Faint 21.48%
    Caramellic 21.37%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    -1.8

    pKa est.
    6.43 (neutral)

    Molecular weight
    189.17 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    392°C

    Melting point expt.

    • 199 °C
    • 199 - 201 °C

    Flash point

    • 226.39 ˚C est.

    Solubility expt.

    • 52 mg/mL

  • Synonyms

    • N-Acetyl-L-glutamic acid
    • 1188-37-0
    • acetylglutamic acid
    • N-acetyl-L-glutamate
    • Acetyl-L-glutamic acid
    • N-Acetylglutamate
    • Acetyl glutamic acid
    • (2S)-2-acetamidopentanedioic acid
    • Ac-Glu-OH
    • L-N-Acetylglutamic acid
    • L-Glutamic acid, N-acetyl-
    • Glutamic acid, N-acetyl-, L-
    • MFCD00002802
    • Glutamic acid, N-acetyl-
    • N-Ac-Glu-OH
    • MA61H539YZ
    • DTXSID3046534
    • CHEBI:17533
    • (S)-2-acetamidopentanedioic acid
    • (S)-2-(acetylamino)pentanedioic acid
    • NCGC00166080-01
    • NLG
    • DTXCID1026534
    • N-Acetyl-L-glutamicAcid
    • Ac-Glu
    • CAS-1188-37-0
    • Ac-L-Glu-OH
    • EINECS 214-708-4
    • acetylglutamate
    • UNII-MA61H539YZ
    • acetyl-glutamate
    • N-acetyl-l-glu
    • DL-Acetylglutamate
    • N-acetyl-glutamate
    • N-acetyl L-glutamate
    • Glutamic acid, N-acetyl- (6CI,7CI)
    • N-Ac-L-Glu
    • n-acetyl glutamic acid
    • Repaglinide Impurity Q
    • N-Acetyl-DL-glutamate
    • N-acetyl-Glutamic acid
    • Spectrum_000981
    • N-Acetylglutamic acid #
    • Spectrum2_001349
    • Spectrum3_001397
    • Spectrum4_000892
    • Spectrum5_001040
    • N-acetyl L-glutamic acid
    • bmse000382
    • EC 214-708-4
    • N-Acetyl-L-glutamic acid?
    • SCHEMBL82128
    • BSPBio_003014
    • KBioGR_001324
    • KBioSS_001461
    • DivK1c_000406
    • SPECTRUM1500703
    • SPBio_001537
    • 2-acetamido-L-Glutaraldehydate
    • (2S)-2-acetamidoglutaric acid
    • CHEMBL1234751
    • FEMA NO. 4752
    • N-ACETYL-S-GLUTAMIC ACID
    • HMS501E08
    • KBio1_000406
    • KBio2_001461
    • KBio2_004029
    • KBio2_006597
    • KBio3_002234
    • MSK8345
    • NINDS_000406
    • HMS1921E14
    • 2-acetamido-L-Glutaraldehydic acid
    • N-Acetylglutamic gamma-semialdehyde
    • Tox21_112308
    • AC9784
    • BDBM50151383
    • CCG-39287
    • EBC-47262
    • s6245
    • SBB058021
    • AKOS015837749
    • Tox21_112308_1
    • (2S)-2-(acetylamino)pentanedioic acid
    • CS-W015956
    • DB04075
    • FA10860
    • HY-W015240
    • Glutamic acid, N-acetyl-, L- (8CI)
    • IDI1_000406
    • NCGC00094839-04
    • NCGC00166080-02
    • AC-24110
    • AS-12953
    • SY017890
    • DB-038054
    • N-Acetyl-L-glutamic acid-gamma-semialdehyde
    • .ALPHA.-(N-ACETYL)-L-GLUTAMIC ACID
    • A0693
    • NS00068576
    • C00624
    • EN300-881279
    • N-Acetyl-L-glutamic acid, ReagentPlus(R), 99%
    • 188A370
    • F222086
    • Q63390524
    • Z98654650
    • 17A85284-85CE-4442-B1DA-2E5EE18AA75F
    • N-Acetyl-L-glutamic acid, Vetec(TM) reagent grade, 99%
    • InChI=1/C7H11NO5/c1-4(9)8-5(7(12)13)2-3-6(10)11/h5H,2-3H2,1H3,(H,8,9)(H,10,11)(H,12,13)/t5-/m0/s
    • 1188-37-0

  • Applications

    N-Acetyl-L-glutamic acid (CAS 1188-37-0) is primarily used as a protected amino acid building block and chemical intermediate in pharmaceutical synthesis and peptide chemistry, enabling the preparation of N-acetylated amino acid derivatives and serving as a starting material for further functionalization. It is also employed in chemical research and development as a chiral building block for the synthesis of more complex molecules. In industrial manufacturing, it can function as a specialty intermediate for the synthesis of polymers or polymer derivatives. Additionally, it may be used as a substrate or reference compound in enzymology and biochemical studies during early-stage drug discovery, with uses governed by local regulations and formulation constraints.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 8.97
    methanol 29.72
    isopropanol 3.97
    water 61.71
    ethyl acetate 0.76
    n-propanol 4.47
    acetone 4.17
    n-butanol 2.17
    acetonitrile 1.02
    DMF 171.4
    toluene 0.22
    isobutanol 2.52
    1,4-dioxane 2.94
    methyl acetate 1.56
    THF 5.68
    2-butanone 2.58
    n-pentanol 1.34
    sec-butanol 3.22
    n-hexane 0.22
    ethylene glycol 30.79
    NMP 116.36
    cyclohexane 0.11
    DMSO 240.65
    n-butyl acetate 0.77
    n-octanol 0.82
    chloroform 0.25
    n-propyl acetate 0.62
    acetic acid 14.88
    dichloromethane 0.56
    cyclohexanone 3.15
    propylene glycol 21.32
    isopropyl acetate 0.56
    DMAc 98.85
    2-ethoxyethanol 14.25
    isopentanol 2.07
    n-heptane 0.13
    ethyl formate 4.64
    1,2-dichloroethane 0.7
    n-hexanol 1.03
    2-methoxyethanol 40.38
    isobutyl acetate 0.23
    tetrachloromethane 0.23
    n-pentyl acetate 0.57
    transcutol 17.84
    n-heptanol 0.7
    ethylbenzene 0.29
    MIBK 1.16
    2-propoxyethanol 6.48
    tert-butanol 6.62
    MTBE 1.44
    2-butoxyethanol 3.22
    propionic acid 6.71
    o-xylene 0.57
    formic acid 96.88
    diethyl ether 0.77
    m-xylene 0.28
    p-xylene 0.41
    chlorobenzene 0.15
    dimethyl carbonate 3.01
    n-octane 0.05
    formamide 87.35
    cyclopentanone 6.16
    2-pentanone 1.39
    anisole 1.18
    cyclopentyl methyl ether 1.48
    gamma-butyrolactone 10.75
    1-methoxy-2-propanol 15.39
    pyridine 1.73
    3-pentanone 1.43
    furfural 19.41
    n-dodecane 0.03
    diethylene glycol 17.91
    diisopropyl ether 0.29
    tert-amyl alcohol 6.41
    acetylacetone 2.88
    n-hexadecane 0.04
    acetophenone 2.01
    methyl propionate 1.88
    isopentyl acetate 0.84
    trichloroethylene 0.83
    n-nonanol 0.76
    cyclohexanol 1.32
    benzyl alcohol 1.85
    2-ethylhexanol 0.69
    isooctanol 0.59
    dipropyl ether 0.7
    1,2-dichlorobenzene 0.32
    ethyl lactate 2.91
    propylene carbonate 4.89
    n-methylformamide 50.23
    2-pentanol 1.14
    n-pentane 0.13
    1-propoxy-2-propanol 3.8
    1-methoxy-2-propyl acetate 2.16
    2-(2-methoxypropoxy) propanol 8.62
    mesitylene 0.27
    ε-caprolactone 3.81
    p-cymene 0.34
    epichlorohydrin 4.99
    1,1,1-trichloroethane 0.25
    2-aminoethanol 28.88
    morpholine-4-carbaldehyde 49.71
    sulfolane 47.68
    2,2,4-trimethylpentane 0.11
    2-methyltetrahydrofuran 2.17
    n-hexyl acetate 0.96
    isooctane 0.05
    2-(2-butoxyethoxy)ethanol 7.49
    sec-butyl acetate 0.36
    tert-butyl acetate 1.14
    decalin 0.1
    glycerin 60.5
    diglyme 14.34
    acrylic acid 10.95
    isopropyl myristate 0.39
    n-butyric acid 3.35
    acetyl acetate 0.7
    di(2-ethylhexyl) phthalate 1.51
    ethyl propionate 0.87
    nitromethane 21.13
    1,2-diethoxyethane 1.31
    benzonitrile 0.81
    trioctyl phosphate 0.93
    1-bromopropane 0.27
    gamma-valerolactone 17.19
    n-decanol 0.55
    triethyl phosphate 1.53
    4-methyl-2-pentanol 0.78
    propionitrile 0.89
    vinylene carbonate 4.78
    1,1,2-trichlorotrifluoroethane 15.48
    DMS 1.61
    cumene 0.32
    2-octanol 0.47
    2-hexanone 0.92
    octyl acetate 0.58
    limonene 0.45
    1,2-dimethoxyethane 17.91
    ethyl orthosilicate 1.22
    tributyl phosphate 1.18
    diacetone alcohol 5.74
    N,N-dimethylaniline 2.14
    acrylonitrile 1.98
    aniline 0.77
    1,3-propanediol 17.57
    bromobenzene 0.11
    dibromomethane 0.32
    1,1,2,2-tetrachloroethane 0.97
    2-methyl-cyclohexyl acetate 1.12
    tetrabutyl urea 2.66
    diisobutyl methanol 0.57
    2-phenylethanol 1.11
    styrene 0.23
    dioctyl adipate 1.02
    dimethyl sulfate 15.37
    ethyl butyrate 0.89
    methyl lactate 8.12
    butyl lactate 2.3
    diethyl carbonate 0.9
    propanediol butyl ether 7.18
    triethyl orthoformate 1.22
    p-tert-butyltoluene 0.34
    methyl 4-tert-butylbenzoate 3.89
    morpholine 5.26
    tert-butylamine 2.19
    n-dodecanol 0.37
    dimethoxymethane 14.74
    ethylene carbonate 2.59
    cyrene 13.77
    2-ethoxyethyl acetate 1.23
    2-ethylhexyl acetate 0.63
    1,2,4-trichlorobenzene 0.46
    4-methylpyridine 1.81
    dibutyl ether 0.48
    2,6-dimethyl-4-heptanol 0.57
    DEF 7.87
    dimethyl isosorbide 11.36
    tetrachloroethylene 0.93
    eugenol 4.59
    triacetin 2.38
    span 80 4.33
    1,4-butanediol 7.11
    1,1-dichloroethane 0.24
    2-methyl-1-pentanol 1.4
    methyl formate 31.95
    2-methyl-1-butanol 2.38
    n-decane 0.06
    butyronitrile 0.66
    3,7-dimethyl-1-octanol 0.77
    1-chlorooctane 0.16
    1-chlorotetradecane 0.07
    n-nonane 0.06
    undecane 0.04
    tert-butylcyclohexane 0.09
    cyclooctane 0.06
    cyclopentanol 2.59
    tetrahydropyran 0.89
    tert-amyl methyl ether 1.71
    2,5,8-trioxanonane 12.64
    1-hexene 0.36
    2-isopropoxyethanol 4.91
    2,2,2-trifluoroethanol 10.49
    methyl butyrate 1.61

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction