N-Acetyl-L-carnosine

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  • Identifiers

    CAS number
    56353-15-2

    Molecular formula
    C11H16N4O4

    SMILES
    CC(=O)NCCC(=O)N[C@@H](CC1=CN=CN1)C(=O)O

    Safety labels

  • Odor profile

    Fragrance
    Odorless 66.54%
    Savory 44.43%
    Meaty 38.77%
    Cooked 26.68%
    Cooling 23.57%
    Roasted 23.39%
    Milky 18.24%
    Burnt 17.29%
    Fishy 17.28%
    Popcorn 16.04%

     

    Flavor
    Odorless 62.67%
    Bitter 54.45%
    Bland 31.27%
    Mild 30.06%
    Very mild 28.7%
    Sweet-like 22.85%
    Yeast 22.02%
    Nitrile 19.49%
    Bread crust 19.42%
    Roasted peanuts 19.4%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    -1.5

    pKa est.
    6.91 (neutral)

    Molecular weight
    268.27 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra fast

    Boiling point est.
    195°C

    Flash point

    • 304.44 ˚C est.

  • Synonyms

    • N-Acetyl-L-carnosine
    • 56353-15-2
    • N-Acetylcarnosine
    • 0TPN86OQIF
    • ACE CNS
    • (2S)-2-(3-acetamidopropanoylamino)-3-(1h-imidazol-5-yl)propanoic acid
    • CHEBI:67249
    • DTXSID30204897
    • RefChem:162690
    • DTXCID60127388
    • NAC Nutritional Lubricant Eye Drops
    • OcluVet NAC Nutritional Lubricant Eye Drops
    • (2S)-2-((3-(acetylamino)propanoyl)amino)-3-(1H-imidazol-5-yl)propanoic acid;N-acetyl-beta-alanyl-L-histidine
    • 260-123-2
    • N-Acetyl carnosine
    • (S)-2-(3-Acetamidopropanamido)-3-(1H-imidazol-4-yl)propanoic acid
    • L-Histidine, N-acetyl-b-alanyl-
    • N-acetyl-beta-alanyl-L-histidine
    • MFCD04039376
    • (2S)-2-{[3-(acetylamino)propanoyl]amino}-3-(1H-imidazol-5-yl)propanoic acid
    • Can-C
    • UNII-0TPN86OQIF
    • Canc
    • Acety Carnosine
    • EINECS 260-123-2
    • Carnosine Impurity 2
    • N-(N-Acetyl-beta-alanyl)-L-histidine
    • CL 1700
    • ACETYL CARNOSINE
    • Nalpha-(N-Acetyl-beta-alanyl)-L-histidine
    • orb1296756
    • SCHEMBL2513184
    • CHEMBL4303521
    • SCHEMBL27675779
    • N-ACETYLCARNOSINE [WHO-DD]
    • (3-Acetamidopropanoyl)-L-histidine
    • (2S)-2-(3-acetamidopropanamido)-3-(1H-imidazol-4-yl)propanoic acid
    • (S)-2-(3-Acetamidopropanamido)-3-(1H-imidazol-4-yl)propanoicacid
    • AKOS016001331
    • AKOS025402233
    • AC-6754
    • EBC-616975
    • FA17121
    • AS-15852
    • BP-41208
    • DA-70508
    • HY-133026
    • CS-0109492
    • N-(N-ACETYL-.BETA.-ALANYL)HISTIDINE
    • L-HISTIDINE, N-ACETYL-.BETA.-ALANYL-
    • 353A152
    • F041052
    • L-HISTIDINE, N-(N-ACETYL-.BETA.-ALANYL)-
    • Q4673297
    • BRD-K52523550-001-01-5
    • HISTIDINE, N-(N-ACETYL-.BETA.-ALANYL)-, L-
    • (S)-2-(3-Acetylamino-propionylamino)-3-(3H-imidazol-4-yl)-propionic acid
    • (S)-2-(3-Acetylaminopropionylamino)-3-(3H-imidazol-4-yl)propionic acid
    • (2S)-2-{[3-(Acetylamino)propanoyl]amino}-3-(1H-imidazol-5-yl)propanoic acid, AldrichCPR
    • (S)-2-(3-ACETYLAMINO-PROPIONYLAMINO)-3-(3H-IMIDAZOL-4-YL)-PROPIONICACID
    • 56353-15-2

  • Applications

    N-Acetyl-L-carnosine (CAS 56353-15-2) is an acetylated dipeptide derivative of carnosine and is typically considered a chemical intermediate and research reagent. In cosmetics and personal care, it is evaluated as an antioxidant and anti-glycation additive for inclusion in anti-aging formulations. In pharmaceutical development, it may serve as an intermediate or excipient to aid formulation stability of active ingredients. In biomaterials and polymer research, it is used as a peptide-building block for peptide-based polymers and hydrogel systems. It has been investigated for ophthalmic formulations, drawing on the carnosine analog concept for eye-care delivery, though practical use depends on formulation constraints and local regulations.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 1.41
    methanol 6.71
    isopropanol 0.79
    water 25.54
    ethyl acetate 0.2
    n-propanol 1.19
    acetone 0.46
    n-butanol 0.72
    acetonitrile 0.46
    DMF 173.35
    toluene 0.03
    isobutanol 0.66
    1,4-dioxane 1.41
    methyl acetate 0.49
    THF 2.1
    2-butanone 0.7
    n-pentanol 0.54
    sec-butanol 0.94
    n-hexane 0.05
    ethylene glycol 8.09
    NMP 119.97
    cyclohexane 0.03
    DMSO 89.21
    n-butyl acetate 0.22
    n-octanol 0.17
    chloroform 0.18
    n-propyl acetate 0.29
    acetic acid 8.97
    dichloromethane 0.29
    cyclohexanone 1.58
    propylene glycol 8.32
    isopropyl acetate 0.15
    DMAc 131.92
    2-ethoxyethanol 8.15
    isopentanol 0.59
    n-heptane 0.03
    ethyl formate 1.25
    1,2-dichloroethane 0.2
    n-hexanol 0.23
    2-methoxyethanol 22.75
    isobutyl acetate 0.15
    tetrachloromethane 0.06
    n-pentyl acetate 0.16
    transcutol 7.27
    n-heptanol 0.21
    ethylbenzene 0.06
    MIBK 0.23
    2-propoxyethanol 3.51
    tert-butanol 0.85
    MTBE 0.22
    2-butoxyethanol 1.91
    propionic acid 2.8
    o-xylene 0.08
    formic acid 65.93
    diethyl ether 0.19
    m-xylene 0.04
    p-xylene 0.11
    chlorobenzene 0.04
    dimethyl carbonate 1.3
    n-octane 0.01
    formamide 65.62
    cyclopentanone 2.89
    2-pentanone 0.32
    anisole 0.25
    cyclopentyl methyl ether 0.46
    gamma-butyrolactone 5.91
    1-methoxy-2-propanol 7.96
    pyridine 0.98
    3-pentanone 0.45
    furfural 11.98
    n-dodecane 0.01
    diethylene glycol 9.13
    diisopropyl ether 0.05
    tert-amyl alcohol 1.09
    acetylacetone 0.62
    n-hexadecane 0.01
    acetophenone 0.58
    methyl propionate 0.73
    isopentyl acetate 0.27
    trichloroethylene 0.37
    n-nonanol 0.19
    cyclohexanol 0.55
    benzyl alcohol 0.65
    2-ethylhexanol 0.15
    isooctanol 0.17
    dipropyl ether 0.25
    1,2-dichlorobenzene 0.08
    ethyl lactate 1.53
    propylene carbonate 2.29
    n-methylformamide 33.75
    2-pentanol 0.31
    n-pentane 0.02
    1-propoxy-2-propanol 1.85
    1-methoxy-2-propyl acetate 0.76
    2-(2-methoxypropoxy) propanol 3.86
    mesitylene 0.04
    ε-caprolactone 2.2
    p-cymene 0.06
    epichlorohydrin 2.36
    1,1,1-trichloroethane 0.08
    2-aminoethanol 9.96
    morpholine-4-carbaldehyde 51.36
    sulfolane 23.17
    2,2,4-trimethylpentane 0.02
    2-methyltetrahydrofuran 0.71
    n-hexyl acetate 0.22
    isooctane 0.01
    2-(2-butoxyethoxy)ethanol 3.54
    sec-butyl acetate 0.16
    tert-butyl acetate 0.22
    decalin 0.02
    glycerin 35.16
    diglyme 7.3
    acrylic acid 5.77
    isopropyl myristate 0.09
    n-butyric acid 1.51
    acetyl acetate 0.19
    di(2-ethylhexyl) phthalate 0.4
    ethyl propionate 0.36
    nitromethane 14.14
    1,2-diethoxyethane 0.46
    benzonitrile 0.36
    trioctyl phosphate 0.22
    1-bromopropane 0.1
    gamma-valerolactone 15.98
    n-decanol 0.14
    triethyl phosphate 0.64
    4-methyl-2-pentanol 0.19
    propionitrile 0.49
    vinylene carbonate 2.45
    1,1,2-trichlorotrifluoroethane 10.87
    DMS 0.53
    cumene 0.06
    2-octanol 0.13
    2-hexanone 0.39
    octyl acetate 0.13
    limonene 0.07
    1,2-dimethoxyethane 9.68
    ethyl orthosilicate 0.54
    tributyl phosphate 0.35
    diacetone alcohol 1.51
    N,N-dimethylaniline 0.52
    acrylonitrile 1.12
    aniline 0.24
    1,3-propanediol 7.13
    bromobenzene 0.03
    dibromomethane 0.12
    1,1,2,2-tetrachloroethane 0.43
    2-methyl-cyclohexyl acetate 0.36
    tetrabutyl urea 0.86
    diisobutyl methanol 0.12
    2-phenylethanol 0.3
    styrene 0.05
    dioctyl adipate 0.27
    dimethyl sulfate 7.33
    ethyl butyrate 0.33
    methyl lactate 4.68
    butyl lactate 0.96
    diethyl carbonate 0.35
    propanediol butyl ether 3.3
    triethyl orthoformate 0.57
    p-tert-butyltoluene 0.05
    methyl 4-tert-butylbenzoate 1.06
    morpholine 3.8
    tert-butylamine 0.25
    n-dodecanol 0.1
    dimethoxymethane 6.12
    ethylene carbonate 1.46
    cyrene 8.39
    2-ethoxyethyl acetate 0.37
    2-ethylhexyl acetate 0.21
    1,2,4-trichlorobenzene 0.14
    4-methylpyridine 0.65
    dibutyl ether 0.16
    2,6-dimethyl-4-heptanol 0.12
    DEF 4.2
    dimethyl isosorbide 5.07
    tetrachloroethylene 0.3
    eugenol 1.84
    triacetin 0.74
    span 80 1.69
    1,4-butanediol 3.59
    1,1-dichloroethane 0.08
    2-methyl-1-pentanol 0.52
    methyl formate 12.64
    2-methyl-1-butanol 0.77
    n-decane 0.02
    butyronitrile 0.36
    3,7-dimethyl-1-octanol 0.15
    1-chlorooctane 0.04
    1-chlorotetradecane 0.02
    n-nonane 0.01
    undecane 0.01
    tert-butylcyclohexane 0.01
    cyclooctane 0.01
    cyclopentanol 1.09
    tetrahydropyran 0.48
    tert-amyl methyl ether 0.35
    2,5,8-trioxanonane 6.12
    1-hexene 0.13
    2-isopropoxyethanol 2.39
    2,2,2-trifluoroethanol 7.32
    methyl butyrate 0.76

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction