Miconazole Nitrate

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  • Identifiers

    CAS number
    22832-87-7

    Molecular formula
    C18H15Cl4N3O4

    SMILES
    C1=CC(=C(C=C1Cl)Cl)COC(CN2C=CN=C2)C3=C(C=C(C=C3)Cl)Cl.[N+](=O)(O)[O-]

    Safety labels

    Irritant
    Irritant

    Environmental Hazard
    Environmental

  • Odor profile

    Fragrance
    Floral 43.84%
    Fruity 38.38%
    Grape 31.5%
    Sweet 30.94%
    Animal 30.72%
    Odorless 29.29%
    Neroli 25.88%
    Powdery 23.46%
    Musk 22.17%
    Fatty 21.31%

     

    Flavor
    Bitter 79.05%
    Odorless 34.61%
    Mild 22.56%
    Bland 22.06%
    Sweet-like 20.2%
    Very strong 19.54%
    Nitrile 19.5%
    Indole 19.35%
    Scallion 19.02%
    Orange flower 18.86%

     

    Odor impact est.
    Low

  • Properties

    pKa est.
    4.81 (weak acid)

    Molecular weight
    479.1 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    569°C

    Flash point

    • 214.49 ˚C est.

    Solubility expt.

    • 26.3 [ug/mL] (The mean of the results at pH 7.4)

  • Synonyms

    • Miconazole nitrate
    • 22832-87-7
    • Dermonistat
    • Micatin
    • Monistat-Derm
    • Miconazole 7
    • M-zole 7 Dual Pack
    • Monistat 3
    • Monistat 5
    • Monistat 7
    • Priconazole
    • M-zole 3 Combination Pack
    • Miconazole 1
    • Miconazole 3
    • Monistat Dual-pak
    • Monistat 3 Combination Pack
    • Monistat 7 Combination Pack
    • Monistat-3 Combination Pack
    • Baza cream antifungal
    • Baza cream
    • Miconazoli nitras
    • VW4H1CYW1K
    • Miconazole Nitrate Combination Pack
    • Monistat 1 Combination Pack
    • Miconazole 3 Combination Pack
    • Miconazole 7 Combination Pack
    • NSC-169434
    • Monistat 3 combination pack (prefilled)
    • 1H-Imidazole, 1-(2-(2,4-dichlorophenyl)-2-((2,4-dichlorophenyl)methoxy)ethyl)-, mononitrate
    • R-14889
    • NSC169434
    • 1-[2-(2,4-dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]imidazole;nitric acid
    • EASOTIC COMPONENT MICONAZOLE NITRATE
    • Antifungal Cream
    • Miconazol Nitrate
    • Micaonazole
    • Acorvio
    • Conazol
    • Femeron
    • Femmesil
    • Lagicam
    • Miconole
    • Miconosol
    • Conzol
    • Freds
    • BioTris
    • Daktarin aktiv
    • Anti-fungal
    • Antifungal Body
    • Baza Antifungal
    • Femmesil Creme
    • Green Tetterine
    • White Tetterine
    • BioTris Flush
    • Davis Miconazole
    • Dermachange Jock
    • Foot Powder
    • Leader Medicated
    • Macerrx Web
    • Miconazorb AF
    • Selan Antifungal
    • Jock Itch
    • Micotrin AP
    • Antifungal Powder
    • Jock Itch Spray
    • Miconasil Nitrate
    • Mycozyl AP
    • Remedy Antifungal
    • Secura Antifungal
    • Triple Antifungal
    • Zeasorb AF
    • Vagistat-3
    • 1-(2-(2,4-dichlorophenyl)-2-((2,4-dichlorophenyl)methoxy)ethyl)imidazole;nitric acid
    • Kendall Antifungal
    • Lagicam Antifungal
    • Nail Md
    • 7 Day Vaginal
    • Miconazole 3 Day
    • Zeasorb Jock Itch
    • Lotrimin Antifungal
    • Nitrate, Miconasil
    • Anti-Fungal Powder
    • DB Antifungal foot
    • Micro-guard (af)
    • Nitrate, Miconazole
    • Athletes Foot Spray
    • Freds Miconazole 3
    • Fungal Nail Renewal
    • Rugby Miconazole 3
    • Silka Athletes Foot
    • Topco Miconazole 3
    • Conofite Cream 2%
    • Antifungal Miconazole
    • careone miconazole 1
    • Equate Miconazole 1
    • Equate Miconazole 3
    • HERS Miconazole 3
    • Leader Miconazole 3
    • Meijer Miconazole 3
    • PiYanPing Antifungal
    • topcare miconazole 3
    • Athletes Foot Liquid
    • Conofite Lotion 1%
    • DERMAFUNGAL
    • Dg Health Miconazole
    • Careone miconazole 7
    • Monistat 3 3 Day
    • Careone Miconazole 3
    • Goodnow Miconazole 1
    • Remedy with Phytoplex
    • Sunmark Miconazole 3
    • Sunmark Miconazole 7
    • Topcare Miconazole 1
    • Topcare Miconazole 7
    • Aloe Vesta Antifungal
    • Basic Care Miconazole
    • Bengama-MICONAZOLE
    • Critic Aid Clear AF
    • Thera Antifungal Body
    • Up and Up Miconazole
    • vagisil brand vagistat
    • Zeasorb Athletes Foot
    • BOA VIDA Antifungal
    • Conzol 1 %
    • Lotrimin AF Deodorant
    • Charmpoo ANTIFUNCAL
    • Charmpoo ANTIFUNGAL
    • 22832-87-7

  • Applications

    Miconazole Nitrate is primarily used as a topical antifungal active pharmaceutical ingredient in human and veterinary dermatology. It is commonly formulated into creams, gels, lotions, powders and solutions to treat dermatophytic infections and candidiasis in humans, and to address fungal skin infections in animals. It is used in compounding and hospital formulary preparations as a standard topical antifungal agent. It is also frequently evaluated in formulation development and research on transdermal delivery and dermatology products.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 19.34
    methanol 11.03
    isopropanol 16.81
    water 0.01
    ethyl acetate 49.29
    n-propanol 27.16
    acetone 38.6
    n-butanol 29.31
    acetonitrile 22.52
    DMF 24.16
    toluene 49.08
    isobutanol 21.78
    1,4-dioxane 70.73
    methyl acetate 44.21
    THF 200.41
    2-butanone 65.83
    n-pentanol 37.05
    sec-butanol 31.47
    n-hexane 0.9
    ethylene glycol 3.59
    NMP 25.76
    cyclohexane 2.29
    DMSO 34.57
    n-butyl acetate 41.07
    n-octanol 22.28
    chloroform 494.88
    n-propyl acetate 48.25
    acetic acid 30.37
    dichloromethane 364.21
    cyclohexanone 77.97
    propylene glycol 10.77
    isopropyl acetate 34.55
    DMAc 95.77
    2-ethoxyethanol 76.56
    isopentanol 27.66
    n-heptane 3.47
    ethyl formate 31.91
    1,2-dichloroethane 90.66
    n-hexanol 26.65
    2-methoxyethanol 53.48
    isobutyl acetate 35.32
    tetrachloromethane 18.38
    n-pentyl acetate 46.1
    transcutol 198.16
    n-heptanol 23.33
    ethylbenzene 24.38
    MIBK 36.22
    2-propoxyethanol 64.04
    tert-butanol 16.29
    MTBE 27.23
    2-butoxyethanol 54.29
    propionic acid 20.2
    o-xylene 22.25
    formic acid 9.9
    diethyl ether 21.43
    m-xylene 23.3
    p-xylene 28.39
    chlorobenzene 60.32
    dimethyl carbonate 23.79
    n-octane 1.73
    formamide 17.57
    cyclopentanone 73.01
    2-pentanone 47.37
    anisole 63.3
    cyclopentyl methyl ether 48.88
    gamma-butyrolactone 62.78
    1-methoxy-2-propanol 50.03
    pyridine 115.38
    3-pentanone 39.38
    furfural 81.73
    n-dodecane 2.01
    diethylene glycol 31.62
    diisopropyl ether 7.6
    tert-amyl alcohol 26.39
    acetylacetone 56.61
    n-hexadecane 2.34
    acetophenone 60.7
    methyl propionate 37.48
    isopentyl acetate 41.68
    trichloroethylene 313.89
    n-nonanol 23.97
    cyclohexanol 33.54
    benzyl alcohol 57.63
    2-ethylhexanol 24.43
    isooctanol 21.57
    dipropyl ether 34.01
    1,2-dichlorobenzene 53.44
    ethyl lactate 31.06
    propylene carbonate 48.91
    n-methylformamide 16.19
    2-pentanol 21.29
    n-pentane 0.97
    1-propoxy-2-propanol 56.91
    1-methoxy-2-propyl acetate 63.15
    2-(2-methoxypropoxy) propanol 66.23
    mesitylene 11.26
    ε-caprolactone 73.27
    p-cymene 17.81
    epichlorohydrin 152.34
    1,1,1-trichloroethane 89.57
    2-aminoethanol 10.65
    morpholine-4-carbaldehyde 54.99
    sulfolane 46.04
    2,2,4-trimethylpentane 1.78
    2-methyltetrahydrofuran 82.54
    n-hexyl acetate 43.93
    isooctane 0.91
    2-(2-butoxyethoxy)ethanol 76.84
    sec-butyl acetate 36.93
    tert-butyl acetate 35.94
    decalin 2.32
    glycerin 14.52
    diglyme 145.64
    acrylic acid 20.14
    isopropyl myristate 21.57
    n-butyric acid 39.08
    acetyl acetate 37.46
    di(2-ethylhexyl) phthalate 27.75
    ethyl propionate 40.48
    nitromethane 50.09
    1,2-diethoxyethane 84.45
    benzonitrile 58.56
    trioctyl phosphate 16.6
    1-bromopropane 55.46
    gamma-valerolactone 103.95
    n-decanol 17.31
    triethyl phosphate 28.08
    4-methyl-2-pentanol 15.24
    propionitrile 28.29
    vinylene carbonate 53.99
    1,1,2-trichlorotrifluoroethane 117.78
    DMS 36.59
    cumene 14.79
    2-octanol 19.74
    2-hexanone 55.65
    octyl acetate 26.44
    limonene 23.78
    1,2-dimethoxyethane 109.69
    ethyl orthosilicate 29.35
    tributyl phosphate 20.3
    diacetone alcohol 40.82
    N,N-dimethylaniline 39.29
    acrylonitrile 36.07
    aniline 48.37
    1,3-propanediol 20.34
    bromobenzene 68.67
    dibromomethane 183.08
    1,1,2,2-tetrachloroethane 205.26
    2-methyl-cyclohexyl acetate 42.78
    tetrabutyl urea 31.97
    diisobutyl methanol 15.95
    2-phenylethanol 48.98
    styrene 29.85
    dioctyl adipate 37.45
    dimethyl sulfate 29.48
    ethyl butyrate 46.87
    methyl lactate 26.64
    butyl lactate 42.65
    diethyl carbonate 34.35
    propanediol butyl ether 49.33
    triethyl orthoformate 43.93
    p-tert-butyltoluene 15.54
    methyl 4-tert-butylbenzoate 55.69
    morpholine 89.03
    tert-butylamine 9.09
    n-dodecanol 12.66
    dimethoxymethane 50.83
    ethylene carbonate 41.84
    cyrene 71.45
    2-ethoxyethyl acetate 73.01
    2-ethylhexyl acetate 34.73
    1,2,4-trichlorobenzene 72.34
    4-methylpyridine 77.43
    dibutyl ether 33.48
    2,6-dimethyl-4-heptanol 15.95
    DEF 39.91
    dimethyl isosorbide 108.83
    tetrachloroethylene 111.31
    eugenol 60.28
    triacetin 59.48
    span 80 51.8
    1,4-butanediol 14.62
    1,1-dichloroethane 101.4
    2-methyl-1-pentanol 38.74
    methyl formate 17.78
    2-methyl-1-butanol 30.79
    n-decane 3.43
    butyronitrile 36.3
    3,7-dimethyl-1-octanol 24.44
    1-chlorooctane 16.99
    1-chlorotetradecane 6.58
    n-nonane 2.68
    undecane 2.56
    tert-butylcyclohexane 2.34
    cyclooctane 1.01
    cyclopentanol 31.12
    tetrahydropyran 87.45
    tert-amyl methyl ether 32.29
    2,5,8-trioxanonane 104.14
    1-hexene 9.07
    2-isopropoxyethanol 55.61
    2,2,2-trifluoroethanol 15.83
    methyl butyrate 48.92

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction