Morpholine

Overview IFRA Request a quote

  • Identifiers

    CAS number
    110-91-8

    Molecular formula
    C4H9NO

    SMILES
    C1COCCN1

    Safety labels

    Flammable
    Flammable

    Corrosive
    Corrosive

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Fishy 57.85%
    Sweet 46.44%
    Animal 40.98%
    Nutty 28.61%
    Musty 25.2%
    Solvent 24.74%
    Cheesy 23.77%
    Oily 21.65%
    Popcorn 21.12%
    Ethereal 20.76%

     

    Flavor
    Roasted 35.44%
    Animal 35.23%
    Bitter 34.56%
    Amine 34.5%
    Ammoniacal 33.93%
    Alkaline 27.69%
    Egg 26.3%
    Vegetable 25.02%
    Cauliflower 24.75%
    Shrimp 24.66%

     

    Odor impact est.
    Low

    Odor threshold

    • Odor Threshold Low: 0.01 [mmHg]. Odor Threshold High: 0.07 [mmHg]. Detection odor threshold from AIHA (mean = 0.011 ppm)
    • Air: 0.01 ppm (v/v)
    • The absolute and recognition threshold odor index of 101 petrochemicals /were tested/ using a trained panel. During a 20 min exposure, 0.036 mg morpholine/cu m was recognized by 50% of the panel and 0.5 mg morpholine/cu m by all of the panel (giving an odor index of 65.9). It was described as an unpleasant fishy smell.

  • Properties

    XLogP3-AA
    -0.9

    pKa est.
    6.12 (neutral)

    Molecular weight
    87.12 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra fast

    Melting point expt.

    • 23.2 °F (NTP, 1992)
    • -4.8 °C
    • MP: 145-147 °C; prisms from alcohol; sparingly soluble in water /Morpholine picrate/
    • Soluble in water, methanol, ethanol, acetone, ethyl acetate, benzene, chloroform; practically insoluble in toluene, xylene, ether, petroleum ether, carbon tetrachloride; MP: 110-111 °C; crystals from ethanol /Morpholine salicylate/
    • -4.9 °C
    • -5 °C
    • 23.2 °F
    • 23 °F

    Boiling point

    • 264 °F at 760 mmHg (NTP, 1992)
    • 128 °C
    • 129 °C
    • 264 °F

    Flash point

    • 33.03 ˚C est.
    • 100 °F (NTP, 1992)
    • 38 °C
    • Anhydrous: 35 °C (closed cup), 38 °C (open cup); 88% solution: 42 °C
    • 35 °C c.c.
    • 98 °F (open cup)
    • (oc) 98 °F

    Solubility expt.

    • Soluble (NTP, 1992)
    • Solluble in organic solvents
    • Immiscible with concn sodium hydroxide soln; miscible with acetone, benzene, ether, castor oil, methanol, ethanol, ethylene glycol, 2-hexanone, linseed oil, turpentine, pine oil; miscible with water with evolution of some heat
    • In water, 1.00X10+6 mg/L /miscible/
    • 1000 mg/mL
    • Solubility in water: miscible
    • Miscible

  • Synonyms

    • MORPHOLINE
    • 110-91-8
    • 1-Oxa-4-azacyclohexane
    • Diethylene oximide
    • Tetrahydro-1,4-oxazine
    • Diethylenimide oxide
    • Diethyleneimide oxide
    • Diethylene imidoxide
    • Drewamine
    • Tetrahydro-2H-1,4-oxazine
    • Tetrahydro-p-oxazine
    • p-Isoxazine, tetrahydro-
    • morpholin
    • Tetrahydro-1,4-isoxazine
    • BASF 238
    • 138048-80-3
    • Caswell No. 584
    • 2H-1,4-Oxazine, tetrahydro-
    • 4H-1,4-Oxazine, tetrahydro-
    • NSC 9376
    • Tetrahydro-p-isoxazine
    • CCRIS 2482
    • HSDB 102
    • EINECS 203-815-1
    • UNII-8B2ZCK305O
    • EPA Pesticide Chemical Code 054701
    • BRN 0102549
    • 8B2ZCK305O
    • DTXSID2025688
    • CHEBI:34856
    • AI3-01231
    • NSC-9376
    • MFCD00005972
    • C4H9NO
    • Tetrahydro-4H-1-4-oxazine
    • DTXCID305688
    • EC 203-815-1
    • 4-27-00-00015 (Beilstein Handbook Reference)
    • MORPHOLINE (IARC)
    • MORPHOLINE [IARC]
    • tetrahydro-14-iso-xazine
    • 1,4-oxazinane
    • CAS-110-91-8
    • MORPHOLINE,REAG
    • MORPHOLINE, PRACT
    • UN2054
    • morphline
    • Morpholine; Molsidomine Imp. E (EP); Molsidomine Impurity E
    • morpho line
    • morpholine-
    • 6LR
    • Morpholine (BASF)
    • 4H-1, tetrahydro-
    • MORPHOLINE [MI]
    • Morpholine [UN2054] [Flammable liquid]
    • MORPHOLINE [FCC]
    • DIEYTHYLENE OXIMIDE
    • MORPHOLINE [HSDB]
    • Morpholine on Rasta Resin
    • WLN: T6M DOTJ
    • NCIMech_000154
    • Tetrahydro-1, 4-isoxazine
    • NCIOpen2_007748
    • Oprea1_317540
    • Tetryhydro-2H-1,4-oxazine
    • Tetrahydro-4H-1,4-Oxazine
    • BIDD:ER0297
    • Morpholine, analytical standard
    • CHEMBL276518
    • NSC9376
    • BCP24054
    • STR00194
    • SYB02456
    • Tox21_202450
    • Tox21_303240
    • STL182843
    • TETRAHYDRO-2H-1, 4-OXAZINE
    • AKOS000118829
    • Morpholine, ACS reagent, >=99.0%
    • Morpholine, ReagentPlus(R), >=99%
    • DB13669
    • NA 2054
    • UN 2054
    • USEPA/OPP Pesticide Code: 054701
    • NCGC00249227-01
    • NCGC00256942-01
    • NCGC00259999-01
    • Morpholine, p.a., ACS reagent, 99.0%
    • DB-030063
    • Morpholine [UN2054] [Flammable liquid]
    • M0465
    • NS00010190
    • EN300-18064
    • Morpholine purified by distillation from glass
    • Morpholine, purified by redistillation, >=99.5%
    • Q410243
    • 1-Oxa-4-azacyclohexane; Tetrahydro-2H-1,4-oxazine
    • 1-Oxa-4-azacyclohexane ; Tetrahydro-2H-1,4-oxazine
    • F2190-0339
    • InChI=1/C4H9NO/c1-3-6-4-2-5-1/h5H,1-4H
    • 203-815-1
    • ScavengePore(TM) phenethyl morpholine, macroporous, 40-70 mesh, extent of labeling: 0.7-1.5 mmol/g loading
    • StratoSpheres(TM) PL-MPH resin, 50-100 mesh, extent of labeling: 3.0-4.0 mmol/g loading, 1 % cross-linked

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 242.56
    methanol 499.09
    isopropanol 87.16
    water 222.81
    ethyl acetate 65.74
    n-propanol 133.9
    acetone 73.06
    n-butanol 91.51
    acetonitrile 145.22
    DMF 300.8
    toluene 10.83
    isobutanol 64.04
    1,4-dioxane 90.44
    methyl acetate 76.22
    THF 128.26
    2-butanone 55.91
    n-pentanol 43.1
    sec-butanol 58.2
    n-hexane 2.85
    ethylene glycol 237.46
    NMP 273.83
    cyclohexane 7.06
    DMSO 335.69
    n-butyl acetate 25.18
    n-octanol 15.13
    chloroform 283.97
    n-propyl acetate 21.0
    acetic acid 700.68
    dichloromethane 253.19
    cyclohexanone 72.65
    propylene glycol 148.59
    isopropyl acetate 19.49
    DMAc 197.73
    2-ethoxyethanol 116.78
    isopentanol 37.85
    n-heptane 5.03
    ethyl formate 96.36
    1,2-dichloroethane 93.76
    n-hexanol 34.47
    2-methoxyethanol 310.96
    isobutyl acetate 9.01
    tetrachloromethane 59.41
    n-pentyl acetate 16.97
    transcutol 163.79
    n-heptanol 20.06
    ethylbenzene 4.23
    MIBK 9.56
    2-propoxyethanol 93.46
    tert-butanol 52.58
    MTBE 14.4
    2-butoxyethanol 57.0
    propionic acid 276.92
    o-xylene 9.49
    formic acid 837.52
    diethyl ether 30.33
    m-xylene 7.21
    p-xylene 6.45
    chlorobenzene 35.71
    dimethyl carbonate 21.85
    n-octane 1.71
    formamide 701.89
    cyclopentanone 120.27
    2-pentanone 30.81
    anisole 13.95
    cyclopentyl methyl ether 39.13
    gamma-butyrolactone 224.49
    1-methoxy-2-propanol 129.05
    pyridine 126.91
    3-pentanone 28.52
    furfural 240.37
    n-dodecane 1.21
    diethylene glycol 136.91
    diisopropyl ether 3.99
    tert-amyl alcohol 40.11
    acetylacetone 31.09
    n-hexadecane 1.24
    acetophenone 21.05
    methyl propionate 62.48
    isopentyl acetate 14.54
    trichloroethylene 211.85
    n-nonanol 13.99
    cyclohexanol 52.12
    benzyl alcohol 38.72
    2-ethylhexanol 16.24
    isooctanol 13.37
    dipropyl ether 18.94
    1,2-dichlorobenzene 33.75
    ethyl lactate 25.16
    propylene carbonate 83.61
    n-methylformamide 358.17
    2-pentanol 29.55
    n-pentane 4.91
    1-propoxy-2-propanol 54.49
    1-methoxy-2-propyl acetate 28.26
    2-(2-methoxypropoxy) propanol 33.97
    mesitylene 4.11
    ε-caprolactone 82.18
    p-cymene 6.16
    epichlorohydrin 144.76
    1,1,1-trichloroethane 64.09
    2-aminoethanol 283.65
    morpholine-4-carbaldehyde 193.63
    sulfolane 222.39
    2,2,4-trimethylpentane 1.78
    2-methyltetrahydrofuran 72.8
    n-hexyl acetate 18.98
    isooctane 0.82
    2-(2-butoxyethoxy)ethanol 55.65
    sec-butyl acetate 9.18
    tert-butyl acetate 11.75
    decalin 1.86
    glycerin 270.3
    diglyme 90.61
    acrylic acid 321.05
    isopropyl myristate 6.07
    n-butyric acid 209.16
    acetyl acetate 44.18
    di(2-ethylhexyl) phthalate 12.9
    ethyl propionate 20.62
    nitromethane 495.6
    1,2-diethoxyethane 26.89
    benzonitrile 43.14
    trioctyl phosphate 8.03
    1-bromopropane 36.74
    gamma-valerolactone 170.9
    n-decanol 9.5
    triethyl phosphate 13.03
    4-methyl-2-pentanol 9.79
    propionitrile 84.1
    vinylene carbonate 91.69
    1,1,2-trichlorotrifluoroethane 269.22
    DMS 19.06
    cumene 3.73
    2-octanol 8.79
    2-hexanone 13.88
    octyl acetate 10.79
    limonene 9.77
    1,2-dimethoxyethane 67.6
    ethyl orthosilicate 11.61
    tributyl phosphate 10.21
    diacetone alcohol 29.58
    N,N-dimethylaniline 12.77
    acrylonitrile 147.25
    aniline 61.72
    1,3-propanediol 219.07
    bromobenzene 24.57
    dibromomethane 130.87
    1,1,2,2-tetrachloroethane 150.47
    2-methyl-cyclohexyl acetate 13.47
    tetrabutyl urea 15.81
    diisobutyl methanol 6.94
    2-phenylethanol 29.74
    styrene 7.43
    dioctyl adipate 12.74
    dimethyl sulfate 47.55
    ethyl butyrate 20.95
    methyl lactate 67.37
    butyl lactate 23.93
    diethyl carbonate 13.49
    propanediol butyl ether 46.4
    triethyl orthoformate 15.46
    p-tert-butyltoluene 5.91
    methyl 4-tert-butylbenzoate 22.76
    morpholine 153.69
    tert-butylamine 28.25
    n-dodecanol 6.97
    dimethoxymethane 68.29
    ethylene carbonate 64.5
    cyrene 42.34
    2-ethoxyethyl acetate 29.34
    2-ethylhexyl acetate 12.29
    1,2,4-trichlorobenzene 42.67
    4-methylpyridine 64.99
    dibutyl ether 10.76
    2,6-dimethyl-4-heptanol 6.94
    DEF 79.95
    dimethyl isosorbide 46.58
    tetrachloroethylene 150.22
    eugenol 32.33
    triacetin 27.07
    span 80 40.15
    1,4-butanediol 84.01
    1,1-dichloroethane 73.23
    2-methyl-1-pentanol 21.9
    methyl formate 170.37
    2-methyl-1-butanol 46.91
    n-decane 1.99
    butyronitrile 65.83
    3,7-dimethyl-1-octanol 11.42
    1-chlorooctane 6.92
    1-chlorotetradecane 2.7
    n-nonane 1.96
    undecane 1.48
    tert-butylcyclohexane 1.52
    cyclooctane 2.29
    cyclopentanol 95.26
    tetrahydropyran 60.18
    tert-amyl methyl ether 13.23
    2,5,8-trioxanonane 64.19
    1-hexene 8.42
    2-isopropoxyethanol 46.36
    2,2,2-trifluoroethanol 332.57
    methyl butyrate 27.92

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction