N-(3-Aminopropyl)morpholine

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  • Identifiers

    CAS number
    123-00-2

    Molecular formula
    C7H16N2O

    SMILES
    C1COCCN1CCCN

    Safety labels

    Corrosive
    Corrosive

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Fishy 83.72%
    Cheesy 50.53%
    Ripe 40.4%
    Odorless 36.75%
    Animal 36.5%
    Meaty 25.23%
    Popcorn 22.12%
    Savory 19.59%
    Nutty 19.49%
    Cooked 17.24%

     

    Flavor
    Roasted 35.79%
    Sulfurous 30.52%
    Ammoniacal 27.24%
    Meaty 27.13%
    Fishy 26.22%
    Fatty 26.18%
    Alkaline 24.56%
    Sulfury 23.7%
    Bouillon 22.69%
    Cauliflower 22.37%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    -0.7

    pKa est.
    5.83 (weak acid)

    Molecular weight
    144.21 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Moderate

    Boiling point est.
    225°C

    Flash point

    • 96.27 ˚C est.

  • Synonyms

    • 123-00-2
    • N-(3-Aminopropyl)morpholine
    • 3-Morpholinopropylamine
    • 3-morpholinopropan-1-amine
    • 4-MORPHOLINEPROPANAMINE
    • N-Aminopropylmorpholine
    • 4-(3-Aminopropyl)morpholine
    • 3-(morpholin-4-yl)propan-1-amine
    • 1-Amino-3-morpholinopropane
    • 4-Morpholinepropylamine
    • Morpholine, 4-(3-aminopropyl)-
    • (3-Aminopropyl)morpholine
    • 3-(4-Morpholinyl)-1-propanamine
    • 4-Aminopropylmorpholine
    • Morpholine, N-aminopropyl-
    • Morpholine, 4-aminopropyl-
    • 3-morpholin-4-ylpropan-1-amine
    • 3-Morpholinopropanamine
    • gamma-Morpholinopropylamine
    • Aminopropylmorpholine
    • N-(3-Aminopropyl)morfolin
    • NSC 1081
    • .gamma.-Morpholinopropylamine
    • 3-Morpholin-4-yl-propylamine
    • CHEBI:86554
    • N-(3-Aminopropyl)morfolin [Czech]
    • EINECS 204-590-2
    • 3-(4-Morpholinyl)propylamine
    • N-(3-aminopropyl)-morpholine
    • 4-(3-aminopropyl)-morpholine
    • BRN 0105104
    • DTXSID4041521
    • AI3-52553
    • NSC-1081
    • MFCD00006184
    • 9A09425QD6
    • 1-morpholino-3-aminopropane
    • N-(3-aminopropyl) morpholine
    • CHEMBL158697
    • DTXCID2021521
    • Morpholine, N-(3-aminopropyl)-
    • 4-(.gamma.-Aminopropyl)morpholine
    • 4-27-00-00411 (Beilstein Handbook Reference)
    • 3-(N-MORPHOLINO)-1-AMINOPROPANE
    • 4-[3-Aminopropyl]morpholine
    • 3-aminopropyl morpholine
    • 3-morpholin-4-ylpropylamine
    • UNII-9A09425QD6
    • NSC1081
    • N-(3-Aminopropyl)morpholine (AMP)
    • NAPM
    • 3-aminopropylmorpholine
    • 3-morpholinylpropylamine
    • 3-morpholino-propylamine
    • N-(aminopropyl)morpholine
    • (3-morpholinopropyl)amine
    • 4-(aminopropyl)morpholine
    • bmse000971
    • bmse000981
    • 3-Morpholino-1-propylamine
    • 4-(3Aminopropyl)morpholine
    • N-(3-aminopropyl)morpholin
    • 3-morpholino-propan-1-amine
    • Oprea1_150673
    • SCHEMBL19922
    • WLN: T6N DOTJ A3Z
    • 3-(4-morpholinyl)propanamine
    • 3-morpholin-4-yl propylamine
    • MLS000556422
    • 3-morpholine-4-yl-propylamine
    • 4-(3-aminopropyl) morpholine
    • 3-Morpholinopropylamine, 98%
    • 4-(3-Aninopropyl)-morpholine
    • (3-morpholin-4-ylpropyl)amine
    • 3-(4-morpholinyl)-propanamine
    • 3-(morpholin-4-yl)propylamine
    • N-(gamma-aminopropyl)morpholine
    • 3-Morpholinopropylamine, Liquid
    • 4-(gamma-Aminopropyl)morpholine
    • [3-(4-morpholinyl)propyl]amine
    • 3-(morpholin-4-yl)-propylamine
    • 3-(N-morpholinyl)-1-propylamine
    • 3-(4-morpholinyl)-1-propylamine
    • 3-(4-Morpholinyl)propan-1-amine
    • 3-morpholin-4-yl-propan-1-amine
    • HMS2384K03
    • 3-(4-morpholinyl)-1-aminopropane
    • 3-(4-morpholinyl)-propan-1-amine
    • STR02269
    • Tox21_302076
    • BDBM50607380
    • STK802951
    • 3-(4-Morpholinyl)-1-propanamine #
    • 3-(MORPHOLINO)-N-PROPYLAMINE
    • AKOS000119857
    • 3-AMINO-1-(MORPHOLINO)PROPANE
    • FD10554
    • Morpholine, 4-(3-aminopropyl)-(8CI)
    • NCGC00246332-01
    • NCGC00255491-01
    • CAS-123-00-2
    • FM160673
    • SMR000147739
    • A0409
    • CS-0008472
    • NS00019770
    • EN300-19625
    • Q27159240
    • F2187-2240
    • Z104474506
    • FC1F27D2-1429-41AC-9F03-C277D41006FA
    • 204-590-2

  • Applications

    Chemical name: N-(3-Aminopropyl)morpholine; CAS number: 123-00-2. N-(3-Aminopropyl)morpholine is primarily used as a chemical intermediate and functional building block in organic synthesis. It serves as a precursor for functional amine motifs in the development of specialty polymers and fine chemicals. In polymer and coating applications, the molecule can act as a curing agent or co-curing component for epoxy resins and polyurethane systems, leveraging the primary amine moiety and the tertiary amine in the morpholine ring. The tertiary amine can function as a catalyst in polyurethane formulations, promoting network formation, while the primary amine can engage in epoxy crosslinking or polyurethane chemistry. It is also used as a precursor for surfactants and other specialty chemicals, enabling tailoring of polarity and reactivity in formulated products. In summary, typical use-cases include: organic synthesis intermediate; epoxy/polyurethane curing agent for coatings and adhesives; polymer crosslinking catalyst and reactive site; surfactant and specialty-chemical precursor in coatings, adhesives, and electronics encapsulation.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 157.27
    methanol 477.46
    isopropanol 35.87
    water 437.59
    ethyl acetate 20.52
    n-propanol 105.64
    acetone 14.02
    n-butanol 59.09
    acetonitrile 25.72
    DMF 96.12
    toluene 4.85
    isobutanol 50.87
    1,4-dioxane 41.75
    methyl acetate 21.48
    THF 39.32
    2-butanone 14.26
    n-pentanol 23.25
    sec-butanol 32.28
    n-hexane 0.7
    ethylene glycol 380.53
    NMP 184.77
    cyclohexane 3.03
    DMSO 262.73
    n-butyl acetate 17.45
    n-octanol 8.37
    chloroform 123.28
    n-propyl acetate 9.73
    acetic acid 699.83
    dichloromethane 117.91
    cyclohexanone 51.0
    propylene glycol 208.33
    isopropyl acetate 7.51
    DMAc 68.82
    2-ethoxyethanol 86.01
    isopentanol 27.07
    n-heptane 2.17
    ethyl formate 62.03
    1,2-dichloroethane 44.18
    n-hexanol 30.78
    2-methoxyethanol 248.88
    isobutyl acetate 5.4
    tetrachloromethane 38.42
    n-pentyl acetate 8.47
    transcutol 113.91
    n-heptanol 14.49
    ethylbenzene 2.07
    MIBK 4.31
    2-propoxyethanol 83.48
    tert-butanol 25.78
    MTBE 4.58
    2-butoxyethanol 43.3
    propionic acid 264.54
    o-xylene 6.23
    formic acid 1255.4
    diethyl ether 5.88
    m-xylene 4.63
    p-xylene 3.04
    chlorobenzene 18.44
    dimethyl carbonate 10.76
    n-octane 0.66
    formamide 606.17
    cyclopentanone 61.37
    2-pentanone 8.73
    anisole 6.31
    cyclopentyl methyl ether 17.5
    gamma-butyrolactone 161.24
    1-methoxy-2-propanol 75.95
    pyridine 50.51
    3-pentanone 9.38
    furfural 240.05
    n-dodecane 0.51
    diethylene glycol 169.32
    diisopropyl ether 1.46
    tert-amyl alcohol 24.55
    acetylacetone 14.39
    n-hexadecane 0.54
    acetophenone 12.32
    methyl propionate 23.56
    isopentyl acetate 12.38
    trichloroethylene 112.99
    n-nonanol 7.41
    cyclohexanol 47.56
    benzyl alcohol 25.62
    2-ethylhexanol 13.95
    isooctanol 10.08
    dipropyl ether 7.54
    1,2-dichlorobenzene 24.58
    ethyl lactate 23.3
    propylene carbonate 87.4
    n-methylformamide 203.74
    2-pentanol 13.9
    n-pentane 1.24
    1-propoxy-2-propanol 43.14
    1-methoxy-2-propyl acetate 21.66
    2-(2-methoxypropoxy) propanol 27.77
    mesitylene 3.25
    ε-caprolactone 71.31
    p-cymene 6.08
    epichlorohydrin 84.27
    1,1,1-trichloroethane 30.03
    2-aminoethanol 377.54
    morpholine-4-carbaldehyde 150.15
    sulfolane 249.28
    2,2,4-trimethylpentane 1.08
    2-methyltetrahydrofuran 28.8
    n-hexyl acetate 9.84
    isooctane 0.51
    2-(2-butoxyethoxy)ethanol 42.44
    sec-butyl acetate 4.58
    tert-butyl acetate 6.34
    decalin 1.25
    glycerin 406.34
    diglyme 70.46
    acrylic acid 353.78
    isopropyl myristate 3.46
    n-butyric acid 192.83
    acetyl acetate 24.43
    di(2-ethylhexyl) phthalate 12.15
    ethyl propionate 9.1
    nitromethane 284.16
    1,2-diethoxyethane 11.28
    benzonitrile 26.0
    trioctyl phosphate 7.83
    1-bromopropane 12.33
    gamma-valerolactone 136.49
    n-decanol 5.2
    triethyl phosphate 14.24
    4-methyl-2-pentanol 5.75
    propionitrile 25.11
    vinylene carbonate 100.5
    1,1,2-trichlorotrifluoroethane 287.18
    DMS 14.35
    cumene 2.41
    2-octanol 5.18
    2-hexanone 5.27
    octyl acetate 6.13
    limonene 8.45
    1,2-dimethoxyethane 34.47
    ethyl orthosilicate 12.59
    tributyl phosphate 9.84
    diacetone alcohol 18.08
    N,N-dimethylaniline 6.08
    acrylonitrile 49.65
    aniline 33.62
    1,3-propanediol 252.61
    bromobenzene 13.62
    dibromomethane 57.29
    1,1,2,2-tetrachloroethane 88.52
    2-methyl-cyclohexyl acetate 13.52
    tetrabutyl urea 11.84
    diisobutyl methanol 5.82
    2-phenylethanol 25.77
    styrene 2.89
    dioctyl adipate 9.21
    dimethyl sulfate 37.43
    ethyl butyrate 14.11
    methyl lactate 49.17
    butyl lactate 21.25
    diethyl carbonate 12.38
    propanediol butyl ether 44.12
    triethyl orthoformate 13.4
    p-tert-butyltoluene 5.89
    methyl 4-tert-butylbenzoate 18.91
    morpholine 73.57
    tert-butylamine 12.06
    n-dodecanol 3.87
    dimethoxymethane 22.51
    ethylene carbonate 65.91
    cyrene 49.33
    2-ethoxyethyl acetate 15.19
    2-ethylhexyl acetate 9.89
    1,2,4-trichlorobenzene 34.54
    4-methylpyridine 27.6
    dibutyl ether 4.09
    2,6-dimethyl-4-heptanol 5.82
    DEF 31.57
    dimethyl isosorbide 47.12
    tetrachloroethylene 103.24
    eugenol 26.04
    triacetin 20.3
    span 80 33.17
    1,4-butanediol 86.25
    1,1-dichloroethane 22.02
    2-methyl-1-pentanol 13.38
    methyl formate 112.79
    2-methyl-1-butanol 37.62
    n-decane 0.75
    butyronitrile 21.15
    3,7-dimethyl-1-octanol 7.64
    1-chlorooctane 3.02
    1-chlorotetradecane 1.35
    n-nonane 0.71
    undecane 0.59
    tert-butylcyclohexane 1.04
    cyclooctane 1.21
    cyclopentanol 73.34
    tetrahydropyran 22.33
    tert-amyl methyl ether 5.67
    2,5,8-trioxanonane 52.69
    1-hexene 1.97
    2-isopropoxyethanol 29.18
    2,2,2-trifluoroethanol 325.94
    methyl butyrate 14.45

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction