N-(2-Aminoethyl)piperidine

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  • Identifiers

    CAS number
    27578-60-5

    Molecular formula
    C7H16N2

    SMILES
    C1CCN(CC1)CCN

    Safety labels

    Flammable
    Flammable

    Corrosive
    Corrosive

  • Odor profile

    Fragrance
    Fishy 87.23%
    Cheesy 57.87%
    Ripe 46.12%
    Animal 44.07%
    Odorless 29.36%
    Popcorn 23.82%
    Meaty 21.89%
    Nutty 21.25%
    Roasted 17.82%
    Oily 17.41%

     

    Flavor
    Ammoniacal 30.68%
    Animal 26.5%
    Roasted 26.04%
    Alkaline 25.89%
    Bitter 25.73%
    Fishy 24.75%
    Shrimp 22.66%
    Sulfurous 22.62%
    Bouillon 21.8%
    Odorless 21.38%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    0.4

    pKa est.
    6.89 (neutral)

    Molecular weight
    128.22 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Fast

    Boiling point est.
    195°C

    Flash point

    • 75.61 ˚C est.

  • Synonyms

    • 27578-60-5
    • N-(2-AMINOETHYL)PIPERIDINE
    • 1-(2-Aminoethyl)piperidine
    • 1-Piperidineethanamine
    • 2-(piperidin-1-yl)ethan-1-amine
    • 2-(piperidin-1-yl)ethanamine
    • 2-piperidin-1-ylethanamine
    • 2-Piperidinoethylamine
    • (2-Piperidin-1-ylethyl)amine
    • N-Aminoethylpiperidine
    • EINECS 248-540-8
    • 2-(1-Piperidinyl)ethylamine
    • AI3-11524
    • Piperidine, 1-(2-aminoethyl)-
    • DTXSID30181977
    • NSC 54993
    • 2-(1-Piperidinyl)ethanamine
    • MFCD00006516
    • 2-Piperidin-1-ylethylamine
    • NSC54993
    • 2-aminoethylpiperidine
    • 2-piperidinoethanamine
    • 1-Piperidineethylamine
    • 2-piperidinylethylamine
    • N-(aminoethyl)piperidine
    • 1-(aminoethyl)piperidine
    • N-(aminoethyl)-piperidine
    • 2-piperdin-1-ylethylamine
    • 2-piperidino-1-ethanamine
    • 1-(2-aminoethyl)piperdine
    • 2-(1-Piperidino)ethylamine
    • 2-Piperidine-1-ylethanamine
    • 2-(1-piperidyl) ethylamine
    • SCHEMBL42457
    • 2-Piperidin-1-yl-ethylamine
    • 1-(2-aminoethyl)-piperidine
    • 2-piperidine-1-yl-ethylamine
    • 1-(2-Aminoethyl) piperidine
    • 2-(piperidin-I-yl)ethanamine
    • (2-piperidin-1-yl)ethylamine
    • 2-(piperidin-1-yl)ethylamine
    • 2-piperidin-1-yl-ethyl amine
    • 2-(1-Piperidinyl)ethanamine #
    • CJNRGSHEMCMUOE-UHFFFAOYSA-
    • DTXCID70104468
    • HMS1767C03
    • 1-(2-Aminoethyl)piperidine, 98%
    • ALBB-021056
    • STR03551
    • NSC-54993
    • STK937194
    • AKOS000201110
    • CS-W007776
    • SB12747
    • 2-piperidin-1-ylethanamine dihydrochloride
    • DB-047247
    • A1026
    • NS00028328
    • EN300-21749
    • P10019
    • F2187-2168
    • InChI=1/C7H16N2/c8-4-7-9-5-2-1-3-6-9/h1-8H2
    • 248-540-8

  • Applications

    N-(2-Aminoethyl)piperidine (27578-60-5) is a versatile amine-containing intermediate used across multiple industries. In pharmaceuticals and medicinal chemistry, it is employed as a building block to access piperidine-containing compounds and as a linker for introducing functional groups in drug discovery. In polymers and plastics, it provides a reactive amine site for functionalization and can act as a curing agent or crosslinker in epoxy- or polyurea-based systems after suitable modification. In coatings, inks and adhesives, it can serve as a curing agent or chain extender to enhance adhesion and network formation. In industrial manufacturing, it is used as a starting material for the synthesis of heterocyclic compounds and other specialty chemicals. It may also find use in surface modification or as a precursor to ligands in catalysis, depending on formulation and regulatory constraints.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 334.04
    methanol 587.27
    isopropanol 136.21
    water 38.81
    ethyl acetate 78.58
    n-propanol 263.72
    acetone 73.72
    n-butanol 202.61
    acetonitrile 107.8
    DMF 168.39
    toluene 25.35
    isobutanol 137.15
    1,4-dioxane 173.96
    methyl acetate 76.53
    THF 237.31
    2-butanone 59.56
    n-pentanol 88.35
    sec-butanol 106.79
    n-hexane 3.99
    ethylene glycol 244.43
    NMP 266.69
    cyclohexane 18.11
    DMSO 358.37
    n-butyl acetate 101.68
    n-octanol 31.31
    chloroform 487.83
    n-propyl acetate 43.97
    acetic acid 801.78
    dichloromethane 407.92
    cyclohexanone 171.88
    propylene glycol 204.36
    isopropyl acetate 32.26
    DMAc 93.21
    2-ethoxyethanol 149.77
    isopentanol 94.42
    n-heptane 14.5
    ethyl formate 162.46
    1,2-dichloroethane 143.08
    n-hexanol 143.72
    2-methoxyethanol 352.13
    isobutyl acetate 26.09
    tetrachloromethane 115.45
    n-pentyl acetate 34.96
    transcutol 205.73
    n-heptanol 57.52
    ethylbenzene 8.96
    MIBK 18.57
    2-propoxyethanol 232.77
    tert-butanol 90.87
    MTBE 24.99
    2-butoxyethanol 111.8
    propionic acid 402.24
    o-xylene 20.22
    formic acid 552.45
    diethyl ether 38.88
    m-xylene 16.26
    p-xylene 13.06
    chlorobenzene 85.63
    dimethyl carbonate 25.35
    n-octane 3.87
    formamide 336.78
    cyclopentanone 215.51
    2-pentanone 43.19
    anisole 24.64
    cyclopentyl methyl ether 84.71
    gamma-butyrolactone 408.53
    1-methoxy-2-propanol 160.07
    pyridine 186.94
    3-pentanone 35.93
    furfural 409.62
    n-dodecane 2.8
    diethylene glycol 250.65
    diisopropyl ether 8.37
    tert-amyl alcohol 72.09
    acetylacetone 48.66
    n-hexadecane 2.99
    acetophenone 34.21
    methyl propionate 67.86
    isopentyl acetate 61.85
    trichloroethylene 309.41
    n-nonanol 27.25
    cyclohexanol 143.29
    benzyl alcohol 63.25
    2-ethylhexanol 67.15
    isooctanol 36.98
    dipropyl ether 52.95
    1,2-dichlorobenzene 83.27
    ethyl lactate 49.35
    propylene carbonate 238.09
    n-methylformamide 282.31
    2-pentanol 65.17
    n-pentane 8.14
    1-propoxy-2-propanol 151.35
    1-methoxy-2-propyl acetate 75.79
    2-(2-methoxypropoxy) propanol 49.83
    mesitylene 10.91
    ε-caprolactone 194.57
    p-cymene 21.62
    epichlorohydrin 243.82
    1,1,1-trichloroethane 124.55
    2-aminoethanol 345.86
    morpholine-4-carbaldehyde 226.08
    sulfolane 417.24
    2,2,4-trimethylpentane 4.77
    2-methyltetrahydrofuran 148.42
    n-hexyl acetate 37.37
    isooctane 2.73
    2-(2-butoxyethoxy)ethanol 79.14
    sec-butyl acetate 19.3
    tert-butyl acetate 24.41
    decalin 5.35
    glycerin 303.04
    diglyme 153.51
    acrylic acid 417.05
    isopropyl myristate 13.55
    n-butyric acid 435.3
    acetyl acetate 64.48
    di(2-ethylhexyl) phthalate 29.87
    ethyl propionate 33.36
    nitromethane 435.99
    1,2-diethoxyethane 52.84
    benzonitrile 90.14
    trioctyl phosphate 23.4
    1-bromopropane 70.83
    gamma-valerolactone 293.82
    n-decanol 20.06
    triethyl phosphate 37.71
    4-methyl-2-pentanol 24.2
    propionitrile 110.0
    vinylene carbonate 236.31
    1,1,2-trichlorotrifluoroethane 356.44
    DMS 33.53
    cumene 8.73
    2-octanol 22.33
    2-hexanone 26.99
    octyl acetate 21.74
    limonene 34.19
    1,2-dimethoxyethane 97.77
    ethyl orthosilicate 35.57
    tributyl phosphate 28.16
    diacetone alcohol 48.74
    N,N-dimethylaniline 18.05
    acrylonitrile 162.97
    aniline 101.98
    1,3-propanediol 329.74
    bromobenzene 68.76
    dibromomethane 222.95
    1,1,2,2-tetrachloroethane 246.56
    2-methyl-cyclohexyl acetate 46.59
    tetrabutyl urea 30.8
    diisobutyl methanol 26.46
    2-phenylethanol 79.18
    styrene 13.5
    dioctyl adipate 27.12
    dimethyl sulfate 54.44
    ethyl butyrate 63.99
    methyl lactate 78.08
    butyl lactate 54.36
    diethyl carbonate 42.03
    propanediol butyl ether 81.26
    triethyl orthoformate 52.79
    p-tert-butyltoluene 20.35
    methyl 4-tert-butylbenzoate 42.06
    morpholine 224.35
    tert-butylamine 50.67
    n-dodecanol 15.58
    dimethoxymethane 64.44
    ethylene carbonate 191.1
    cyrene 72.0
    2-ethoxyethyl acetate 47.38
    2-ethylhexyl acetate 50.05
    1,2,4-trichlorobenzene 106.65
    4-methylpyridine 105.54
    dibutyl ether 24.19
    2,6-dimethyl-4-heptanol 26.46
    DEF 83.51
    dimethyl isosorbide 96.53
    tetrachloroethylene 230.06
    eugenol 53.06
    triacetin 46.95
    span 80 70.07
    1,4-butanediol 114.49
    1,1-dichloroethane 116.62
    2-methyl-1-pentanol 48.52
    methyl formate 178.81
    2-methyl-1-butanol 104.41
    n-decane 4.28
    butyronitrile 110.05
    3,7-dimethyl-1-octanol 28.27
    1-chlorooctane 15.96
    1-chlorotetradecane 6.71
    n-nonane 4.21
    undecane 3.29
    tert-butylcyclohexane 4.64
    cyclooctane 5.77
    cyclopentanol 213.21
    tetrahydropyran 136.6
    tert-amyl methyl ether 24.09
    2,5,8-trioxanonane 94.37
    1-hexene 11.88
    2-isopropoxyethanol 72.66
    2,2,2-trifluoroethanol 278.78
    methyl butyrate 52.41

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction