Minocycline hydrochloride

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  • Identifiers

    CAS number
    13614-98-7

    Molecular formula
    C23H28ClN3O7

    SMILES
    CN(C)[C@H]1[C@@H]2C[C@@H]3CC4=C(C=CC(=C4C(=C3C(=O)[C@@]2(C(=C(C1=O)C(=O)N)O)O)O)O)N(C)C.Cl

    Safety labels

  • Odor profile

    Fragrance
    Odorless 72.54%
    Cooling 24.47%
    Sweet 24.07%
    Savory 23.38%
    Bitter 19.79%
    Milky 18.33%
    Burnt 16.95%
    Mint 15.14%
    Spicy 13.94%
    Dry 12.85%

     

    Flavor
    Bitter 89.82%
    Odorless 33.45%
    Bland 25.54%
    Sweet-like 20.6%
    Cedarleaf 19.93%
    Nitrile 18.75%
    Lovage 18.68%
    Parsley 18.17%
    Very mild 18.06%
    Basil 18.03%

     

    Odor impact est.
    Odorless

  • Properties

    pKa est.
    6.72 (neutral)

    Molecular weight
    493.9 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    2112°C

    Flash point

    • 289.37 ˚C est.

  • Synonyms

    • MINOCYCLINE HYDROCHLORIDE
    • 13614-98-7
    • Minocycline HCl
    • Arestin
    • Minomycin
    • Minocin
    • Solodyn
    • Dynacin
    • Periocline
    • Ximino
    • Vectrin
    • (4S,4aS,5aR,12aS)-4,7-bis(dimethylamino)-3,10,12,12a-tetrahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide hydrochloride
    • Minocycline (hydrochloride)
    • Minomax
    • [4S-(4alpha,4aalpha,5aalpha,12aalpha)]-4,7-Bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxonaphthacene-2-carboxamide monohydrochloride
    • MFCD00083669
    • Mynocine hydrochloride
    • Minocycline (as hydrochloride)
    • (4S,4aS,5aR,12aR)-4,7-bis(dimethylamino)-1,10,11,12a-tetrahydroxy-3,12-dioxo-4a,5,5a,6-tetrahydro-4H-tetracene-2-carboxamide;hydrochloride
    • DTXSID8044545
    • NSC 141993
    • 4,7-Bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-2-naphthacenecarboxamide monohydrochloride
    • 0020414E5U
    • Tri-mino
    • NSC-141993
    • C23H28ClN3O7
    • DTXCID6024545
    • Acnez
    • Minocycline, Hydrochloride
    • Minomycin chloride
    • (4S-(4alpha,4aalpha,5aalpha,12aalpha))-4,7-Bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxonaphthacene-2-carboxamide monohydrochloride
    • EINECS 237-099-7
    • Minocycline hydrochloride (internal use)
    • Lederderm
    • Mynocine
    • UNII-0020414E5U
    • NCGC00096006-01
    • Prestwick_626
    • Arestin (TN)
    • Dynacin (TN)
    • Minocin (TN)
    • Solodyn (TN)
    • Minocycline hydrochloride [USP:JAN]
    • 7-Dimethylamino-6-demethyl-6-deoxytetracycline, HCl
    • Minocyclinhydrochlorid
    • AMZEEQ
    • EMROSI
    • MINOLIRA
    • ZILXI
    • minomycin hydrochloride
    • 2-Naphthacenecarboxamide, 4,7-bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-, hydrochloride (1:2), (4S,4aS,5aR,12aS)-
    • SCHEMBL2537
    • CAS-13614-98-7
    • Minocycline Hydrochloride RS
    • Minocycline hydrochloride CRS
    • 2-Naphthacenecarboxamide, 4,7-bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-, monohydrochloride, (4S-(4alpha,4aalpha,5aalpha,12aalpha))-
    • MLS002548863
    • SPECTRUM1500414
    • FXFM-244
    • orb1309771
    • CHEMBL1200881
    • CHEMBL4576719
    • SCHEMBL27275823
    • MSK4104
    • HMS1568P12
    • Pharmakon1600-01500414
    • [4S-(4alpha,4aalpha,5aalpha,12aalpha)]-4,7-Bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxonaphthacene-2-carboxamide monohydrochloride;[4S-(4alpha,4aalpha,5aalpha,12aalpha)]-4,7-Bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxonaphthacene-2-carboxamide monohydrochloride
    • Tox21_111250
    • Tox21_113183
    • Tox21_301590
    • CCG-40107
    • EBC-99036
    • HB4617
    • HY-17412R
    • NSC757120
    • s4226
    • MINOCYCLINE HYDROCHLORIDE [MI]
    • Minocycline hydrochloride, crystalline
    • AKOS015951312
    • Minocycline for system suitability CRS
    • Minocycline hydrochloride (JP18/USP)
    • Tox21_111250_1
    • AM11587
    • CS-1256
    • Minocycline (hydrochloride) (Standard)
    • MINOCYCLINE HYDROCHLORIDE [JAN]
    • NC00460
    • NSC-757120
    • MINOCYCLINE HYDROCHLORIDE [MART.]
    • MINOCYCLINE HYDROCHLORIDE [VANDF]
    • NCGC00178854-03
    • NCGC00255988-01
    • 2-Naphthacenecarboxamide, 4,7-bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-, monohydrochloride
    • AC-22362
    • AK183886
    • AS-75306
    • DA-75552
    • HY-17412
    • MINOCYCLINE HYDROCHLORIDE [USP-RS]
    • MINOCYCLINE HYDROCHLORIDE [WHO-DD]
    • PD003090
    • SMR001906766
    • SY007836
    • M2288
    • NS00076430
    • D00850
    • MINOCYCLINE HYDROCHLORIDE [ORANGE BOOK]
    • SBI-0051449.0002
    • MINOCYCLINE HYDROCHLORIDE [USP MONOGRAPH]
    • 614M987
    • SR-01000075625
    • SR-01000075625-1
    • Q27104777
    • Minocycline hydrochloride, European Pharmacopoeia (EP) Reference Standard
    • Minocycline Hydrochloride, Pharmaceutical Secondary Standard; Certified Reference Material
    • Minocycline hydrochloride, United States Pharmacopeia (USP) Reference Standard
    • (4S,12aS,4aS,5aR)-4,7-bis(dimethylamino)-3,10,12,12a-tetrahydroxy-1,11-dioxo-4,5,6,12a,4a,5a-hexahydronaphthacene-2-carboxamide Hydrochloride
    • (4S,4aS,5aR,12aR)-4,7-bis(dimethylamino)-1,10,11,12a-tetrahydroxy-3,12-dioxo-4a,5,5a,6-tetrahydro-4H-tetracene-2-carboxamide hydrochloride
    • (4S,4aS,5aR,12aS)-4,7-Bis(dimethylamino)-3,10,12,12a-tetrahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide--hydrogen chloride (1/1)
    • (4S,4aS,5aR,12aS)-4,7-bis(dimethylamino)-3,10,12,12a-tetrahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamidehydrochloride
    • 2-NAPHTHACENECARBOXAMIDE, 4,7-BIS(DIMETHYLAMINO)-1,4,4A,5,5A,6,11,12A-OCTAHYDRO-3,10,12,12A-TETRAHYDROXY-1,11-DIOXO-, MONOHYDROCHLORIDE, (4S-(4.ALPHA.,4A.ALPHA.,5A.ALPHA.,12A.ALPHA.))-
    • 13614-98-7

  • Applications

    Minocycline hydrochloride (CAS 13614-98-7) is primarily used as an active pharmaceutical ingredient in antibiotic drug products, developed in oral and topical dosage forms where permitted by regulatory jurisdictions. It is also evaluated in pharmaceutical R&D as a lead compound for analytical method development and SAR studies. In laboratories, it often serves as a reference standard for analytical methods such as HPLC/LC-MS and UV spectroscopy and for quality control in manufacturing. Additionally, it may be investigated for veterinary applications in approved systems and shows potential in formulation development and dosage-form research related to antibiotics, subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 0.77
    methanol 2.01
    isopropanol 0.23
    water 0.08
    ethyl acetate 0.39
    n-propanol 0.57
    acetone 0.59
    n-butanol 0.27
    acetonitrile 0.63
    DMF 5.38
    toluene 0.2
    isobutanol 0.2
    1,4-dioxane 2.27
    methyl acetate 0.6
    THF 2.94
    2-butanone 0.69
    n-pentanol 0.43
    sec-butanol 0.16
    n-hexane 0.04
    ethylene glycol 2.32
    NMP 12.81
    cyclohexane 0.03
    DMSO 8.41
    n-butyl acetate 0.24
    n-octanol 0.06
    chloroform 0.64
    n-propyl acetate 0.44
    acetic acid 3.54
    dichloromethane 0.85
    cyclohexanone 1.23
    propylene glycol 1.02
    isopropyl acetate 0.15
    DMAc 5.9
    2-ethoxyethanol 2.93
    isopentanol 0.14
    n-heptane 0.02
    ethyl formate 0.67
    1,2-dichloroethane 0.59
    n-hexanol 0.26
    2-methoxyethanol 5.0
    isobutyl acetate 0.18
    tetrachloromethane 0.14
    n-pentyl acetate 0.19
    transcutol 1.0
    n-heptanol 0.16
    ethylbenzene 0.14
    MIBK 0.16
    2-propoxyethanol 2.57
    tert-butanol 0.12
    MTBE 0.05
    2-butoxyethanol 1.09
    propionic acid 0.98
    o-xylene 0.11
    formic acid 11.42
    diethyl ether 0.25
    m-xylene 0.12
    p-xylene 0.18
    chlorobenzene 0.17
    dimethyl carbonate 0.92
    n-octane 0.01
    formamide 8.54
    cyclopentanone 2.43
    2-pentanone 0.38
    anisole 0.23
    cyclopentyl methyl ether 0.49
    gamma-butyrolactone 4.04
    1-methoxy-2-propanol 1.72
    pyridine 2.07
    3-pentanone 0.43
    furfural 4.2
    n-dodecane 0.0
    diethylene glycol 5.05
    diisopropyl ether 0.03
    tert-amyl alcohol 0.1
    acetylacetone 0.58
    n-hexadecane 0.0
    acetophenone 0.51
    methyl propionate 0.83
    isopentyl acetate 0.15
    trichloroethylene 1.23
    n-nonanol 0.07
    cyclohexanol 0.22
    benzyl alcohol 0.6
    2-ethylhexanol 0.1
    isooctanol 0.09
    dipropyl ether 0.21
    1,2-dichlorobenzene 0.18
    ethyl lactate 0.64
    propylene carbonate 1.0
    n-methylformamide 4.22
    2-pentanol 0.09
    n-pentane 0.02
    1-propoxy-2-propanol 0.8
    1-methoxy-2-propyl acetate 0.52
    2-(2-methoxypropoxy) propanol 0.46
    mesitylene 0.05
    ε-caprolactone 1.23
    p-cymene 0.05
    epichlorohydrin 3.11
    1,1,1-trichloroethane 0.17
    2-aminoethanol 1.96
    morpholine-4-carbaldehyde 8.1
    sulfolane 8.17
    2,2,4-trimethylpentane 0.0
    2-methyltetrahydrofuran 0.72
    n-hexyl acetate 0.12
    isooctane 0.0
    2-(2-butoxyethoxy)ethanol 0.7
    sec-butyl acetate 0.15
    tert-butyl acetate 0.11
    decalin 0.02
    glycerin 4.87
    diglyme 1.44
    acrylic acid 2.04
    isopropyl myristate 0.04
    n-butyric acid 0.6
    acetyl acetate 0.28
    di(2-ethylhexyl) phthalate 0.15
    ethyl propionate 0.36
    nitromethane 4.89
    1,2-diethoxyethane 0.27
    benzonitrile 0.43
    trioctyl phosphate 0.1
    1-bromopropane 0.21
    gamma-valerolactone 6.73
    n-decanol 0.05
    triethyl phosphate 0.19
    4-methyl-2-pentanol 0.05
    propionitrile 0.5
    vinylene carbonate 1.27
    1,1,2-trichlorotrifluoroethane 6.67
    DMS 0.36
    cumene 0.07
    2-octanol 0.06
    2-hexanone 0.52
    octyl acetate 0.07
    limonene 0.06
    1,2-dimethoxyethane 2.79
    ethyl orthosilicate 0.16
    tributyl phosphate 0.09
    diacetone alcohol 0.45
    N,N-dimethylaniline 0.22
    acrylonitrile 1.2
    aniline 0.39
    1,3-propanediol 1.66
    bromobenzene 0.13
    dibromomethane 0.45
    1,1,2,2-tetrachloroethane 0.82
    2-methyl-cyclohexyl acetate 0.24
    tetrabutyl urea 0.2
    diisobutyl methanol 0.04
    2-phenylethanol 0.49
    styrene 0.12
    dioctyl adipate 0.11
    dimethyl sulfate 2.12
    ethyl butyrate 0.23
    methyl lactate 1.43
    butyl lactate 0.35
    diethyl carbonate 0.18
    propanediol butyl ether 0.7
    triethyl orthoformate 0.21
    p-tert-butyltoluene 0.04
    methyl 4-tert-butylbenzoate 0.33
    morpholine 2.8
    tert-butylamine 0.04
    n-dodecanol 0.03
    dimethoxymethane 2.52
    ethylene carbonate 0.86
    cyrene 3.01
    2-ethoxyethyl acetate 0.45
    2-ethylhexyl acetate 0.14
    1,2,4-trichlorobenzene 0.3
    4-methylpyridine 0.81
    dibutyl ether 0.05
    2,6-dimethyl-4-heptanol 0.04
    DEF 0.99
    dimethyl isosorbide 1.41
    tetrachloroethylene 0.88
    eugenol 0.57
    triacetin 0.28
    span 80 0.45
    1,4-butanediol 1.07
    1,1-dichloroethane 0.2
    2-methyl-1-pentanol 0.2
    methyl formate 3.07
    2-methyl-1-butanol 0.16
    n-decane 0.01
    butyronitrile 0.3
    3,7-dimethyl-1-octanol 0.03
    1-chlorooctane 0.02
    1-chlorotetradecane 0.01
    n-nonane 0.01
    undecane 0.01
    tert-butylcyclohexane 0.01
    cyclooctane 0.01
    cyclopentanol 0.5
    tetrahydropyran 0.62
    tert-amyl methyl ether 0.07
    2,5,8-trioxanonane 0.95
    1-hexene 0.14
    2-isopropoxyethanol 1.07
    2,2,2-trifluoroethanol 2.5
    methyl butyrate 0.5

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction