Minoxidil

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  • Identifiers

    CAS number
    38304-91-5

    Molecular formula
    C9H15N5O

    SMILES
    C1CCN(CC1)C2=NC(=N)N(C(=C2)N)O

  • Odor profile

    Fragrance
    Odorless 58.18%
    Roasted 25.72%
    Animal 23.51%
    Burnt 22.72%
    Nutty 21.28%
    Meaty 20.6%
    Fishy 20.48%
    Popcorn 19.72%
    Bitter 19.58%
    Savory 18.69%

     

    Flavor
    Bitter 80.79%
    Odorless 28.16%
    Roasted 22.87%
    Cereal 20.4%
    Alkaline 20.3%
    Bread crust 20.13%
    Very strong 19.9%
    Cedarleaf 19.89%
    Nitrile 19.84%
    Sweet-like 19.75%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    1.2

    pKa est.
    6.57 (neutral)

    Molecular weight
    209.25 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    740°C

    Flash point

    • 224.21 ˚C est.

    Solubility expt.

    • >31.4 [ug/mL] (The mean of the results at pH 7.4)

  • Synonyms

    • minoxidil
    • 38304-91-5
    • Rogaine
    • Loniten
    • Minoximen
    • Regaine
    • Theroxidil
    • Alopexil
    • Alostil
    • Tricoxidil
    • Lonolox
    • Normoxidil
    • Prexidil
    • Minodyl
    • Pierminox
    • RiUP
    • Mintop
    • 2,4-Pyrimidinediamine, 6-(1-piperidinyl)-, 3-oxide
    • 6-(1-Piperidinyl)-2,4-pyrimidinediamine 3-oxide
    • U-10858
    • 3-hydroxy-2-imino-6-piperidin-1-ylpyrimidin-4-amine
    • MFCD00063409
    • CHEBI:6942
    • 6-(piperidin-1-yl)pyrimidine-2,4-diamine 3-oxide
    • U-10,858
    • 6-Amino-1,2-dihydro-1-hydroxy-2-imino-4-piperidinopyrimidine
    • NSC-757106
    • 6-(1-piperidinyl)-2,4-pyrimidinediamine-3-oxide
    • MLS000028566
    • DTXSID9040685
    • 6-amino-2-imino-4-(piperidin-1-yl)-1,2-dihydropyrimidin-1-ol
    • 6-(1-Piperidinyl)pyrimidine-2,4-diamine 3-oxide
    • Minossidile [Italian]
    • Minoxidilum [INN-Latin]
    • NCGC00015673-08
    • Minoxidilum
    • SMR000058963
    • CAS-38304-91-5
    • Rogaine for Men
    • Apo-Gain
    • 6-Piperidin-1-ylpyrimidine-2,4-diamine 3-oxide
    • 2,6-diamino-4-(piperidin-1-yl)pyrimidin-1-ium-1-olate
    • DTXCID7020685
    • Neoxidil
    • Avacor and Mintop
    • SMR000326812
    • Loniten (TN)
    • Rogaine (TN)
    • Riup (TN)
    • 2,4-Diamino-6-piperidinopyrimidine 3-oxide
    • SR-01000075331
    • SR-05000001479
    • Regaine For Men
    • Regaine For Women
    • Prestwick_521
    • 3-hydroxy-2-imino-6-(1-piperidyl)pyrimidin-4-amine
    • TM-160
    • Men''''s Rogaine
    • Women''''s rogaine
    • Rogaine Extra Strength
    • Spectrum_000969
    • Tocris-0583
    • MINOXIDIL [INN]
    • MINOXIDIL [JAN]
    • MINOXIDIL [MI]
    • Minoxidil Extra Strength
    • MINOXIDIL [HSDB]
    • MINOXIDIL [USAN]
    • regid855572
    • Opera_ID_1150
    • Prestwick0_000020
    • Prestwick1_000020
    • Prestwick2_000020
    • Prestwick3_000020
    • Spectrum2_001053
    • Spectrum3_000509
    • Spectrum4_000063
    • Spectrum5_001299
    • Lopac-M-4145
    • MINOXIDIL [VANDF]
    • M1389
    • CHEMBL802
    • MINOXIDIL [MART.]
    • M 4145
    • MINOXIDIL [USP-RS]
    • MINOXIDIL [WHO-DD]
    • Minoxidil (U-10858)
    • Minoxidil (JAN/USP/INN)
    • CBiol_001798
    • Lopac0_000786
    • SCHEMBL29698
    • BSPBio_000059
    • BSPBio_001385
    • BSPBio_002037
    • KBioGR_000105
    • KBioGR_000585
    • KBioSS_000105
    • KBioSS_001449
    • MLS000859953
    • MLS001077294
    • DivK1c_000160
    • SCHEMBL232565
    • SPECTRUM1500415
    • Minoxidil - Bio-X trade mark
    • SPBio_001006
    • SPBio_001980
    • BPBio1_000065
    • CHEMBL609587
    • GTPL4254
    • Minoxidil, >=99% (TLC)
    • SGCUT00112
    • MINOXIDIL [ORANGE BOOK]
    • CHEMBL1372483
    • MINOXIDIL [EP MONOGRAPH]
    • BCBcMAP01_000193
    • BDBM81463
    • CHEBI:92128
    • HMS500H22
    • KBio1_000160
    • KBio2_000105
    • KBio2_001449
    • KBio2_002673
    • KBio2_004017
    • KBio2_005241
    • KBio2_006585
    • KBio3_000209
    • KBio3_000210
    • KBio3_001537

  • Applications

    Minoxidil (CAS 38304-91-5) is a chemical commonly used across pharmaceutical and cosmetic applications, serving as an active pharmaceutical ingredient in drug formulations and as a topical component in hair-care cosmetic products. In pharmaceutical development, it is employed as an active compound; in cosmetics/personal care, it is formulated into topical hair-care products. In chemical synthesis, Minoxidil can be used as a building block or precursor for the preparation of related pharmaceutical and bioactive derivatives, and it is often involved in research and development activities in medicinal chemistry and organic synthesis. Its use is subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 23.86
    methanol 51.22
    isopropanol 12.07
    water 2.73
    ethyl acetate 8.12
    n-propanol 20.87
    acetone 13.54
    n-butanol 16.66
    acetonitrile 6.71
    DMF 77.06
    toluene 1.8
    isobutanol 12.15
    1,4-dioxane 9.62
    methyl acetate 7.97
    THF 40.24
    2-butanone 12.12
    n-pentanol 7.85
    sec-butanol 9.33
    n-hexane 0.07
    ethylene glycol 70.21
    NMP 135.75
    cyclohexane 0.23
    DMSO 350.4
    n-butyl acetate 7.38
    n-octanol 0.76
    chloroform 15.68
    n-propyl acetate 4.57
    acetic acid 156.85
    dichloromethane 22.68
    cyclohexanone 28.33
    propylene glycol 118.8
    isopropyl acetate 4.49
    DMAc 88.26
    2-ethoxyethanol 36.18
    isopentanol 11.03
    n-heptane 0.13
    ethyl formate 26.86
    1,2-dichloroethane 15.5
    n-hexanol 6.3
    2-methoxyethanol 120.35
    isobutyl acetate 2.87
    tetrachloromethane 3.33
    n-pentyl acetate 3.15
    transcutol 39.01
    n-heptanol 2.44
    ethylbenzene 0.75
    MIBK 4.43
    2-propoxyethanol 33.01
    tert-butanol 9.91
    MTBE 1.61
    2-butoxyethanol 14.88
    propionic acid 54.1
    o-xylene 1.73
    formic acid 222.33
    diethyl ether 1.35
    m-xylene 1.75
    p-xylene 1.34
    chlorobenzene 5.32
    dimethyl carbonate 11.58
    n-octane 0.05
    formamide 212.38
    cyclopentanone 62.71
    2-pentanone 7.73
    anisole 2.53
    cyclopentyl methyl ether 6.39
    gamma-butyrolactone 113.4
    1-methoxy-2-propanol 56.87
    pyridine 22.34
    3-pentanone 4.93
    furfural 136.96
    n-dodecane 0.04
    diethylene glycol 72.28
    diisopropyl ether 0.49
    tert-amyl alcohol 8.53
    acetylacetone 17.18
    n-hexadecane 0.04
    acetophenone 7.25
    methyl propionate 11.32
    isopentyl acetate 7.18
    trichloroethylene 36.64
    n-nonanol 0.87
    cyclohexanol 9.53
    benzyl alcohol 12.84
    2-ethylhexanol 2.94
    isooctanol 2.2
    dipropyl ether 1.29
    1,2-dichlorobenzene 6.22
    ethyl lactate 14.26
    propylene carbonate 58.73
    n-methylformamide 87.09
    2-pentanol 4.69
    n-pentane 0.12
    1-propoxy-2-propanol 16.42
    1-methoxy-2-propyl acetate 14.11
    2-(2-methoxypropoxy) propanol 12.97
    mesitylene 1.18
    ε-caprolactone 31.15
    p-cymene 1.46
    epichlorohydrin 72.69
    1,1,1-trichloroethane 7.05
    2-aminoethanol 81.65
    morpholine-4-carbaldehyde 66.47
    sulfolane 224.03
    2,2,4-trimethylpentane 0.13
    2-methyltetrahydrofuran 14.7
    n-hexyl acetate 2.45
    isooctane 0.08
    2-(2-butoxyethoxy)ethanol 17.16
    sec-butyl acetate 2.52
    tert-butyl acetate 5.03
    decalin 0.14
    glycerin 207.75
    diglyme 26.69
    acrylic acid 84.17
    isopropyl myristate 0.94
    n-butyric acid 58.4
    acetyl acetate 9.63
    di(2-ethylhexyl) phthalate 5.47
    ethyl propionate 3.96
    nitromethane 119.33
    1,2-diethoxyethane 2.88
    benzonitrile 11.19
    trioctyl phosphate 3.29
    1-bromopropane 2.95
    gamma-valerolactone 101.95
    n-decanol 0.71
    triethyl phosphate 5.76
    4-methyl-2-pentanol 2.88
    propionitrile 6.48
    vinylene carbonate 46.82
    1,1,2-trichlorotrifluoroethane 162.87
    DMS 7.51
    cumene 0.77
    2-octanol 0.88
    2-hexanone 3.7
    octyl acetate 1.62
    limonene 1.66
    1,2-dimethoxyethane 18.93
    ethyl orthosilicate 4.45
    tributyl phosphate 3.91
    diacetone alcohol 20.43
    N,N-dimethylaniline 2.32
    acrylonitrile 16.79
    aniline 10.3
    1,3-propanediol 85.22
    bromobenzene 3.82
    dibromomethane 9.37
    1,1,2,2-tetrachloroethane 30.63
    2-methyl-cyclohexyl acetate 5.75
    tetrabutyl urea 4.84
    diisobutyl methanol 1.77
    2-phenylethanol 10.79
    styrene 0.9
    dioctyl adipate 3.25
    dimethyl sulfate 46.98
    ethyl butyrate 5.23
    methyl lactate 43.24
    butyl lactate 10.67
    diethyl carbonate 5.45
    propanediol butyl ether 16.74
    triethyl orthoformate 4.64
    p-tert-butyltoluene 1.36
    methyl 4-tert-butylbenzoate 8.99
    morpholine 22.49
    tert-butylamine 2.61
    n-dodecanol 0.57
    dimethoxymethane 19.12
    ethylene carbonate 34.1
    cyrene 34.98
    2-ethoxyethyl acetate 7.32
    2-ethylhexyl acetate 4.87
    1,2,4-trichlorobenzene 10.83
    4-methylpyridine 12.26
    dibutyl ether 0.48
    2,6-dimethyl-4-heptanol 1.77
    DEF 15.53
    dimethyl isosorbide 27.54
    tetrachloroethylene 20.98
    eugenol 12.59
    triacetin 6.93
    span 80 12.57
    1,4-butanediol 30.68
    1,1-dichloroethane 6.64
    2-methyl-1-pentanol 6.64
    methyl formate 61.68
    2-methyl-1-butanol 10.65
    n-decane 0.05
    butyronitrile 7.82
    3,7-dimethyl-1-octanol 1.34
    1-chlorooctane 0.24
    1-chlorotetradecane 0.15
    n-nonane 0.04
    undecane 0.04
    tert-butylcyclohexane 0.12
    cyclooctane 0.09
    cyclopentanol 22.36
    tetrahydropyran 6.39
    tert-amyl methyl ether 1.74
    2,5,8-trioxanonane 21.93
    1-hexene 0.35
    2-isopropoxyethanol 15.06
    2,2,2-trifluoroethanol 81.18
    methyl butyrate 7.67

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction