Monatin

Overview IFRA Request a quote

  • Identifiers

    CAS number
    146142-94-1

    Molecular formula
    C14H16N2O5

    SMILES
    C1=CC=C2C(=C1)C(=CN2)C[C@](C[C@@H](C(=O)O)N)(C(=O)O)O

    Safety labels

  • Odor profile

    Fragrance
    Odorless 68.02%
    Sweet 30.25%
    Savory 29.51%
    Bitter 23.88%
    Milky 23.24%
    Cooked 19.97%
    Balsamic 17.79%
    Fruity 17.59%
    Cooling 16.9%
    Grape 16.39%

     

    Flavor
    Odorless 66.06%
    Bitter 65.3%
    Bland 34.67%
    Mild 30.45%
    Very mild 28.38%
    Sweet-like 24.38%
    Yeast 20.86%
    Nitrile 19.32%
    Orange flower 18.71%
    Heather 18.45%

     

    Odor impact est.
    Odorless

  • Properties

    XLogP3-AA
    -2.2

    pKa est.
    4.68 (weak acid)

    Molecular weight
    292.29 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    550°C

    Flash point

    • 315.03 ˚C est.

  • Synonyms

    • Monatin
    • 146142-94-1
    • (2S,4S)-4-amino-2-hydroxy-2-(1H-indol-3-ylmethyl)pentanedioic acid
    • DTXSID60432020
    • RefChem:159487
    • DTXCID20382850
    • (4S)-4-Hydroxy-4-(1H-indol-3-ylmethyl)-L-glutamic acid
    • Monatin, (2S,4S)-
    • TL342VQ3GR
    • SCHEMBL2700624
    • SCHEMBL29361006
    • (2S,4S)-4-amino-2-hydroxy-2-[(1H-indol-3-yl)methyl]pentanedioic acid
    • AKOS005145817
    • Q754363
    • L-Glutamic acid, 4-hydroxy-4-(1H-indol-3-ylmethyl)-, (4S)-
    • (2S,4S)-2-((1H-Indol-3-yl)methyl)-4-amino-2-hydroxypentanedioic acid
    • (2R,4S)-4-AZANYL-2-(1H-INDOL-3-YLMETHYL)-2-OXIDANYL-PENTANEDIOIC ACID
    • 146142-94-1

  • Applications

    Monatin (CAS 146142-94-1) is a high-intensity sweetener evaluated as a sugar substitute for various industrial formulations. In practice, it is used to sweeten food and beverage formulations and may help reduce caloric content; it is considered for flavor formulations and confectionery products such as candies, chocolates, and baked goods; it can serve as a sweetener in pharmaceuticals and nutraceuticals, including syrups, liquid medications, and chewable dosage forms; the flavor industry may use monatin to tune sweetness in flavor formulations; and its use in cosmetics/personal care or oral care products is possible under appropriate regulatory allowances and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 2.89
    methanol 8.3
    isopropanol 1.6
    water 12.85
    ethyl acetate 1.67
    n-propanol 1.59
    acetone 2.75
    n-butanol 1.29
    acetonitrile 0.76
    DMF 98.04
    toluene 0.09
    isobutanol 0.78
    1,4-dioxane 3.75
    methyl acetate 1.61
    THF 8.51
    2-butanone 2.2
    n-pentanol 0.95
    sec-butanol 1.58
    n-hexane 0.07
    ethylene glycol 37.74
    NMP 71.15
    cyclohexane 0.06
    DMSO 51.87
    n-butyl acetate 0.48
    n-octanol 0.21
    chloroform 0.05
    n-propyl acetate 0.75
    acetic acid 21.53
    dichloromethane 0.08
    cyclohexanone 2.13
    propylene glycol 20.82
    isopropyl acetate 1.02
    DMAc 111.33
    2-ethoxyethanol 30.2
    isopentanol 0.98
    n-heptane 0.1
    ethyl formate 1.64
    1,2-dichloroethane 0.12
    n-hexanol 0.77
    2-methoxyethanol 79.64
    isobutyl acetate 0.19
    tetrachloromethane 0.04
    n-pentyl acetate 0.4
    transcutol 12.29
    n-heptanol 0.68
    ethylbenzene 0.11
    MIBK 0.93
    2-propoxyethanol 12.02
    tert-butanol 1.69
    MTBE 0.64
    2-butoxyethanol 5.38
    propionic acid 3.86
    o-xylene 0.15
    formic acid 146.43
    diethyl ether 1.0
    m-xylene 0.11
    p-xylene 0.16
    chlorobenzene 0.04
    dimethyl carbonate 5.82
    n-octane 0.06
    formamide 150.69
    cyclopentanone 6.0
    2-pentanone 2.09
    anisole 0.62
    cyclopentyl methyl ether 2.18
    gamma-butyrolactone 9.95
    1-methoxy-2-propanol 40.28
    pyridine 1.32
    3-pentanone 1.63
    furfural 9.86
    n-dodecane 0.03
    diethylene glycol 41.88
    diisopropyl ether 0.27
    tert-amyl alcohol 2.03
    acetylacetone 5.11
    n-hexadecane 0.03
    acetophenone 1.04
    methyl propionate 3.64
    isopentyl acetate 0.38
    trichloroethylene 0.22
    n-nonanol 0.3
    cyclohexanol 1.3
    benzyl alcohol 1.08
    2-ethylhexanol 0.38
    isooctanol 0.48
    dipropyl ether 1.1
    1,2-dichlorobenzene 0.06
    ethyl lactate 3.32
    propylene carbonate 2.59
    n-methylformamide 28.61
    2-pentanol 1.07
    n-pentane 0.05
    1-propoxy-2-propanol 5.02
    1-methoxy-2-propyl acetate 2.49
    2-(2-methoxypropoxy) propanol 5.47
    mesitylene 0.09
    ε-caprolactone 3.15
    p-cymene 0.09
    epichlorohydrin 3.15
    1,1,1-trichloroethane 0.04
    2-aminoethanol 26.41
    morpholine-4-carbaldehyde 62.16
    sulfolane 24.29
    2,2,4-trimethylpentane 0.03
    2-methyltetrahydrofuran 2.63
    n-hexyl acetate 0.32
    isooctane 0.01
    2-(2-butoxyethoxy)ethanol 7.56
    sec-butyl acetate 0.5
    tert-butyl acetate 1.2
    decalin 0.03
    glycerin 127.67
    diglyme 15.25
    acrylic acid 7.25
    isopropyl myristate 0.19
    n-butyric acid 3.59
    acetyl acetate 0.81
    di(2-ethylhexyl) phthalate 0.38
    ethyl propionate 1.24
    nitromethane 29.82
    1,2-diethoxyethane 1.28
    benzonitrile 0.26
    trioctyl phosphate 0.29
    1-bromopropane 0.06
    gamma-valerolactone 22.61
    n-decanol 0.26
    triethyl phosphate 0.72
    4-methyl-2-pentanol 0.56
    propionitrile 0.42
    vinylene carbonate 1.56
    1,1,2-trichlorotrifluoroethane 12.69
    DMS 0.92
    cumene 0.1
    2-octanol 0.35
    2-hexanone 0.87
    octyl acetate 0.29
    limonene 0.14
    1,2-dimethoxyethane 17.78
    ethyl orthosilicate 0.71
    tributyl phosphate 0.28
    diacetone alcohol 7.6
    N,N-dimethylaniline 0.84
    acrylonitrile 0.89
    aniline 0.6
    1,3-propanediol 22.93
    bromobenzene 0.02
    dibromomethane 0.04
    1,1,2,2-tetrachloroethane 0.26
    2-methyl-cyclohexyl acetate 0.44
    tetrabutyl urea 0.85
    diisobutyl methanol 0.28
    2-phenylethanol 0.71
    styrene 0.1
    dioctyl adipate 0.35
    dimethyl sulfate 12.1
    ethyl butyrate 0.79
    methyl lactate 17.06
    butyl lactate 1.38
    diethyl carbonate 0.52
    propanediol butyl ether 4.41
    triethyl orthoformate 1.02
    p-tert-butyltoluene 0.09
    methyl 4-tert-butylbenzoate 1.71
    morpholine 7.87
    tert-butylamine 0.43
    n-dodecanol 0.23
    dimethoxymethane 30.13
    ethylene carbonate 1.21
    cyrene 13.31
    2-ethoxyethyl acetate 1.28
    2-ethylhexyl acetate 0.28
    1,2,4-trichlorobenzene 0.1
    4-methylpyridine 0.83
    dibutyl ether 0.29
    2,6-dimethyl-4-heptanol 0.28
    DEF 9.79
    dimethyl isosorbide 6.48
    tetrachloroethylene 0.29
    eugenol 2.98
    triacetin 1.32
    span 80 3.22
    1,4-butanediol 8.29
    1,1-dichloroethane 0.05
    2-methyl-1-pentanol 0.77
    methyl formate 15.14
    2-methyl-1-butanol 1.14
    n-decane 0.04
    butyronitrile 0.38
    3,7-dimethyl-1-octanol 0.17
    1-chlorooctane 0.06
    1-chlorotetradecane 0.04
    n-nonane 0.04
    undecane 0.03
    tert-butylcyclohexane 0.02
    cyclooctane 0.04
    cyclopentanol 2.34
    tetrahydropyran 1.23
    tert-amyl methyl ether 1.1
    2,5,8-trioxanonane 12.67
    1-hexene 0.17
    2-isopropoxyethanol 8.96
    2,2,2-trifluoroethanol 12.74
    methyl butyrate 1.83

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction