Monoethanolamine thioglycolate

Overview IFRA Request a quote

  • Identifiers

    CAS number
    126-97-6

    Molecular formula
    C4H11NO3S

    SMILES
    C(CO)N.C(C(=O)O)S

    Safety labels

    Corrosive
    Corrosive

    Acute Toxic
    Acute Toxic

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Fishy 66.03%
    Odorless 50.45%
    Cheesy 28.81%
    Alcoholic 28.17%
    Ripe 28.09%
    Sweet 21.78%
    Oily 19.99%
    Pungent 16.32%
    Solvent 15.97%
    Fermented 14.87%

     

    Flavor
    Odorless 51.97%
    Bitter 33.7%
    Alcoholic 30.53%
    Pungent 28.3%
    Fishy 27.34%
    Very slight 23.31%
    Sweet-like 22.9%
    Sweet 22.26%
    Sulfurous 21.88%
    Cauliflower 20.81%

     

    Odor impact est.
    Low

  • Properties

    pKa est.
    6.43 (neutral)

    Molecular weight
    153.2 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Moderately fast

    Boiling point est.
    168°C

    Flash point

    • 78.16 ˚C est.

  • Synonyms

    • 126-97-6
    • Ethanolamine thioglycolate
    • Monoethanolamine thioglycolate
    • (2-Hydroxyethyl)ammonium mercaptoacetate
    • EINECS 204-815-4
    • EC 204-815-4
    • 263SH5220T
    • DTXSID7059569
    • THIOGLYCOLIC ACID MONOETHANOLAMINE SALT
    • N-(2-HYDROXYETHYL)AMMONIUM THIOGLYCOLATE
    • ETHANOL, 2-AMINO-, MERCAPTOACETATE (SALT)
    • RefChem:819297
    • DTXCID5033880
    • ETHANOLAMINE THIOGLYCOLATE [INCI]
    • 2-aminoethanol;2-sulfanylacetic acid
    • MFCD00050789
    • Ethanolamine thioglycolate (ca. 85% in water)
    • 2-aminoethanol,2-sulfanylacetic acid
    • Ethanolamine Mercaptoacetate
    • UNII-263SH5220T
    • SCHEMBL59544
    • XTJCJAPNPGGFED-UHFFFAOYSA-N
    • AS-75819
    • E0813
    • Sulfanylacetic acid--2-aminoethan-1-ol (1/1)
    • Q27254042
    • Ethanolamine thioglycolate (~85% in water), AldrichCPR
    • 126-97-6

  • Applications

    Monoethanolamine thioglycolate (CAS 126-97-6) is primarily used in cosmetics and personal care as a depilatory reducing agent to break disulfide bonds in keratin and enable hair removal. It is also employed in hair shaping formulations such as perming or relaxing products as a reducing agent to reform hair. Beyond cosmetics, the compound serves as a chemical intermediate for the synthesis of thiol-functional compounds and specialty polymers, allowing the introduction of thiol groups and subsequent crosslinking. Additionally, it can function as a processing aid and pH-adjusting component in formulation development for cosmetics and household cleaning products, with its salt form helping to stabilize systems under certain conditions.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 38.64
    methanol 174.13
    isopropanol 8.94
    water 3295.17
    ethyl acetate 2.58
    n-propanol 19.53
    acetone 5.3
    n-butanol 11.58
    acetonitrile 7.3
    DMF 72.47
    toluene 0.39
    isobutanol 8.84
    1,4-dioxane 4.74
    methyl acetate 3.23
    THF 9.62
    2-butanone 2.94
    n-pentanol 4.94
    sec-butanol 6.18
    n-hexane 0.24
    ethylene glycol 256.18
    NMP 86.68
    cyclohexane 0.52
    DMSO 107.46
    n-butyl acetate 2.89
    n-octanol 1.46
    chloroform 2.92
    n-propyl acetate 1.8
    acetic acid 329.21
    dichloromethane 2.91
    cyclohexanone 7.69
    propylene glycol 102.9
    isopropyl acetate 1.22
    DMAc 35.96
    2-ethoxyethanol 23.53
    isopentanol 5.32
    n-heptane 0.56
    ethyl formate 13.89
    1,2-dichloroethane 1.67
    n-hexanol 5.35
    2-methoxyethanol 81.05
    isobutyl acetate 0.93
    tetrachloromethane 1.87
    n-pentyl acetate 1.72
    transcutol 21.72
    n-heptanol 3.28
    ethylbenzene 0.23
    MIBK 1.0
    2-propoxyethanol 20.96
    tert-butanol 5.35
    MTBE 0.76
    2-butoxyethanol 14.15
    propionic acid 60.26
    o-xylene 0.52
    formic acid 1442.24
    diethyl ether 0.98
    m-xylene 0.41
    p-xylene 0.4
    chlorobenzene 0.89
    dimethyl carbonate 3.47
    n-octane 0.18
    formamide 560.84
    cyclopentanone 13.98
    2-pentanone 2.14
    anisole 0.74
    cyclopentyl methyl ether 3.21
    gamma-butyrolactone 28.51
    1-methoxy-2-propanol 24.97
    pyridine 5.72
    3-pentanone 1.72
    furfural 46.12
    n-dodecane 0.09
    diethylene glycol 63.37
    diisopropyl ether 0.3
    tert-amyl alcohol 4.76
    acetylacetone 3.2
    n-hexadecane 0.09
    acetophenone 1.68
    methyl propionate 3.78
    isopentyl acetate 1.77
    trichloroethylene 3.93
    n-nonanol 1.28
    cyclohexanol 7.6
    benzyl alcohol 3.94
    2-ethylhexanol 2.27
    isooctanol 2.05
    dipropyl ether 1.53
    1,2-dichlorobenzene 1.03
    ethyl lactate 5.87
    propylene carbonate 12.51
    n-methylformamide 109.51
    2-pentanol 3.05
    n-pentane 0.33
    1-propoxy-2-propanol 11.0
    1-methoxy-2-propyl acetate 3.49
    2-(2-methoxypropoxy) propanol 6.41
    mesitylene 0.33
    ε-caprolactone 10.72
    p-cymene 0.56
    epichlorohydrin 7.66
    1,1,1-trichloroethane 0.89
    2-aminoethanol 189.59
    morpholine-4-carbaldehyde 49.0
    sulfolane 58.92
    2,2,4-trimethylpentane 0.18
    2-methyltetrahydrofuran 3.99
    n-hexyl acetate 1.5
    isooctane 0.09
    2-(2-butoxyethoxy)ethanol 10.54
    sec-butyl acetate 0.75
    tert-butyl acetate 1.05
    decalin 0.16
    glycerin 263.76
    diglyme 15.24
    acrylic acid 109.6
    isopropyl myristate 0.46
    n-butyric acid 44.53
    acetyl acetate 3.08
    di(2-ethylhexyl) phthalate 1.87
    ethyl propionate 1.41
    nitromethane 103.34
    1,2-diethoxyethane 1.64
    benzonitrile 2.66
    trioctyl phosphate 1.48
    1-bromopropane 0.63
    gamma-valerolactone 30.74
    n-decanol 0.9
    triethyl phosphate 2.03
    4-methyl-2-pentanol 1.24
    propionitrile 4.31
    vinylene carbonate 14.68
    1,1,2-trichlorotrifluoroethane 55.16
    DMS 1.92
    cumene 0.26
    2-octanol 1.15
    2-hexanone 1.18
    octyl acetate 0.89
    limonene 0.84
    1,2-dimethoxyethane 9.23
    ethyl orthosilicate 1.9
    tributyl phosphate 1.71
    diacetone alcohol 5.04
    N,N-dimethylaniline 1.01
    acrylonitrile 10.34
    aniline 3.66
    1,3-propanediol 110.15
    bromobenzene 0.5
    dibromomethane 1.59
    1,1,2,2-tetrachloroethane 3.02
    2-methyl-cyclohexyl acetate 1.72
    tetrabutyl urea 2.59
    diisobutyl methanol 0.92
    2-phenylethanol 3.19
    styrene 0.32
    dioctyl adipate 1.26
    dimethyl sulfate 10.56
    ethyl butyrate 2.41
    methyl lactate 17.14
    butyl lactate 6.01
    diethyl carbonate 1.58
    propanediol butyl ether 17.16
    triethyl orthoformate 2.33
    p-tert-butyltoluene 0.49
    methyl 4-tert-butylbenzoate 3.19
    morpholine 11.2
    tert-butylamine 2.31
    n-dodecanol 0.67
    dimethoxymethane 7.38
    ethylene carbonate 9.58
    cyrene 13.92
    2-ethoxyethyl acetate 2.43
    2-ethylhexyl acetate 1.41
    1,2,4-trichlorobenzene 1.22
    4-methylpyridine 3.27
    dibutyl ether 0.6
    2,6-dimethyl-4-heptanol 0.92
    DEF 8.93
    dimethyl isosorbide 9.19
    tetrachloroethylene 5.62
    eugenol 6.02
    triacetin 2.83
    span 80 9.43
    1,4-butanediol 38.61
    1,1-dichloroethane 0.83
    2-methyl-1-pentanol 2.85
    methyl formate 51.04
    2-methyl-1-butanol 6.77
    n-decane 0.14
    butyronitrile 4.14
    3,7-dimethyl-1-octanol 0.95
    1-chlorooctane 0.28
    1-chlorotetradecane 0.14
    n-nonane 0.14
    undecane 0.1
    tert-butylcyclohexane 0.13
    cyclooctane 0.22
    cyclopentanol 16.02
    tetrahydropyran 2.55
    tert-amyl methyl ether 0.85
    2,5,8-trioxanonane 11.31
    1-hexene 0.46
    2-isopropoxyethanol 7.64
    2,2,2-trifluoroethanol 172.75
    methyl butyrate 2.96

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction