N-[3-(Hexadecyloxy)-2-hydroxypropyl]-N-(2-hydroxyethyl)decanamide

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  • Identifiers

    CAS number
    143378-76-1

    Molecular formula
    C31H63NO4

    SMILES
    CCCCCCCCCCCCCCCCOCC(CN(CCO)C(=O)CCCCCCCCC)O

    Safety labels

  • Odor profile

    Fragrance
    Waxy 47.65%
    Oily 38.12%
    Odorless 33.6%
    Fatty 33.28%
    Fresh 29.66%
    Woody 26.42%
    Fishy 24.1%
    Sweet 23.59%
    Savory 22.84%
    Citrus 22.45%

     

    Flavor
    Bland 37.48%
    Mild 35.57%
    Odorless 31.5%
    Waxy 29.35%
    Fatty 29.28%
    Faint 25.89%
    Oily 22.83%
    Slightly waxy 22.66%
    Bay oil 21.43%
    Delicate 21.38%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    10.1

    pKa est.
    7.67 (neutral)

    Molecular weight
    513.8 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    742°C

    Flash point

    • 253.61 ˚C est.

  • Synonyms

    • 143378-76-1
    • N-[3-(HEXADECYLOXY)-2-HYDROXYPROPYL]-N-(2-HYDROXYETHYL)DECANAMIDE
    • SCHEMBL2423400
    • DTXSID60624084
    • VLFFJRWJENWEBR-UHFFFAOYSA-N
    • 143378-76-1

  • Applications

    N-[3-(Hexadecyloxy)-2-hydroxypropyl]-N-(2-hydroxyethyl)decanamide (CAS 143378-76-1) is an amphiphilic amide that can function as a nonionic surfactant and co-emulsifier in formulations. In practice, it may be used in cosmetics/personal care as an emollient surfactant and conditioning agent; in household cleaning products as a surfactant and wetting agent; in coatings and inks to improve pigment dispersion and substrate wetting; in polymers/plastics processing as a processing aid or lubricant; and in industrial manufacturing as an emulsion stabilizer or surfactant additive, with usage limited by local regulations and formulation constraints.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 14.6
    methanol 31.02
    isopropanol 12.0
    water 1.67
    ethyl acetate 120.1
    n-propanol 23.02
    acetone 74.32
    n-butanol 21.47
    acetonitrile 34.59
    DMF 168.3
    toluene 39.75
    isobutanol 21.84
    1,4-dioxane 102.41
    methyl acetate 88.66
    THF 231.66
    2-butanone 101.08
    n-pentanol 20.83
    sec-butanol 25.56
    n-hexane 6.0
    ethylene glycol 5.05
    NMP 559.86
    cyclohexane 32.4
    DMSO 236.6
    n-butyl acetate 92.69
    n-octanol 34.17
    chloroform 290.71
    n-propyl acetate 118.07
    acetic acid 112.96
    dichloromethane 314.15
    cyclohexanone 327.31
    propylene glycol 9.3
    isopropyl acetate 102.33
    DMAc 436.35
    2-ethoxyethanol 65.3
    isopentanol 27.02
    n-heptane 7.4
    ethyl formate 70.43
    1,2-dichloroethane 196.54
    n-hexanol 17.61
    2-methoxyethanol 66.9
    isobutyl acetate 69.71
    tetrachloromethane 84.72
    n-pentyl acetate 182.66
    transcutol 303.29
    n-heptanol 33.22
    ethylbenzene 27.75
    MIBK 80.41
    2-propoxyethanol 55.37
    tert-butanol 24.38
    MTBE 47.21
    2-butoxyethanol 107.1
    propionic acid 78.42
    o-xylene 46.96
    formic acid 46.16
    diethyl ether 38.48
    m-xylene 32.35
    p-xylene 41.12
    chlorobenzene 78.26
    dimethyl carbonate 66.04
    n-octane 4.63
    formamide 70.1
    cyclopentanone 325.14
    2-pentanone 94.94
    anisole 55.3
    cyclopentyl methyl ether 147.75
    gamma-butyrolactone 387.78
    1-methoxy-2-propanol 64.04
    pyridine 129.86
    3-pentanone 105.41
    furfural 281.68
    n-dodecane 2.64
    diethylene glycol 31.07
    diisopropyl ether 21.74
    tert-amyl alcohol 42.04
    acetylacetone 171.47
    n-hexadecane 3.09
    acetophenone 108.74
    methyl propionate 114.94
    isopentyl acetate 95.96
    trichloroethylene 366.74
    n-nonanol 35.51
    cyclohexanol 70.13
    benzyl alcohol 43.28
    2-ethylhexanol 25.22
    isooctanol 34.66
    dipropyl ether 47.43
    1,2-dichlorobenzene 109.08
    ethyl lactate 66.59
    propylene carbonate 245.16
    n-methylformamide 73.66
    2-pentanol 20.44
    n-pentane 4.8
    1-propoxy-2-propanol 65.38
    1-methoxy-2-propyl acetate 112.24
    2-(2-methoxypropoxy) propanol 86.37
    mesitylene 25.46
    ε-caprolactone 347.39
    p-cymene 26.22
    epichlorohydrin 290.5
    1,1,1-trichloroethane 231.1
    2-aminoethanol 14.6
    morpholine-4-carbaldehyde 290.12
    sulfolane 712.23
    2,2,4-trimethylpentane 7.55
    2-methyltetrahydrofuran 181.55
    n-hexyl acetate 148.41
    isooctane 2.7
    2-(2-butoxyethoxy)ethanol 109.31
    sec-butyl acetate 91.24
    tert-butyl acetate 128.7
    decalin 12.09
    glycerin 23.35
    diglyme 288.34
    acrylic acid 70.52
    isopropyl myristate 39.61
    n-butyric acid 129.97
    acetyl acetate 114.84
    di(2-ethylhexyl) phthalate 47.51
    ethyl propionate 110.35
    nitromethane 227.37
    1,2-diethoxyethane 108.09
    benzonitrile 62.32
    trioctyl phosphate 35.38
    1-bromopropane 77.21
    gamma-valerolactone 459.44
    n-decanol 20.94
    triethyl phosphate 83.19
    4-methyl-2-pentanol 17.15
    propionitrile 35.96
    vinylene carbonate 210.74
    1,1,2-trichlorotrifluoroethane 294.52
    DMS 105.71
    cumene 22.21
    2-octanol 29.73
    2-hexanone 85.28
    octyl acetate 57.53
    limonene 44.42
    1,2-dimethoxyethane 136.01
    ethyl orthosilicate 77.51
    tributyl phosphate 50.18
    diacetone alcohol 121.74
    N,N-dimethylaniline 51.49
    acrylonitrile 48.26
    aniline 45.46
    1,3-propanediol 22.81
    bromobenzene 86.01
    dibromomethane 175.66
    1,1,2,2-tetrachloroethane 348.16
    2-methyl-cyclohexyl acetate 98.57
    tetrabutyl urea 73.64
    diisobutyl methanol 19.19
    2-phenylethanol 36.0
    styrene 31.14
    dioctyl adipate 84.58
    dimethyl sulfate 192.15
    ethyl butyrate 108.92
    methyl lactate 68.16
    butyl lactate 136.35
    diethyl carbonate 72.46
    propanediol butyl ether 79.38
    triethyl orthoformate 101.44
    p-tert-butyltoluene 23.79
    methyl 4-tert-butylbenzoate 140.24
    morpholine 140.46
    tert-butylamine 16.16
    n-dodecanol 13.74
    dimethoxymethane 86.61
    ethylene carbonate 190.17
    cyrene 123.15
    2-ethoxyethyl acetate 216.71
    2-ethylhexyl acetate 85.26
    1,2,4-trichlorobenzene 147.77
    4-methylpyridine 111.78
    dibutyl ether 56.76
    2,6-dimethyl-4-heptanol 19.19
    DEF 185.63
    dimethyl isosorbide 190.02
    tetrachloroethylene 265.28
    eugenol 110.55
    triacetin 220.46
    span 80 79.52
    1,4-butanediol 13.36
    1,1-dichloroethane 136.69
    2-methyl-1-pentanol 28.41
    methyl formate 65.63
    2-methyl-1-butanol 31.66
    n-decane 6.34
    butyronitrile 36.22
    3,7-dimethyl-1-octanol 31.81
    1-chlorooctane 33.28
    1-chlorotetradecane 9.29
    n-nonane 5.95
    undecane 3.78
    tert-butylcyclohexane 8.01
    cyclooctane 9.06
    cyclopentanol 70.67
    tetrahydropyran 139.74
    tert-amyl methyl ether 64.29
    2,5,8-trioxanonane 149.13
    1-hexene 16.12
    2-isopropoxyethanol 54.16
    2,2,2-trifluoroethanol 91.0
    methyl butyrate 155.18

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction